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Protein

Epithelial membrane protein 1

Gene

Emp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial membrane protein 1
Short name:
EMP-1
Alternative name(s):
Tumor-associated membrane protein
Gene namesi
Name:Emp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2552. Emp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence analysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence analysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Epithelial membrane protein 1PRO_0000164657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP54848.

Expressioni

Tissue specificityi

Most prominently found in the gastrointestinal tract, skin, lung, and brain but not in liver.

Gene expression databases

GenevisibleiP54848. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011580.

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW7W. Eukaryota.
ENOG410Z5WT. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiP54848.
OMAiCWLCILV.
OrthoDBiEOG7F24VG.
PhylomeDBiP54848.
TreeFamiTF330414.

Family and domain databases

InterProiIPR003932. EMP_1.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF6. PTHR10671:SF6. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01454. EPMEMPROT1.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLLAGLFV VHIATAIMLF VSTIANVWMV ADGIDSSIGL WKNCTSGSCD
60 70 80 90 100
GSLSYGNDDA IKAVQAFMIL SIIFSIISLV VFVFQLFTME KGNRFFLSGS
110 120 130 140 150
TMLVCWLCIL IGVSIYTHHY AHSEGNFFPS SHQGYCFILT WICFCFSFII
160
GILYMVLRKK
Length:160
Mass (Da):17,826
Last modified:October 1, 1996 - v1
Checksum:i3B3144A22B93860F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54212 mRNA. Translation: CAA90939.1.
BC087031 mRNA. Translation: AAH87031.1.
RefSeqiNP_036975.1. NM_012843.2.
XP_006237577.1. XM_006237515.2.
XP_008761591.1. XM_008763369.1.
UniGeneiRn.19723.

Genome annotation databases

EnsembliENSRNOT00000011580; ENSRNOP00000011580; ENSRNOG00000008676.
ENSRNOT00000079785; ENSRNOP00000070837; ENSRNOG00000008676.
GeneIDi25314.
KEGGirno:25314.
UCSCiRGD:2552. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54212 mRNA. Translation: CAA90939.1.
BC087031 mRNA. Translation: AAH87031.1.
RefSeqiNP_036975.1. NM_012843.2.
XP_006237577.1. XM_006237515.2.
XP_008761591.1. XM_008763369.1.
UniGeneiRn.19723.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011580.

Proteomic databases

PaxDbiP54848.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011580; ENSRNOP00000011580; ENSRNOG00000008676.
ENSRNOT00000079785; ENSRNOP00000070837; ENSRNOG00000008676.
GeneIDi25314.
KEGGirno:25314.
UCSCiRGD:2552. rat.

Organism-specific databases

CTDi2012.
RGDi2552. Emp1.

Phylogenomic databases

eggNOGiENOG410IW7W. Eukaryota.
ENOG410Z5WT. LUCA.
GeneTreeiENSGT00510000046328.
HOGENOMiHOG000059542.
HOVERGENiHBG001690.
InParanoidiP54848.
OMAiCWLCILV.
OrthoDBiEOG7F24VG.
PhylomeDBiP54848.
TreeFamiTF330414.

Miscellaneous databases

PROiP54848.

Gene expression databases

GenevisibleiP54848. RN.

Family and domain databases

InterProiIPR003932. EMP_1.
IPR004031. PMP22/EMP/MP20/Claudin.
IPR004032. PMP22_EMP_MP20.
[Graphical view]
PANTHERiPTHR10671:SF6. PTHR10671:SF6. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01453. EPMEMFAMILY.
PR01454. EPMEMPROT1.
PROSITEiPS01221. PMP22_1. 1 hit.
PS01222. PMP22_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family."
    Taylor V., Welcher A.A., Suter U.
    J. Biol. Chem. 270:28824-28833(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiEMP1_RAT
AccessioniPrimary (citable) accession number: P54848
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.