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P54871

- HMCS_CAEEL

UniProt

P54871 - HMCS_CAEEL

Protein

Hydroxymethylglutaryl-CoA synthase

Gene

F25B4.6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (20 Jun 2002)
      Previous versions | rss
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    Functioni

    This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.By similarity

    Catalytic activityi

    Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei92 – 921Proton donor/acceptorPROSITE-ProRule annotation
    Active sitei124 – 1241Acyl-thioester intermediatePROSITE-ProRule annotation
    Active sitei257 – 2571Proton donor/acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. hydroxymethylglutaryl-CoA synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: InterPro
    2. sterol biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Enzyme and pathway databases

    BRENDAi2.3.3.10. 1045.
    ReactomeiREACT_183198. PPARA activates gene expression.
    REACT_197719. Activation of gene expression by SREBF (SREBP).
    UniPathwayiUPA00058; UER00102.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxymethylglutaryl-CoA synthase (EC:2.3.3.10)
    Short name:
    HMG-CoA synthase
    Alternative name(s):
    3-hydroxy-3-methylglutaryl coenzyme A synthase
    Gene namesi
    ORF Names:F25B4.6
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome V

    Organism-specific databases

    WormBaseiF25B4.6; CE09624; WBGene00017769.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 462462Hydroxymethylglutaryl-CoA synthasePRO_0000213754Add
    BLAST

    Proteomic databases

    PaxDbiP54871.
    PRIDEiP54871.

    Interactioni

    Protein-protein interaction databases

    BioGridi44005. 1 interaction.
    IntActiP54871. 1 interaction.
    STRINGi6239.F25B4.6.

    Structurei

    3D structure databases

    ProteinModelPortaliP54871.
    SMRiP54871. Positions 13-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMG-CoA synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG3425.
    GeneTreeiENSGT00390000006096.
    HOGENOMiHOG000012351.
    InParanoidiP54871.
    KOiK01641.
    OMAiAIAFLIC.
    OrthoDBiEOG741Z1W.
    PhylomeDBiP54871.

    Family and domain databases

    Gene3Di3.40.47.10. 1 hit.
    InterProiIPR000590. HMG_CoA_synt_AS.
    IPR013746. HMG_CoA_synt_C_dom.
    IPR013528. HMG_CoA_synth_N.
    IPR010122. HMG_CoA_synthase_euk.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF08540. HMG_CoA_synt_C. 1 hit.
    PF01154. HMG_CoA_synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 3 hits.
    TIGRFAMsiTIGR01833. HMG-CoA-S_euk. 1 hit.
    PROSITEiPS01226. HMG_COA_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54871-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLGQLSYTP VTDVGIGAIE LYFPQNFVDQ NDLEKFNNVS SGKYTIGLGQ    50
    QQMGFCSDNE DIVSISLTVT RKLIETYKIS TDSIGCLVVG TETMIDKSKS 100
    VKTALMDLFP GNSDIEGVDI KNACFGGAQA LLHAIDWVTV NHPLDKKNAI 150
    VVVADIAIYE EGPARCTGGA GAIAFLICPD ASIPIDRQFS ACHMKNTWDF 200
    FKPITPIPSE YPVVDGSLSL SSYLEAVRMT YTYFISKVNR HTTGIDGLNS 250
    FDGVFLHSPF TKMVQKGLAV MNYTDSQLRH KQLNGNGVDH KLDENDRAGL 300
    AKMIELSAQV WKEKTDPYLV FNRRIGNMYT PSLFAQLLAY LAADDCVTGE 350
    KSILFFAYGS GLASAIFPGR VRQTSNLDKI RQVAIRAIKR LDDRIQFTPE 400
    EFTETLQKRE VFLRSKEIPK SPSETSLFPN TYFLDNMDKL YRRSYTLHEE 450
    PNGVQNGNGI HH 462
    Length:462
    Mass (Da):51,416
    Last modified:June 20, 2002 - v2
    Checksum:i89BDE382588F6D9F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080538 Genomic DNA. Translation: CCD64508.1.
    U12787 mRNA. Translation: AAA92672.1.
    PIRiT25726.
    RefSeqiNP_504496.1. NM_072095.3.
    UniGeneiCel.3914.

    Genome annotation databases

    EnsemblMetazoaiF25B4.6; F25B4.6; WBGene00017769.
    GeneIDi178956.
    KEGGicel:CELE_F25B4.6.
    UCSCiF25B4.6. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080538 Genomic DNA. Translation: CCD64508.1 .
    U12787 mRNA. Translation: AAA92672.1 .
    PIRi T25726.
    RefSeqi NP_504496.1. NM_072095.3.
    UniGenei Cel.3914.

    3D structure databases

    ProteinModelPortali P54871.
    SMRi P54871. Positions 13-445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 44005. 1 interaction.
    IntActi P54871. 1 interaction.
    STRINGi 6239.F25B4.6.

    Proteomic databases

    PaxDbi P54871.
    PRIDEi P54871.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F25B4.6 ; F25B4.6 ; WBGene00017769 .
    GeneIDi 178956.
    KEGGi cel:CELE_F25B4.6.
    UCSCi F25B4.6. c. elegans.

    Organism-specific databases

    CTDi 178956.
    WormBasei F25B4.6 ; CE09624 ; WBGene00017769 .

    Phylogenomic databases

    eggNOGi COG3425.
    GeneTreei ENSGT00390000006096.
    HOGENOMi HOG000012351.
    InParanoidi P54871.
    KOi K01641.
    OMAi AIAFLIC.
    OrthoDBi EOG741Z1W.
    PhylomeDBi P54871.

    Enzyme and pathway databases

    UniPathwayi UPA00058 ; UER00102 .
    BRENDAi 2.3.3.10. 1045.
    Reactomei REACT_183198. PPARA activates gene expression.
    REACT_197719. Activation of gene expression by SREBF (SREBP).

    Miscellaneous databases

    NextBioi 903278.

    Family and domain databases

    Gene3Di 3.40.47.10. 1 hit.
    InterProi IPR000590. HMG_CoA_synt_AS.
    IPR013746. HMG_CoA_synt_C_dom.
    IPR013528. HMG_CoA_synth_N.
    IPR010122. HMG_CoA_synthase_euk.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF08540. HMG_CoA_synt_C. 1 hit.
    PF01154. HMG_CoA_synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 3 hits.
    TIGRFAMsi TIGR01833. HMG-CoA-S_euk. 1 hit.
    PROSITEi PS01226. HMG_COA_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution."
      Boukaftane Y., Duncan A., Wang S., Labuda D., Robert M.-F., Sarrazin J., Schappert K.T., Mitchell G.A.
      Genomics 23:552-559(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-462.

    Entry informationi

    Entry nameiHMCS_CAEEL
    AccessioniPrimary (citable) accession number: P54871
    Secondary accession number(s): Q22962
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: June 20, 2002
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3