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Protein

Epithelial membrane protein 3

Gene

EMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in cell proliferation and cell-cell interactions.

GO - Biological processi

  • bleb assembly Source: UniProtKB
  • cell death Source: UniProtKB
  • cell growth Source: InterPro
  • negative regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial membrane protein 3
Short name:
EMP-3
Alternative name(s):
Hematopoietic neural membrane protein 1
Short name:
HNMP-1
Protein YMP
Gene namesi
Name:EMP3
Synonyms:YMP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3335. EMP3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence analysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27772.

Polymorphism and mutation databases

BioMutaiEMP3.
DMDMi1706644.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Epithelial membrane protein 3PRO_0000164660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP54852.
MaxQBiP54852.
PaxDbiP54852.
PeptideAtlasiP54852.
PRIDEiP54852.
TopDownProteomicsiP54852.

PTM databases

iPTMnetiP54852.
PhosphoSiteiP54852.
SwissPalmiP54852.

Expressioni

Gene expression databases

BgeeiENSG00000142227.
CleanExiHS_EMP3.
ExpressionAtlasiP54852. baseline and differential.
GenevisibleiP54852. HS.

Organism-specific databases

HPAiHPA051163.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EDAQ928383EBI-3907816,EBI-529425

Protein-protein interaction databases

BioGridi108329. 2 interactions.
IntActiP54852. 3 interactions.
STRINGi9606.ENSP00000270221.

Structurei

3D structure databases

ProteinModelPortaliP54852.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY40. Eukaryota.
ENOG4111MF9. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiP54852.
OMAiSDLWYNC.
OrthoDBiEOG091G0RF4.
PhylomeDBiP54852.
TreeFamiTF330414.

Family and domain databases

InterProiIPR003934. EMP_3.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF8. PTHR10671:SF8. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01456. EPMEMPROT3.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54852-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLLLVVSA LHILILILLF VATLDKSWWT LPGKESLNLW YDCTWNNDTK
60 70 80 90 100
TWACSNVSEN GWLKAVQVLM VLSLILCCLS FILFMFQLYT MRRGGLFYAT
110 120 130 140 150
GLCQLCTSVA VFTGALIYAI HAEEILEKHP RGGSFGYCFA LAWVAFPLAL
160
VSGIIYIHLR KRE
Length:163
Mass (Da):18,429
Last modified:October 1, 1996 - v1
Checksum:i2B5DF55938825940
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1012TG → HR in CAA64394 (PubMed:8917086).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti125 – 1251I → V.
Corresponds to variant rs4893 [ dbSNP | Ensembl ].
VAR_050609

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52101 mRNA. Translation: AAC50920.1.
X94771 mRNA. Translation: CAA64394.1.
U87947 mRNA. Translation: AAC51730.1.
BT007124 mRNA. Translation: AAP35788.1.
CR541955 mRNA. Translation: CAG46753.1.
CH471177 Genomic DNA. Translation: EAW52333.1.
BC009718 mRNA. Translation: AAH09718.1.
CCDSiCCDS12715.1.
PIRiJC5045.
RefSeqiNP_001300834.1. NM_001313905.1.
NP_001416.1. NM_001425.2.
XP_011524907.1. XM_011526605.2.
UniGeneiHs.9999.

Genome annotation databases

EnsembliENST00000270221; ENSP00000270221; ENSG00000142227.
ENST00000597279; ENSP00000469194; ENSG00000142227.
GeneIDi2014.
KEGGihsa:2014.
UCSCiuc002piv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52101 mRNA. Translation: AAC50920.1.
X94771 mRNA. Translation: CAA64394.1.
U87947 mRNA. Translation: AAC51730.1.
BT007124 mRNA. Translation: AAP35788.1.
CR541955 mRNA. Translation: CAG46753.1.
CH471177 Genomic DNA. Translation: EAW52333.1.
BC009718 mRNA. Translation: AAH09718.1.
CCDSiCCDS12715.1.
PIRiJC5045.
RefSeqiNP_001300834.1. NM_001313905.1.
NP_001416.1. NM_001425.2.
XP_011524907.1. XM_011526605.2.
UniGeneiHs.9999.

3D structure databases

ProteinModelPortaliP54852.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108329. 2 interactions.
IntActiP54852. 3 interactions.
STRINGi9606.ENSP00000270221.

PTM databases

iPTMnetiP54852.
PhosphoSiteiP54852.
SwissPalmiP54852.

Polymorphism and mutation databases

BioMutaiEMP3.
DMDMi1706644.

Proteomic databases

EPDiP54852.
MaxQBiP54852.
PaxDbiP54852.
PeptideAtlasiP54852.
PRIDEiP54852.
TopDownProteomicsiP54852.

Protocols and materials databases

DNASUi2014.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270221; ENSP00000270221; ENSG00000142227.
ENST00000597279; ENSP00000469194; ENSG00000142227.
GeneIDi2014.
KEGGihsa:2014.
UCSCiuc002piv.3. human.

Organism-specific databases

CTDi2014.
GeneCardsiEMP3.
HGNCiHGNC:3335. EMP3.
HPAiHPA051163.
MIMi602335. gene.
neXtProtiNX_P54852.
PharmGKBiPA27772.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY40. Eukaryota.
ENOG4111MF9. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiP54852.
OMAiSDLWYNC.
OrthoDBiEOG091G0RF4.
PhylomeDBiP54852.
TreeFamiTF330414.

Miscellaneous databases

GeneWikiiEMP3.
GenomeRNAii2014.
PROiP54852.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142227.
CleanExiHS_EMP3.
ExpressionAtlasiP54852. baseline and differential.
GenevisibleiP54852. HS.

Family and domain databases

InterProiIPR003934. EMP_3.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF8. PTHR10671:SF8. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01456. EPMEMPROT3.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMP3_HUMAN
AccessioniPrimary (citable) accession number: P54852
Secondary accession number(s): Q6FH01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.