Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P54846

- NRL_MOUSE

UniProt

P54846 - NRL_MOUSE

Protein

Neural retina-specific leucine zipper protein

Gene

Nrl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B.By similarity

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. positive regulation of rhodopsin gene expression Source: MGI
    2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    3. regulation of rhodopsin gene expression Source: MGI
    4. regulation of transcription, DNA-templated Source: MGI
    5. retinal rod cell development Source: MGI
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neural retina-specific leucine zipper protein
    Short name:
    NRL
    Gene namesi
    Name:Nrl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:102567. Nrl.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Photoreceptor precursors in retina produce only cones that primarily express S-opsin.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 237237Neural retina-specific leucine zipper proteinPRO_0000076634Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki20 – 20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
    Cross-linki24 – 24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

    Post-translational modificationi

    Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation.1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PRIDEiP54846.

    PTM databases

    PhosphoSiteiP54846.

    Expressioni

    Tissue specificityi

    Neural retina.

    Gene expression databases

    BgeeiP54846.
    CleanExiMM_NRL.
    GenevestigatoriP54846.

    Interactioni

    Subunit structurei

    Interacts with FIZ1. This interaction represses transactivation By similarity. Interacts (via the leucine-zipper domain) with CRX By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000054457.

    Structurei

    3D structure databases

    ProteinModelPortaliP54846.
    SMRiP54846. Positions 131-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini159 – 22264bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni30 – 9364Minimal transactivation domain (MTD)By similarityAdd
    BLAST
    Regioni159 – 18527Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni187 – 20822Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The minimal transactivation domain (MTD) is conserved across the MAF family, it may activate trancription by recruiting TBP and associated factors at the promoters of target genes.By similarity

    Sequence similaritiesi

    Belongs to the bZIP family.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG271139.
    HOGENOMiHOG000261683.
    HOVERGENiHBG000313.
    InParanoidiP54846.
    KOiK09038.
    OMAiGDHAHFF.
    OrthoDBiEOG7BGHMQ.
    PhylomeDBiP54846.
    TreeFamiTF325689.

    Family and domain databases

    Gene3Di1.10.880.10. 1 hit.
    InterProiIPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR013592. Maf_TF_N.
    IPR028575. Nrl.
    IPR008917. TF_DNA-bd.
    IPR024874. Transciption_factor_Maf.
    [Graphical view]
    PANTHERiPTHR10129. PTHR10129. 1 hit.
    PTHR10129:SF5. PTHR10129:SF5. 1 hit.
    PfamiPF03131. bZIP_Maf. 1 hit.
    PF08383. Maf_N. 1 hit.
    [Graphical view]
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF47454. SSF47454. 1 hit.
    PROSITEiPS50217. BZIP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54846-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFPPSPLAM EYVNDFDLMK FEIKREPSEG RSGVPTASLG STPYSSVPPS    50
    PTFSEPGMVG GGEAPRPGLE ELYWLATLQQ QLGSDEVLGL SPDEAVELLQ 100
    NQGPVSMEGP LGYYSGSPGE TGAQHVQLPE RFSDAALVSM SVRELNRQLR 150
    GCGRDEALRL KQRRRTLKNR GYAQACRSKR LQQRRGLEAE RARLAAQLDA 200
    LRAEVARLAR ERDLYKARCD RLTSGGPGSD DHTHLFL 237
    Length:237
    Mass (Da):26,083
    Last modified:October 1, 1996 - v1
    Checksum:iAF1A2B3772C95EC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14935 mRNA. Translation: AAA16843.1.
    BC031440 mRNA. Translation: AAH31440.1.
    CCDSiCCDS27113.1.
    PIRiA48912.
    RefSeqiNP_001129546.1. NM_001136074.2.
    NP_001258845.1. NM_001271916.1.
    NP_001258846.1. NM_001271917.1.
    NP_032762.1. NM_008736.3.
    UniGeneiMm.20422.

    Genome annotation databases

    EnsembliENSMUST00000062232; ENSMUSP00000054457; ENSMUSG00000040632.
    ENSMUST00000111404; ENSMUSP00000107035; ENSMUSG00000040632.
    ENSMUST00000178694; ENSMUSP00000136445; ENSMUSG00000040632.
    GeneIDi18185.
    KEGGimmu:18185.
    UCSCiuc007tyu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14935 mRNA. Translation: AAA16843.1 .
    BC031440 mRNA. Translation: AAH31440.1 .
    CCDSi CCDS27113.1.
    PIRi A48912.
    RefSeqi NP_001129546.1. NM_001136074.2.
    NP_001258845.1. NM_001271916.1.
    NP_001258846.1. NM_001271917.1.
    NP_032762.1. NM_008736.3.
    UniGenei Mm.20422.

    3D structure databases

    ProteinModelPortali P54846.
    SMRi P54846. Positions 131-222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000054457.

    PTM databases

    PhosphoSitei P54846.

    Proteomic databases

    PRIDEi P54846.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062232 ; ENSMUSP00000054457 ; ENSMUSG00000040632 .
    ENSMUST00000111404 ; ENSMUSP00000107035 ; ENSMUSG00000040632 .
    ENSMUST00000178694 ; ENSMUSP00000136445 ; ENSMUSG00000040632 .
    GeneIDi 18185.
    KEGGi mmu:18185.
    UCSCi uc007tyu.2. mouse.

    Organism-specific databases

    CTDi 4901.
    MGIi MGI:102567. Nrl.

    Phylogenomic databases

    eggNOGi NOG271139.
    HOGENOMi HOG000261683.
    HOVERGENi HBG000313.
    InParanoidi P54846.
    KOi K09038.
    OMAi GDHAHFF.
    OrthoDBi EOG7BGHMQ.
    PhylomeDBi P54846.
    TreeFami TF325689.

    Miscellaneous databases

    ChiTaRSi NRL. mouse.
    NextBioi 293502.
    PROi P54846.
    SOURCEi Search...

    Gene expression databases

    Bgeei P54846.
    CleanExi MM_NRL.
    Genevestigatori P54846.

    Family and domain databases

    Gene3Di 1.10.880.10. 1 hit.
    InterProi IPR004827. bZIP.
    IPR004826. bZIP_Maf.
    IPR013592. Maf_TF_N.
    IPR028575. Nrl.
    IPR008917. TF_DNA-bd.
    IPR024874. Transciption_factor_Maf.
    [Graphical view ]
    PANTHERi PTHR10129. PTHR10129. 1 hit.
    PTHR10129:SF5. PTHR10129:SF5. 1 hit.
    Pfami PF03131. bZIP_Maf. 1 hit.
    PF08383. Maf_N. 1 hit.
    [Graphical view ]
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47454. SSF47454. 1 hit.
    PROSITEi PS50217. BZIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of the murine neural retina leucine zipper gene, Nrl."
      Farjo Q., Jackson A.U., Xu J., Gryzenia M., Skolnick C., Agarwal N., Swaroop A.
      Genomics 18:216-222(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Retina.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina.
    3. "Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation."
      Roger J.E., Nellissery J., Kim D.S., Swaroop A.
      J. Biol. Chem. 285:25637-25644(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, SUMOYLATION AT LYS-20 AND LYS-24.

    Entry informationi

    Entry nameiNRL_MOUSE
    AccessioniPrimary (citable) accession number: P54846
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3