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Protein

Dynamin-related protein DNM1

Gene

DNM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-associated force-producing protein that participates mitochondrial fission. Fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. Functions antagonistically with FZO1.2 Publications

Miscellaneous

Present with 9600 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

GTP + H2O = GDP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi35 – 42GTPSequence analysis8
Nucleotide bindingi175 – 179GTPSequence analysis5
Nucleotide bindingi244 – 247GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW
  • identical protein binding Source: SGD
  • microtubule binding Source: GO_Central
  • protein homodimerization activity Source: SGD

GO - Biological processi

  • chronological cell aging Source: SGD
  • dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
  • macroautophagy Source: SGD
  • membrane fusion Source: GO_Central
  • membrane organization Source: ParkinsonsUK-UCL
  • mitochondrial fission Source: UniProtKB
  • mitochondrion inheritance Source: SGD
  • mitochondrion organization Source: SGD
  • peroxisome fission Source: SGD
  • peroxisome organization Source: SGD
  • protein homooligomerization Source: SGD
  • vesicle organization Source: ParkinsonsUK-UCL

Keywordsi

Molecular functionHydrolase, Motor protein
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32106-MONOMER
ReactomeiR-SCE-75153 Apoptotic execution phase

Names & Taxonomyi

Protein namesi
Recommended name:
Dynamin-related protein DNM1 (EC:3.6.5.5)
Gene namesi
Name:DNM1
Ordered Locus Names:YLL001W
ORF Names:L1381
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL001W
SGDiS000003924 DNM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi705K → A: Induces an increase of mitochondrial fission. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002065861 – 757Dynamin-related protein DNM1Add BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei629PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP54861
PaxDbiP54861
PRIDEiP54861

PTM databases

iPTMnetiP54861

Interactioni

Subunit structurei

Interacts with FIS1 and MDV1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-6002,EBI-6002

GO - Molecular functioni

  • identical protein binding Source: SGD
  • microtubule binding Source: GO_Central
  • protein homodimerization activity Source: SGD

Protein-protein interaction databases

BioGridi31273, 205 interactors
DIPiDIP-1908N
IntActiP54861, 27 interactors
MINTiP54861
STRINGi4932.YLL001W

Structurei

3D structure databases

ProteinModelPortaliP54861
SMRiP54861
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 333Dynamin-type GPROSITE-ProRule annotationAdd BLAST309
Domaini670 – 757GEDPROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 42G1 motifPROSITE-ProRule annotation8
Regioni61 – 63G2 motifPROSITE-ProRule annotation3
Regioni175 – 178G3 motifPROSITE-ProRule annotation4
Regioni244 – 247G4 motifPROSITE-ProRule annotation4
Regioni274 – 277G5 motifPROSITE-ProRule annotation4

Domaini

The GTPase domain modulates a rate-limiting step in mitochondrial membrane fission.

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00910000144225
HOGENOMiHOG000161068
InParanoidiP54861
KOiK17065
OMAiHHIPNRR
OrthoDBiEOG092C16PN

Family and domain databases

CDDicd08771 DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequencei

Sequence statusi: Complete.

P54861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLEDLIPT VNKLQDVMYD SGIDTLDLPI LAVVGSQSSG KSSILETLVG
60 70 80 90 100
RDFLPRGTGI VTRRPLVLQL NNISPNSPLI EEDDNSVNPH DEVTKISGFE
110 120 130 140 150
AGTKPLEYRG KERNHADEWG EFLHIPGKRF YDFDDIKREI ENETARIAGK
160 170 180 190 200
DKGISKIPIN LKVFSPHVLN LTLVDLPGIT KVPIGEQPPD IEKQIKNLIL
210 220 230 240 250
DYIATPNCLI LAVSPANVDL VNSESLKLAR EVDPQGKRTI GVITKLDLMD
260 270 280 290 300
SGTNALDILS GKMYPLKLGF VGVVNRSQQD IQLNKTVEES LDKEEDYFRK
310 320 330 340 350
HPVYRTISTK CGTRYLAKLL NQTLLSHIRD KLPDIKTKLN TLISQTEQEL
360 370 380 390 400
ARYGGVGATT NESRASLVLQ LMNKFSTNFI SSIDGTSSDI NTKELCGGAR
410 420 430 440 450
IYYIYNNVFG NSLKSIDPTS NLSVLDVRTA IRNSTGPRPT LFVPELAFDL
460 470 480 490 500
LVKPQIKLLL EPSQRCVELV YEELMKICHK CGSAELARYP KLKSMLIEVI
510 520 530 540 550
SELLRERLQP TRSYVESLID IHRAYINTNH PNFLSATEAM DDIMKTRRKR
560 570 580 590 600
NQELLKSKLS QQENGQTNGI NGTSSISSNI DQDSAKNSDY DDDGIDAESK
610 620 630 640 650
QTKDKFLNYF FGKDKKGQPV FDASDKKRSI AGDGNIEDFR NLQISDFSLG
660 670 680 690 700
DIDDLENAEP PLTEREELEC ELIKRLIVSY FDIIREMIED QVPKAVMCLL
710 720 730 740 750
VNYCKDSVQN RLVTKLYKET LFEELLVEDQ TLAQDRELCV KSLGVYKKAA

TLISNIL
Length:757
Mass (Da):84,972
Last modified:October 1, 1996 - v1
Checksum:iEBEF8793C5951770
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124H → ISPD in AAA99998 (PubMed:7622557).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40588 Genomic DNA Translation: AAA99998.1
X91488 Genomic DNA Translation: CAA62769.1
Z73106 Genomic DNA Translation: CAA97444.1
BK006945 Genomic DNA Translation: DAA09318.1
PIRiS64742
RefSeqiNP_013100.1, NM_001181821.1

Genome annotation databases

EnsemblFungiiYLL001W; YLL001W; YLL001W
GeneIDi850686
KEGGisce:YLL001W

Similar proteinsi

Entry informationi

Entry nameiDNM1_YEAST
AccessioniPrimary (citable) accession number: P54861
Secondary accession number(s): D6VY02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
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