ID   DNLI_METTF              Reviewed;         557 AA.
AC   P54875;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   24-MAR-2009, entry version 51.
DE   RecName: Full=DNA ligase;
DE            EC=6.5.1.1;
DE   AltName: Full=Polydeoxyribonucleotide synthase [ATP];
GN   Name=lig;
OS   Methanobacterium thermoformicicum.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=145262;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 3720 / Z-245;
RX   MEDLINE=97158688; PubMed=9006048;
RA   Noelling J., Reeve J.N.;
RT   "Growth- and substrate-dependent transcription of the formate
RT   dehydrogenase (fdhCAB) operon in Methanobacterium thermoformicicum Z-
RT   245.";
RL   J. Bacteriol. 179:899-908(1997).
CC   -!- FUNCTION: DNA ligase that seals nicks in double-stranded DNA
CC       during DNA replication, DNA recombination and DNA repair (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) +
CC       (deoxyribonucleotide)(m) = AMP + diphosphate +
CC       (deoxyribonucleotide)(n+m).
CC   -!- COFACTOR: Divalent metal cations (By similarity).
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
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DR   EMBL; U52681; AAC44823.1; -; Genomic_DNA.
DR   BRENDA; 6.5.1.1; 258835.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:HAMAP.
DR   GO; GO:0006281; P:DNA repair; IEA:HAMAP.
DR   GO; GO:0006260; P:DNA replication; IEA:HAMAP.
DR   HAMAP; MF_00407; -; 1.
DR   InterPro; IPR000977; DNA_ligase.
DR   InterPro; IPR012309; DNA_ligase_A_C.
DR   InterPro; IPR012310; DNA_ligase_A_M.
DR   InterPro; IPR012308; DNA_ligase_A_N.
DR   InterPro; IPR016059; DNA_ligase_CS.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; DNA damage; DNA recombination;
KW   DNA repair; DNA replication; Ligase; Metal-binding;
KW   Nucleotide-binding.
FT   CHAIN         1    557       DNA ligase.
FT                                /FTId=PRO_0000059608.
FT   ACT_SITE    251    251       N6-AMP-lysine intermediate (By
FT                                similarity).
FT   BINDING     249    249       ATP (By similarity).
FT   BINDING     256    256       ATP (By similarity).
FT   BINDING     271    271       ATP (By similarity).
FT   BINDING     301    301       ATP (By similarity).
FT   BINDING     340    340       ATP (By similarity).
FT   BINDING     417    417       ATP (By similarity).
FT   BINDING     423    423       ATP (By similarity).
SQ   SEQUENCE   557 AA;  62822 MW;  C328FE239AD1CBAA CRC64;
     MKELLYMELA EVYHRLESTT KRLEKTEILA ELLRSVDKEL LPDVTILMLG RVFPIWSEEE
     LGVGIKLLMK AISLVVGVSM DEIEDEIREQ GDIGLASEKL FSRKTQTTFF SQPLTVEFVY
     SRLKALASAS GDRAQSKKIN ILVEVLSQAK PLEARYITRT VLEELRVGVA EGIIRDAIAR
     AFEVDPALVE RAHMLTNDLG MVAAVAREEG EPGLGRLNLE PGRPVKPMLA QLASSIESAI
     TELGRAFCET KYDGIRVQIH RCGDEVSIFT RRLENITAAV PEILEGVEEA LPADDYIVEG
     EIIVTMDGRP ASFQYILQRV RRKYDVDRLT REVPLSLFLF DVLYHRGPLI DEPLWHRREV
     LESILSEIPG RVEASRMVDV GPDNLDDALW LFKESIREGH EGIMIKDTEA PYIPGIRGKK
     MLKFKAEPET LDLIVVGGTY GRGKRAHLVG SYLLAVRDEK SGELKTIAHV ATGLDDQTLQ
     DLSERMENLK VERRGRKIRV KPEIILEVAY SEIVRSPEYE SGYSLRFPVV KRIRDDLSPD
     DIDTLGRVIS LFKQGFS
//