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P54829

- PTN5_HUMAN

UniProt

P54829 - PTN5_HUMAN

Protein

Tyrosine-protein phosphatase non-receptor type 5

Gene

PTPN5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 4 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei461 – 4611SubstrateBy similarity
    Active sitei496 – 4961Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei540 – 5401SubstrateBy similarity

    GO - Molecular functioni

    1. phosphotyrosine binding Source: UniProtKB
    2. protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. protein dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    BRENDAi3.1.3.48. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 5 (EC:3.1.3.48)
    Alternative name(s):
    Neural-specific protein-tyrosine phosphatase
    Striatum-enriched protein-tyrosine phosphatase
    Short name:
    STEP
    Gene namesi
    Name:PTPN5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:9657. PTPN5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34001.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 565565Tyrosine-protein phosphatase non-receptor type 5PRO_0000363657Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei245 – 2451Phosphoserine; by PKA1 Publication
    Modified residuei255 – 2551Phosphothreonine; by MAPK1 Publication
    Modified residuei268 – 2681Phosphoserine; by MAPK1 Publication

    Post-translational modificationi

    Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP54829.
    PRIDEiP54829.

    PTM databases

    PhosphoSiteiP54829.

    Expressioni

    Gene expression databases

    ArrayExpressiP54829.
    BgeeiP54829.
    CleanExiHS_PTPN5.
    GenevestigatoriP54829.

    Organism-specific databases

    HPAiHPA031014.

    Interactioni

    Protein-protein interaction databases

    BioGridi124312. 10 interactions.
    IntActiP54829. 5 interactions.
    STRINGi9606.ENSP00000351342.

    Structurei

    Secondary structure

    1
    565
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi287 – 2937
    Helixi297 – 3048
    Helixi314 – 3163
    Helixi322 – 3254
    Helixi335 – 3373
    Beta strandi338 – 3403
    Turni349 – 3524
    Beta strandi355 – 3595
    Helixi362 – 3643
    Beta strandi368 – 3736
    Helixi377 – 3793
    Helixi380 – 39011
    Beta strandi394 – 3985
    Helixi401 – 4033
    Turni404 – 4063
    Beta strandi414 – 4196
    Beta strandi422 – 43110
    Beta strandi433 – 44311
    Beta strandi448 – 4569
    Helixi465 – 4673
    Helixi468 – 48417
    Beta strandi492 – 5009
    Helixi501 – 51919
    Helixi524 – 53411
    Helixi542 – 55918

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BIJX-ray2.05A282-563[»]
    2BV5X-ray1.80A280-561[»]
    2CJZX-ray1.70A282-563[»]
    ProteinModelPortaliP54829.
    SMRiP54829. Positions 280-561.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP54829.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini300 – 555256Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni496 – 5027Substrate binding

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000294188.
    HOVERGENiHBG001594.
    InParanoidiP54829.
    KOiK18018.
    OMAiCTPGCSE.
    OrthoDBiEOG7288QX.
    PhylomeDBiP54829.
    TreeFamiTF331016.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR008356. Tyr_Pase_KIM-con.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001997. PTPRR. 1 hit.
    PRINTSiPR01778. KIMPTPASE.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P54829-1) [UniParc]FASTAAdd to Basket

