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P54870 (HMCS2_BLAGE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxymethylglutaryl-CoA synthase 2

Short name=HMG-CoA synthase 2
EC=2.3.3.10
Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthase 2
Gene names
Name:HMGCS-2
OrganismBlattella germanica (German cockroach) (Blatta germanica)
Taxonomic identifier6973 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase By similarity.

Catalytic activity

Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.

Sequence similarities

Belongs to the HMG-CoA synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Hydroxymethylglutaryl-CoA synthase 2
PRO_0000213753

Sites

Active site861Proton donor/acceptor By similarity
Active site1201Acyl-thioester intermediate By similarity
Active site2551Proton donor/acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P54870 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: DD030356548A63B1

FASTA45551,425
        10         20         30         40         50         60 
MAHWPEDVGI IGIEMIFPSL YVDQAELETY DEVSPGKYTM GLGQDKMGVC TDREDINSLC 

        70         80         90        100        110        120 
LTAVDKLMER NNIDYNDIGW LEVGTETILD KVKSVKTVLM QLFEESGNTD VEGIDTINAC 

       130        140        150        160        170        180 
YRGTAALFNA LIWIESSSWD GRYAIVVAAD IAIYAKECSP TGGAGALLML IGANAPIVID 

       190        200        210        220        230        240 
RGVRASHMKH AYDFYKPDLM SEYPVVDGKL SVQCYLSALD HCYPRFCSKT EKYLKRCGKE 

       250        260        270        280        290        300 
NTKIDLDYFD AFVFHSPYCK LVQKSVARLV LNDFIQYPEK YQDLQQLRNL KFEDTYFDRD 

       310        320        330        340        350        360 
IEKIFMDKSK QLFEKKTKPS LMLANQVGNM YTTSLYGGLV SLLISEDIGE LAGKCICMFS 

       370        380        390        400        410        420 
YGSGFAASMF SLHISTDSSP GSTLSRLVTN LTHIKPQVQQ RVKLSPGEFE NIMEIREQNH 

       430        440        450 
HKAPYTPVAS PNTLFPGTWY LESIDSMHRR KYKRV 

« Hide

References

[1]"Blattella germanica has two HMG-CoA synthase genes. Both are regulated in the ovary during the gonadotrophic cycle."
Buesa C., Martinez-Gonzalez J., Casals N., Haro D., Piulachs M.D., Belles X., Hegardt F.G.
J. Biol. Chem. 269:11707-11713(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X77516 mRNA. Translation: CAA54652.1.
PIRA53565.

3D structure databases

ProteinModelPortalP54870.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.3.3.10. 875.
UniPathwayUPA00058; UER00102.

Family and domain databases

Gene3D3.40.47.10. 1 hit.
InterProIPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]
SUPFAMSSF53901. SSF53901. 3 hits.
TIGRFAMsTIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEPS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHMCS2_BLAGE
AccessionPrimary (citable) accession number: P54870
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways