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Reviewed, UniProtKB/Swiss-Prot P54894 (ARGC2_ANASP)

Last modified June 16, 2009. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase 2
      Short name=AGPR 2
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase 2
      Short name=NAGSA dehydrogenase 2
Gene names
Name: argC2
Synonyms: argC
Ordered Locus Names: all2498
OrganismAnabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionN-acetyl-gamma-glutamyl-phosphate reductase activity

Inferred from electronic annotation. Source: HAMAP

NAD or NADH binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322N-acetyl-gamma-glutamyl-phosphate reductase 2 HAMAP MF_01110
PRO_0000112503

Sites

Active site1171 By similarity

Sequences

Sequence LengthMass (Da)Tools
P54894-1 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 1C41BA71630942F0

FASTA32234,823
        10         20         30         40         50         60 
MNKPKIFIDG EAGTTGLQIY SRLNERDDIE LVSIAASKRK DADERAKLLN SVDVAILCLP 

        70         80         90        100        110        120 
DDAAREAVSL VNSSQVKILD ASTAYRTAQG WVYGFPEMNP GQREKIANAQ FVSNPGCYPT 

       130        140        150        160        170        180 
GFLACVRPLI AQGILPSSFP ITINAVSGYS GGGKSLIQKY DSFHEQQKGA TSDYPFGIYG 

       190        200        210        220        230        240 
LQFGHKHVKE MHQHSGLASP PLFIPAVGDF EQGMLVQIPL PLWTLDNPPS GEEIHQAIAQ 

       250        260        270        280        290        300 
YYQGEKFVQV APFKDPSLLR DGTFLDATAV NGTNIVQVFV FGNDNTKEAL LVARLDNLGK 

       310        320 
GASGAAVQNL NIMLGLPEEL GL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of arginine auxotrophs, cloning by mutant complementation, and sequence analysis of the argC gene from the cyanobacterium Anabaena species PCC 7120."
Floriano B., Herrero A., Flores E.
Mol. Microbiol. 6:2085-2094(1992) [PubMed: 1406250] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Analysis of expression of the argC and argD genes in the cyanobacterium Anabaena sp. strain PCC 7120."
Floriano B., Herrero A., Flores E.
J. Bacteriol. 176:6397-6401(1994) [PubMed: 7929012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

X65511 Genomic DNA. Translation: CAA46483.1.
BA000019 Genomic DNA. Translation: BAB74197.1.
PIRAC2118.
S24753.
RefSeqNP_486538.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1106095.
GenomeReviewsGene locus all2498 in contig BA000019_GR.
KEGGana:all2498.
NMPDRfig|103690.1.peg.2805.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP54894.
OMAP54894. FRQGMLV.

Enzyme and pathway databases

BioCycNSP103690:ALL2498-MON.

Family and domain databases

HAMAPMF_01110.
[Tree]
InterProIPR000706. AGPR_act_site.
IPR010136. AGPR_subtype.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
ProDomPD003765. AGPR_act_site. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01851. argC_other. 1 hit.
PROSITEPS01224. ARGC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGC2_ANASP
AccessionPrimary (citable) accession number: P54894
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents