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Protein

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Gene

PDE6G

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processSensory transduction, Vision
LigandcGMP

Enzyme and pathway databases

ReactomeiR-CFA-2485179. Activation of the phototransduction cascade.
R-CFA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
R-CFA-4086398. Ca2+ pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (EC:3.1.4.35)
Short name:
GMP-PDE gamma
Gene namesi
Name:PDE6G
Synonyms:PDEG
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001661141 – 87Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammaAdd BLAST87

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP54827.

Expressioni

Gene expression databases

BgeeiENSCAFG00000005767.

Interactioni

Subunit structurei

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000008629.

Chemistry databases

BindingDBiP54827.

Structurei

3D structure databases

ProteinModelPortaliP54827.
SMRiP54827.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 45Arg/Lys-rich (basic)Add BLAST22

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IZA8. Eukaryota.
ENOG410YN07. LUCA.
GeneTreeiENSGT00390000013260.
HOGENOMiHOG000261673.
HOVERGENiHBG000447.
InParanoidiP54827.
KOiK13759.
OMAiTRVMGGP.
OrthoDBiEOG091G14J5.
TreeFamiTF333297.

Family and domain databases

Gene3Di4.10.1120.10. 1 hit.
InterProiView protein in InterPro
IPR006952. PDE6_gamma.
PANTHERiPTHR12122. PTHR12122. 1 hit.
PfamiView protein in Pfam
PF04868. PDE6_gamma. 1 hit.
PIRSFiPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.

Sequencei

Sequence statusi: Complete.

P54827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLEPPKAEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF
60 70 80
GDDIPGMEGL GTDITVICPW EAFNHLELHE LAQYGII
Length:87
Mass (Da):9,651
Last modified:October 1, 1996 - v1
Checksum:i8EA7C7A1D7D14B9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49359 mRNA. Translation: AAB40379.1.
U49360 Genomic DNA. Translation: AAB00116.1.
Z69973 Genomic DNA. Translation: CAA93815.1.
PIRiJC5329.
RefSeqiNP_001003235.1. NM_001003235.1.
XP_013971663.1. XM_014116188.1.
UniGeneiCfa.3772.

Genome annotation databases

EnsembliENSCAFT00000009298; ENSCAFP00000008629; ENSCAFG00000005767.
GeneIDi403911.
KEGGicfa:403911.

Similar proteinsi

Entry informationi

Entry nameiCNRG_CANLF
AccessioniPrimary (citable) accession number: P54827
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 30, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families