P54827 (CNRG_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Short name=GMP-PDE gamma
EC=3.1.4.35

Gene names

Name:	PDE6G
Synonyms:	PDEG

Organism

Canis familiaris (Dog) (Canis lupus familiaris)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Catalytic activity	Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.
Subunit structure	Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.
Sequence similarities	Belongs to the rod/cone cGMP-PDE gamma subunit family.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Ligand	cGMP
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3',5'-cyclic-GMP phosphodiesterase activity Inferred from electronic annotation. Source: EC cGMP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 87	87	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma		PRO_0000166114
Regions
	Compositional bias	24 – 45	22	Arg/Lys-rich (basic)

Sequences

	Sequence		Length	Mass (Da)
	P54827 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 8EA7C7A1D7D14B9E	FASTA	87	9,651
	10 20 30 40 50 60 MNLEPPKAEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL 70 80 GTDITVICPW EAFNHLELHE LAQYGII

References

[1]	"Cloning and characterization of the cDNA and gene encoding the gamma-subunit of cGMP-phosphodiesterase in canine retinal rod photoreceptor cells." Wang W., Acland G.M., Aguirre G.D., Ray K. Gene 181:1-5(1996) [PubMed: 8973300] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Retina.
[2]	"Cloning of the cDNA encoding rod photoreceptor cGMP-phosphodiesterase alpha and gamma subunits from the retinal degenerate Labrador retriever dog." Kylma T., Paulin L., Hurwitz M.Y., Hurwitz R.L., Kommonen B. Res. Vet. Sci. 62:293-296(1997) [PubMed: 9300552] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Labrador retriever. Tissue: Retina.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U49359 mRNA. Translation: AAB40379.1. U49360 Genomic DNA. Translation: AAB00116.1. Z69973 Genomic DNA. Translation: CAA93815.1.
PIR	JC5329.
RefSeq	NP_001003235.1. NM_001003235.1.
UniGene	Cfa.3772.
3D structure databases
ProteinModelPortal	P54827.
SMR	P54827. Positions 1-87.
ModBase	Search...
Protein-protein interaction databases
STRING	P54827.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSCAFT00000009298; ENSCAFP00000008629; ENSCAFG00000005767.
GeneID	403911.
KEGG	cfa:403911.
Organism-specific databases
CTD	5148.
Phylogenomic databases
eggNOG	maNOG20541.
GeneTree	ENSGT00390000013260.
HOVERGEN	HBG000447.
InParanoid	P54827.
OMA	DCSRRES.
OrthoDB	EOG43210Q.
PhylomeDB	P54827.
Family and domain databases
InterPro	IPR006952. PDE6_gamma. [Graphical view]
KO	K13759.
PANTHER	PTHR12122. PDE6_gamma. 1 hit.
Pfam	PF04868. PDE6_gamma. 1 hit. [Graphical view]
PIRSF	PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNet	Search...
Other
BindingDB	P54827.

Entry information

Entry name

CNRG_CANFA

Accession

Primary (citable) accession number: P54827

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 16, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program