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P54846

- NRL_MOUSE

UniProt

P54846 - NRL_MOUSE

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Protein

Neural retina-specific leucine zipper protein

Gene

Nrl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B.By similarity

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. positive regulation of rhodopsin gene expression Source: MGI
  2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  3. regulation of rhodopsin gene expression Source: MGI
  4. regulation of transcription, DNA-templated Source: MGI
  5. retinal rod cell development Source: MGI
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neural retina-specific leucine zipper protein
Short name:
NRL
Gene namesi
Name:Nrl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:102567. Nrl.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Photoreceptor precursors in retina produce only cones that primarily express S-opsin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Neural retina-specific leucine zipper proteinPRO_0000076634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki20 – 20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linki24 – 24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationi

Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiP54846.

PTM databases

PhosphoSiteiP54846.

Expressioni

Tissue specificityi

Neural retina.

Gene expression databases

BgeeiP54846.
CleanExiMM_NRL.
ExpressionAtlasiP54846. differential.
GenevestigatoriP54846.

Interactioni

Subunit structurei

Interacts with FIZ1. This interaction represses transactivation (By similarity). Interacts (via the leucine-zipper domain) with CRX (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054457.

Structurei

3D structure databases

ProteinModelPortaliP54846.
SMRiP54846. Positions 131-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini159 – 22264bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 9364Minimal transactivation domain (MTD)By similarityAdd
BLAST
Regioni159 – 18527Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni187 – 20822Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Domaini

The minimal transactivation domain (MTD) is conserved across the MAF family, it may activate trancription by recruiting TBP and associated factors at the promoters of target genes.By similarity

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG271139.
HOGENOMiHOG000261683.
HOVERGENiHBG000313.
InParanoidiP54846.
KOiK09038.
OMAiGDHAHFF.
OrthoDBiEOG7BGHMQ.
PhylomeDBiP54846.
TreeFamiTF325689.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR013592. Maf_TF_N.
IPR028575. Nrl.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF5. PTHR10129:SF5. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
PF08383. Maf_N. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54846-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFPPSPLAM EYVNDFDLMK FEIKREPSEG RSGVPTASLG STPYSSVPPS
60 70 80 90 100
PTFSEPGMVG GGEAPRPGLE ELYWLATLQQ QLGSDEVLGL SPDEAVELLQ
110 120 130 140 150
NQGPVSMEGP LGYYSGSPGE TGAQHVQLPE RFSDAALVSM SVRELNRQLR
160 170 180 190 200
GCGRDEALRL KQRRRTLKNR GYAQACRSKR LQQRRGLEAE RARLAAQLDA
210 220 230
LRAEVARLAR ERDLYKARCD RLTSGGPGSD DHTHLFL
Length:237
Mass (Da):26,083
Last modified:October 1, 1996 - v1
Checksum:iAF1A2B3772C95EC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14935 mRNA. Translation: AAA16843.1.
BC031440 mRNA. Translation: AAH31440.1.
CCDSiCCDS27113.1.
PIRiA48912.
RefSeqiNP_001129546.1. NM_001136074.2.
NP_001258845.1. NM_001271916.1.
NP_001258846.1. NM_001271917.1.
NP_032762.1. NM_008736.3.
UniGeneiMm.20422.

Genome annotation databases

EnsembliENSMUST00000062232; ENSMUSP00000054457; ENSMUSG00000040632.
ENSMUST00000111404; ENSMUSP00000107035; ENSMUSG00000040632.
ENSMUST00000178694; ENSMUSP00000136445; ENSMUSG00000040632.
GeneIDi18185.
KEGGimmu:18185.
UCSCiuc007tyu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14935 mRNA. Translation: AAA16843.1 .
BC031440 mRNA. Translation: AAH31440.1 .
CCDSi CCDS27113.1.
PIRi A48912.
RefSeqi NP_001129546.1. NM_001136074.2.
NP_001258845.1. NM_001271916.1.
NP_001258846.1. NM_001271917.1.
NP_032762.1. NM_008736.3.
UniGenei Mm.20422.

3D structure databases

ProteinModelPortali P54846.
SMRi P54846. Positions 131-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000054457.

PTM databases

PhosphoSitei P54846.

Proteomic databases

PRIDEi P54846.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062232 ; ENSMUSP00000054457 ; ENSMUSG00000040632 .
ENSMUST00000111404 ; ENSMUSP00000107035 ; ENSMUSG00000040632 .
ENSMUST00000178694 ; ENSMUSP00000136445 ; ENSMUSG00000040632 .
GeneIDi 18185.
KEGGi mmu:18185.
UCSCi uc007tyu.2. mouse.

Organism-specific databases

CTDi 4901.
MGIi MGI:102567. Nrl.

Phylogenomic databases

eggNOGi NOG271139.
HOGENOMi HOG000261683.
HOVERGENi HBG000313.
InParanoidi P54846.
KOi K09038.
OMAi GDHAHFF.
OrthoDBi EOG7BGHMQ.
PhylomeDBi P54846.
TreeFami TF325689.

Miscellaneous databases

ChiTaRSi Nrl. mouse.
NextBioi 293502.
PROi P54846.
SOURCEi Search...

Gene expression databases

Bgeei P54846.
CleanExi MM_NRL.
ExpressionAtlasi P54846. differential.
Genevestigatori P54846.

Family and domain databases

Gene3Di 1.10.880.10. 1 hit.
InterProi IPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR013592. Maf_TF_N.
IPR028575. Nrl.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf.
[Graphical view ]
PANTHERi PTHR10129. PTHR10129. 1 hit.
PTHR10129:SF5. PTHR10129:SF5. 1 hit.
Pfami PF03131. bZIP_Maf. 1 hit.
PF08383. Maf_N. 1 hit.
[Graphical view ]
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
SUPFAMi SSF47454. SSF47454. 1 hit.
PROSITEi PS50217. BZIP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of the murine neural retina leucine zipper gene, Nrl."
    Farjo Q., Jackson A.U., Xu J., Gryzenia M., Skolnick C., Agarwal N., Swaroop A.
    Genomics 18:216-222(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Retina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  3. "Sumoylation of bZIP transcription factor NRL modulates target gene expression during photoreceptor differentiation."
    Roger J.E., Nellissery J., Kim D.S., Swaroop A.
    J. Biol. Chem. 285:25637-25644(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, SUMOYLATION AT LYS-20 AND LYS-24.

Entry informationi

Entry nameiNRL_MOUSE
AccessioniPrimary (citable) accession number: P54846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3