Reviewed,
UniProtKB/Swiss-Prot P54870 (HMCS2_BLAGE)
Last modified
September 22, 2009.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Hydroxymethylglutaryl-CoA synthase 2 Short name=HMG-CoA synthase 2 EC=2.3.3.10 Alternative name(s): 3-hydroxy-3-methylglutaryl coenzyme A synthase 2 | ||
| Gene names |
| ||
| Organism | Blattella germanica (German cockroach) | ||
| Taxonomic identifier | 6973 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Orthopteroidea › Dictyoptera › Blattaria › Blattellidae › Blattellinae › Blattella |
Protein attributes
| Sequence length | 455 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase By similarity. |
| Catalytic activity | Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. |
| Pathway | |
| Sequence similarities | Belongs to the HMG-CoA synthase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Molecular function | Transferase |
| Gene Ontology (GO) | |
| Biological process | isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro sterol biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | hydroxymethylglutaryl-CoA synthase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Blattella germanica has two HMG-CoA synthase genes. Both are regulated in the ovary during the gonadotrophic cycle." Buesa C., Martinez-Gonzalez J., Casals N., Haro D., Piulachs M.D., Belles X., Hegardt F.G. J. Biol. Chem. 269:11707-11713(1994) [PubMed: 7909314] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| X77516 mRNA. Translation: CAA54652.1. | |
| PIR | A53565. |
3D structure databases | |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 2.3.3.10. 264229. |
Family and domain databases | |
| InterPro | IPR000590. HMG_CoA_synt_AS. IPR013746. HMG_CoA_synt_C. IPR013528. HMG_CoA_synth_N. IPR010122. HMG_CoA_synthase_euk. [Graphical view] |
| Pfam | PF08540. HMG_CoA_synt_C. 1 hit. PF01154. HMG_CoA_synt_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01833. HMG-CoA-S_euk. 1 hit. |
| PROSITE | PS01226. HMG_COA_SYNTHASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HMCS2_BLAGE | ||||||||
| Accession | Primary (citable) accession number: P54870 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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