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P54829

- PTN5_HUMAN

UniProt

P54829 - PTN5_HUMAN

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Protein
Tyrosine-protein phosphatase non-receptor type 5
Gene
PTPN5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei461 – 4611Substrate By similarity
Active sitei496 – 4961Phosphocysteine intermediate By similarity
Binding sitei540 – 5401Substrate By similarity

GO - Molecular functioni

  1. phosphotyrosine binding Source: UniProtKB
  2. protein tyrosine phosphatase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.48. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 5 (EC:3.1.3.48)
Alternative name(s):
Neural-specific protein-tyrosine phosphatase
Striatum-enriched protein-tyrosine phosphatase
Short name:
STEP
Gene namesi
Name:PTPN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9657. PTPN5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Transmembranei146 – 16621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34001.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Tyrosine-protein phosphatase non-receptor type 5
PRO_0000363657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei245 – 2451Phosphoserine; by PKA1 Publication
Modified residuei255 – 2551Phosphothreonine; by MAPK1 Publication
Modified residuei268 – 2681Phosphoserine; by MAPK1 Publication

Post-translational modificationi

Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP54829.
PRIDEiP54829.

PTM databases

PhosphoSiteiP54829.

Expressioni

Gene expression databases

ArrayExpressiP54829.
BgeeiP54829.
CleanExiHS_PTPN5.
GenevestigatoriP54829.

Organism-specific databases

HPAiHPA031014.

Interactioni

Protein-protein interaction databases

BioGridi124312. 10 interactions.
IntActiP54829. 5 interactions.
STRINGi9606.ENSP00000351342.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi287 – 2937
Helixi297 – 3048
Helixi314 – 3163
Helixi322 – 3254
Helixi335 – 3373
Beta strandi338 – 3403
Turni349 – 3524
Beta strandi355 – 3595
Helixi362 – 3643
Beta strandi368 – 3736
Helixi377 – 3793
Helixi380 – 39011
Beta strandi394 – 3985
Helixi401 – 4033
Turni404 – 4063
Beta strandi414 – 4196
Beta strandi422 – 43110
Beta strandi433 – 44311
Beta strandi448 – 4569
Helixi465 – 4673
Helixi468 – 48417
Beta strandi492 – 5009
Helixi501 – 51919
Helixi524 – 53411
Helixi542 – 55918

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BIJX-ray2.05A282-563[»]
2BV5X-ray1.80A280-561[»]
2CJZX-ray1.70A282-563[»]
ProteinModelPortaliP54829.
SMRiP54829. Positions 280-561.

Miscellaneous databases

EvolutionaryTraceiP54829.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini300 – 555256Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni496 – 5027Substrate binding

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000294188.
HOVERGENiHBG001594.
InParanoidiP54829.
KOiK18018.
OMAiCTPGCSE.
OrthoDBiEOG7288QX.
PhylomeDBiP54829.
TreeFamiTF331016.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF001997. PTPRR. 1 hit.
PRINTSiPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P54829-1) [UniParc]FASTAAdd to Basket

Also known as: STEP61

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNYEGARSER ENHAADDSEG GALDMCCSER LPGLPQPIVM EALDEAEGLQ    50
DSQREMPPPP PPSPPSDPAQ KPPPRGAGSH SLTVRSSLCL FAASQFLLAC 100
GVLWFSGYGH IWSQNATNLV SSLLTLLKQL EPTAWLDSGT WGVPSLLLVF 150
LSVGLVLVTT LVWHLLRTPP EPPTPLPPED RRQSVSRQPS FTYSEWMEEK 200
IEDDFLDLDP VPETPVFDCV MDIKPEADPT SLTVKSMGLQ ERRGSNVSLT 250
LDMCTPGCNE EGFGYLMSPR EESAREYLLS ASRVLQAEEL HEKALDPFLL 300
QAEFFEIPMN FVDPKEYDIP GLVRKNRYKT ILPNPHSRVC LTSPDPDDPL 350
SSYINANYIR GYGGEEKVYI ATQGPIVSTV ADFWRMVWQE HTPIIVMITN 400
IEEMNEKCTE YWPEEQVAYD GVEITVQKVI HTEDYRLRLI SLKSGTEERG 450
LKHYWFTSWP DQKTPDRAPP LLHLVREVEE AAQQEGPHCA PIIVHCSAGI 500
GRTGCFIATS ICCQQLRQEG VVDILKTTCQ LRQDRGGMIQ TCEQYQFVHH 550
VMSLYEKQLS HQSPE 565
Length:565
Mass (Da):63,538
Last modified:January 11, 2011 - v4
Checksum:iDE32BEFFEFF7C494
GO
Isoform 2 (identifier: P54829-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-129: Missing.

