Reviewed, UniProtKB/Swiss-Prot P54899 (ARGC_SYNY3)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	sll0080

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112465
Sites
	Active site	154	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54899-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: C9746F0120E2C8BB	FASTA	351	38,209
	10 20 30 40 50 60 MGNEKARVGI IGASGYGGIQ LVRLLLEHPQ VELTYLAGHS SAGKPYSDLY PHLTHRVNLT 70 80 90 100 110 120 IEPIDLEAIA SRCDAVFLGL PNGLACDMAP ALLAKGCKVL DLSADYRFRN LNTYTEWYKK 130 140 150 160 170 180 DRQDQATNNQ AVYGLPELYR DAIRDAQLIG CPGCYPTASL LALSPLLKQG FIVPETAIID 190 200 210 220 230 240 AKSGTSGGGR EAKVNMLLAE AEGSLGAYGV AKHRHTPEIE QIASDLAGTE LRVQFTPHLI 250 260 270 280 290 300 PMVRGILATV YATLRDPGLV RDDLITIYSA FYRASPFVKI LPHGVYPQTK WAWGTNLCYI 310 320 330 340 350 GIEVDPRTGR VIVLSAIDNL VKGQAGQAVQ CLNLMMGWEE SLGLPQLAFY P

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA10557.1.
PIR	S76613.
RefSeq	NP_442487.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P54899. 3 interactions.
STRING	P54899.
Genome annotation databases
GeneID	952334.
GenomeReviews	Gene locus sll0080 in contig BA000022_GR.
KEGG	syn:sll0080.
NMPDR	fig|1148.1.peg.2588.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG294213.
OMA	TAEDCTT.
Enzyme and pathway databases
BioCyc	SSP1148:SLL0080-MON.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_SYNY3

Accession

Primary (citable) accession number: P54899

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	December 15, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)