SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P54827

- CNRG_CANFA

UniProt

P54827 - CNRG_CANFA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Gene
PDE6G, PDEG
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
  2. cGMP binding Source: InterPro

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  3. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
  4. response to stimulus Source: UniProtKB-KW
  5. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

cGMP

Enzyme and pathway databases

ReactomeiREACT_174228. Activation of the phototransduction cascade.
REACT_174305. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_175273. Ca2+ pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:PDE6G
Synonyms:PDEG
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 9

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8787Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
PRO_0000166114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP54827.

Interactioni

Subunit structurei

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000008629.

Structurei

3D structure databases

ProteinModelPortaliP54827.
SMRiP54827. Positions 1-87.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 4522Arg/Lys-rich (basic)
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG44345.
GeneTreeiENSGT00390000013260.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
InParanoidiP54827.
KOiK13759.
OMAiTRVMGGP.
OrthoDBiEOG7SN8FW.
TreeFamiTF333297.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiIPR006952. PDE6_gamma.
[Graphical view]
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

Sequencei

Sequence statusi: Complete.

P54827-1 [UniParc]FASTAAdd to Basket

« Hide

MNLEPPKAEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF   50
GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII 87
Length:87
Mass (Da):9,651
Last modified:October 1, 1996 - v1
Checksum:i8EA7C7A1D7D14B9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49359 mRNA. Translation: AAB40379.1.
U49360 Genomic DNA. Translation: AAB00116.1.
Z69973 Genomic DNA. Translation: CAA93815.1.
PIRiJC5329.
RefSeqiNP_001003235.1. NM_001003235.1.
UniGeneiCfa.3772.

Genome annotation databases

EnsembliENSCAFT00000009298; ENSCAFP00000008629; ENSCAFG00000005767.
GeneIDi403911.
KEGGicfa:403911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49359 mRNA. Translation: AAB40379.1 .
U49360 Genomic DNA. Translation: AAB00116.1 .
Z69973 Genomic DNA. Translation: CAA93815.1 .
PIRi JC5329.
RefSeqi NP_001003235.1. NM_001003235.1.
UniGenei Cfa.3772.

3D structure databases

ProteinModelPortali P54827.
SMRi P54827. Positions 1-87.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000008629.

Chemistry

BindingDBi P54827.

Proteomic databases

PaxDbi P54827.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000009298 ; ENSCAFP00000008629 ; ENSCAFG00000005767 .
GeneIDi 403911.
KEGGi cfa:403911.

Organism-specific databases

CTDi 5148.

Phylogenomic databases

eggNOGi NOG44345.
GeneTreei ENSGT00390000013260.
HOGENOMi HOG000261673.
HOVERGENi HBG000447.
InParanoidi P54827.
KOi K13759.
OMAi TRVMGGP.
OrthoDBi EOG7SN8FW.
TreeFami TF333297.

Enzyme and pathway databases

Reactomei REACT_174228. Activation of the phototransduction cascade.
REACT_174305. Inactivation, recovery and regulation of the phototransduction cascade.
REACT_175273. Ca2+ pathway.

Miscellaneous databases

NextBioi 20817403.

Family and domain databases

Gene3Di 4.10.1120.10. 1 hit.
InterProi IPR006952. PDE6_gamma.
[Graphical view ]
PANTHERi PTHR12122. PTHR12122. 1 hit.
Pfami PF04868. PDE6_gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of the cDNA and gene encoding the gamma-subunit of cGMP-phosphodiesterase in canine retinal rod photoreceptor cells."
    Wang W., Acland G.M., Aguirre G.D., Ray K.
    Gene 181:1-5(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Retina.
  2. "Cloning of the cDNA encoding rod photoreceptor cGMP-phosphodiesterase alpha and gamma subunits from the retinal degenerate Labrador retriever dog."
    Kylma T., Paulin L., Hurwitz M.Y., Hurwitz R.L., Kommonen B.
    Res. Vet. Sci. 62:293-296(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Labrador retriever.
    Tissue: Retina.

Entry informationi

Entry nameiCNRG_CANFA
AccessioniPrimary (citable) accession number: P54827
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi