ID   CNRG_CANLF              Reviewed;          87 AA.
AC   P54827;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   27-MAR-2024, entry version 131.
DE   RecName: Full=Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma;
DE            Short=GMP-PDE gamma;
DE            EC=3.1.4.35;
GN   Name=PDE6G; Synonyms=PDEG;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Retina;
RX   PubMed=8973300; DOI=10.1016/s0378-1119(96)00319-8;
RA   Wang W., Acland G.M., Aguirre G.D., Ray K.;
RT   "Cloning and characterization of the cDNA and gene encoding the gamma-
RT   subunit of cGMP-phosphodiesterase in canine retinal rod photoreceptor
RT   cells.";
RL   Gene 181:1-5(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Labrador retriever; TISSUE=Retina;
RX   PubMed=9300552; DOI=10.1016/s0034-5288(97)90208-3;
RA   Kylma T., Paulin L., Hurwitz M.Y., Hurwitz R.L., Kommonen B.;
RT   "Cloning of the cDNA encoding rod photoreceptor cGMP-phosphodiesterase
RT   alpha and gamma subunits from the retinal degenerate Labrador retriever
RT   dog.";
RL   Res. Vet. Sci. 62:293-296(1997).
CC   -!- FUNCTION: Participates in processes of transmission and amplification
CC       of the visual signal. cGMP-PDEs are the effector molecules in G-
CC       protein-mediated phototransduction in vertebrate rods and cones.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic GMP + H2O = GMP + H(+); Xref=Rhea:RHEA:16957,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57746,
CC         ChEBI:CHEBI:58115; EC=3.1.4.35;
CC   -!- SUBUNIT: Oligomer composed of two catalytic chains (alpha and beta), an
CC       inhibitory chain (gamma) and the delta chain.
CC   -!- SIMILARITY: Belongs to the rod/cone cGMP-PDE gamma subunit family.
CC       {ECO:0000305}.
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DR   EMBL; U49359; AAB40379.1; -; mRNA.
DR   EMBL; U49360; AAB00116.1; -; Genomic_DNA.
DR   EMBL; Z69973; CAA93815.1; -; Genomic_DNA.
DR   PIR; JC5329; JC5329.
DR   RefSeq; NP_001003235.1; NM_001003235.1.
DR   RefSeq; XP_013971663.1; XM_014116188.1.
DR   AlphaFoldDB; P54827; -.
DR   BMRB; P54827; -.
DR   SMR; P54827; -.
DR   STRING; 9615.ENSCAFP00000008629; -.
DR   BindingDB; P54827; -.
DR   PaxDb; 9612-ENSCAFP00000008629; -.
DR   Ensembl; ENSCAFT00000009298.4; ENSCAFP00000008629.4; ENSCAFG00000005767.4.
DR   Ensembl; ENSCAFT00030029095.1; ENSCAFP00030025364.1; ENSCAFG00030015801.1.
DR   Ensembl; ENSCAFT00040000937.1; ENSCAFP00040000790.1; ENSCAFG00040000536.1.
DR   Ensembl; ENSCAFT00805029073; ENSCAFP00805022791; ENSCAFG00805016025.
DR   GeneID; 403911; -.
DR   KEGG; cfa:403911; -.
DR   CTD; 5148; -.
DR   VGNC; VGNC:44361; PDE6G.
DR   eggNOG; ENOG502S20G; Eukaryota.
DR   HOGENOM; CLU_170469_0_0_1; -.
DR   InParanoid; P54827; -.
DR   OMA; KGRGWHP; -.
DR   OrthoDB; 5320589at2759; -.
DR   TreeFam; TF333297; -.
DR   Reactome; R-CFA-2485179; Activation of the phototransduction cascade.
DR   Reactome; R-CFA-2514859; Inactivation, recovery and regulation of the phototransduction cascade.
DR   Reactome; R-CFA-4086398; Ca2+ pathway.
DR   Proteomes; UP000002254; Chromosome 9.
DR   Proteomes; UP000694429; Chromosome 9.
DR   Proteomes; UP000694542; Chromosome 9.
DR   Proteomes; UP000805418; Unplaced.
DR   GO; GO:0042622; C:photoreceptor outer segment membrane; IBA:GO_Central.
DR   GO; GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030553; F:cGMP binding; IEA:InterPro.
DR   GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0045745; P:positive regulation of G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.1120.10; Retinal cGMP phosphodiesterase, gamma subunit; 1.
DR   InterPro; IPR006952; PDE6_gamma.
DR   InterPro; IPR037030; PDE6_gamma_sf.
DR   PANTHER; PTHR12122; RETINAL CONE RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE GAMMA-SUBUNIT-RELATED; 1.
DR   PANTHER; PTHR12122:SF4; RETINAL ROD RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA; 1.
DR   Pfam; PF04868; PDE6_gamma; 1.
DR   PIRSF; PIRSF000969; 35-cGMP_Pdiase_g; 1.
PE   3: Inferred from homology;
KW   Acetylation; cGMP; Hydrolase; Reference proteome; Sensory transduction;
KW   Vision.
FT   CHAIN           1..87
FT                   /note="Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic
FT                   phosphodiesterase subunit gamma"
FT                   /id="PRO_0000166114"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:P04972"
SQ   SEQUENCE   87 AA;  9651 MW;  8EA7C7A1D7D14B9E CRC64;
     MNLEPPKAEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL
     GTDITVICPW EAFNHLELHE LAQYGII
//