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P54827 (CNRG_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Short name=GMP-PDE gamma
EC=3.1.4.35
Gene names
Name:PDE6G
Synonyms:PDEG
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length87 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

Catalytic activity

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.

Subunit structure

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

Sequence similarities

Belongs to the rod/cone cGMP-PDE gamma subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8787Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
PRO_0000166114

Regions

Compositional bias24 – 4522Arg/Lys-rich (basic)

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
P54827 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 8EA7C7A1D7D14B9E

FASTA879,651
        10         20         30         40         50         60 
MNLEPPKAEI RSATRVIGGP VTPRKGPPKF KQRQTRQFKS KPPKKGVQGF GDDIPGMEGL 

        70         80 
GTDITVICPW EAFNHLELHE LAQYGII 

« Hide

References

[1]"Cloning and characterization of the cDNA and gene encoding the gamma-subunit of cGMP-phosphodiesterase in canine retinal rod photoreceptor cells."
Wang W., Acland G.M., Aguirre G.D., Ray K.
Gene 181:1-5(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Retina.
[2]"Cloning of the cDNA encoding rod photoreceptor cGMP-phosphodiesterase alpha and gamma subunits from the retinal degenerate Labrador retriever dog."
Kylma T., Paulin L., Hurwitz M.Y., Hurwitz R.L., Kommonen B.
Res. Vet. Sci. 62:293-296(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Labrador retriever.
Tissue: Retina.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U49359 mRNA. Translation: AAB40379.1.
U49360 Genomic DNA. Translation: AAB00116.1.
Z69973 Genomic DNA. Translation: CAA93815.1.
PIRJC5329.
RefSeqNP_001003235.1. NM_001003235.1.
UniGeneCfa.3772.

3D structure databases

ProteinModelPortalP54827.
SMRP54827. Positions 1-87.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000008629.

Chemistry

BindingDBP54827.

Proteomic databases

PaxDbP54827.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000009298; ENSCAFP00000008629; ENSCAFG00000005767.
GeneID403911.
KEGGcfa:403911.

Organism-specific databases

CTD5148.

Phylogenomic databases

eggNOGNOG44345.
GeneTreeENSGT00390000013260.
HOGENOMHOG000261673.
HOVERGENHBG000447.
InParanoidP54827.
KOK13759.
OMATRVMGGP.
OrthoDBEOG7SN8FW.
TreeFamTF333297.

Family and domain databases

Gene3D4.10.1120.10. 1 hit.
InterProIPR006952. PDE6_gamma.
[Graphical view]
PANTHERPTHR12122. PTHR12122. 1 hit.
PfamPF04868. PDE6_gamma. 1 hit.
[Graphical view]
PIRSFPIRSF000969. 35-cGMP_Pdiase_g. 1 hit.
ProtoNetSearch...

Other

NextBio20817403.

Entry information

Entry nameCNRG_CANFA
AccessionPrimary (citable) accession number: P54827
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families