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P54855

- UDB15_HUMAN

UniProt

P54855 - UDB15_HUMAN

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Protein

UDP-glucuronosyltransferase 2B15

Gene

UGT2B15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: BHF-UCL

GO - Biological processi

  1. cellular glucuronidation Source: BHF-UCL
  2. steroid metabolic process Source: ProtInc
  3. xenobiotic metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 2681.
ReactomeiREACT_6784. Glucuronidation.
SABIO-RKP54855.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B15 (EC:2.4.1.17)
Short name:
UDPGT 2B15
Alternative name(s):
HLUG4
UDP-glucuronosyltransferase 2B8
Short name:
UDPGT 2B8
UDPGTh-3
Gene namesi
Name:UGT2B15
Synonyms:UGT2B8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:12546. UGT2B15.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37188.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 530507UDP-glucuronosyltransferase 2B15PRO_0000036039Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)1 Publication
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP54855.
PRIDEiP54855.

PTM databases

PhosphoSiteiP54855.

Expressioni

Tissue specificityi

Expressed in many tissues. Present in liver, prostate and testis.1 Publication

Gene expression databases

BgeeiP54855.
CleanExiHS_UGT2B15.
GenevestigatoriP54855.

Organism-specific databases

HPAiHPA045108.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341045.

Structurei

3D structure databases

ProteinModelPortaliP54855.
SMRiP54855. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei495 – 51521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiP54855.
KOiK00699.
OMAiKEQSAMI.
OrthoDBiEOG7GBFWS.
PhylomeDBiP54855.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54855-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLKWTSVFL LIQLSCYFSS GSCGKVLVWP TEYSHWINMK TILEELVQRG
60 70 80 90 100
HEVTVLTSSA STLVNASKSS AIKLEVYPTS LTKNYLEDSL LKILDRWIYG
110 120 130 140 150
VSKNTFWSYF SQLQELCWEY YDYSNKLCKD AVLNKKLMMK LQESKFDVIL
160 170 180 190 200
ADALNPCGEL LAELFNIPFL YSLRFSVGYT FEKNGGGFLF PPSYVPVVMS
210 220 230 240 250
ELSDQMIFME RIKNMIHMLY FDFWFQIYDL KKWDQFYSEV LGRPTTLFET
260 270 280 290 300
MGKAEMWLIR TYWDFEFPRP FLPNVDFVGG LHCKPAKPLP KEMEEFVQSS
310 320 330 340 350
GENGIVVFSL GSMISNMSEE SANMIASALA QIPQKVLWRF DGKKPNTLGS
360 370 380 390 400
NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ
410 420 430 440 450
HDNIAHMKAK GAALSVDIRT MSSRDLLNAL KSVINDPVYK ENVMKLSRIH
460 470 480 490 500
HDQPMKPLDR AVFWIEFVMR HKGAKHLRVA AHNLTWIQYH SLDVIAFLLA
510 520 530
CVATVIFIIT KFCLFCFRKL AKKGKKKKRD
Length:530
Mass (Da):61,036
Last modified:May 3, 2011 - v3
Checksum:iEB2DAE838769C955
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191E → A in AAA83406. (PubMed:2116769)Curated
Sequence conflicti145 – 1451K → R in AAA83406. (PubMed:2116769)Curated
Sequence conflicti150 – 1556LADALN → PGDPVF in AAA83406. (PubMed:2116769)Curated
Sequence conflicti162 – 1621A → S in AAA83406. (PubMed:2116769)Curated
Sequence conflicti165 – 1651F → L in AAA83406. (PubMed:2116769)Curated
Sequence conflicti170 – 1778LYSLRFSV → VYRSRISR in AAA83406. (PubMed:2116769)Curated
Sequence conflicti181 – 1811F → I in AAA83406. (PubMed:2116769)Curated
Sequence conflicti203 – 2031S → I in AAA83406. (PubMed:2116769)Curated
Sequence conflicti293 – 2931M → L in AAA83406. (PubMed:2116769)Curated
Sequence conflicti401 – 4011H → D in AAA83406. (PubMed:2116769)Curated
Sequence conflicti443 – 4431V → A in AAA83406. (PubMed:2116769)Curated
Sequence conflicti501 – 5011C → W in AAA83406. (PubMed:2116769)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851Y → D.2 Publications
Corresponds to variant rs1902023 [ dbSNP | Ensembl ].
VAR_007713
Natural varianti523 – 5231K → T.5 Publications
Corresponds to variant rs4148269 [ dbSNP | Ensembl ].
VAR_018348

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF548389 mRNA. Translation: AAN40695.1.
U08854 mRNA. Translation: AAC50077.1.
AF180322 mRNA. Translation: AAD55093.1.
AK289419 mRNA. Translation: BAF82108.1.
AC019173 Genomic DNA. No translation available.
AC147055 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05574.1.
U06641 mRNA. Translation: AAA83406.1.
CCDSiCCDS3524.1.
PIRiA48633.
S11309.
RefSeqiNP_001067.2. NM_001076.3.
UniGeneiHs.150207.

