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Protein

Sodium channel subunit beta-2

Gene

Scn2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel subunit beta-2
Gene namesi
Name:Scn2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3633. Scn2b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 159130ExtracellularSequence analysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence analysisAdd
BLAST
Topological domaini181 – 21535CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • voltage-gated sodium channel complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 29291 PublicationAdd
BLAST
Chaini30 – 215186Sodium channel subunit beta-2PRO_0000014932Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi50 ↔ 127PROSITE-ProRule annotation
Disulfide bondi55 – 55Interchain; with alpha subunitPROSITE-ProRule annotation
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Modified residuei192 – 1921PhosphoserineCombined sources
Modified residuei204 – 2041PhosphothreonineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP54900.
PRIDEiP54900.

PTM databases

iPTMnetiP54900.
PhosphoSiteiP54900.

Expressioni

Tissue specificityi

Brain specific.

Developmental stagei

Detected in the earliest phase of neurogenesis in brain, and expression is greatly increased concomitant with axon extension and synaptogenesis.

Gene expression databases

GenevisibleiP54900. RN.

Interactioni

Subunit structurei

The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Interacts with SCN10A and TNR.2 Publications

Protein-protein interaction databases

BioGridi247388. 1 interaction.
STRINGi10116.ENSRNOP00000021819.

Structurei

3D structure databases

ProteinModelPortaliP54900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 154123Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II8M. Eukaryota.
ENOG4111M25. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000118120.
HOVERGENiHBG003443.
InParanoidiP54900.
KOiK04846.
OMAiHGKIYLQ.
OrthoDBiEOG7NSB42.
PhylomeDBiP54900.
TreeFamiTF331728.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029873. SCN2B.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF3. PTHR13869:SF3. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRDAWLPRP AFSLTGLSLF FSLVPSGRSM EVTVPTTLSV LNGSDTRLPC
60 70 80 90 100
TFNSCYTVNH KQFSLNWTYQ ECSNCSEEMF LQFRMKIINL KLERFGDRVE
110 120 130 140 150
FSGNPSKYDV SVTLKNVQLE DEGIYNCYIT NPPDRHRGHG KIYLQVLLEV
160 170 180 190 200
PPERDSTVAV IVGASVGGFL AVVILVLMVV KCVRRKKEQK LSTDDLKTEE
210
EGKTDGEGNA EDGAK
Length:215
Mass (Da):24,145
Last modified:October 1, 1996 - v1
Checksum:i23D432EA83C1459D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti80 – 801F → V.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37026 mRNA. Translation: AAC52967.1.
PIRiA57843.
RefSeqiNP_037009.1. NM_012877.1.
UniGeneiRn.88636.

Genome annotation databases

EnsembliENSRNOT00000021819; ENSRNOP00000021819; ENSRNOG00000016221.
GeneIDi25349.
KEGGirno:25349.
UCSCiRGD:3633. rat.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37026 mRNA. Translation: AAC52967.1.
PIRiA57843.
RefSeqiNP_037009.1. NM_012877.1.
UniGeneiRn.88636.

3D structure databases

ProteinModelPortaliP54900.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247388. 1 interaction.
STRINGi10116.ENSRNOP00000021819.

PTM databases

iPTMnetiP54900.
PhosphoSiteiP54900.

Proteomic databases

PaxDbiP54900.
PRIDEiP54900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021819; ENSRNOP00000021819; ENSRNOG00000016221.
GeneIDi25349.
KEGGirno:25349.
UCSCiRGD:3633. rat.

Organism-specific databases

CTDi6327.
RGDi3633. Scn2b.

Phylogenomic databases

eggNOGiENOG410II8M. Eukaryota.
ENOG4111M25. LUCA.
GeneTreeiENSGT00640000091161.
HOGENOMiHOG000118120.
HOVERGENiHBG003443.
InParanoidiP54900.
KOiK04846.
OMAiHGKIYLQ.
OrthoDBiEOG7NSB42.
PhylomeDBiP54900.
TreeFamiTF331728.

Miscellaneous databases

PROiP54900.

Gene expression databases

GenevisibleiP54900. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000920. Myelin_P0-rel.
IPR029873. SCN2B.
[Graphical view]
PANTHERiPTHR13869. PTHR13869. 1 hit.
PTHR13869:SF3. PTHR13869:SF3. 1 hit.
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR00213. MYELINP0.
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif."
    Isom L.L., Ragsdale D.S., de Jongh K.S., Westenbroek R.E., Reber B.F.X., Scheuer T., Catterall W.A.
    Cell 83:433-442(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-58; 95-134 AND 142-151.
  2. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 29-61; 99-135 AND 191-197, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  3. "Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R."
    Srinivasan J., Schachner M., Catterall W.A.
    Proc. Natl. Acad. Sci. U.S.A. 95:15753-15757(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH TNR, FUNCTION.
  4. "Role of auxiliary beta1-, beta2-, and beta3-subunits and their interaction with Na(v)1.8 voltage-gated sodium channel."
    Vijayaragavan K., Powell A.J., Kinghorn I.J., Chahine M.
    Biochem. Biophys. Res. Commun. 319:531-540(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH SCN10A.
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192 AND THR-204, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSCN2B_RAT
AccessioniPrimary (citable) accession number: P54900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.