    Also known as: STEP61

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNYEGARSER ENHAADDSEG GALDMCCSER LPGLPQPIVM EALDEAEGLQ    50
    DSQREMPPPP PPSPPSDPAQ KPPPRGAGSH SLTVRSSLCL FAASQFLLAC 100
    GVLWFSGYGH IWSQNATNLV SSLLTLLKQL EPTAWLDSGT WGVPSLLLVF 150
    LSVGLVLVTT LVWHLLRTPP EPPTPLPPED RRQSVSRQPS FTYSEWMEEK 200
    IEDDFLDLDP VPETPVFDCV MDIKPEADPT SLTVKSMGLQ ERRGSNVSLT 250
    LDMCTPGCNE EGFGYLMSPR EESAREYLLS ASRVLQAEEL HEKALDPFLL 300
    QAEFFEIPMN FVDPKEYDIP GLVRKNRYKT ILPNPHSRVC LTSPDPDDPL 350
    SSYINANYIR GYGGEEKVYI ATQGPIVSTV ADFWRMVWQE HTPIIVMITN 400
    IEEMNEKCTE YWPEEQVAYD GVEITVQKVI HTEDYRLRLI SLKSGTEERG 450
    LKHYWFTSWP DQKTPDRAPP LLHLVREVEE AAQQEGPHCA PIIVHCSAGI 500
    GRTGCFIATS ICCQQLRQEG VVDILKTTCQ LRQDRGGMIQ TCEQYQFVHH 550
    VMSLYEKQLS HQSPE 565
    Length:565
    Mass (Da):63,538
    Last modified:January 11, 2011 - v4
    Checksum:iDE32BEFFEFF7C494
    GO
    Isoform 2 (identifier: P54829-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         98-129: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:533
    Mass (Da):60,035
    Checksum:iA27BA66C3292C132
    GO
    Isoform 3 (identifier: P54829-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-24: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:541
    Mass (Da):60,961
    Checksum:iFE808E1908C2AB58
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 343PGL → LGR in AAA87555. (PubMed:7490079)Curated
    Sequence conflicti104 – 1041W → R in BAC03548. (PubMed:14702039)Curated
    Sequence conflicti107 – 1071G → A in CAD38632. (PubMed:17974005)Curated
    Sequence conflicti110 – 1101H → D in CAD38632. (PubMed:17974005)Curated
    Sequence conflicti111 – 1111I → M in AAA87555. (PubMed:7490079)Curated
    Sequence conflicti134 – 1341A → S in AAA87555. (PubMed:7490079)Curated
    Sequence conflicti145 – 1451S → G in AAA87555. (PubMed:7490079)Curated
    Sequence conflicti162 – 1621V → L in CAD38632. (PubMed:17974005)Curated
    Sequence conflicti313 – 3131D → V in AAA87555. (PubMed:7490079)Curated
    Sequence conflicti322 – 3232LV → RC in AAA87555. (PubMed:7490079)Curated
    Sequence conflicti541 – 5411T → H in AAA87555. (PubMed:7490079)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti170 – 1701P → A.2 Publications
    Corresponds to variant rs4757707 [ dbSNP | Ensembl ].
    VAR_054369
    Natural varianti561 – 5611H → R.
    Corresponds to variant rs11024773 [ dbSNP | Ensembl ].
    VAR_054370

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2424Missing in isoform 3. 1 PublicationVSP_054561Add
    BLAST
    Alternative sequencei98 – 12932Missing in isoform 2. 1 PublicationVSP_042654Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090923 mRNA. Translation: BAC03548.1.
    AK127312 mRNA. Translation: BAG54479.1.
    AK295604 mRNA. Translation: BAH12122.1.
    AK316270 mRNA. Translation: BAH14641.1.
    AL832541 mRNA. Translation: CAD38632.2.
    AC103974 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68363.1.
    CH471064 Genomic DNA. Translation: EAW68365.1.
    CH471064 Genomic DNA. Translation: EAW68367.1.
    BC064807 mRNA. Translation: AAH64807.1.
    U27831 mRNA. Translation: AAA87555.1.
    CCDSiCCDS41626.1. [P54829-2]
    CCDS60746.1. [P54829-3]
    CCDS7845.1. [P54829-1]
    RefSeqiNP_001035059.1. NM_001039970.1. [P54829-2]
    NP_001265165.1. NM_001278236.1. [P54829-2]
    NP_001265167.1. NM_001278238.1. [P54829-3]
    NP_001265168.1. NM_001278239.1.
    NP_008837.1. NM_006906.1. [P54829-1]
    NP_116170.3. NM_032781.3. [P54829-1]
    UniGeneiHs.79092.

    Genome annotation databases

    EnsembliENST00000358540; ENSP00000351342; ENSG00000110786. [P54829-1]
    ENST00000396168; ENSP00000379471; ENSG00000110786. [P54829-3]
    ENST00000396170; ENSP00000379473; ENSG00000110786. [P54829-2]
    GeneIDi84867.
    KEGGihsa:84867.
    UCSCiuc001mpb.4. human. [P54829-2]
    uc001mpc.4. human. [P54829-1]

