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Protein

Hexose transporter HXT11

Gene

HXT11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • galactose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transport Source: SGD
  • xylitol transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33544-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.

Protein family/group databases

TCDBi2.A.1.1.105. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Hexose transporter HXT11
Alternative name(s):
Low-affinity glucose transporter LGT3
Gene namesi
Name:HXT11
Synonyms:LGT3
Ordered Locus Names:YOL156W
ORF Names:AOB567, O0414
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL156W.
SGDiS000005516. HXT11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656CytoplasmicSequence analysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini78 – 11235ExtracellularSequence analysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini134 – 1396CytoplasmicSequence analysis
Transmembranei140 – 16021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini161 – 17010ExtracellularSequence analysis
Transmembranei171 – 19121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini192 – 1976CytoplasmicSequence analysis
Transmembranei198 – 21821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 23214ExtracellularSequence analysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini254 – 33683CytoplasmicSequence analysisAdd
BLAST
Transmembranei337 – 35317Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini354 – 3596ExtracellularSequence analysis
Transmembranei360 – 37718Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini378 – 3847CytoplasmicSequence analysis
Transmembranei385 – 40521Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini406 – 42924ExtracellularSequence analysisAdd
BLAST
Transmembranei430 – 45021Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini451 – 46717CytoplasmicSequence analysisAdd
BLAST
Transmembranei468 – 48821Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini489 – 4891ExtracellularSequence analysis
Transmembranei490 – 51021Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini511 – 56757CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Hexose transporter HXT11PRO_0000050401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171PhosphoserineBy similarity
Modified residuei21 – 211PhosphoserineBy similarity
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei35 – 351PhosphoserineBy similarity
Modified residuei38 – 381PhosphoserineBy similarity
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Interactioni

Protein-protein interaction databases

BioGridi34262. 30 interactions.
DIPiDIP-4071N.
IntActiP54862. 2 interactions.
MINTiMINT-554111.

Structurei

3D structure databases

ProteinModelPortaliP54862.
SMRiP54862. Positions 64-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP54862.
KOiK08139.
OrthoDBiEOG73JM4H.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54862-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGVNNTSAN ELSTTMSNSN SAVGAPSVKT EHGDSKNSLN LDANEPPIDL
60 70 80 90 100
PQKPLSAYTT VAILCLMIAF GGFIFGWDTG TISGFVNLSD FIRRFGQKND
110 120 130 140 150
KGTYYLSKVR MGLIVSIFNI GCAIGGIVLS KVGDIYGRRI GLITVTAIYV
160 170 180 190 200
VGILIQITSI NKWYQYFIGR IISGLGVGGI AVLSPMLISE VAPKHIRGTL
210 220 230 240 250
VQLYQLMGTM GIFLGYCTNY GTKNYHNATQ WRVGLGLCFA WATFMVSGMM
260 270 280 290 300
FVPESPRYLI EVGKDEEAKR SLSKSNKVSV DDPALLVEYD TIKAGIELEK
310 320 330 340 350
LAGNASWSEL LSTKTKVFQR VLMGVMIQSL QQLTGDNYFF YYGTTIFKSV
360 370 380 390 400
GLKDSFQTSI IIGVVNFFSS FIAVYTIERF GRRTCLLWGA ASMLCCFAVF
410 420 430 440 450
ASVGVTKLWP QGSSHQDITS QGAGNCMIVF TMFFIFSFAT TWAGGCYVIV
460 470 480 490 500
SETFPLRVKS RGMAIATAAN WMWGFLISFF TPFITGAINF YYGYVFLGCL
510 520 530 540 550
VFAYFYVFFF VPETKGLTLE EVNTMWLEGV PAWKSASWVP PERRTADYDA
560
DAIDHDNRPI YKRFFSS
Length:567
Mass (Da):62,733
Last modified:October 1, 1996 - v1
Checksum:i3A86EC9AC954DBB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82621 Genomic DNA. Translation: CAA57942.1.
X89715 Genomic DNA. Translation: CAA61859.1.
Z74898 Genomic DNA. Translation: CAA99178.1.
BK006948 Genomic DNA. Translation: DAA10630.1.
PIRiS49600.
RefSeqiNP_014486.1. NM_001183409.1.

Genome annotation databases

EnsemblFungiiYOL156W; YOL156W; YOL156W.
GeneIDi854009.
KEGGisce:YOL156W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82621 Genomic DNA. Translation: CAA57942.1.
X89715 Genomic DNA. Translation: CAA61859.1.
Z74898 Genomic DNA. Translation: CAA99178.1.
BK006948 Genomic DNA. Translation: DAA10630.1.
PIRiS49600.
RefSeqiNP_014486.1. NM_001183409.1.

3D structure databases

ProteinModelPortaliP54862.
SMRiP54862. Positions 64-526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34262. 30 interactions.
DIPiDIP-4071N.
IntActiP54862. 2 interactions.
MINTiMINT-554111.

Protein family/group databases

TCDBi2.A.1.1.105. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL156W; YOL156W; YOL156W.
GeneIDi854009.
KEGGisce:YOL156W.

Organism-specific databases

EuPathDBiFungiDB:YOL156W.
SGDiS000005516. HXT11.

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP54862.
KOiK08139.
OrthoDBiEOG73JM4H.

Enzyme and pathway databases

BioCyciYEAST:G3O-33544-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

PROiP54862.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Wesolowski-Louvel M.
    Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of the DNA sequence of a 15,500 bp fragment near the left telomere of chromosome XV from Saccharomyces cerevisiae reveals a putative sugar transporter, a carboxypeptidase homologue and two new open reading frames."
    Gamo F.-J., Lafuente M.J., Casamayor A., Arino J., Aldea M., Casas C., Herrero E., Gancedo C.
    Yeast 12:709-714(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiHXT11_YEAST
AccessioniPrimary (citable) accession number: P54862
Secondary accession number(s): D6W1R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.