ID   JUN_SERCA               Reviewed;         314 AA.
AC   P54864;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   RecName: Full=Transcription factor Jun {ECO:0000305};
DE   AltName: Full=Proto-oncogene c-Jun;
DE   AltName: Full=Transcription factor AP-1 subunit Jun {ECO:0000305};
GN   Name=JUN;
OS   Serinus canaria (Island canary) (Fringilla canaria).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Fringillidae;
OC   Carduelinae; Serinus.
OX   NCBI_TaxID=9135;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wasserschlager; TISSUE=Brain;
RX   PubMed=7898314; DOI=10.1016/0169-328x(94)90013-2;
RA   Nastiuk K.L., Mello C.V., George J.M., Clayton D.F.;
RT   "Immediate-early gene responses in the avian song control system: cloning
RT   and expression analysis of the canary c-jun cDNA.";
RL   Brain Res. Mol. Brain Res. 27:299-309(1994).
CC   -!- FUNCTION: Transcription factor that recognizes and binds to the
CC       enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated
CC       KRAS-mediated transcriptional activation of USP28. May bind to the
CC       USP28 promoter. {ECO:0000250|UniProtKB:P05412}.
CC   -!- SUBUNIT: Interacts with FOS to form a dimer.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the bZIP family. Jun subfamily. {ECO:0000305}.
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DR   EMBL; L35273; AAA49537.1; -; mRNA.
DR   RefSeq; XP_009087016.1; XM_009088768.1.
DR   AlphaFoldDB; P54864; -.
DR   SMR; P54864; -.
DR   GeneID; 103815057; -.
DR   KEGG; scan:103815057; -.
DR   CTD; 3725; -.
DR   OrthoDB; 4493275at2759; -.
DR   Proteomes; UP000694409; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd14696; bZIP_Jun; 1.
DR   Gene3D; 1.20.5.170; -; 1.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR005643; JNK.
DR   InterPro; IPR002112; Leuzip_Jun.
DR   InterPro; IPR008917; TF_DNA-bd_sf.
DR   PANTHER; PTHR11462; JUN TRANSCRIPTION FACTOR-RELATED; 1.
DR   PANTHER; PTHR11462:SF8; TRANSCRIPTION FACTOR JUN; 1.
DR   Pfam; PF00170; bZIP_1; 1.
DR   Pfam; PF03957; Jun; 1.
DR   PRINTS; PR00043; LEUZIPPRJUN.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF47454; A DNA-binding domain in eukaryotic transcription factors; 1.
DR   SUPFAM; SSF57959; Leucine zipper domain; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Proto-oncogene; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..314
FT                   /note="Transcription factor Jun"
FT                   /id="PRO_0000076435"
FT   DOMAIN          235..298
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          235..262
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          263..291
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ   SEQUENCE   314 AA;  34518 MW;  87E936AC37AC2731 CRC64;
     MSAKMEPTFY EDALSAGFAP PESGGYGYNN AKVLKQNMTL NLSDPSSNLK PHLRNKNADI
     LTSPDVGLLK LASPELERLI IQSSNGLITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE
     LHNQNTLPSV TSAAQPVTSG MAPVSSMAGS TSFNTSLHSE PPVYANLSNF NPNALSSAPN
     YNANSMGYAP QHHINPQMPV QHPRLQALKE EPQTVPEMPG ETPPLSPIDM ESQERIKAER
     KRMRNRIAAS KCRKRKLERI ARLEEKVKTL KAQNSELAST ANMLREQVAQ LKQKVMNHVN
     SGCQLMLTQQ LQTF
//