ID   ARGC2_ANASP             Reviewed;         322 AA.
AC   P54894;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JUN-2009, entry version 64.
DE   RecName: Full=N-acetyl-gamma-glutamyl-phosphate reductase 2;
DE            Short=AGPR 2;
DE            EC=1.2.1.38;
DE   AltName: Full=N-acetyl-glutamate semialdehyde dehydrogenase 2;
DE            Short=NAGSA dehydrogenase 2;
GN   Name=argC2; Synonyms=argC; OrderedLocusNames=all2498;
OS   Anabaena sp. (strain PCC 7120).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=93023834; PubMed=1406250;
RX   DOI=10.1111/j.1365-2958.1992.tb01381.x;
RA   Floriano B., Herrero A., Flores E.;
RT   "Isolation of arginine auxotrophs, cloning by mutant complementation,
RT   and sequence analysis of the argC gene from the cyanobacterium
RT   Anabaena species PCC 7120.";
RL   Mol. Microbiol. 6:2085-2094(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=95014086; PubMed=7929012;
RA   Floriano B., Herrero A., Flores E.;
RT   "Analysis of expression of the argC and argD genes in the
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   J. Bacteriol. 176:6397-6401(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21595285; PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S.,
RA   Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T.,
RA   Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
RA   Nakazaki N., Shimpo S., Sugimoto M., Takazawa M., Yamada M.,
RA   Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- CATALYTIC ACTIVITY: N-acetyl-L-glutamate 5-semialdehyde + NADP(+)
CC       + phosphate = N-acetyl-5-glutamyl phosphate + NADPH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-
CC       acetyl-L-ornithine from L-glutamate: step 3/4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the NAGSA dehydrogenase family. Type 2
CC       subfamily.
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DR   EMBL; X65511; CAA46483.1; -; Genomic_DNA.
DR   EMBL; BA000019; BAB74197.1; -; Genomic_DNA.
DR   PIR; AC2118; AC2118.
DR   PIR; S24753; S24753.
DR   RefSeq; NP_486538.1; -.
DR   GeneID; 1106095; -.
DR   GenomeReviews; BA000019_GR; all2498.
DR   KEGG; ana:all2498; -.
DR   NMPDR; fig|103690.1.peg.2805; -.
DR   HOGENOM; P54894; -.
DR   OMA; P54894; FRQGMLV.
DR   BioCyc; NSP103690:ALL2498-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003942; F:N-acetyl-gamma-glutamyl-phosphate reductase...; IEA:HAMAP.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0006526; P:arginine biosynthetic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01110; -; 1.
DR   InterPro; IPR000706; AGPR_act_site.
DR   InterPro; IPR010136; AGPR_subtype.
DR   InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   ProDom; PD003765; AGPR_act_site; 1.
DR   TIGRFAMs; TIGR01851; argC_other; 1.
DR   PROSITE; PS01224; ARGC; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome;
KW   Cytoplasm; NADP; Oxidoreductase.
FT   CHAIN         1    322       N-acetyl-gamma-glutamyl-phosphate
FT                                reductase 2.
FT                                /FTId=PRO_0000112503.
FT   ACT_SITE    117    117       By similarity.
SQ   SEQUENCE   322 AA;  34823 MW;  1C41BA71630942F0 CRC64;
     MNKPKIFIDG EAGTTGLQIY SRLNERDDIE LVSIAASKRK DADERAKLLN SVDVAILCLP
     DDAAREAVSL VNSSQVKILD ASTAYRTAQG WVYGFPEMNP GQREKIANAQ FVSNPGCYPT
     GFLACVRPLI AQGILPSSFP ITINAVSGYS GGGKSLIQKY DSFHEQQKGA TSDYPFGIYG
     LQFGHKHVKE MHQHSGLASP PLFIPAVGDF EQGMLVQIPL PLWTLDNPPS GEEIHQAIAQ
     YYQGEKFVQV APFKDPSLLR DGTFLDATAV NGTNIVQVFV FGNDNTKEAL LVARLDNLGK
     GASGAAVQNL NIMLGLPEEL GL
//