Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P54870

- HMCS2_BLAGE

UniProt

P54870 - HMCS2_BLAGE

Protein

Hydroxymethylglutaryl-CoA synthase 2

Gene

HMGCS-2

Organism
Blattella germanica (German cockroach) (Blatta germanica)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.By similarity

    Catalytic activityi

    Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Proton donor/acceptorPROSITE-ProRule annotation
    Active sitei120 – 1201Acyl-thioester intermediatePROSITE-ProRule annotation
    Active sitei255 – 2551Proton donor/acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. hydroxymethylglutaryl-CoA synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: InterPro
    2. sterol biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Enzyme and pathway databases

    BRENDAi2.3.3.10. 875.
    UniPathwayiUPA00058; UER00102.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxymethylglutaryl-CoA synthase 2 (EC:2.3.3.10)
    Short name:
    HMG-CoA synthase 2
    Alternative name(s):
    3-hydroxy-3-methylglutaryl coenzyme A synthase 2
    Gene namesi
    Name:HMGCS-2
    OrganismiBlattella germanica (German cockroach) (Blatta germanica)
    Taxonomic identifieri6973 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaDictyopteraBlattodeaBlaberoideaEctobiidaeBlattellinaeBlattella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Hydroxymethylglutaryl-CoA synthase 2PRO_0000213753Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP54870.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMG-CoA synthase family.Curated

    Family and domain databases

    Gene3Di3.40.47.10. 1 hit.
    InterProiIPR000590. HMG_CoA_synt_AS.
    IPR013746. HMG_CoA_synt_C_dom.
    IPR013528. HMG_CoA_synth_N.
    IPR010122. HMG_CoA_synthase_euk.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF08540. HMG_CoA_synt_C. 1 hit.
    PF01154. HMG_CoA_synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 3 hits.
    TIGRFAMsiTIGR01833. HMG-CoA-S_euk. 1 hit.
    PROSITEiPS01226. HMG_COA_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54870-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHWPEDVGI IGIEMIFPSL YVDQAELETY DEVSPGKYTM GLGQDKMGVC    50
    TDREDINSLC LTAVDKLMER NNIDYNDIGW LEVGTETILD KVKSVKTVLM 100
    QLFEESGNTD VEGIDTINAC YRGTAALFNA LIWIESSSWD GRYAIVVAAD 150
    IAIYAKECSP TGGAGALLML IGANAPIVID RGVRASHMKH AYDFYKPDLM 200
    SEYPVVDGKL SVQCYLSALD HCYPRFCSKT EKYLKRCGKE NTKIDLDYFD 250
    AFVFHSPYCK LVQKSVARLV LNDFIQYPEK YQDLQQLRNL KFEDTYFDRD 300
    IEKIFMDKSK QLFEKKTKPS LMLANQVGNM YTTSLYGGLV SLLISEDIGE 350
    LAGKCICMFS YGSGFAASMF SLHISTDSSP GSTLSRLVTN LTHIKPQVQQ 400
    RVKLSPGEFE NIMEIREQNH HKAPYTPVAS PNTLFPGTWY LESIDSMHRR 450
    KYKRV 455
    Length:455
    Mass (Da):51,425
    Last modified:October 1, 1996 - v1
    Checksum:iDD030356548A63B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77516 mRNA. Translation: CAA54652.1.
    PIRiA53565.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77516 mRNA. Translation: CAA54652.1 .
    PIRi A53565.

    3D structure databases

    ProteinModelPortali P54870.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00058 ; UER00102 .
    BRENDAi 2.3.3.10. 875.

    Family and domain databases

    Gene3Di 3.40.47.10. 1 hit.
    InterProi IPR000590. HMG_CoA_synt_AS.
    IPR013746. HMG_CoA_synt_C_dom.
    IPR013528. HMG_CoA_synth_N.
    IPR010122. HMG_CoA_synthase_euk.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF08540. HMG_CoA_synt_C. 1 hit.
    PF01154. HMG_CoA_synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 3 hits.
    TIGRFAMsi TIGR01833. HMG-CoA-S_euk. 1 hit.
    PROSITEi PS01226. HMG_COA_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Blattella germanica has two HMG-CoA synthase genes. Both are regulated in the ovary during the gonadotrophic cycle."
      Buesa C., Martinez-Gonzalez J., Casals N., Haro D., Piulachs M.D., Belles X., Hegardt F.G.
      J. Biol. Chem. 269:11707-11713(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHMCS2_BLAGE
    AccessioniPrimary (citable) accession number: P54870
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3