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Protein

Sensor-like histidine kinase senX3

Gene

senX3

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probably forms part of a two-component regulatory system senX3/regX3. Phosphorylates regX3 (Probable).Curated

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.13.3. 3504.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor-like histidine kinase senX3 (EC:2.7.13.3)
Gene namesi
Name:senX3
Ordered Locus Names:ML2440
ORF Names:B2168_C3_247
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML2440.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Sensor-like histidine kinase senX3PRO_0000074875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei167 – 1671Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272631.ML2440.

Structurei

3D structure databases

ProteinModelPortaliP54883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 380217Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0642. LUCA.
HOGENOMiHOG000223176.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVFSALLLA GVLSGLAFVV GIVAGIRLSP RLIERRQRLA NEWAGITVLQ
60 70 80 90 100
MLQRIIALMP LGAAVVDTYR DVVYLNEQAK ELGLVRDRQL DDQAWRAAQQ
110 120 130 140 150
ALGGDDVEFD LLPGKRPAAG RSGLSVHGHA RLLSEKDRRF AVVFVHDQSD
160 170 180 190 200
YVRMEAARRD FVANVSHELK TPVGAMALLA EALLASADDA ETVSRFAEKV
210 220 230 240 250
LIEANRLGYM VAELIELSRL QGAERLPNVT DIDVDIIVSE AIARHKVAAD
260 270 280 290 300
TAAIEVRTDP PSGLRVLGDQ TLLVTALANL VSNAIAYSPG GSLVSISRRR
310 320 330 340 350
RGDNIEIAVT DRGIGIALED QERVFERFFR GDKARSRATG GSGLGLAIVK
360 370 380 390 400
HVAANHNGSI GVWSKPGTGS TFTLSIPAAM PLYQDNDEQS GQPRGCDMWL
410 420 430 440
NRPQREEEEF KSMTPAQAMM QSEVTRGNVN DKCPDCGGRG IAG
Length:443
Mass (Da):47,967
Last modified:October 1, 1996 - v1
Checksum:i3951C1F5CD6731BB
GO

Sequence cautioni

The sequence CAC31957.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00018 Genomic DNA. Translation: AAA17241.1.
AL583925 Genomic DNA. Translation: CAC31957.1. Different initiation.
PIRiE87214.
S72905.
RefSeqiWP_010908900.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31957; CAC31957; CAC31957.
PATRICi18059545. VBIMycLep78757_4687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00018 Genomic DNA. Translation: AAA17241.1.
AL583925 Genomic DNA. Translation: CAC31957.1. Different initiation.
PIRiE87214.
S72905.
RefSeqiWP_010908900.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP54883.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML2440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31957; CAC31957; CAC31957.
PATRICi18059545. VBIMycLep78757_4687.

Organism-specific databases

LepromaiML2440.

Phylogenomic databases

eggNOGiCOG0642. LUCA.
HOGENOMiHOG000223176.
OrthoDBiEOG6G4VQG.

Enzyme and pathway databases

BRENDAi2.7.13.3. 3504.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiSEX3_MYCLE
AccessioniPrimary (citable) accession number: P54883
Secondary accession number(s): Q9CB51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 11, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.