Reviewed,
UniProtKB/Swiss-Prot P54852 (EMP3_HUMAN)
Last modified
June 16, 2009.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Epithelial membrane protein 3 Short name=EMP-3 Alternative name(s): Protein YMP Hematopoietic neural membrane protein HNMP-1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 163 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Probably involved in cell proliferation and cell-cell interactions. |
| Subcellular location | |
| Sequence similarities | Belongs to the PMP-22/EMP/MP20 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | cell growth Inferred from electronic annotation. Source: InterPro negative regulation of cell proliferation Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 163 | 163 | Epithelial membrane protein 3 | PRO_0000164660 | |||||
Regions | |||||||||
| Transmembrane | 4 – 24 | 21 | Potential | ||||||
| Transmembrane | 66 – 86 | 21 | Potential | ||||||
| Transmembrane | 100 – 120 | 21 | Potential | ||||||
| Transmembrane | 139 – 159 | 21 | Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 47 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 56 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 125 | 1 | I → V: dbSNP rs4893. | VAR_050609 | |||||
Experimental info | |||||||||
| Sequence conflict | 100 – 101 | 2 | TG → HR in CAA64394. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins." Ben-Porath I., Benvenisty N. Gene 183:69-75(1996) [PubMed: 8996089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family." Taylor V., Suter U. Gene 175:115-120(1996) [PubMed: 8917086] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spleen. |
| [3] | "HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury." Bolin L.M., McNeil T., Lucian L.A., Devaux B., Franz-Bacon K., Gorman D.M., Zurawski S., Murray R., McClanahan T.K. J. Neurosci. 17:5493-5502(1997) [PubMed: 9204931] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U52101 mRNA. Translation: AAC50920.1. X94771 mRNA. Translation: CAA64394.1. U87947 mRNA. Translation: AAC51730.1. BT007124 mRNA. Translation: AAP35788.1. BC009718 mRNA. Translation: AAH09718.1. | |
| IPI | IPI00008901. |
| PIR | JC5045. |
| RefSeq | NP_001416.1. |
| UniGene | Hs.9999 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P54852. |
Genome annotation databases | |
| Ensembl | ENSG00000142227. Homo sapiens. [Contig view] |
| GeneID | 2014. |
| KEGG | hsa:2014. |
Organism-specific databases | |
| GeneCards | GC19P053520. |
| H-InvDB | HIX0015288. |
| HGNC | HGNC:3335. EMP3. |
| MIM | 602335. gene. |
| PharmGKB | PA27772. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P54852. |
| HOVERGEN | P54852. |
| OMA | P54852. WLQAVQV. |
Gene expression databases | |
| ArrayExpress | P54852. |
| Bgee | P54852. |
| CleanEx | HS_EMP3. |
| GermOnline | ENSG00000142227. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR003934. EMP_3. IPR004031. PMP22/EMP/MP20/Claudin. IPR004032. PMP22_EMP_MP20. [Graphical view] |
| PANTHER | PTHR10671. PMP22_EMP_MP20. 1 hit. |
| Pfam | PF00822. PMP22_Claudin. 1 hit. [Graphical view] |
| PRINTS | PR01453. EPMEMFAMILY. PR01456. EPMEMPROT3. |
| PROSITE | PS01221. PMP22_1. 1 hit. PS01222. PMP22_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 8159. |
| SOURCE | Search... |
Entry information
| Entry name | EMP3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P54852 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


