Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P54827

- CNRG_CANFA

UniProt

P54827 - CNRG_CANFA

Protein

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

PDE6G

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB-EC
    2. cGMP binding Source: InterPro

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
    3. positive regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    4. response to stimulus Source: UniProtKB-KW
    5. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Sensory transduction, Vision

    Keywords - Ligandi

    cGMP

    Enzyme and pathway databases

    ReactomeiREACT_174228. Activation of the phototransduction cascade.
    REACT_174305. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_175273. Ca2+ pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
    Short name:
    GMP-PDE gamma
    Gene namesi
    Name:PDE6G
    Synonyms:PDEG
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 9

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8787Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaPRO_0000166114Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP54827.

    Interactioni

    Subunit structurei

    Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000008629.

    Structurei

    3D structure databases

    ProteinModelPortaliP54827.
    SMRiP54827. Positions 1-87.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi24 – 4522Arg/Lys-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG44345.
    GeneTreeiENSGT00390000013260.
    HOGENOMiHOG000261673.
    HOVERGENiHBG000447.
    InParanoidiP54827.
    KOiK13759.
    OMAiTRVMGGP.
    OrthoDBiEOG7SN8FW.
    TreeFamiTF333297.

    Family and domain databases

    Gene3Di4.10.1120.10. 1 hit.
    InterProiIPR006952. PDE6_gamma.
    [Graphical view]
    PANTHERiPTHR12122. PTHR12122. 1 hit.
    PfamiPF04868. PDE6_gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P54827-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLEPPKAEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF   50
    GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII 87
    Length:87
    Mass (Da):9,651
    Last modified:October 1, 1996 - v1
    Checksum:i8EA7C7A1D7D14B9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49359 mRNA. Translation: AAB40379.1.
    U49360 Genomic DNA. Translation: AAB00116.1.
    Z69973 Genomic DNA. Translation: CAA93815.1.
    PIRiJC5329.
    RefSeqiNP_001003235.1. NM_001003235.1.
    UniGeneiCfa.3772.

    Genome annotation databases

    EnsembliENSCAFT00000009298; ENSCAFP00000008629; ENSCAFG00000005767.
    GeneIDi403911.
    KEGGicfa:403911.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49359 mRNA. Translation: AAB40379.1 .
    U49360 Genomic DNA. Translation: AAB00116.1 .
    Z69973 Genomic DNA. Translation: CAA93815.1 .
    PIRi JC5329.
    RefSeqi NP_001003235.1. NM_001003235.1.
    UniGenei Cfa.3772.

    3D structure databases

    ProteinModelPortali P54827.
    SMRi P54827. Positions 1-87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000008629.

    Chemistry

    BindingDBi P54827.

    Proteomic databases

    PaxDbi P54827.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000009298 ; ENSCAFP00000008629 ; ENSCAFG00000005767 .
    GeneIDi 403911.
    KEGGi cfa:403911.

    Organism-specific databases

    CTDi 5148.

    Phylogenomic databases

    eggNOGi NOG44345.
    GeneTreei ENSGT00390000013260.
    HOGENOMi HOG000261673.
    HOVERGENi HBG000447.
    InParanoidi P54827.
    KOi K13759.
    OMAi TRVMGGP.
    OrthoDBi EOG7SN8FW.
    TreeFami TF333297.

    Enzyme and pathway databases

    Reactomei REACT_174228. Activation of the phototransduction cascade.
    REACT_174305. Inactivation, recovery and regulation of the phototransduction cascade.
    REACT_175273. Ca2+ pathway.

    Miscellaneous databases

    NextBioi 20817403.

    Family and domain databases

    Gene3Di 4.10.1120.10. 1 hit.
    InterProi IPR006952. PDE6_gamma.
    [Graphical view ]
    PANTHERi PTHR12122. PTHR12122. 1 hit.
    Pfami PF04868. PDE6_gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the cDNA and gene encoding the gamma-subunit of cGMP-phosphodiesterase in canine retinal rod photoreceptor cells."
      Wang W., Acland G.M., Aguirre G.D., Ray K.
      Gene 181:1-5(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Retina.
    2. "Cloning of the cDNA encoding rod photoreceptor cGMP-phosphodiesterase alpha and gamma subunits from the retinal degenerate Labrador retriever dog."
      Kylma T., Paulin L., Hurwitz M.Y., Hurwitz R.L., Kommonen B.
      Res. Vet. Sci. 62:293-296(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Labrador retriever.
      Tissue: Retina.

    Entry informationi

    Entry nameiCNRG_CANFA
    AccessioniPrimary (citable) accession number: P54827
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3