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P54834

- TYRO_CANFA

UniProt

P54834 - TYRO_CANFA

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Protein

Tyrosinase

Gene
TYR
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone By similarity.

Catalytic activityi

2 L-dopa + O2 = 2 dopaquinone + 2 H2O.
L-tyrosine + O2 = dopaquinone + H2O.

Cofactori

Binds 2 copper ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi180 – 1801Copper A By similarity
Metal bindingi202 – 2021Copper A By similarity
Metal bindingi211 – 2111Copper A By similarity
Metal bindingi363 – 3631Copper B By similarity
Metal bindingi367 – 3671Copper B By similarity
Metal bindingi390 – 3901Copper B By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. monophenol monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosinase (EC:1.14.18.1)
Alternative name(s):
Monophenol monooxygenase
Gene namesi
Name:TYR
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 473455Lumenal, melanosome Reviewed predictionAdd
BLAST
Transmembranei474 – 49421Helical; Reviewed predictionAdd
BLAST
Topological domaini495 – 53036Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. melanosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed predictionAdd
BLAST
Chaini19 – 530512TyrosinasePRO_0000035877Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi111 – 1111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi230 – 2301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi337 – 3371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi371 – 3711N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP54834.

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG08919.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiP54834.
KOiK00505.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54834-1 [UniParc]FASTAAdd to Basket

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MLLAALCCLL WSFRTSTGHF PRACASSKSL MEKECCPPWS GDGSPCGQLS    50
GRGACQDIIL SNAPFGPQFP FTGVDDRESW PSVFYNRTCQ CFGNFMGFNC 100
GNCKFGFWGQ NCTEKRLLVR KNIFDLSVPE KNKFLAYLTL AKHTTSPDYV 150
IPTGTYGQMN NGSTPMFNDI NIYDLFVWMH YYVSRDTLLG GSEIWKDIDF 200
AHEAPGFLPW HRLFLLLWEQ EIQKLTGDEN FTIPYWDWRD AKSCDICTDE 250
YMGGRNPANP NLLSPASFFS SWQIVCTRLE EYNSRQALCD GTPEGPLLRN 300
PGNHDKARTP RLPSSADVEF CLSLTQYESD SMDKAANFSF RNTLEGFASP 350
LTGIADASQS SMHNALHIYM NGTMSQVPGS ANDPIFLLHH AFVDSIFEQW 400
LRRHHPLREV YPEANAPIGH NRESYMVPFI PLYRNGDLFI SSRDLGYDYS 450
NLQESERDIF QDYIKPYLEQ ASRIWPWLIG AAVVGCVVTA VLGGLTSLLC 500
RRNRKQLHEE KQPLLMEKED YHSLLYQTHL 530
Length:530
Mass (Da):60,336
Last modified:April 12, 2005 - v2
Checksum:iB1C45F6362ACF0E3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31L → V in AAA86420. 1 Publication
Sequence conflicti7 – 71C → R in AAA86420. 1 Publication
Sequence conflicti59 – 591I → V in AAA86420. 1 Publication
Sequence conflicti115 – 1151K → R in AAA86420. 1 Publication
Sequence conflicti132 – 1321N → D in AAA86420. 1 Publication
Sequence conflicti212 – 2121R → T in AAA86420. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY336053 mRNA. Translation: AAQ17535.1.
U42219 Genomic DNA. Translation: AAA86420.1.
RefSeqiNP_001002941.1. NM_001002941.1.
UniGeneiCfa.104.

Genome annotation databases

GeneIDi403405.
KEGGicfa:403405.

Cross-referencesi

Web resourcesi

Protein Spotlight

Snowy stardom - Issue 49 of August 2004

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY336053 mRNA. Translation: AAQ17535.1 .
U42219 Genomic DNA. Translation: AAA86420.1 .
RefSeqi NP_001002941.1. NM_001002941.1.
UniGenei Cfa.104.

3D structure databases

ProteinModelPortali P54834.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403405.
KEGGi cfa:403405.

Organism-specific databases

CTDi 7299.

Phylogenomic databases

eggNOGi NOG08919.
HOGENOMi HOG000118376.
HOVERGENi HBG003553.
InParanoidi P54834.
KOi K00505.

Miscellaneous databases

NextBioi 20816926.

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 1 hit.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Schmutz S.M., Berryere T.G.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Doberman pinscher.
    Tissue: Skin.
  2. "Cloning and chromosomal in situ hybridization of the dog tyrosinase exon 1."
    Tang Q., Williams R.W., Hogan D., Valentine V., Goldowitz D.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-273.

Entry informationi

Entry nameiTYRO_CANFA
AccessioniPrimary (citable) accession number: P54834
Secondary accession number(s): Q7YRB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 12, 2005
Last modified: June 11, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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