P54852 (EMP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Epithelial membrane protein 3
Short name=EMP-3

Alternative name(s):
Hematopoietic neural membrane protein 1
Short name=HNMP-1
Protein YMP

Gene names

Name:	EMP3
Synonyms:	YMP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably involved in cell proliferation and cell-cell interactions.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell growth Inferred from electronic annotation. Source: InterPro negative regulation of cell proliferation Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 163	163	Epithelial membrane protein 3		PRO_0000164660
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	66 – 86	21	Helical; Potential
	Transmembrane	100 – 120	21	Helical; Potential
	Transmembrane	139 – 159	21	Helical; Potential
Amino acid modifications
	Glycosylation	47	1	N-linked (GlcNAc...) Potential
	Glycosylation	56	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	125	1	I → V. Corresponds to variant rs4893 [ dbSNP | Ensembl ].		VAR_050609
Experimental info
	Sequence conflict	100 – 101	2	TG → HR in CAA64394. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P54852 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 2B5DF55938825940	FASTA	163	18,429
	10 20 30 40 50 60 MSLLLLVVSA LHILILILLF VATLDKSWWT LPGKESLNLW YDCTWNNDTK TWACSNVSEN 70 80 90 100 110 120 GWLKAVQVLM VLSLILCCLS FILFMFQLYT MRRGGLFYAT GLCQLCTSVA VFTGALIYAI 130 140 150 160 HAEEILEKHP RGGSFGYCFA LAWVAFPLAL VSGIIYIHLR KRE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins." Ben-Porath I., Benvenisty N. Gene 183:69-75(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Epithelial membrane protein-2 and epithelial membrane protein-3: two novel members of the peripheral myelin protein 22 gene family." Taylor V., Suter U. Gene 175:115-120(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spleen.
[3]	"HNMP-1: a novel hematopoietic and neural membrane protein differentially regulated in neural development and injury." Bolin L.M., McNeil T., Lucian L.A., Devaux B., Franz-Bacon K., Gorman D.M., Zurawski S., Murray R., McClanahan T.K. J. Neurosci. 17:5493-5502(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U52101 mRNA. Translation: AAC50920.1. X94771 mRNA. Translation: CAA64394.1. U87947 mRNA. Translation: AAC51730.1. BT007124 mRNA. Translation: AAP35788.1. CR541955 mRNA. Translation: CAG46753.1. CH471177 Genomic DNA. Translation: EAW52333.1. BC009718 mRNA. Translation: AAH09718.1.
IPI	IPI00008901.
PIR	JC5045.
RefSeq	NP_001416.1. NM_001425.2.
UniGene	Hs.9999.
3D structure databases
ProteinModelPortal	P54852.
ModBase	Search...
Protein-protein interaction databases
IntAct	P54852. 2 interactions.
STRING	9606.ENSP00000270221.
Polymorphism databases
DMDM	1706644.
Proteomic databases
PaxDb	P54852.
PRIDE	P54852.
Protocols and materials databases
DNASU	2014.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000270221; ENSP00000270221; ENSG00000142227. ENST00000597279; ENSP00000469194; ENSG00000142227.
GeneID	2014.
KEGG	hsa:2014.
UCSC	uc002piv.2. human.
Organism-specific databases
CTD	2014.
GeneCards	GC19P048829.
HGNC	HGNC:3335. EMP3.
HPA	HPA051163.
MIM	602335. gene.
neXtProt	NX_P54852.
PharmGKB	PA27772.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45653.
HOGENOM	HOG000059542.
HOVERGEN	HBG001690.
InParanoid	P54852.
OMA	WLQAVQV.
OrthoDB	EOG4B8JFC.
PhylomeDB	P54852.
Gene expression databases
Bgee	P54852.
CleanEx	HS_EMP3.
Genevestigator	P54852.
GermOnline	ENSG00000142227. Homo sapiens.
Family and domain databases
InterPro	IPR003934. EMP_3. IPR004031. PMP22/EMP/MP20/Claudin. IPR004032. PMP22_EMP_MP20. [Graphical view]
Pfam	PF00822. PMP22_Claudin. 1 hit. [Graphical view]
PRINTS	PR01453. EPMEMFAMILY. PR01456. EPMEMPROT3.
PROSITE	PS01221. PMP22_1. 1 hit. PS01222. PMP22_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2014.
NextBio	8159.
SOURCE	Search...

Entry information

Entry name

EMP3_HUMAN

Accession

Primary (citable) accession number: P54852
Secondary accession number(s): Q6FH01

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.