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Protein

UDP-glucuronosyltransferase 2B15

Gene

UGT2B15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: UniProtKB

GO - Biological processi

  • cellular glucuronidation Source: UniProtKB
  • steroid metabolic process Source: ProtInc
  • xenobiotic metabolic process Source: ProtInc

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiR-HSA-156588. Glucuronidation.
SABIO-RKiP54855.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Chemistry databases

SwissLipidsiSLP:000001709.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B15 (EC:2.4.1.17)
Short name:
UDPGT 2B15
Alternative name(s):
HLUG4
UDP-glucuronosyltransferase 2B8
Short name:
UDPGT 2B8
UDPGTh-3
Gene namesi
Name:UGT2B15
Synonyms:UGT2B8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:12546. UGT2B15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi7366.
MalaCardsiUGT2B15.
OpenTargetsiENSG00000196620.
PharmGKBiPA37188.

Chemistry databases

ChEMBLiCHEMBL6161.
DrugBankiDB00316. Acetaminophen.
DB06695. Dabigatran etexilate.
DB00973. Ezetimibe.
DB00186. Lorazepam.
DB00295. Morphine.
DB00842. Oxazepam.
DB00197. Troglitazone.
DB00313. Valproic Acid.

Polymorphism and mutation databases

BioMutaiUGT2B15.
DMDMi332278237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003603924 – 530UDP-glucuronosyltransferase 2B15Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP54855.
PaxDbiP54855.
PeptideAtlasiP54855.
PRIDEiP54855.

PTM databases

iPTMnetiP54855.
PhosphoSitePlusiP54855.

Expressioni

Tissue specificityi

Expressed in many tissues. Present in liver, prostate and testis.1 Publication

Gene expression databases

BgeeiENSG00000196620.
CleanExiHS_UGT2B15.
GenevisibleiP54855. HS.

Organism-specific databases

HPAiHPA045108.

Interactioni

Protein-protein interaction databases

BioGridi113213. 1 interactor.
STRINGi9606.ENSP00000341045.

Structurei

3D structure databases

ProteinModelPortaliP54855.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP54855.
KOiK00699.
OMAiWDTKKWD.
OrthoDBiEOG091G06JC.
PhylomeDBiP54855.
TreeFamiTF315472.

Family and domain databases

InterProiView protein in InterPro
IPR002213. UDP_glucos_trans.
IPR035595. UDP_glycos_trans_CS.
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiView protein in Pfam
PF00201. UDPGT. 1 hit.
PROSITEiView protein in PROSITE
PS00375. UDPGT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKWTSVFL LIQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVQRG
60 70 80 90 100
HEVTVLTSSA STLVNASKSS AIKLEVYPTS LTKNYLEDSL LKILDRWIYG
110 120 130 140 150
VSKNTFWSYF SQLQELCWEY YDYSNKLCKD AVLNKKLMMK LQESKFDVIL
160 170 180 190 200
ADALNPCGEL LAELFNIPFL YSLRFSVGYT FEKNGGGFLF PPSYVPVVMS
210 220 230 240 250
ELSDQMIFME RIKNMIHMLY FDFWFQIYDL KKWDQFYSEV LGRPTTLFET
260 270 280 290 300
MGKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS
310 320 330 340 350
GENGIVVFSL GSMISNMSEE SANMIASALA QIPQKVLWRF DGKKPNTLGS
360 370 380 390 400
NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ
410 420 430 440 450
HDNIAHMKAK GAALSVDIRT MSSRDLLNAL KSVINDPVYK ENVMKLSRIH
460 470 480 490 500
HDQPMKPLDR AVFWIEFVMR HKGAKHLRVA AHNLTWIQYH SLDVIAFLLA
510 520 530
CVATVIFIIT KFCLFCFRKL AKKGKKKKRD
Length:530
Mass (Da):61,036
Last modified:May 3, 2011 - v3
Checksum:iEB2DAE838769C955
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119E → A in AAA83406 (PubMed:2116769).Curated1
Sequence conflicti145K → R in AAA83406 (PubMed:2116769).Curated1
Sequence conflicti150 – 155LADALN → PGDPVF in AAA83406 (PubMed:2116769).Curated6
Sequence conflicti162A → S in AAA83406 (PubMed:2116769).Curated1
Sequence conflicti165F → L in AAA83406 (PubMed:2116769).Curated1
Sequence conflicti170 – 177LYSLRFSV → VYRSRISR in AAA83406 (PubMed:2116769).Curated8
Sequence conflicti181F → I in AAA83406 (PubMed:2116769).Curated1
Sequence conflicti203S → I in AAA83406 (PubMed:2116769).Curated1
Sequence conflicti293M → L in AAA83406 (PubMed:2116769).Curated1
Sequence conflicti401H → D in AAA83406 (PubMed:2116769).Curated1
Sequence conflicti443V → A in AAA83406 (PubMed:2116769).Curated1
Sequence conflicti501C → W in AAA83406 (PubMed:2116769).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00771385Y → D2 PublicationsCorresponds to variant dbSNP:rs1902023Ensembl.1
Natural variantiVAR_018348523K → T5 PublicationsCorresponds to variant dbSNP:rs4148269Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF548389 mRNA. Translation: AAN40695.1.
U08854 mRNA. Translation: AAC50077.1.
AF180322 mRNA. Translation: AAD55093.1.
AK289419 mRNA. Translation: BAF82108.1.
AC019173 Genomic DNA. No translation available.
AC147055 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05574.1.
U06641 mRNA. Translation: AAA83406.1.
CCDSiCCDS3524.1.
PIRiA48633.
S11309.
RefSeqiNP_001067.2. NM_001076.3.
UniGeneiHs.150207.

Genome annotation databases

EnsembliENST00000338206; ENSP00000341045; ENSG00000196620.
GeneIDi7366.
KEGGihsa:7366.
UCSCiuc021xow.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUDB15_HUMAN
AccessioniPrimary (citable) accession number: P54855
Secondary accession number(s): A6NDX0
, A6NNJ4, A8K054, P23765, Q9UK63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 3, 2011
Last modified: August 30, 2017
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

PubMed:2116769 thought that this was a separate form (UGT2B8). The name UGT2B8 has now been reused for a rat enzyme.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families