Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P54855

- UDB15_HUMAN

UniProt

P54855 - UDB15_HUMAN

Protein

UDP-glucuronosyltransferase 2B15

Gene

UGT2B15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (03 May 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: BHF-UCL

    GO - Biological processi

    1. cellular glucuronidation Source: BHF-UCL
    2. steroid metabolic process Source: ProtInc
    3. xenobiotic metabolic process Source: ProtInc

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 2681.
    ReactomeiREACT_6784. Glucuronidation.
    SABIO-RKP54855.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B15 (EC:2.4.1.17)
    Short name:
    UDPGT 2B15
    Alternative name(s):
    HLUG4
    UDP-glucuronosyltransferase 2B8
    Short name:
    UDPGT 2B8
    UDPGTh-3
    Gene namesi
    Name:UGT2B15
    Synonyms:UGT2B8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:12546. UGT2B15.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37188.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 530507UDP-glucuronosyltransferase 2B15PRO_0000036039Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651N-linked (GlcNAc...)1 Publication
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP54855.
    PRIDEiP54855.

    PTM databases

    PhosphoSiteiP54855.

    Expressioni

    Tissue specificityi

    Expressed in many tissues. Present in liver, prostate and testis.1 Publication

    Gene expression databases

    BgeeiP54855.
    CleanExiHS_UGT2B15.
    GenevestigatoriP54855.

    Organism-specific databases

    HPAiHPA045108.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000341045.

    Structurei

    3D structure databases

    ProteinModelPortaliP54855.
    SMRiP54855. Positions 286-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei495 – 51521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.
    InParanoidiP54855.
    KOiK00699.
    OMAiKEQSAMI.
    OrthoDBiEOG7GBFWS.
    PhylomeDBiP54855.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P54855-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLKWTSVFL LIQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVQRG    50
    HEVTVLTSSA STLVNASKSS AIKLEVYPTS LTKNYLEDSL LKILDRWIYG 100
    VSKNTFWSYF SQLQELCWEY YDYSNKLCKD AVLNKKLMMK LQESKFDVIL 150
    ADALNPCGEL LAELFNIPFL YSLRFSVGYT FEKNGGGFLF PPSYVPVVMS 200
    ELSDQMIFME RIKNMIHMLY FDFWFQIYDL KKWDQFYSEV LGRPTTLFET 250
    MGKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS 300
    GENGIVVFSL GSMISNMSEE SANMIASALA QIPQKVLWRF DGKKPNTLGS 350
    NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ 400
    HDNIAHMKAK GAALSVDIRT MSSRDLLNAL KSVINDPVYK ENVMKLSRIH 450
    HDQPMKPLDR AVFWIEFVMR HKGAKHLRVA AHNLTWIQYH SLDVIAFLLA 500
    CVATVIFIIT KFCLFCFRKL AKKGKKKKRD 530
    Length:530
    Mass (Da):61,036
    Last modified:May 3, 2011 - v3
    Checksum:iEB2DAE838769C955
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti119 – 1191E → A in AAA83406. (PubMed:2116769)Curated
    Sequence conflicti145 – 1451K → R in AAA83406. (PubMed:2116769)Curated
    Sequence conflicti150 – 1556LADALN → PGDPVF in AAA83406. (PubMed:2116769)Curated
    Sequence conflicti162 – 1621A → S in AAA83406. (PubMed:2116769)Curated
    Sequence conflicti165 – 1651F → L in AAA83406. (PubMed:2116769)Curated
    Sequence conflicti170 – 1778LYSLRFSV → VYRSRISR in AAA83406. (PubMed:2116769)Curated
    Sequence conflicti181 – 1811F → I in AAA83406. (PubMed:2116769)Curated
    Sequence conflicti203 – 2031S → I in AAA83406. (PubMed:2116769)Curated
    Sequence conflicti293 – 2931M → L in AAA83406. (PubMed:2116769)Curated
    Sequence conflicti401 – 4011H → D in AAA83406. (PubMed:2116769)Curated
    Sequence conflicti443 – 4431V → A in AAA83406. (PubMed:2116769)Curated
    Sequence conflicti501 – 5011C → W in AAA83406. (PubMed:2116769)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851Y → D.2 Publications
    Corresponds to variant rs1902023 [ dbSNP | Ensembl ].
    VAR_007713
    Natural varianti523 – 5231K → T.5 Publications
    Corresponds to variant rs4148269 [ dbSNP | Ensembl ].
    VAR_018348

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF548389 mRNA. Translation: AAN40695.1.
    U08854 mRNA. Translation: AAC50077.1.
    AF180322 mRNA. Translation: AAD55093.1.
    AK289419 mRNA. Translation: BAF82108.1.
    AC019173 Genomic DNA. No translation available.
    AC147055 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX05574.1.
    U06641 mRNA. Translation: AAA83406.1.
    CCDSiCCDS3524.1.
    PIRiA48633.
    S11309.
    RefSeqiNP_001067.2. NM_001076.3.
    UniGeneiHs.150207.

