P54852 (EMP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 105.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Epithelial membrane protein 3 Short name=EMP-3 Alternative name(s): Hematopoietic neural membrane protein 1 Short name=HNMP-1 Protein YMP | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 163 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Probably involved in cell proliferation and cell-cell interactions. |
| Subcellular location | |
| Sequence similarities | Belongs to the PMP-22/EMP/MP20 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane Transmembrane helix |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | cell growth Inferred from electronic annotation. Source: InterPro negative regulation of cell proliferationTraceable author statement Ref.1. Source: ProtInc |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 163 | 163 | Epithelial membrane protein 3 | PRO_0000164660 | |||||
Regions | |||||||||
| Transmembrane | 4 – 24 | 21 | Helical; Potential | ||||||
| Transmembrane | 66 – 86 | 21 | Helical; Potential | ||||||
| Transmembrane | 100 – 120 | 21 | Helical; Potential | ||||||
| Transmembrane | 139 – 159 | 21 | Helical; Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 47 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 56 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 125 | 1 | I → V. Corresponds to variant rs4893 [ dbSNP | Ensembl ]. | VAR_050609 | |||||
Experimental info | |||||||||
| Sequence conflict | 100 – 101 | 2 | TG → HR in CAA64394. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins." Ben-Porath I., Benvenisty N. Gene 183:69-75(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family." Taylor V., Suter U. Gene 175:115-120(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spleen. |
| [3] | "HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury." Bolin L.M., McNeil T., Lucian L.A., Devaux B., Franz-Bacon K., Gorman D.M., Zurawski S., Murray R., McClanahan T.K. J. Neurosci. 17:5493-5502(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U52101 mRNA. Translation: AAC50920.1. X94771 mRNA. Translation: CAA64394.1. U87947 mRNA. Translation: AAC51730.1. BT007124 mRNA. Translation: AAP35788.1. CR541955 mRNA. Translation: CAG46753.1. CH471177 Genomic DNA. Translation: EAW52333.1. BC009718 mRNA. Translation: AAH09718.1. |
| IPI | IPI00008901. |
| PIR | JC5045. |
| RefSeq | NP_001416.1. NM_001425.2. |
| UniGene | Hs.9999. |
3D structure databases | |
| ProteinModelPortal | P54852. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P54852. 2 interactions. |
| STRING | 9606.ENSP00000270221. |
Polymorphism databases | |
| DMDM | 1706644. |
Proteomic databases | |
| PaxDb | P54852. |
| PRIDE | P54852. |
Protocols and materials databases | |
| DNASU | 2014. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000270221; ENSP00000270221; ENSG00000142227. ENST00000597279; ENSP00000469194; ENSG00000142227. |
| GeneID | 2014. |
| KEGG | hsa:2014. |
| UCSC | uc002piv.2. human. |
Organism-specific databases | |
| CTD | 2014. |
| GeneCards | GC19P048829. |
| HGNC | HGNC:3335. EMP3. |
| HPA | HPA051163. |
| MIM | 602335. gene. |
| neXtProt | NX_P54852. |
| PharmGKB | PA27772. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG45653. |
| HOGENOM | HOG000059542. |
| HOVERGEN | HBG001690. |
| InParanoid | P54852. |
| OMA | WLQAVQV. |
| OrthoDB | EOG4B8JFC. |
| PhylomeDB | P54852. |
Gene expression databases | |
| Bgee | P54852. |
| CleanEx | HS_EMP3. |
| Genevestigator | P54852. |
| GermOnline | ENSG00000142227. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR003934. EMP_3. IPR004031. PMP22/EMP/MP20/Claudin. IPR004032. PMP22_EMP_MP20. [Graphical view] |
| Pfam | PF00822. PMP22_Claudin. 1 hit. [Graphical view] |
| PRINTS | PR01453. EPMEMFAMILY. PR01456. EPMEMPROT3. |
| PROSITE | PS01221. PMP22_1. 1 hit. PS01222. PMP22_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 2014. |
| NextBio | 8159. |
| SOURCE | Search... |
Entry information
| Entry name | EMP3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P54852 Secondary accession number(s): Q6FH01 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
