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Protein

Hexose transporter HXT11

Gene

HXT11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • galactose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transport Source: SGD
  • xylitol transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33544-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.105. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Hexose transporter HXT11
Alternative name(s):
Low-affinity glucose transporter LGT3
Gene namesi
Name:HXT11
Synonyms:LGT3
Ordered Locus Names:YOL156W
ORF Names:AOB567, O0414
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL156W.
SGDiS000005516. HXT11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56CytoplasmicSequence analysisAdd BLAST56
Transmembranei57 – 77Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini78 – 112ExtracellularSequence analysisAdd BLAST35
Transmembranei113 – 133Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini134 – 139CytoplasmicSequence analysis6
Transmembranei140 – 160Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini161 – 170ExtracellularSequence analysis10
Transmembranei171 – 191Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini192 – 197CytoplasmicSequence analysis6
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 232ExtracellularSequence analysisAdd BLAST14
Transmembranei233 – 253Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini254 – 336CytoplasmicSequence analysisAdd BLAST83
Transmembranei337 – 353Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini354 – 359ExtracellularSequence analysis6
Transmembranei360 – 377Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini378 – 384CytoplasmicSequence analysis7
Transmembranei385 – 405Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini406 – 429ExtracellularSequence analysisAdd BLAST24
Transmembranei430 – 450Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini451 – 467CytoplasmicSequence analysisAdd BLAST17
Transmembranei468 – 488Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini489ExtracellularSequence analysis1
Transmembranei490 – 510Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini511 – 567CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504011 – 567Hexose transporter HXT11Add BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineBy similarity1
Modified residuei21PhosphoserineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei38PhosphoserineBy similarity1
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Glycosylationi227N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP54862.

Interactioni

Protein-protein interaction databases

BioGridi34262. 30 interactors.
DIPiDIP-4071N.
IntActiP54862. 2 interactors.
MINTiMINT-554111.

Structurei

3D structure databases

ProteinModelPortaliP54862.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP54862.
KOiK08139.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54862-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGVNNTSAN ELSTTMSNSN SAVGAPSVKT EHGDSKNSLN LDANEPPIDL
60 70 80 90 100
PQKPLSAYTT VAILCLMIAF GGFIFGWDTG TISGFVNLSD FIRRFGQKND
110 120 130 140 150
KGTYYLSKVR MGLIVSIFNI GCAIGGIVLS KVGDIYGRRI GLITVTAIYV
160 170 180 190 200
VGILIQITSI NKWYQYFIGR IISGLGVGGI AVLSPMLISE VAPKHIRGTL
210 220 230 240 250
VQLYQLMGTM GIFLGYCTNY GTKNYHNATQ WRVGLGLCFA WATFMVSGMM
260 270 280 290 300
FVPESPRYLI EVGKDEEAKR SLSKSNKVSV DDPALLVEYD TIKAGIELEK
310 320 330 340 350
LAGNASWSEL LSTKTKVFQR VLMGVMIQSL QQLTGDNYFF YYGTTIFKSV
360 370 380 390 400
GLKDSFQTSI IIGVVNFFSS FIAVYTIERF GRRTCLLWGA ASMLCCFAVF
410 420 430 440 450
ASVGVTKLWP QGSSHQDITS QGAGNCMIVF TMFFIFSFAT TWAGGCYVIV
460 470 480 490 500
SETFPLRVKS RGMAIATAAN WMWGFLISFF TPFITGAINF YYGYVFLGCL
510 520 530 540 550
VFAYFYVFFF VPETKGLTLE EVNTMWLEGV PAWKSASWVP PERRTADYDA
560
DAIDHDNRPI YKRFFSS
Length:567
Mass (Da):62,733
Last modified:October 1, 1996 - v1
Checksum:i3A86EC9AC954DBB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82621 Genomic DNA. Translation: CAA57942.1.
X89715 Genomic DNA. Translation: CAA61859.1.
Z74898 Genomic DNA. Translation: CAA99178.1.
BK006948 Genomic DNA. Translation: DAA10630.1.
PIRiS49600.
RefSeqiNP_014486.1. NM_001183409.1.

Genome annotation databases

EnsemblFungiiYOL156W; YOL156W; YOL156W.
GeneIDi854009.
KEGGisce:YOL156W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82621 Genomic DNA. Translation: CAA57942.1.
X89715 Genomic DNA. Translation: CAA61859.1.
Z74898 Genomic DNA. Translation: CAA99178.1.
BK006948 Genomic DNA. Translation: DAA10630.1.
PIRiS49600.
RefSeqiNP_014486.1. NM_001183409.1.

3D structure databases

ProteinModelPortaliP54862.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34262. 30 interactors.
DIPiDIP-4071N.
IntActiP54862. 2 interactors.
MINTiMINT-554111.

Protein family/group databases

TCDBi2.A.1.1.105. the major facilitator superfamily (mfs).

Proteomic databases

PRIDEiP54862.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL156W; YOL156W; YOL156W.
GeneIDi854009.
KEGGisce:YOL156W.

Organism-specific databases

EuPathDBiFungiDB:YOL156W.
SGDiS000005516. HXT11.

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP54862.
KOiK08139.
OrthoDBiEOG092C1Q5W.

Enzyme and pathway databases

BioCyciYEAST:G3O-33544-MONOMER.

Miscellaneous databases

PROiP54862.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXT11_YEAST
AccessioniPrimary (citable) accession number: P54862
Secondary accession number(s): D6W1R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.