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P54864

- JUN_SERCA

UniProt

P54864 - JUN_SERCA

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Protein

Transcription factor AP-1

Gene
JUN
Organism
Serinus canaria (Island canary) (Fringilla canaria)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-1
Alternative name(s):
Proto-oncogene c-Jun
Gene namesi
Name:JUN
OrganismiSerinus canaria (Island canary) (Fringilla canaria)
Taxonomic identifieri9135 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaFringillidaeCarduelinaeSerinus

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Transcription factor AP-1PRO_0000076435Add
BLAST

Interactioni

Subunit structurei

Interacts with FOS to form a dimer.

Structurei

3D structure databases

ProteinModelPortaliP54864.
SMRiP54864. Positions 240-291.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 29864bZIPAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni235 – 26228Basic motif By similarityAdd
BLAST
Regioni263 – 29129Leucine-zipper By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.

Phylogenomic databases

HOVERGENiHBG001722.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54864-1 [UniParc]FASTAAdd to Basket

« Hide

MSAKMEPTFY EDALSAGFAP PESGGYGYNN AKVLKQNMTL NLSDPSSNLK    50
PHLRNKNADI LTSPDVGLLK LASPELERLI IQSSNGLITT TPTPTQFLCP 100
KNVTDEQEGF AEGFVRALAE LHNQNTLPSV TSAAQPVTSG MAPVSSMAGS 150
TSFNTSLHSE PPVYANLSNF NPNALSSAPN YNANSMGYAP QHHINPQMPV 200
QHPRLQALKE EPQTVPEMPG ETPPLSPIDM ESQERIKAER KRMRNRIAAS 250
KCRKRKLERI ARLEEKVKTL KAQNSELAST ANMLREQVAQ LKQKVMNHVN 300
SGCQLMLTQQ LQTF 314
Length:314
Mass (Da):34,518
Last modified:October 1, 1996 - v1
Checksum:i87E936AC37AC2731
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L35273 mRNA. Translation: AAA49537.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L35273 mRNA. Translation: AAA49537.1 .

3D structure databases

ProteinModelPortali P54864.
SMRi P54864. Positions 240-291.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG001722.

Family and domain databases

Gene3Di 1.10.880.10. 1 hit.
InterProi IPR004827. bZIP.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view ]
PRINTSi PR00043. LEUZIPPRJUN.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47454. SSF47454. 1 hit.
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Immediate-early gene responses in the avian song control system: cloning and expression analysis of the canary c-jun cDNA."
    Nastiuk K.L., Mello C.V., George J.M., Clayton D.F.
    Brain Res. Mol. Brain Res. 27:299-309(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wasserschlager.
    Tissue: Brain.

Entry informationi

Entry nameiJUN_SERCA
AccessioniPrimary (citable) accession number: P54864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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