Note: No experimental confirmation available.

Show »
Length:533
Mass (Da):60,035
Checksum:iA27BA66C3292C132
GO
Isoform 3 (identifier: P54829-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Note: No experimental confirmation available.

Show »
Length:541
Mass (Da):60,961
Checksum:iFE808E1908C2AB58
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1701P → A.2 Publications
Corresponds to variant rs4757707 [ dbSNP | Ensembl ].
VAR_054369
Natural varianti561 – 5611H → R.
Corresponds to variant rs11024773 [ dbSNP | Ensembl ].
VAR_054370

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2424Missing in isoform 3.
VSP_054561Add
BLAST
Alternative sequencei98 – 12932Missing in isoform 2.
VSP_042654Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 343PGL → LGR in AAA87555. 1 Publication
Sequence conflicti104 – 1041W → R in BAC03548. 1 Publication
Sequence conflicti107 – 1071G → A in CAD38632. 1 Publication
Sequence conflicti110 – 1101H → D in CAD38632. 1 Publication
Sequence conflicti111 – 1111I → M in AAA87555. 1 Publication
Sequence conflicti134 – 1341A → S in AAA87555. 1 Publication
Sequence conflicti145 – 1451S → G in AAA87555. 1 Publication
Sequence conflicti162 – 1621V → L in CAD38632. 1 Publication
Sequence conflicti313 – 3131D → V in AAA87555. 1 Publication
Sequence conflicti322 – 3232LV → RC in AAA87555. 1 Publication
Sequence conflicti541 – 5411T → H in AAA87555. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090923 mRNA. Translation: BAC03548.1.
AK127312 mRNA. Translation: BAG54479.1.
AK295604 mRNA. Translation: BAH12122.1.
AK316270 mRNA. Translation: BAH14641.1.
AL832541 mRNA. Translation: CAD38632.2.
AC103974 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68363.1.
CH471064 Genomic DNA. Translation: EAW68365.1.
CH471064 Genomic DNA. Translation: EAW68367.1.
BC064807 mRNA. Translation: AAH64807.1.
U27831 mRNA. Translation: AAA87555.1.
CCDSiCCDS41626.1. [P54829-2]
CCDS60746.1. [P54829-3]
CCDS7845.1. [P54829-1]
RefSeqiNP_001035059.1. NM_001039970.1. [P54829-2]
NP_001265165.1. NM_001278236.1. [P54829-2]
NP_001265167.1. NM_001278238.1. [P54829-3]
NP_001265168.1. NM_001278239.1.
NP_008837.1. NM_006906.1. [P54829-1]
NP_116170.3. NM_032781.3. [P54829-1]
UniGeneiHs.79092.

Genome annotation databases

EnsembliENST00000358540; ENSP00000351342; ENSG00000110786. [P54829-1]
ENST00000396167; ENSP00000379470; ENSG00000110786. [P54829-2]
ENST00000396168; ENSP00000379471; ENSG00000110786.
ENST00000396170; ENSP00000379473; ENSG00000110786. [P54829-2]
ENST00000396171; ENSP00000379474; ENSG00000110786. [P54829-1]
GeneIDi84867.
KEGGihsa:84867.
UCSCiuc001mpb.4. human. [P54829-2]
uc001mpc.4. human. [P54829-1]

