P54849 (EMP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Epithelial membrane protein 1
Short name=EMP-1

Alternative name(s):
CL-20
Protein B4B
Tumor-associated membrane protein

Gene names

Name:	EMP1
Synonyms:	B4B, TMP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	157 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the PMP-22/EMP/MP20 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell growth Inferred from electronic annotation. Source: InterPro cell proliferation Traceable author statement. Source: ProtInc epidermis development Traceable author statement. Source: ProtInc
Cellular component	integral to membrane Traceable author statement. Source: ProtInc membrane fraction Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 157	157	Epithelial membrane protein 1		PRO_0000164653
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	67 – 87	21	Helical; Potential
	Transmembrane	95 – 115	21	Helical; Potential
	Transmembrane	134 – 154	21	Helical; Potential
Amino acid modifications
	Glycosylation	43	1	N-linked (GlcNAc...) Potential
	Glycosylation	46	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	57	1	S → N. Corresponds to variant rs34412222 [ dbSNP | Ensembl ].		VAR_050608

Sequences

	Sequence		Length	Mass (Da)
	P54849 [UniParc]. Last modified July 15, 1998. Version 3. Checksum: B470B4ADC5C16821	FASTA	157	17,563
	10 20 30 40 50 60 MLVLLAGIFV VHIATVIMLF VSTIANVWLV SNTVDASVGL WKNCTNISCS DSLSYASEDA 70 80 90 100 110 120 LKTVQAFMIL SIIFCVIALL VFVFQLFTME KGNRFFLSGA TTLVCWLCIL VGVSIYTSHY 130 140 150 ANRDGTQYHH GYSYILGWIC FCFSFIIGVL YLVLRKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a tumor-associated gene, a member of a novel family of genes encoding membrane glycoproteins." Ben-Porath I., Benvenisty N. Gene 183:69-75(1996) [PubMed: 8996089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal kidney.
[2]	Ben-Porath I., Benvenisty N. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 83.
[3]	"cDNA cloning, genomic structure, and chromosome mapping of the human epithelial membrane protein CL-20 gene (EMP1), a member of the PMP22 family." Chen Y., Medvedev A., Ruzanov P., Marvin K.W., Jetten A.M. Genomics 41:40-48(1997) [PubMed: 9126480] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"B4B, a novel growth-arrest gene, is expressed by a subset of progenitor/pre-B lymphocytes negative for cytoplasmic mu-chain." Ruegg C.L., Wu H., Fagnoni F.F., Engleman E.G., Laus R. J. Immunol. 157:72-80(1996) [PubMed: 8683158] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[5]	"Differential gene expression in human mammary carcinoma cells: identification of a new member of a receptor family." Schiemann S., Rueckels M., Engelholm L.H., Schwirzke M., Bruenner N., Weidle U.H. Anticancer Res. 17:13-20(1997) [PubMed: 9066625] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U43916 mRNA. Translation: AAC51783.1. U77085 mRNA. Translation: AAC51207.1. Z50751 mRNA. Translation: CAA90627.1. Y07909 mRNA. Translation: CAA69217.1. AK312246 mRNA. Translation: BAG35178.1. CH471094 Genomic DNA. Translation: EAW96304.1. BC047300 mRNA. Translation: AAH47300.1.
IPI	IPI00008880.
PIR	G02355.
RefSeq	NP_001414.1. NM_001423.2.
UniGene	Hs.719042.
3D structure databases
ProteinModelPortal	P54849.
ModBase	Search...
Protein-protein interaction databases
IntAct	P54849. 1 interaction.
STRING	P54849.
Polymorphism databases
DMDM	3041684.
Proteomic databases
PRIDE	P54849.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000256951; ENSP00000256951; ENSG00000134531. ENST00000431267; ENSP00000410755; ENSG00000134531.
GeneID	2012.
KEGG	hsa:2012.
UCSC	uc001rbr.1. human.
Organism-specific databases
CTD	2012.
GeneCards	GC12P013249.
H-InvDB	HIX0026380.
HGNC	HGNC:3333. EMP1.
MIM	602333. gene.
neXtProt	NX_P54849.
PharmGKB	PA27770.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14292.
GeneTree	ENSGT00510000046328.
HOGENOM	HBG443769.
HOVERGEN	HBG001690.
InParanoid	P54849.
OMA	YTHHYAN.
OrthoDB	EOG4FFD37.
PhylomeDB	P54849.
Gene expression databases
ArrayExpress	P54849.
Bgee	P54849.
CleanEx	HS_EMP1.
Genevestigator	P54849.
GermOnline	ENSG00000134531. Homo sapiens.
Family and domain databases
InterPro	IPR003932. EMP_1. IPR004031. PMP22/EMP/MP20/Claudin. IPR004032. PMP22_EMP_MP20. [Graphical view]
PANTHER	PTHR10671:SF6. EMP_1. 1 hit.
Pfam	PF00822. PMP22_Claudin. 1 hit. [Graphical view]
PRINTS	PR01453. EPMEMFAMILY. PR01454. EPMEMPROT1.
PROSITE	PS01221. PMP22_1. 1 hit. PS01222. PMP22_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	8151.
SOURCE	Search...

Entry information

Entry name

EMP1_HUMAN

Accession

Primary (citable) accession number: P54849
Secondary accession number(s): B2R5N1 , O00681, Q13481, Q13834

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 15, 1998
Last modified:	January 25, 2012
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.