Genome annotation databases

EnsembliENST00000338206; ENSP00000341045; ENSG00000196620.
ENST00000616841; ENSP00000482004; ENSG00000196620.
GeneIDi7366.
KEGGihsa:7366.
UCSCiuc021xow.1. human.

Polymorphism databases

DMDMi332278237.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF548389 mRNA. Translation: AAN40695.1 .
U08854 mRNA. Translation: AAC50077.1 .
AF180322 mRNA. Translation: AAD55093.1 .
AK289419 mRNA. Translation: BAF82108.1 .
AC019173 Genomic DNA. No translation available.
AC147055 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05574.1 .
U06641 mRNA. Translation: AAA83406.1 .
CCDSi CCDS3524.1.
PIRi A48633.
S11309.
RefSeqi NP_001067.2. NM_001076.3.
UniGenei Hs.150207.

3D structure databases

ProteinModelPortali P54855.
SMRi P54855. Positions 286-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000341045.

Chemistry

ChEMBLi CHEMBL6161.
DrugBanki DB00316. Acetaminophen.
DB06695. Dabigatran etexilate.
DB00973. Ezetimibe.
DB00186. Lorazepam.
DB00295. Morphine.
DB00842. Oxazepam.
DB00313. Valproic Acid.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei P54855.

Polymorphism databases

DMDMi 332278237.

Proteomic databases

PaxDbi P54855.
PRIDEi P54855.

Protocols and materials databases

DNASUi 7366.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338206 ; ENSP00000341045 ; ENSG00000196620 .
ENST00000616841 ; ENSP00000482004 ; ENSG00000196620 .
GeneIDi 7366.
KEGGi hsa:7366.
UCSCi uc021xow.1. human.

Organism-specific databases

CTDi 7366.
GeneCardsi GC04M069561.
H-InvDB HIX0031375.
HIX0164240.
HGNCi HGNC:12546. UGT2B15.
HPAi HPA045108.
MIMi 600069. gene.
neXtProti NX_P54855.
PharmGKBi PA37188.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1819.
GeneTreei ENSGT00760000118949.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
InParanoidi P54855.
KOi K00699.
OMAi KEQSAMI.
OrthoDBi EOG7GBFWS.
PhylomeDBi P54855.
TreeFami TF315472.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 2681.
Reactomei REACT_6784. Glucuronidation.
SABIO-RK P54855.

Miscellaneous databases

GeneWikii UGT2B15.
GenomeRNAii 7366.
NextBioi 28842.
PROi P54855.
SOURCEi Search...

Gene expression databases

Bgeei P54855.
CleanExi HS_UGT2B15.
Genevestigatori P54855.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms."
    Chen F., Ritter J.K., Wang M.G., McBride O.W., Lubet R.A., Owens I.S.
    Biochemistry 32:10648-10657(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY, VARIANTS ASP-85 AND THR-523.
    Tissue: Liver.
  2. "Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates."
    Green M.D., Oturu E.M., Tephly T.R.
    Drug Metab. Dispos. 22:799-805(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ASP-85 AND THR-523.
    Tissue: Liver.
  3. "Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene."
    Levesque E., Beaulieu M., Green M.D., Tephly T.R., Belanger A., Hum D.W.
    Pharmacogenetics 7:317-325(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-523.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-523.
    Tissue: Mammary gland.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase."
    Coffman B.L., Tephly T.R., Irshaid Y.M., Green M.D., Smith C., Jackson M.R., Wooster R., Burchell B.
    Arch. Biochem. Biophys. 281:170-175(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-530, PARTIAL PROTEIN SEQUENCE.
    Tissue: Liver.
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-65.
    Tissue: Liver.
  9. Cited for: VARIANT THR-523.

Entry informationi

Entry nameiUDB15_HUMAN
AccessioniPrimary (citable) accession number: P54855
Secondary accession number(s): A6NDX0
, A6NNJ4, A8K054, P23765, Q9UK63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 3, 2011
Last modified: October 29, 2014
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

PubMed:2116769 thought that this was a separate form (UGT2B8). The name UGT2B8 has now been reused for a rat enzyme.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3