Reviewed,
UniProtKB/Swiss-Prot P54874 (HMCS_SCHPO)
Last modified
November 3, 2009.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Hydroxymethylglutaryl-CoA synthase Short name=HMG-CoA synthase EC=2.3.3.10 Alternative name(s): 3-hydroxy-3-methylglutaryl coenzyme A synthase | ||||||
| Gene names |
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| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||||
| Taxonomic identifier | 4896 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 447 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase By similarity. |
| Catalytic activity | Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. |
| Pathway | |
| Sequence similarities | Belongs to the HMG-CoA synthase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Molecular function | Transferase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | acetyl-CoA metabolic process Ref.1 Inferred from mutant phenotype. Source: GeneDB_SPombe ergosterol biosynthetic process Ref.1Inferred from mutant phenotype. Source: GeneDB_SPombe farnesyl diphosphate biosynthetic process, mevalonate pathway Ref.1Inferred from mutant phenotype. Source: GeneDB_SPombe |
| Cellular component | cytosol Inferred from direct assay. Source: GeneDB_SPombe endoplasmic reticulumInferred by curator. Source: GeneDB_SPombe nucleusInferred from direct assay. Source: GeneDB_SPombe |
| Molecular function | hydroxymethylglutaryl-CoA synthase activity Ref.1 Inferred from mutant phenotype. Source: GeneDB_SPombe |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and sequencing of the hcs gene, which encodes 3-hydroxy-3-methylglutaryl coenzyme A synthase of Schizosaccharomyces pombe." Katayama S., Adachi N., Takao K., Nakagawa T., Matsuda H., Kawamukai M. Yeast 11:1533-1537(1995) [PubMed: 8750242] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [3] | "Phosphoproteome analysis of fission yeast." Wilson-Grady J.T., Villen J., Gygi S.P. J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-398, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| U32187 Genomic DNA. Translation: AAB17601.1. CU329670 Genomic DNA. Translation: CAB11060.1. | |
| PIR | S61875. |
| RefSeq | NP_593859.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P54874. |
Genome annotation databases | |
| GeneID | 2543141. |
| GenomeReviews | Gene locus hcs1 in contig CU329670_GR. |
| KEGG | spo:SPAC4F8.14c. |
| NMPDR | fig|4896.1.peg.3829. |
Organism-specific databases | |
| GeneDB_Spombe | SPAC4F8.14c. |
Phylogenomic databases | |
| OMA | CLTVVQN. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-001509-MON. |
| BRENDA | 2.3.3.10. 653. |
Gene expression databases | |
| ArrayExpress | P54874. |
Family and domain databases | |
| InterPro | IPR000590. HMG_CoA_synt_AS. IPR013746. HMG_CoA_synt_C. IPR013528. HMG_CoA_synth_N. IPR010122. HMG_CoA_synthase_euk. [Graphical view] |
| Pfam | PF08540. HMG_CoA_synt_C. 1 hit. PF01154. HMG_CoA_synt_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01833. HMG-CoA-S_euk. 1 hit. |
| PROSITE | PS01226. HMG_COA_SYNTHASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HMCS_SCHPO | ||||||||
| Accession | Primary (citable) accession number: P54874 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


