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P54864 (JUN_SERCA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor AP-1
Alternative name(s):
Proto-oncogene c-Jun
Gene names
Name:JUN
OrganismSerinus canaria (Island canary) (Fringilla canaria)
Taxonomic identifier9135 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaFringillidaeCarduelinaeSerinus

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.

Subunit structure

Interacts with FOS to form a dimer.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the bZIP family. Jun subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DiseaseProto-oncogene
   LigandDNA-binding
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Transcription factor AP-1
PRO_0000076435

Regions

Domain235 – 29864bZIP
Region235 – 26228Basic motif By similarity
Region263 – 29129Leucine-zipper By similarity

Sequences

Sequence LengthMass (Da)Tools
P54864 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 87E936AC37AC2731

FASTA31434,518
        10         20         30         40         50         60 
MSAKMEPTFY EDALSAGFAP PESGGYGYNN AKVLKQNMTL NLSDPSSNLK PHLRNKNADI 

        70         80         90        100        110        120 
LTSPDVGLLK LASPELERLI IQSSNGLITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE 

       130        140        150        160        170        180 
LHNQNTLPSV TSAAQPVTSG MAPVSSMAGS TSFNTSLHSE PPVYANLSNF NPNALSSAPN 

       190        200        210        220        230        240 
YNANSMGYAP QHHINPQMPV QHPRLQALKE EPQTVPEMPG ETPPLSPIDM ESQERIKAER 

       250        260        270        280        290        300 
KRMRNRIAAS KCRKRKLERI ARLEEKVKTL KAQNSELAST ANMLREQVAQ LKQKVMNHVN 

       310 
SGCQLMLTQQ LQTF 

« Hide

References

[1]"Immediate-early gene responses in the avian song control system: cloning and expression analysis of the canary c-jun cDNA."
Nastiuk K.L., Mello C.V., George J.M., Clayton D.F.
Brain Res. Mol. Brain Res. 27:299-309(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wasserschlager.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L35273 mRNA. Translation: AAA49537.1.

3D structure databases

ProteinModelPortalP54864.
SMRP54864. Positions 240-291.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG001722.

Family and domain databases

Gene3D1.10.880.10. 1 hit.
InterProIPR004827. bZIP.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]
PRINTSPR00043. LEUZIPPRJUN.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMSSF47454. SSF47454. 1 hit.
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameJUN_SERCA
AccessionPrimary (citable) accession number: P54864
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families