    Genome annotation databases

    EnsembliENST00000338206; ENSP00000341045; ENSG00000196620.
    GeneIDi7366.
    KEGGihsa:7366.
    UCSCiuc021xow.1. human.

    Polymorphism databases

    DMDMi332278237.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF548389 mRNA. Translation: AAN40695.1 .
    U08854 mRNA. Translation: AAC50077.1 .
    AF180322 mRNA. Translation: AAD55093.1 .
    AK289419 mRNA. Translation: BAF82108.1 .
    AC019173 Genomic DNA. No translation available.
    AC147055 Genomic DNA. No translation available.
    CH471057 Genomic DNA. Translation: EAX05574.1 .
    U06641 mRNA. Translation: AAA83406.1 .
    CCDSi CCDS3524.1.
    PIRi A48633.
    S11309.
    RefSeqi NP_001067.2. NM_001076.3.
    UniGenei Hs.150207.

    3D structure databases

    ProteinModelPortali P54855.
    SMRi P54855. Positions 286-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000341045.

    Chemistry

    ChEMBLi CHEMBL6161.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei P54855.

    Polymorphism databases

    DMDMi 332278237.

    Proteomic databases

    PaxDbi P54855.
    PRIDEi P54855.

    Protocols and materials databases

    DNASUi 7366.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338206 ; ENSP00000341045 ; ENSG00000196620 .
    GeneIDi 7366.
    KEGGi hsa:7366.
    UCSCi uc021xow.1. human.

    Organism-specific databases

    CTDi 7366.
    GeneCardsi GC04M069561.
    H-InvDB HIX0031375.
    HIX0164240.
    HGNCi HGNC:12546. UGT2B15.
    HPAi HPA045108.
    MIMi 600069. gene.
    neXtProti NX_P54855.
    PharmGKBi PA37188.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.
    InParanoidi P54855.
    KOi K00699.
    OMAi KEQSAMI.
    OrthoDBi EOG7GBFWS.
    PhylomeDBi P54855.
    TreeFami TF315472.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 2681.
    Reactomei REACT_6784. Glucuronidation.
    SABIO-RK P54855.

    Miscellaneous databases

    GeneWikii UGT2B15.
    GenomeRNAii 7366.
    NextBioi 28842.
    PROi P54855.
    SOURCEi Search...

    Gene expression databases

    Bgeei P54855.
    CleanExi HS_UGT2B15.
    Genevestigatori P54855.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms."
      Chen F., Ritter J.K., Wang M.G., McBride O.W., Lubet R.A., Owens I.S.
      Biochemistry 32:10648-10657(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY, VARIANTS ASP-85 AND THR-523.
      Tissue: Liver.
    2. "Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates."
      Green M.D., Oturu E.M., Tephly T.R.
      Drug Metab. Dispos. 22:799-805(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASP-85 AND THR-523.
      Tissue: Liver.
    3. "Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene."
      Levesque E., Beaulieu M., Green M.D., Tephly T.R., Belanger A., Hum D.W.
      Pharmacogenetics 7:317-325(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-523.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-523.
      Tissue: Mammary gland.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase."
      Coffman B.L., Tephly T.R., Irshaid Y.M., Green M.D., Smith C., Jackson M.R., Wooster R., Burchell B.
      Arch. Biochem. Biophys. 281:170-175(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-530, PARTIAL PROTEIN SEQUENCE.
      Tissue: Liver.
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-65.
      Tissue: Liver.
    9. Cited for: VARIANT THR-523.

    Entry informationi

    Entry nameiUDB15_HUMAN
    AccessioniPrimary (citable) accession number: P54855
    Secondary accession number(s): A6NDX0
    , A6NNJ4, A8K054, P23765, Q9UK63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    PubMed:2116769 thought that this was a separate form (UGT2B8). The name UGT2B8 has now been reused for a rat enzyme.Curated

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3