    Polymorphism databases

    DMDMi317373540.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090923 mRNA. Translation: BAC03548.1 .
    AK127312 mRNA. Translation: BAG54479.1 .
    AK295604 mRNA. Translation: BAH12122.1 .
    AK316270 mRNA. Translation: BAH14641.1 .
    AL832541 mRNA. Translation: CAD38632.2 .
    AC103974 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68363.1 .
    CH471064 Genomic DNA. Translation: EAW68365.1 .
    CH471064 Genomic DNA. Translation: EAW68367.1 .
    BC064807 mRNA. Translation: AAH64807.1 .
    U27831 mRNA. Translation: AAA87555.1 .
    CCDSi CCDS41626.1. [P54829-2 ]
    CCDS60746.1. [P54829-3 ]
    CCDS7845.1. [P54829-1 ]
    RefSeqi NP_001035059.1. NM_001039970.1. [P54829-2 ]
    NP_001265165.1. NM_001278236.1. [P54829-2 ]
    NP_001265167.1. NM_001278238.1. [P54829-3 ]
    NP_001265168.1. NM_001278239.1.
    NP_008837.1. NM_006906.1. [P54829-1 ]
    NP_116170.3. NM_032781.3. [P54829-1 ]
    UniGenei Hs.79092.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BIJ X-ray 2.05 A 282-563 [» ]
    2BV5 X-ray 1.80 A 280-561 [» ]
    2CJZ X-ray 1.70 A 282-563 [» ]
    ProteinModelPortali P54829.
    SMRi P54829. Positions 280-561.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124312. 10 interactions.
    IntActi P54829. 5 interactions.
    STRINGi 9606.ENSP00000351342.

    Chemistry

    BindingDBi P54829.
    ChEMBLi CHEMBL2007628.

    PTM databases

    PhosphoSitei P54829.

    Polymorphism databases

    DMDMi 317373540.

    Proteomic databases

    PaxDbi P54829.
    PRIDEi P54829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358540 ; ENSP00000351342 ; ENSG00000110786 . [P54829-1 ]
    ENST00000396168 ; ENSP00000379471 ; ENSG00000110786 . [P54829-3 ]
    ENST00000396170 ; ENSP00000379473 ; ENSG00000110786 . [P54829-2 ]
    GeneIDi 84867.
    KEGGi hsa:84867.
    UCSCi uc001mpb.4. human. [P54829-2 ]
    uc001mpc.4. human. [P54829-1 ]

    Organism-specific databases

    CTDi 84867.
    GeneCardsi GC11M018706.
    HGNCi HGNC:9657. PTPN5.
    HPAi HPA031014.
    MIMi 176879. gene.
    neXtProti NX_P54829.
    PharmGKBi PA34001.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000294188.
    HOVERGENi HBG001594.
    InParanoidi P54829.
    KOi K18018.
    OMAi CTPGCSE.
    OrthoDBi EOG7288QX.
    PhylomeDBi P54829.
    TreeFami TF331016.

    Enzyme and pathway databases

    BRENDAi 3.1.3.48. 2681.

    Miscellaneous databases

    EvolutionaryTracei P54829.
    GeneWikii PTPN5.
    GenomeRNAii 84867.
    NextBioi 35480892.
    PROi P54829.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P54829.
    Bgeei P54829.
    CleanExi HS_PTPN5.
    Genevestigatori P54829.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR008356. Tyr_Pase_KIM-con.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001997. PTPRR. 1 hit.
    PRINTSi PR01778. KIMPTPASE.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ALA-170.
      Tissue: Amygdala, Brain and Hippocampus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-170.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. "Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci."
      Li X., Luna J., Lombroso P.J., Francke U.
      Genomics 28:442-449(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-565 (ISOFORM 1).
      Tissue: Brain.
    7. "Dephosphorylation of specific sites in the kinase-specificity sequence domain leads to ubiquitin-mediated degradation of the tyrosine phosphatase STEP."
      Mukherjee S., Poddar R., Deb I., Paul S.
      Biochem. J. 440:115-125(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-245; THR-255 AND SER-268, FUNCTION.
    8. "Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases."
      Eswaran J., von Kries J.P., Marsden B., Longman E., Debreczeni J.E., Ugochukwu E., Turnbull A., Lee W.H., Knapp S., Barr A.J.
      Biochem. J. 395:483-491(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 280-563 IN COMPLEX WITH SUBSTRATE ANALOG.

    Entry informationi

    Entry nameiPTN5_HUMAN
    AccessioniPrimary (citable) accession number: P54829
    Secondary accession number(s): B3KXG7
    , B7Z386, B7ZAF5, D3DQY7, Q6P1Z2, Q8N2A1, Q8NDP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 129 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3