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P54871

- HMCS_CAEEL

UniProt

P54871 - HMCS_CAEEL

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Protein

Hydroxymethylglutaryl-CoA synthase

Gene
F25B4.6
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase By similarity.

Catalytic activityi

Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921Proton donor/acceptor By similarity
Active sitei124 – 1241Acyl-thioester intermediate By similarity
Active sitei257 – 2571Proton donor/acceptor By similarity

GO - Molecular functioni

  1. hydroxymethylglutaryl-CoA synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoprenoid biosynthetic process Source: InterPro
  2. sterol biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Enzyme and pathway databases

BRENDAi2.3.3.10. 1045.
ReactomeiREACT_183198. PPARA activates gene expression.
REACT_197719. Activation of gene expression by SREBF (SREBP).
UniPathwayiUPA00058; UER00102.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylglutaryl-CoA synthase (EC:2.3.3.10)
Short name:
HMG-CoA synthase
Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene namesi
ORF Names:F25B4.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiF25B4.6; CE09624; WBGene00017769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Hydroxymethylglutaryl-CoA synthasePRO_0000213754Add
BLAST

Proteomic databases

PaxDbiP54871.
PRIDEiP54871.

Interactioni

Protein-protein interaction databases

BioGridi44005. 1 interaction.
IntActiP54871. 1 interaction.
STRINGi6239.F25B4.6.

Structurei

3D structure databases

ProteinModelPortaliP54871.
SMRiP54871. Positions 13-445.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMG-CoA synthase family.

Phylogenomic databases

eggNOGiCOG3425.
GeneTreeiENSGT00390000006096.
HOGENOMiHOG000012351.
InParanoidiP54871.
KOiK01641.
OMAiAIAFLIC.
OrthoDBiEOG741Z1W.
PhylomeDBiP54871.

Family and domain databases

Gene3Di3.40.47.10. 1 hit.
InterProiIPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 3 hits.
TIGRFAMsiTIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEiPS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54871-1 [UniParc]FASTAAdd to Basket

« Hide

MSLGQLSYTP VTDVGIGAIE LYFPQNFVDQ NDLEKFNNVS SGKYTIGLGQ    50
QQMGFCSDNE DIVSISLTVT RKLIETYKIS TDSIGCLVVG TETMIDKSKS 100
VKTALMDLFP GNSDIEGVDI KNACFGGAQA LLHAIDWVTV NHPLDKKNAI 150
VVVADIAIYE EGPARCTGGA GAIAFLICPD ASIPIDRQFS ACHMKNTWDF 200
FKPITPIPSE YPVVDGSLSL SSYLEAVRMT YTYFISKVNR HTTGIDGLNS 250
FDGVFLHSPF TKMVQKGLAV MNYTDSQLRH KQLNGNGVDH KLDENDRAGL 300
AKMIELSAQV WKEKTDPYLV FNRRIGNMYT PSLFAQLLAY LAADDCVTGE 350
KSILFFAYGS GLASAIFPGR VRQTSNLDKI RQVAIRAIKR LDDRIQFTPE 400
EFTETLQKRE VFLRSKEIPK SPSETSLFPN TYFLDNMDKL YRRSYTLHEE 450
PNGVQNGNGI HH 462
Length:462
Mass (Da):51,416
Last modified:June 20, 2002 - v2
Checksum:i89BDE382588F6D9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080538 Genomic DNA. Translation: CCD64508.1.
U12787 mRNA. Translation: AAA92672.1.
PIRiT25726.
RefSeqiNP_504496.1. NM_072095.3.
UniGeneiCel.3914.

Genome annotation databases

EnsemblMetazoaiF25B4.6; F25B4.6; WBGene00017769.
GeneIDi178956.
KEGGicel:CELE_F25B4.6.
UCSCiF25B4.6. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080538 Genomic DNA. Translation: CCD64508.1 .
U12787 mRNA. Translation: AAA92672.1 .
PIRi T25726.
RefSeqi NP_504496.1. NM_072095.3.
UniGenei Cel.3914.

3D structure databases

ProteinModelPortali P54871.
SMRi P54871. Positions 13-445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 44005. 1 interaction.
IntActi P54871. 1 interaction.
STRINGi 6239.F25B4.6.

Proteomic databases

PaxDbi P54871.
PRIDEi P54871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F25B4.6 ; F25B4.6 ; WBGene00017769 .
GeneIDi 178956.
KEGGi cel:CELE_F25B4.6.
UCSCi F25B4.6. c. elegans.

Organism-specific databases

CTDi 178956.
WormBasei F25B4.6 ; CE09624 ; WBGene00017769 .

Phylogenomic databases

eggNOGi COG3425.
GeneTreei ENSGT00390000006096.
HOGENOMi HOG000012351.
InParanoidi P54871.
KOi K01641.
OMAi AIAFLIC.
OrthoDBi EOG741Z1W.
PhylomeDBi P54871.

Enzyme and pathway databases

UniPathwayi UPA00058 ; UER00102 .
BRENDAi 2.3.3.10. 1045.
Reactomei REACT_183198. PPARA activates gene expression.
REACT_197719. Activation of gene expression by SREBF (SREBP).

Miscellaneous databases

NextBioi 903278.

Family and domain databases

Gene3Di 3.40.47.10. 1 hit.
InterProi IPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 3 hits.
TIGRFAMsi TIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEi PS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution."
    Boukaftane Y., Duncan A., Wang S., Labuda D., Robert M.-F., Sarrazin J., Schappert K.T., Mitchell G.A.
    Genomics 23:552-559(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-462.

Entry informationi

Entry nameiHMCS_CAEEL
AccessioniPrimary (citable) accession number: P54871
Secondary accession number(s): Q22962
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 20, 2002
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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