Reviewed, UniProtKB/Swiss-Prot P54894 (ARGC2_ANASP)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase 2
      Short name=AGPR 2
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase 2
      Short name=NAGSA dehydrogenase 2

Gene names

Name:	argC2
Synonyms:	argC
Ordered Locus Names:	all2498

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	N-acetyl-gamma-glutamyl-phosphate reductase 2 HAMAP MF_01110		PRO_0000112503
Sites
	Active site	117	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54894-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 1C41BA71630942F0	FASTA	322	34,823
	10 20 30 40 50 60 MNKPKIFIDG EAGTTGLQIY SRLNERDDIE LVSIAASKRK DADERAKLLN SVDVAILCLP 70 80 90 100 110 120 DDAAREAVSL VNSSQVKILD ASTAYRTAQG WVYGFPEMNP GQREKIANAQ FVSNPGCYPT 130 140 150 160 170 180 GFLACVRPLI AQGILPSSFP ITINAVSGYS GGGKSLIQKY DSFHEQQKGA TSDYPFGIYG 190 200 210 220 230 240 LQFGHKHVKE MHQHSGLASP PLFIPAVGDF EQGMLVQIPL PLWTLDNPPS GEEIHQAIAQ 250 260 270 280 290 300 YYQGEKFVQV APFKDPSLLR DGTFLDATAV NGTNIVQVFV FGNDNTKEAL LVARLDNLGK 310 320 GASGAAVQNL NIMLGLPEEL GL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of arginine auxotrophs, cloning by mutant complementation, and sequence analysis of the argC gene from the cyanobacterium Anabaena species PCC 7120." Floriano B., Herrero A., Flores E. Mol. Microbiol. 6:2085-2094(1992) [PubMed: 1406250] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of expression of the argC and argD genes in the cyanobacterium Anabaena sp. strain PCC 7120." Floriano B., Herrero A., Flores E. J. Bacteriol. 176:6397-6401(1994) [PubMed: 7929012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X65511 Genomic DNA. Translation: CAA46483.1. BA000019 Genomic DNA. Translation: BAB74197.1.
PIR	AC2118. S24753.
RefSeq	NP_486538.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1106095.
GenomeReviews	Gene locus all2498 in contig BA000019_GR.
KEGG	ana:all2498.
NMPDR	fig|103690.1.peg.2805.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P54894.
OMA	P54894. FRQGMLV.
Enzyme and pathway databases
BioCyc	NSP103690:ALL2498-MON.
Family and domain databases
HAMAP	MF_01110. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR010136. AGPR_subtype. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01851. argC_other. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC2_ANASP

Accession

Primary (citable) accession number: P54894

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)