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Protein

Hexose transporter HXT15

Gene

HXT15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • carbohydrate:proton symporter activity Source: GO_Central
  • fructose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transmembrane transport Source: SGD
  • mannitol transport Source: SGD
  • sorbitol transport Source: SGD
  • transmembrane transport Source: SGD
  • xylitol transport Source: SGD

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29620-MONOMER
ReactomeiR-SCE-189200 Cellular hexose transport
R-SCE-8856825 Cargo recognition for clathrin-mediated endocytosis

Protein family/group databases

TCDBi2.A.1.1.107 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Hexose transporter HXT15
Gene namesi
Name:HXT15
Ordered Locus Names:YDL245C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL245C
SGDiS000002404 HXT15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55CytoplasmicSequence analysisAdd BLAST55
Transmembranei56 – 76Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini77 – 112ExtracellularSequence analysisAdd BLAST36
Transmembranei113 – 133Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini134 – 139CytoplasmicSequence analysis6
Transmembranei140 – 160Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini161 – 170ExtracellularSequence analysis10
Transmembranei171 – 191Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini192 – 197CytoplasmicSequence analysis6
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 232ExtracellularSequence analysisAdd BLAST14
Transmembranei233 – 253Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini254 – 336CytoplasmicSequence analysisAdd BLAST83
Transmembranei337 – 353Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini354 – 359ExtracellularSequence analysis6
Transmembranei360 – 377Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini378 – 384CytoplasmicSequence analysis7
Transmembranei385 – 405Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini406 – 427ExtracellularSequence analysisAdd BLAST22
Transmembranei428 – 448Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini449 – 465CytoplasmicSequence analysisAdd BLAST17
Transmembranei466 – 486Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini487ExtracellularSequence analysis1
Transmembranei488 – 508Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini509 – 567CytoplasmicSequence analysisAdd BLAST59

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504041 – 567Hexose transporter HXT15Add BLAST567

Proteomic databases

PaxDbiP54854
PRIDEiP54854

PTM databases

iPTMnetiP54854

Interactioni

Protein-protein interaction databases

BioGridi31867, 31 interactors
DIPiDIP-7210N
IntActiP54854, 2 interactors
MINTiP54854
STRINGi4932.YDL245C

Structurei

3D structure databases

ProteinModelPortaliP54854
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000149265
HOGENOMiHOG000202870
InParanoidiP54854
KOiK08139
OrthoDBiEOG092C1Q5W

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P54854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEQSSPEI NADNLNSSAA DVHVQPPGEK EWSDGFYDKE VINGNTPDAP
60 70 80 90 100
KRGFLGYLII YLLCYPVSFG GFLPGWDSGI TAGFINMDNF KMNFGSYKHS
110 120 130 140 150
TGEYYLSNVR MGLLVAMFSV GCSIGGVAFA RLADTLGRRL AIVIVVLVYM
160 170 180 190 200
VGAIIQISSN HKWYQYFVGK IIYGLGAGGC SVLCPMLLSE IAPTDLRGGL
210 220 230 240 250
VSLYQLNMTF GIFLGYCSVY GTRKYSNTAQ WRIPVGLCFL WALIIIVGML
260 270 280 290 300
LVPESPRYLI ECERHEEACV SIAKINKVSP EDPWVLKQAD EINAGVLAQR
310 320 330 340 350
ELGEASWKEL FSVKTKVLQR LITGILVQTF LQLTGENYFF FYGTTIFKSV
360 370 380 390 400
GLTDGFETSI VLGTVNFFST IIAVMVVDKI GRRKCLLFGA ASMMACMVIF
410 420 430 440 450
ASIGVKCLYP HGQDGPSSKG AGNAMIVFTC FYIFCFATTW APVAYIVVAE
460 470 480 490 500
SFPSKVKSKA MSISTAFNWL WQFLIGFFTP FITGSIHFYY GYVFVGCLVA
510 520 530 540 550
MFLYVFFFLP ETIGLSLEEI QLLYEEGIKP WKSASWVPPS RRGASSRETE
560
AKKKSWKEVL KFPKSFN
Length:567
Mass (Da):62,931
Last modified:October 1, 1996 - v1
Checksum:i5CD7824822DFD130
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92891 Genomic DNA Translation: CAA63484.1
Z74293 Genomic DNA Translation: CAA98825.1
BK006938 Genomic DNA Translation: DAA11622.1
PIRiS67809
RefSeqiNP_010036.1, NM_001180305.1

Genome annotation databases

EnsemblFungiiYDL245C; YDL245C; YDL245C
GeneIDi851352
KEGGisce:YDL245C

Similar proteinsi

Entry informationi

Entry nameiHXT15_YEAST
AccessioniPrimary (citable) accession number: P54854
Secondary accession number(s): D6VRB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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