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P54864

- JUN_SERCA

UniProt

P54864 - JUN_SERCA

Protein

Transcription factor AP-1

Gene

JUN

Organism
Serinus canaria (Island canary) (Fringilla canaria)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor AP-1
    Alternative name(s):
    Proto-oncogene c-Jun
    Gene namesi
    Name:JUN
    OrganismiSerinus canaria (Island canary) (Fringilla canaria)
    Taxonomic identifieri9135 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaFringillidaeCarduelinaeSerinus

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Transcription factor AP-1PRO_0000076435Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with FOS to form a dimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP54864.
    SMRiP54864. Positions 240-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini235 – 29864bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni235 – 26228Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni263 – 29129Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. Jun subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG001722.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    InterProiIPR004827. bZIP.
    IPR005643. JNK.
    IPR002112. Leuzip_Jun.
    IPR008917. TF_DNA-bd.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    PF03957. Jun. 1 hit.
    [Graphical view]
    PRINTSiPR00043. LEUZIPPRJUN.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54864-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAKMEPTFY EDALSAGFAP PESGGYGYNN AKVLKQNMTL NLSDPSSNLK    50
    PHLRNKNADI LTSPDVGLLK LASPELERLI IQSSNGLITT TPTPTQFLCP 100
    KNVTDEQEGF AEGFVRALAE LHNQNTLPSV TSAAQPVTSG MAPVSSMAGS 150
    TSFNTSLHSE PPVYANLSNF NPNALSSAPN YNANSMGYAP QHHINPQMPV 200
    QHPRLQALKE EPQTVPEMPG ETPPLSPIDM ESQERIKAER KRMRNRIAAS 250
    KCRKRKLERI ARLEEKVKTL KAQNSELAST ANMLREQVAQ LKQKVMNHVN 300
    SGCQLMLTQQ LQTF 314
    Length:314
    Mass (Da):34,518
    Last modified:October 1, 1996 - v1
    Checksum:i87E936AC37AC2731
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35273 mRNA. Translation: AAA49537.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35273 mRNA. Translation: AAA49537.1 .

    3D structure databases

    ProteinModelPortali P54864.
    SMRi P54864. Positions 240-291.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG001722.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    InterProi IPR004827. bZIP.
    IPR005643. JNK.
    IPR002112. Leuzip_Jun.
    IPR008917. TF_DNA-bd.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    PF03957. Jun. 1 hit.
    [Graphical view ]
    PRINTSi PR00043. LEUZIPPRJUN.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Immediate-early gene responses in the avian song control system: cloning and expression analysis of the canary c-jun cDNA."
      Nastiuk K.L., Mello C.V., George J.M., Clayton D.F.
      Brain Res. Mol. Brain Res. 27:299-309(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wasserschlager.
      Tissue: Brain.

    Entry informationi

    Entry nameiJUN_SERCA
    AccessioniPrimary (citable) accession number: P54864
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3