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Protein

Dynamin-related protein DNM1

Gene

DNM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein that participates mitochondrial fission. Fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Functions antagonistically with FZO1.2 Publications

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 42GTPSequence analysis8
Nucleotide bindingi175 – 179GTPSequence analysis5
Nucleotide bindingi244 – 247GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW
  • identical protein binding Source: SGD
  • microtubule binding Source: GO_Central
  • protein homodimerization activity Source: SGD

GO - Biological processi

  • chronological cell aging Source: SGD
  • dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
  • macroautophagy Source: SGD
  • membrane fusion Source: GO_Central
  • mitochondrial fission Source: UniProtKB
  • mitochondrion inheritance Source: SGD
  • mitochondrion localization Source: SGD
  • mitochondrion organization Source: SGD
  • peroxisome fission Source: SGD
  • peroxisome organization Source: SGD
  • protein homooligomerization Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Motor protein

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32106-MONOMER.
ReactomeiR-SCE-75153. Apoptotic execution phase.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-related protein DNM1 (EC:3.6.5.5)
Gene namesi
Name:DNM1
Ordered Locus Names:YLL001W
ORF Names:L1381
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL001W.
SGDiS000003924. DNM1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • mitochondrial outer membrane Source: SGD
  • mitochondrion Source: UniProtKB
  • peroxisome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi705K → A: Induces an increase of mitochondrial fission. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065861 – 757Dynamin-related protein DNM1Add BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei629PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP54861.
PRIDEiP54861.

PTM databases

iPTMnetiP54861.

Interactioni

Subunit structurei

Interacts with FIS1 and MDV1.2 Publications

GO - Molecular functioni

  • identical protein binding Source: SGD
  • microtubule binding Source: GO_Central
  • protein homodimerization activity Source: SGD

Protein-protein interaction databases

BioGridi31273. 110 interactors.
DIPiDIP-1908N.
IntActiP54861. 25 interactors.
MINTiMINT-389570.

Structurei

3D structure databases

ProteinModelPortaliP54861.
SMRiP54861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 333Dynamin-type GAdd BLAST309
Domaini670 – 757GEDPROSITE-ProRule annotationAdd BLAST88

Domaini

The GTPase domain modulates a rate-limiting step in mitochondrial membrane fission.

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119213.
HOGENOMiHOG000161068.
InParanoidiP54861.
KOiK17065.
OMAiNASESRW.
OrthoDBiEOG092C16PN.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 3 hits.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLEDLIPT VNKLQDVMYD SGIDTLDLPI LAVVGSQSSG KSSILETLVG
60 70 80 90 100
RDFLPRGTGI VTRRPLVLQL NNISPNSPLI EEDDNSVNPH DEVTKISGFE
110 120 130 140 150
AGTKPLEYRG KERNHADEWG EFLHIPGKRF YDFDDIKREI ENETARIAGK
160 170 180 190 200
DKGISKIPIN LKVFSPHVLN LTLVDLPGIT KVPIGEQPPD IEKQIKNLIL
210 220 230 240 250
DYIATPNCLI LAVSPANVDL VNSESLKLAR EVDPQGKRTI GVITKLDLMD
260 270 280 290 300
SGTNALDILS GKMYPLKLGF VGVVNRSQQD IQLNKTVEES LDKEEDYFRK
310 320 330 340 350
HPVYRTISTK CGTRYLAKLL NQTLLSHIRD KLPDIKTKLN TLISQTEQEL
360 370 380 390 400
ARYGGVGATT NESRASLVLQ LMNKFSTNFI SSIDGTSSDI NTKELCGGAR
410 420 430 440 450
IYYIYNNVFG NSLKSIDPTS NLSVLDVRTA IRNSTGPRPT LFVPELAFDL
460 470 480 490 500
LVKPQIKLLL EPSQRCVELV YEELMKICHK CGSAELARYP KLKSMLIEVI
510 520 530 540 550
SELLRERLQP TRSYVESLID IHRAYINTNH PNFLSATEAM DDIMKTRRKR
560 570 580 590 600
NQELLKSKLS QQENGQTNGI NGTSSISSNI DQDSAKNSDY DDDGIDAESK
610 620 630 640 650
QTKDKFLNYF FGKDKKGQPV FDASDKKRSI AGDGNIEDFR NLQISDFSLG
660 670 680 690 700
DIDDLENAEP PLTEREELEC ELIKRLIVSY FDIIREMIED QVPKAVMCLL
710 720 730 740 750
VNYCKDSVQN RLVTKLYKET LFEELLVEDQ TLAQDRELCV KSLGVYKKAA

TLISNIL
Length:757
Mass (Da):84,972
Last modified:October 1, 1996 - v1
Checksum:iEBEF8793C5951770
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124H → ISPD in AAA99998 (PubMed:7622557).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40588 Genomic DNA. Translation: AAA99998.1.
X91488 Genomic DNA. Translation: CAA62769.1.
Z73106 Genomic DNA. Translation: CAA97444.1.
BK006945 Genomic DNA. Translation: DAA09318.1.
PIRiS64742.
RefSeqiNP_013100.1. NM_001181821.1.

Genome annotation databases

EnsemblFungiiYLL001W; YLL001W; YLL001W.
GeneIDi850686.
KEGGisce:YLL001W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40588 Genomic DNA. Translation: AAA99998.1.
X91488 Genomic DNA. Translation: CAA62769.1.
Z73106 Genomic DNA. Translation: CAA97444.1.
BK006945 Genomic DNA. Translation: DAA09318.1.
PIRiS64742.
RefSeqiNP_013100.1. NM_001181821.1.

3D structure databases

ProteinModelPortaliP54861.
SMRiP54861.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31273. 110 interactors.
DIPiDIP-1908N.
IntActiP54861. 25 interactors.
MINTiMINT-389570.

PTM databases

iPTMnetiP54861.

Proteomic databases

MaxQBiP54861.
PRIDEiP54861.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL001W; YLL001W; YLL001W.
GeneIDi850686.
KEGGisce:YLL001W.

Organism-specific databases

EuPathDBiFungiDB:YLL001W.
SGDiS000003924. DNM1.

Phylogenomic databases

GeneTreeiENSGT00760000119213.
HOGENOMiHOG000161068.
InParanoidiP54861.
KOiK17065.
OMAiNASESRW.
OrthoDBiEOG092C16PN.

Enzyme and pathway databases

BioCyciYEAST:G3O-32106-MONOMER.
ReactomeiR-SCE-75153. Apoptotic execution phase.

Miscellaneous databases

PROiP54861.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 3 hits.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNM1_YEAST
AccessioniPrimary (citable) accession number: P54861
Secondary accession number(s): D6VY02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 9600 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.