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P54871 (HMCS_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxymethylglutaryl-CoA synthase

Short name=HMG-CoA synthase
EC=2.3.3.10
Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene names
ORF Names:F25B4.6
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase By similarity.

Catalytic activity

Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.

Sequence similarities

Belongs to the HMG-CoA synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Hydroxymethylglutaryl-CoA synthase
PRO_0000213754

Sites

Active site1241 Potential

Sequences

Sequence LengthMass (Da)Tools
P54871 [UniParc].

Last modified June 20, 2002. Version 2.
Checksum: 89BDE382588F6D9F

FASTA46251,416
        10         20         30         40         50         60 
MSLGQLSYTP VTDVGIGAIE LYFPQNFVDQ NDLEKFNNVS SGKYTIGLGQ QQMGFCSDNE 

        70         80         90        100        110        120 
DIVSISLTVT RKLIETYKIS TDSIGCLVVG TETMIDKSKS VKTALMDLFP GNSDIEGVDI 

       130        140        150        160        170        180 
KNACFGGAQA LLHAIDWVTV NHPLDKKNAI VVVADIAIYE EGPARCTGGA GAIAFLICPD 

       190        200        210        220        230        240 
ASIPIDRQFS ACHMKNTWDF FKPITPIPSE YPVVDGSLSL SSYLEAVRMT YTYFISKVNR 

       250        260        270        280        290        300 
HTTGIDGLNS FDGVFLHSPF TKMVQKGLAV MNYTDSQLRH KQLNGNGVDH KLDENDRAGL 

       310        320        330        340        350        360 
AKMIELSAQV WKEKTDPYLV FNRRIGNMYT PSLFAQLLAY LAADDCVTGE KSILFFAYGS 

       370        380        390        400        410        420 
GLASAIFPGR VRQTSNLDKI RQVAIRAIKR LDDRIQFTPE EFTETLQKRE VFLRSKEIPK 

       430        440        450        460 
SPSETSLFPN TYFLDNMDKL YRRSYTLHEE PNGVQNGNGI HH 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"Human mitochondrial HMG CoA synthase: liver cDNA and partial genomic cloning, chromosome mapping to 1p12-p13, and possible role in vertebrate evolution."
Boukaftane Y., Duncan A., Wang S., Labuda D., Robert M.-F., Sarrazin J., Schappert K.T., Mitchell G.A.
Genomics 23:552-559(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-462.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080538 Genomic DNA. Translation: CCD64508.1.
U12787 mRNA. Translation: AAA92672.1.
PIRT25726.
RefSeqNP_504496.1. NM_072095.3.
UniGeneCel.3914.

3D structure databases

ProteinModelPortalP54871.
SMRP54871. Positions 13-445.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid44005. 1 interaction.
IntActP54871. 1 interaction.
STRING6239.F25B4.6.

Proteomic databases

PaxDbP54871.
PRIDEP54871.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF25B4.6; F25B4.6; F25B4.6.
GeneID178956.
KEGGcel:CELE_F25B4.6.
UCSCF25B4.6. c. elegans.

Organism-specific databases

CTD178956.
WormBaseF25B4.6; CE09624; WBGene00017769.

Phylogenomic databases

eggNOGCOG3425.
GeneTreeENSGT00390000006096.
HOGENOMHOG000012351.
InParanoidP54871.
KOK01641.
OMAWIESSYW.
OrthoDBEOG741Z1W.

Enzyme and pathway databases

BRENDA2.3.3.10. 1045.
UniPathwayUPA00058; UER00102.

Family and domain databases

Gene3D3.40.47.10. 1 hit.
InterProIPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]
SUPFAMSSF53901. SSF53901. 3 hits.
TIGRFAMsTIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEPS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio903278.

Entry information

Entry nameHMCS_CAEEL
AccessionPrimary (citable) accession number: P54871
Secondary accession number(s): Q22962
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 20, 2002
Last modified: February 19, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase