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Protein

Epithelial membrane protein 1

Gene

Emp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Epithelial membrane protein 1
Short name:
EMP-1
Alternative name(s):
Tumor-associated membrane protein
Gene namesi
Name:Emp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2552 Emp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001646571 – 160Epithelial membrane protein 1Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP54848

Expressioni

Tissue specificityi

Most prominently found in the gastrointestinal tract, skin, lung, and brain but not in liver.

Gene expression databases

BgeeiENSRNOG00000008676
GenevisibleiP54848 RN

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW7W Eukaryota
ENOG410Z5WT LUCA
GeneTreeiENSGT00510000046328
HOGENOMiHOG000059542
HOVERGENiHBG001690
InParanoidiP54848
OMAiWICFCFS
PhylomeDBiP54848
TreeFamiTF330414

Family and domain databases

InterProiView protein in InterPro
IPR003932 EMP_1
IPR004031 PMP22/EMP/MP20/Claudin
IPR004032 PMP22_EMP_MP20
PANTHERiPTHR10671:SF6 PTHR10671:SF6, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01453 EPMEMFAMILY
PR01454 EPMEMPROT1
PROSITEiView protein in PROSITE
PS01221 PMP22_1, 1 hit
PS01222 PMP22_2, 1 hit

Sequencei

Sequence statusi: Complete.

P54848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLLAGLFV VHIATAIMLF VSTIANVWMV ADGIDSSIGL WKNCTSGSCD
60 70 80 90 100
GSLSYGNDDA IKAVQAFMIL SIIFSIISLV VFVFQLFTME KGNRFFLSGS
110 120 130 140 150
TMLVCWLCIL IGVSIYTHHY AHSEGNFFPS SHQGYCFILT WICFCFSFII
160
GILYMVLRKK
Length:160
Mass (Da):17,826
Last modified:October 1, 1996 - v1
Checksum:i3B3144A22B93860F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54212 mRNA Translation: CAA90939.1
BC087031 mRNA Translation: AAH87031.1
RefSeqiNP_036975.1, NM_012843.2
XP_008761591.1, XM_008763369.2
UniGeneiRn.19723

Genome annotation databases

EnsembliENSRNOT00000011580; ENSRNOP00000011580; ENSRNOG00000008676
ENSRNOT00000079785; ENSRNOP00000070837; ENSRNOG00000008676
GeneIDi25314
KEGGirno:25314
UCSCiRGD:2552 rat

Similar proteinsi

Entry informationi

Entry nameiEMP1_RAT
AccessioniPrimary (citable) accession number: P54848
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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