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P54870

- HMCS2_BLAGE

UniProt

P54870 - HMCS2_BLAGE

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Protein

Hydroxymethylglutaryl-CoA synthase 2

Gene

HMGCS-2

Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.By similarity

Catalytic activityi

Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton donor/acceptorPROSITE-ProRule annotation
Active sitei120 – 1201Acyl-thioester intermediatePROSITE-ProRule annotation
Active sitei255 – 2551Proton donor/acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. hydroxymethylglutaryl-CoA synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoprenoid biosynthetic process Source: InterPro
  2. sterol biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Enzyme and pathway databases

BRENDAi2.3.3.10. 875.
UniPathwayiUPA00058; UER00102.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylglutaryl-CoA synthase 2 (EC:2.3.3.10)
Short name:
HMG-CoA synthase 2
Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthase 2
Gene namesi
Name:HMGCS-2
OrganismiBlattella germanica (German cockroach) (Blatta germanica)
Taxonomic identifieri6973 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Hydroxymethylglutaryl-CoA synthase 2PRO_0000213753Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP54870.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMG-CoA synthase family.Curated

Family and domain databases

Gene3Di3.40.47.10. 1 hit.
InterProiIPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 3 hits.
TIGRFAMsiTIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEiPS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54870-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHWPEDVGI IGIEMIFPSL YVDQAELETY DEVSPGKYTM GLGQDKMGVC
60 70 80 90 100
TDREDINSLC LTAVDKLMER NNIDYNDIGW LEVGTETILD KVKSVKTVLM
110 120 130 140 150
QLFEESGNTD VEGIDTINAC YRGTAALFNA LIWIESSSWD GRYAIVVAAD
160 170 180 190 200
IAIYAKECSP TGGAGALLML IGANAPIVID RGVRASHMKH AYDFYKPDLM
210 220 230 240 250
SEYPVVDGKL SVQCYLSALD HCYPRFCSKT EKYLKRCGKE NTKIDLDYFD
260 270 280 290 300
AFVFHSPYCK LVQKSVARLV LNDFIQYPEK YQDLQQLRNL KFEDTYFDRD
310 320 330 340 350
IEKIFMDKSK QLFEKKTKPS LMLANQVGNM YTTSLYGGLV SLLISEDIGE
360 370 380 390 400
LAGKCICMFS YGSGFAASMF SLHISTDSSP GSTLSRLVTN LTHIKPQVQQ
410 420 430 440 450
RVKLSPGEFE NIMEIREQNH HKAPYTPVAS PNTLFPGTWY LESIDSMHRR

KYKRV
Length:455
Mass (Da):51,425
Last modified:October 1, 1996 - v1
Checksum:iDD030356548A63B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77516 mRNA. Translation: CAA54652.1.
PIRiA53565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77516 mRNA. Translation: CAA54652.1 .
PIRi A53565.

3D structure databases

ProteinModelPortali P54870.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00058 ; UER00102 .
BRENDAi 2.3.3.10. 875.

Family and domain databases

Gene3Di 3.40.47.10. 1 hit.
InterProi IPR000590. HMG_CoA_synt_AS.
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 3 hits.
TIGRFAMsi TIGR01833. HMG-CoA-S_euk. 1 hit.
PROSITEi PS01226. HMG_COA_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Blattella germanica has two HMG-CoA synthase genes. Both are regulated in the ovary during the gonadotrophic cycle."
    Buesa C., Martinez-Gonzalez J., Casals N., Haro D., Piulachs M.D., Belles X., Hegardt F.G.
    J. Biol. Chem. 269:11707-11713(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHMCS2_BLAGE
AccessioniPrimary (citable) accession number: P54870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 1, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3