Reviewed,
UniProtKB/Swiss-Prot P54871 (HMCS_CAEEL)
Last modified
November 3, 2009.
Version 74.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Hydroxymethylglutaryl-CoA synthase Short name=HMG-CoA synthase EC=2.3.3.10 Alternative name(s): 3-hydroxy-3-methylglutaryl coenzyme A synthase | ||
| Gene names |
| ||
| Organism | Caenorhabditis elegans [Complete proteome] | ||
| Taxonomic identifier | 6239 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 462 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase By similarity. |
| Catalytic activity | Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. |
| Pathway | |
| Sequence similarities | Belongs to the HMG-CoA synthase family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| [2] | "Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution." Boukaftane Y., Duncan A., Wang S., Labuda D., Robert M.-F., Sarrazin J., Schappert K.T., Mitchell G.A. Genomics 23:552-559(1994) [PubMed: 7851882] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-462. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U64842 Genomic DNA. Translation: AAB37084.1. U12787 mRNA. Translation: AAA92672.1. | |
| PIR | T25726. |
| RefSeq | NP_504496.1. |
| UniGene | Cel.3914 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P54871. 1 interaction. |
| STRING | P54871. |
Genome annotation databases | |
| Ensembl | F25B4.6; F25B4.6; F25B4.6; Caenorhabditis elegans. [Genome view] |
| GeneID | 178956. |
| KEGG | cel:F25B4.6. |
| NMPDR | fig|6239.3.peg.17952. |
| UCSC | F25B4.6. c. elegans. |
Organism-specific databases | |
| CTD | 178956. |
| WormBase | WBGene00017769. F25B4.6. |
| WormPep | F25B4.6. CE09624. [WorfDB] |
Phylogenomic databases | |
| OMA | HNGNTYT. |
Enzyme and pathway databases | |
| BRENDA | 2.3.3.10. 672. |
Gene expression databases | |
| ArrayExpress | P54871. |
Family and domain databases | |
| InterPro | IPR000590. HMG_CoA_synt_AS. IPR013746. HMG_CoA_synt_C. IPR013528. HMG_CoA_synth_N. IPR010122. HMG_CoA_synthase_euk. [Graphical view] |
| Pfam | PF08540. HMG_CoA_synt_C. 1 hit. PF01154. HMG_CoA_synt_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01833. HMG-CoA-S_euk. 1 hit. |
| PROSITE | PS01226. HMG_COA_SYNTHASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 903278. |
Entry information
| Entry name | HMCS_CAEEL | ||||||||
| Accession | Primary (citable) accession number: P54871 Secondary accession number(s): Q22962 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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