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Protein

Lipase 2

Gene

TGL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Lipolytic activity towards triacylglycerols and diacylglycerols with short-chain fatty acids.

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

pH dependencei

Optimum pH is 8.0.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei144 – 1441Charge relay systemBy similarity

GO - Molecular functioni

  • triglyceride lipase activity Source: SGD

GO - Biological processi

  • triglyceride catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciYEAST:YDR058C-MONOMER.

Protein family/group databases

ESTHERiyeast-tgl2. PGAP1.

Chemistry

SwissLipidsiSLP:000001353.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipase 2 (EC:3.1.1.3)
Alternative name(s):
Triacylglycerol lipase 2
Gene namesi
Name:TGL2
Ordered Locus Names:YDR058C
ORF Names:D4225, YD9609.12C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR058C.
SGDiS000002465. TGL2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Lipase 2PRO_0000090380Add
BLAST

Proteomic databases

MaxQBiP54857.

Interactioni

Protein-protein interaction databases

BioGridi32111. 51 interactions.
MINTiMINT-2784615.

Structurei

3D structure databases

ProteinModelPortaliP54857.
SMRiP54857. Positions 19-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000186395.
InParanoidiP54857.
KOiK01046.
OMAiSSKWGEY.
OrthoDBiEOG092C2V87.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR012908. PGAP1-like.
[Graphical view]
PfamiPF07819. PGAP1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.

Sequencei

Sequence statusi: Complete.

P54857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNDNKANDI IIDSVKVPDS YKPPKNPIVF CHGLSGFDKL ILIPSVFHLT
60 70 80 90 100
NLISNSIVHN MAENFMQDDE DKSDNKYTNL LEIEYWIGVK KFLQSKGCTV
110 120 130 140 150
ITTKVPGFGS IEERAMALDA QLQKEVKKIE SKDKRHSLNL IAHSMGGLDC
160 170 180 190 200
RYLICNIKNR NYDILSLTTI STPHRGSEMA DYVVDLFENL NALRVSQKIL
210 220 230 240 250
PICFYQLTTA YMKYFNLVTP NSPKVSYFSY GCSFVPKWYN VFCTPWKIVY
260 270 280 290 300
ERSKGCPNDG LVTINSSKWG EYRGTLKDMD HLDVINWKNK LQDDWSKFFR
310 320
TTTVGEKVDI LNFYLKITDD LARKGF
Length:326
Mass (Da):37,500
Last modified:October 1, 1996 - v1
Checksum:i3D2421611ED72CE9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041K → N in AAS56017 (PubMed:17322287).Curated
Sequence conflicti300 – 3001R → H in CAA66637 (PubMed:9544243).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98000 Genomic DNA. Translation: CAA66637.1.
X84162 Genomic DNA. Translation: CAA58974.1.
Z49209 Genomic DNA. Translation: CAA89087.1.
Z74354 Genomic DNA. Translation: CAA98876.1.
AY557691 Genomic DNA. Translation: AAS56017.1.
BK006938 Genomic DNA. Translation: DAA11904.1.
PIRiS54042.
RefSeqiNP_010343.1. NM_001180366.1.

Genome annotation databases

EnsemblFungiiYDR058C; YDR058C; YDR058C.
GeneIDi851628.
KEGGisce:YDR058C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98000 Genomic DNA. Translation: CAA66637.1.
X84162 Genomic DNA. Translation: CAA58974.1.
Z49209 Genomic DNA. Translation: CAA89087.1.
Z74354 Genomic DNA. Translation: CAA98876.1.
AY557691 Genomic DNA. Translation: AAS56017.1.
BK006938 Genomic DNA. Translation: DAA11904.1.
PIRiS54042.
RefSeqiNP_010343.1. NM_001180366.1.

3D structure databases

ProteinModelPortaliP54857.
SMRiP54857. Positions 19-183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32111. 51 interactions.
MINTiMINT-2784615.

Chemistry

SwissLipidsiSLP:000001353.

Protein family/group databases

ESTHERiyeast-tgl2. PGAP1.

Proteomic databases

MaxQBiP54857.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR058C; YDR058C; YDR058C.
GeneIDi851628.
KEGGisce:YDR058C.

Organism-specific databases

EuPathDBiFungiDB:YDR058C.
SGDiS000002465. TGL2.

Phylogenomic databases

HOGENOMiHOG000186395.
InParanoidiP54857.
KOiK01046.
OMAiSSKWGEY.
OrthoDBiEOG092C2V87.

Enzyme and pathway databases

BioCyciYEAST:YDR058C-MONOMER.

Miscellaneous databases

PROiP54857.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR012908. PGAP1-like.
[Graphical view]
PfamiPF07819. PGAP1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiTGL2_YEAST
AccessioniPrimary (citable) accession number: P54857
Secondary accession number(s): D6VS44, E9P8S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.