Reviewed, UniProtKB/Swiss-Prot P54852 (EMP3_HUMAN)

Names and origin

Protein names

Recommended name:
    Epithelial membrane protein 3
      Short name=EMP-3
Alternative name(s):
    Protein YMP
    Hematopoietic neural membrane protein
    HNMP-1

Gene names

Name:	EMP3
Synonyms:	YMP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probably involved in cell proliferation and cell-cell interactions.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell growth Inferred from electronic annotation. Source: InterPro negative regulation of cell proliferation Ref.1 Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 163	163	Epithelial membrane protein 3		PRO_0000164660
Regions
	Transmembrane	4 – 24	21	Potential
	Transmembrane	66 – 86	21	Potential
	Transmembrane	100 – 120	21	Potential
	Transmembrane	139 – 159	21	Potential
Amino acid modifications
	Glycosylation	47	1	N-linked (GlcNAc...) Potential
	Glycosylation	56	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	125	1	I → V: dbSNP rs4893.		VAR_050609
Experimental info
	Sequence conflict	100 – 101	2	TG → HR in CAA64394. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P54852-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 2B5DF55938825940	FASTA	163	18,429
	10 20 30 40 50 60 MSLLLLVVSA LHILILILLF VATLDKSWWT LPGKESLNLW YDCTWNNDTK TWACSNVSEN 70 80 90 100 110 120 GWLKAVQVLM VLSLILCCLS FILFMFQLYT MRRGGLFYAT GLCQLCTSVA VFTGALIYAI 130 140 150 160 HAEEILEKHP RGGSFGYCFA LAWVAFPLAL VSGIIYIHLR KRE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins." Ben-Porath I., Benvenisty N. Gene 183:69-75(1996) [PubMed: 8996089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family." Taylor V., Suter U. Gene 175:115-120(1996) [PubMed: 8917086] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spleen.
[3]	"HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury." Bolin L.M., McNeil T., Lucian L.A., Devaux B., Franz-Bacon K., Gorman D.M., Zurawski S., Murray R., McClanahan T.K. J. Neurosci. 17:5493-5502(1997) [PubMed: 9204931] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U52101 mRNA. Translation: AAC50920.1. X94771 mRNA. Translation: CAA64394.1. U87947 mRNA. Translation: AAC51730.1. BT007124 mRNA. Translation: AAP35788.1. BC009718 mRNA. Translation: AAH09718.1.
IPI	IPI00008901.
PIR	JC5045.
RefSeq	NP_001416.1.
UniGene	Hs.9999
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P54852.
Genome annotation databases
Ensembl	ENSG00000142227. Homo sapiens. [Contig view]
GeneID	2014.
KEGG	hsa:2014.
Organism-specific databases
GeneCards	GC19P053520.
H-InvDB	HIX0015288.
HGNC	HGNC:3335. EMP3.
MIM	602335. gene.
PharmGKB	PA27772.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P54852.
HOVERGEN	P54852.
OMA	P54852. WLQAVQV.
Gene expression databases
ArrayExpress	P54852.
Bgee	P54852.
CleanEx	HS_EMP3.
GermOnline	ENSG00000142227. Homo sapiens.
Family and domain databases
InterPro	IPR003934. EMP_3. IPR004031. PMP22/EMP/MP20/Claudin. IPR004032. PMP22_EMP_MP20. [Graphical view]
PANTHER	PTHR10671. PMP22_EMP_MP20. 1 hit.
Pfam	PF00822. PMP22_Claudin. 1 hit. [Graphical view]
PRINTS	PR01453. EPMEMFAMILY. PR01456. EPMEMPROT3.
PROSITE	PS01221. PMP22_1. 1 hit. PS01222. PMP22_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	8159.
SOURCE	Search...

Entry information

Entry name

EMP3_HUMAN

Accession

Primary (citable) accession number: P54852

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)