Polymorphism databases

DMDMi317373540.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090923 mRNA. Translation: BAC03548.1 .
AK127312 mRNA. Translation: BAG54479.1 .
AK295604 mRNA. Translation: BAH12122.1 .
AK316270 mRNA. Translation: BAH14641.1 .
AL832541 mRNA. Translation: CAD38632.2 .
AC103974 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68363.1 .
CH471064 Genomic DNA. Translation: EAW68365.1 .
CH471064 Genomic DNA. Translation: EAW68367.1 .
BC064807 mRNA. Translation: AAH64807.1 .
U27831 mRNA. Translation: AAA87555.1 .
CCDSi CCDS41626.1. [P54829-2 ]
CCDS60746.1. [P54829-3 ]
CCDS7845.1. [P54829-1 ]
RefSeqi NP_001035059.1. NM_001039970.1. [P54829-2 ]
NP_001265165.1. NM_001278236.1. [P54829-2 ]
NP_001265167.1. NM_001278238.1. [P54829-3 ]
NP_001265168.1. NM_001278239.1.
NP_008837.1. NM_006906.1. [P54829-1 ]
NP_116170.3. NM_032781.3. [P54829-1 ]
UniGenei Hs.79092.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BIJ X-ray 2.05 A 282-563 [» ]
2BV5 X-ray 1.80 A 280-561 [» ]
2CJZ X-ray 1.70 A 282-563 [» ]
ProteinModelPortali P54829.
SMRi P54829. Positions 280-561.
ModBasei Search...

Protein-protein interaction databases

BioGridi 124312. 10 interactions.
IntActi P54829. 5 interactions.
STRINGi 9606.ENSP00000351342.

Chemistry

BindingDBi P54829.
ChEMBLi CHEMBL2007628.

PTM databases

PhosphoSitei P54829.

Polymorphism databases

DMDMi 317373540.

Proteomic databases

PaxDbi P54829.
PRIDEi P54829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358540 ; ENSP00000351342 ; ENSG00000110786 . [P54829-1 ]
ENST00000396167 ; ENSP00000379470 ; ENSG00000110786 . [P54829-2 ]
ENST00000396168 ; ENSP00000379471 ; ENSG00000110786 .
ENST00000396170 ; ENSP00000379473 ; ENSG00000110786 . [P54829-2 ]
ENST00000396171 ; ENSP00000379474 ; ENSG00000110786 . [P54829-1 ]
GeneIDi 84867.
KEGGi hsa:84867.
UCSCi uc001mpb.4. human. [P54829-2 ]
uc001mpc.4. human. [P54829-1 ]

Organism-specific databases

CTDi 84867.
GeneCardsi GC11M018706.
HGNCi HGNC:9657. PTPN5.
HPAi HPA031014.
MIMi 176879. gene.
neXtProti NX_P54829.
PharmGKBi PA34001.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000294188.
HOVERGENi HBG001594.
InParanoidi P54829.
KOi K18018.
OMAi CTPGCSE.
OrthoDBi EOG7288QX.
PhylomeDBi P54829.
TreeFami TF331016.

Enzyme and pathway databases

BRENDAi 3.1.3.48. 2681.

Miscellaneous databases

EvolutionaryTracei P54829.
GeneWikii PTPN5.
GenomeRNAii 84867.
NextBioi 35480892.
PROi P54829.
SOURCEi Search...

Gene expression databases

ArrayExpressi P54829.
Bgeei P54829.
CleanExi HS_PTPN5.
Genevestigatori P54829.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001997. PTPRR. 1 hit.
PRINTSi PR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ALA-170.
    Tissue: Amygdala, Brain and Hippocampus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-170.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. "Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci."
    Li X., Luna J., Lombroso P.J., Francke U.
    Genomics 28:442-449(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-565 (ISOFORM 1).
    Tissue: Brain.
  7. "Dephosphorylation of specific sites in the kinase-specificity sequence domain leads to ubiquitin-mediated degradation of the tyrosine phosphatase STEP."
    Mukherjee S., Poddar R., Deb I., Paul S.
    Biochem. J. 440:115-125(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-245; THR-255 AND SER-268, FUNCTION.
  8. "Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases."
    Eswaran J., von Kries J.P., Marsden B., Longman E., Debreczeni J.E., Ugochukwu E., Turnbull A., Lee W.H., Knapp S., Barr A.J.
    Biochem. J. 395:483-491(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 280-563 IN COMPLEX WITH SUBSTRATE ANALOG.

Entry informationi

Entry nameiPTN5_HUMAN
AccessioniPrimary (citable) accession number: P54829
Secondary accession number(s): B3KXG7
, B7Z386, B7ZAF5, D3DQY7, Q6P1Z2, Q8N2A1, Q8NDP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 128 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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