Reviewed, UniProtKB/Swiss-Prot P54893 (P5CR_THET2)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase
      Short name=P5C reductase
      Short name=P5CR
    EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	TT_C0500

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]

Taxonomic identifier

262724 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Pyrroline-5-carboxylate reductase		PRO_0000187309

Sequences

	Sequence		Length	Mass (Da)
	P54893-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 3435C3A8F4299B3E	FASTA	261	27,819
	10 20 30 40 50 60 MRLAFVGLGK MGRSILKGAL ERGFLRPEEV GVLGRTPERS RELAEPFGVR PLTRADLGMA 70 80 90 100 110 120 ERVLIAVQPR DFPALAPEIA HHRLGYISIM AGISTSVLAR RLDNRRVVRA MPNLAVVIGE 130 140 150 160 170 180 SSTALTALKE AREAEDLAFA RALFATVGDV YEIPEHLFDA FTGMSASAPA YLAVVAEALA 190 200 210 220 230 240 DAGVKMGMPR ALALRLAADA LAATGELLKG RHPAQVKDEV ASPGGTTIHG LHALEARAVR 250 260 AAFYEAVEAA TRRGHELGES E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and sequence analysis of the proC gene encoding delta 1-pyrroline-5-carboxylate reductase from an extremely thermophilic eubacterium Thermus thermophilus." Hoshino T., Kosuge T., Hidaka Y., Tabata K., Nakahara T. Biochem. Biophys. Res. Commun. 199:410-417(1994) [PubMed: 8123043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of the extreme thermophile Thermus thermophilus." Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H., Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C., Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P., Kramer W., Merkl R., Gottschalk G., Fritz H.-J. Nat. Biotechnol. 22:547-553(2004) [PubMed: 15064768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	D25413 Genomic DNA. Translation: BAA05001.1. AE017221 Genomic DNA. Translation: AAS80848.1.
RefSeq	YP_004475.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2775949.
GenomeReviews	Gene locus TT_C0500 in contig AE017221_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P54893.
OMA	P54893. IGESSTA.
Enzyme and pathway databases
BioCyc	TTHE262724:TT_C0500-MON.
Family and domain databases
InterPro	IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR_THET2

Accession

Primary (citable) accession number: P54893

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)