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Protein

Neural retina-specific leucine zipper protein

Gene

Nrl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds in a sequence-specific manner to the rhodopsin promoter.By similarity

GO - Molecular functioni

GO - Biological processi

  • positive regulation of rhodopsin gene expression Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of rhodopsin gene expression Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • retinal rod cell development Source: MGI

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neural retina-specific leucine zipper protein
Short name:
NRL
Gene namesi
Name:Nrl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:102567 Nrl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Photoreceptor precursors in retina produce only cones that primarily express S-opsin.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766341 – 237Neural retina-specific leucine zipper proteinAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki24Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication

Post-translational modificationi

Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation.1 Publication
Phosphorylated.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP54846
PRIDEiP54846

PTM databases

iPTMnetiP54846
PhosphoSitePlusiP54846

Expressioni

Tissue specificityi

Expressed in the retina (at protein level) (PubMed:11477108).1 Publication

Gene expression databases

BgeeiENSMUSG00000040632
CleanExiMM_NRL
ExpressionAtlasiP54846 baseline and differential
GenevisibleiP54846 MM

Interactioni

Subunit structurei

Interacts with FIZ1; this interaction represses transactivation. Interacts (via the leucine-zipper domain) with CRX.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054457

Structurei

3D structure databases

ProteinModelPortaliP54846
SMRiP54846
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 222bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 93Minimal transactivation domain (MTD)By similarityAdd BLAST64
Regioni159 – 185Basic motifPROSITE-ProRule annotationAdd BLAST27
Regioni187 – 208Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Domaini

The minimal transactivation domain (MTD) is conserved across the MAF family, it may activate transcription by recruiting TBP and associated factors at the promoters of target genes.By similarity

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG4196 Eukaryota
ENOG41102C7 LUCA
GeneTreeiENSGT00550000074549
HOGENOMiHOG000261683
HOVERGENiHBG000313
InParanoidiP54846
KOiK09038
OMAiEGPHGYY
OrthoDBiEOG091G0H46
PhylomeDBiP54846
TreeFamiTF325689

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR013592 Maf_TF_N
IPR028575 Nrl
IPR008917 TF_DNA-bd_sf
IPR024874 Transciption_factor_Maf_fam
PANTHERiPTHR10129 PTHR10129, 1 hit
PTHR10129:SF24 PTHR10129:SF24, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
PF08383 Maf_N, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

P54846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPPSPLAM EYVNDFDLMK FEIKREPSEG RSGVPTASLG STPYSSVPPS
60 70 80 90 100
PTFSEPGMVG GGEAPRPGLE ELYWLATLQQ QLGSDEVLGL SPDEAVELLQ
110 120 130 140 150
NQGPVSMEGP LGYYSGSPGE TGAQHVQLPE RFSDAALVSM SVRELNRQLR
160 170 180 190 200
GCGRDEALRL KQRRRTLKNR GYAQACRSKR LQQRRGLEAE RARLAAQLDA
210 220 230
LRAEVARLAR ERDLYKARCD RLTSGGPGSD DHTHLFL
Length:237
Mass (Da):26,083
Last modified:October 1, 1996 - v1
Checksum:iAF1A2B3772C95EC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14935 mRNA Translation: AAA16843.1
BC031440 mRNA Translation: AAH31440.1
CCDSiCCDS27113.1
PIRiA48912
RefSeqiNP_001129546.1, NM_001136074.2
NP_001258845.1, NM_001271916.1
NP_001258846.1, NM_001271917.1
NP_032762.1, NM_008736.3
UniGeneiMm.20422

Genome annotation databases

EnsembliENSMUST00000062232; ENSMUSP00000054457; ENSMUSG00000040632
ENSMUST00000111404; ENSMUSP00000107035; ENSMUSG00000040632
ENSMUST00000178694; ENSMUSP00000136445; ENSMUSG00000040632
GeneIDi18185
KEGGimmu:18185
UCSCiuc007tyu.3 mouse

Similar proteinsi

Entry informationi

Entry nameiNRL_MOUSE
AccessioniPrimary (citable) accession number: P54846
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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