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Protein

Neural retina-specific leucine zipper protein

Gene

Nrl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B.By similarity

GO - Molecular functioni

GO - Biological processi

  • positive regulation of rhodopsin gene expression Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of rhodopsin gene expression Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • retinal rod cell development Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neural retina-specific leucine zipper protein
Short name:
NRL
Gene namesi
Name:Nrl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:102567. Nrl.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Photoreceptor precursors in retina produce only cones that primarily express S-opsin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766341 – 237Neural retina-specific leucine zipper proteinAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication

Post-translational modificationi

Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP54846.
PRIDEiP54846.

PTM databases

iPTMnetiP54846.
PhosphoSitePlusiP54846.

Expressioni

Tissue specificityi

Neural retina.

Gene expression databases

BgeeiENSMUSG00000040632.
CleanExiMM_NRL.
ExpressionAtlasiP54846. baseline and differential.
GenevisibleiP54846. MM.

Interactioni

Subunit structurei

Interacts with FIZ1. This interaction represses transactivation (By similarity). Interacts (via the leucine-zipper domain) with CRX (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054457.

Structurei

3D structure databases

ProteinModelPortaliP54846.
SMRiP54846.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 222bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 93Minimal transactivation domain (MTD)By similarityAdd BLAST64
Regioni159 – 185Basic motifPROSITE-ProRule annotationAdd BLAST27
Regioni187 – 208Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Domaini

The minimal transactivation domain (MTD) is conserved across the MAF family, it may activate transcription by recruiting TBP and associated factors at the promoters of target genes.By similarity

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG4196. Eukaryota.
ENOG41102C7. LUCA.
GeneTreeiENSGT00550000074549.
HOGENOMiHOG000261683.
HOVERGENiHBG000313.
InParanoidiP54846.
KOiK09038.
OMAiGDHAHFF.
OrthoDBiEOG091G0H46.
PhylomeDBiP54846.
TreeFamiTF325689.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiView protein in InterPro
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR013592. Maf_TF_N.
IPR028575. Nrl.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf_fam.
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF39. PTHR10129:SF39. 1 hit.
PfamiView protein in Pfam
PF03131. bZIP_Maf. 1 hit.
PF08383. Maf_N. 1 hit.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.

Sequencei

Sequence statusi: Complete.

P54846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPPSPLAM EYVNDFDLMK FEIKREPSEG RSGVPTASLG STPYSSVPPS
60 70 80 90 100
PTFSEPGMVG GGEAPRPGLE ELYWLATLQQ QLGSDEVLGL SPDEAVELLQ
110 120 130 140 150
NQGPVSMEGP LGYYSGSPGE TGAQHVQLPE RFSDAALVSM SVRELNRQLR
160 170 180 190 200
GCGRDEALRL KQRRRTLKNR GYAQACRSKR LQQRRGLEAE RARLAAQLDA
210 220 230
LRAEVARLAR ERDLYKARCD RLTSGGPGSD DHTHLFL
Length:237
Mass (Da):26,083
Last modified:October 1, 1996 - v1
Checksum:iAF1A2B3772C95EC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14935 mRNA. Translation: AAA16843.1.
BC031440 mRNA. Translation: AAH31440.1.
CCDSiCCDS27113.1.
PIRiA48912.
RefSeqiNP_001129546.1. NM_001136074.2.
NP_001258845.1. NM_001271916.1.
NP_001258846.1. NM_001271917.1.
NP_032762.1. NM_008736.3.
UniGeneiMm.20422.

Genome annotation databases

EnsembliENSMUST00000062232; ENSMUSP00000054457; ENSMUSG00000040632.
ENSMUST00000111404; ENSMUSP00000107035; ENSMUSG00000040632.
ENSMUST00000178694; ENSMUSP00000136445; ENSMUSG00000040632.
GeneIDi18185.
KEGGimmu:18185.
UCSCiuc007tyu.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14935 mRNA. Translation: AAA16843.1.
BC031440 mRNA. Translation: AAH31440.1.
CCDSiCCDS27113.1.
PIRiA48912.
RefSeqiNP_001129546.1. NM_001136074.2.
NP_001258845.1. NM_001271916.1.
NP_001258846.1. NM_001271917.1.
NP_032762.1. NM_008736.3.
UniGeneiMm.20422.

3D structure databases

ProteinModelPortaliP54846.
SMRiP54846.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054457.

PTM databases

iPTMnetiP54846.
PhosphoSitePlusiP54846.

Proteomic databases

PaxDbiP54846.
PRIDEiP54846.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062232; ENSMUSP00000054457; ENSMUSG00000040632.
ENSMUST00000111404; ENSMUSP00000107035; ENSMUSG00000040632.
ENSMUST00000178694; ENSMUSP00000136445; ENSMUSG00000040632.
GeneIDi18185.
KEGGimmu:18185.
UCSCiuc007tyu.3. mouse.

Organism-specific databases

CTDi4901.
MGIiMGI:102567. Nrl.

Phylogenomic databases

eggNOGiKOG4196. Eukaryota.
ENOG41102C7. LUCA.
GeneTreeiENSGT00550000074549.
HOGENOMiHOG000261683.
HOVERGENiHBG000313.
InParanoidiP54846.
KOiK09038.
OMAiGDHAHFF.
OrthoDBiEOG091G0H46.
PhylomeDBiP54846.
TreeFamiTF325689.

Miscellaneous databases

ChiTaRSiNrl. mouse.
PROiPR:P54846.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040632.
CleanExiMM_NRL.
ExpressionAtlasiP54846. baseline and differential.
GenevisibleiP54846. MM.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiView protein in InterPro
IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR013592. Maf_TF_N.
IPR028575. Nrl.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf_fam.
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF39. PTHR10129:SF39. 1 hit.
PfamiView protein in Pfam
PF03131. bZIP_Maf. 1 hit.
PF08383. Maf_N. 1 hit.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNRL_MOUSE
AccessioniPrimary (citable) accession number: P54846
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 15, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.