P54870 (HMCS2_BLAGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hydroxymethylglutaryl-CoA synthase 2
Short name=HMG-CoA synthase 2
EC=2.3.3.10

Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthase 2

Gene names

Name:

HMGCS-2

Organism

Blattella germanica (German cockroach) (Blatta germanica)

Taxonomic identifier

6973 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Orthopteroidea › Dictyoptera › Blattodea › Blaberoidea › Ectobiidae › Blattellinae › Blattella

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase By similarity.
Catalytic activity	Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
Pathway	Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
Sequence similarities	Belongs to the HMG-CoA synthase family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Steroid biosynthesis Steroid metabolism Sterol biosynthesis Sterol metabolism
Molecular function	Transferase
Gene Ontology (GO)
Biological_process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	hydroxymethylglutaryl-CoA synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Hydroxymethylglutaryl-CoA synthase 2		PRO_0000213753
Sites
	Active site	120	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	P54870 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: DD030356548A63B1	FASTA	455	51,425
	10 20 30 40 50 60 MAHWPEDVGI IGIEMIFPSL YVDQAELETY DEVSPGKYTM GLGQDKMGVC TDREDINSLC 70 80 90 100 110 120 LTAVDKLMER NNIDYNDIGW LEVGTETILD KVKSVKTVLM QLFEESGNTD VEGIDTINAC 130 140 150 160 170 180 YRGTAALFNA LIWIESSSWD GRYAIVVAAD IAIYAKECSP TGGAGALLML IGANAPIVID 190 200 210 220 230 240 RGVRASHMKH AYDFYKPDLM SEYPVVDGKL SVQCYLSALD HCYPRFCSKT EKYLKRCGKE 250 260 270 280 290 300 NTKIDLDYFD AFVFHSPYCK LVQKSVARLV LNDFIQYPEK YQDLQQLRNL KFEDTYFDRD 310 320 330 340 350 360 IEKIFMDKSK QLFEKKTKPS LMLANQVGNM YTTSLYGGLV SLLISEDIGE LAGKCICMFS 370 380 390 400 410 420 YGSGFAASMF SLHISTDSSP GSTLSRLVTN LTHIKPQVQQ RVKLSPGEFE NIMEIREQNH 430 440 450 HKAPYTPVAS PNTLFPGTWY LESIDSMHRR KYKRV

References

[1]

"Blattella germanica has two HMG-CoA synthase genes. Both are regulated in the ovary during the gonadotrophic cycle." Buesa C., Martinez-Gonzalez J., Casals N., Haro D., Piulachs M.D., Belles X., Hegardt F.G. J. Biol. Chem. 269:11707-11713(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X77516 mRNA. Translation: CAA54652.1.
PIR	A53565.
3D structure databases
ProteinModelPortal	P54870.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	2.3.3.10. 875.
UniPathway	UPA00058; UER00102.
Family and domain databases
Gene3D	3.40.47.10. 1 hit.
InterPro	IPR000590. HMG_CoA_synt_AS. IPR013746. HMG_CoA_synt_C. IPR013528. HMG_CoA_synth_N. IPR010122. HMG_CoA_synthase_euk. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Pfam	PF08540. HMG_CoA_synt_C. 1 hit. PF01154. HMG_CoA_synt_N. 1 hit. [Graphical view]
SUPFAM	SSF53901. Thiolase-like. 2 hits.
TIGRFAMs	TIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITE	PS01226. HMG_COA_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HMCS2_BLAGE

Accession

Primary (citable) accession number: P54870

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)