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P54826

- GAS1_HUMAN

UniProt

P54826 - GAS1_HUMAN

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Protein

Growth arrest-specific protein 1

Gene

GAS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.1 Publication

GO - Biological processi

  1. axon guidance Source: Ensembl
  2. camera-type eye development Source: Ensembl
  3. cell cycle arrest Source: UniProtKB-KW
  4. cell fate commitment Source: UniProtKB
  5. cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
  6. cerebellum morphogenesis Source: Ensembl
  7. developmental growth Source: UniProtKB
  8. dorsal/ventral neural tube patterning Source: Ensembl
  9. embryonic cranial skeleton morphogenesis Source: Ensembl
  10. embryonic digit morphogenesis Source: Ensembl
  11. eye morphogenesis Source: Ensembl
  12. middle ear morphogenesis Source: Ensembl
  13. negative regulation of apoptotic process Source: Ensembl
  14. negative regulation of cell growth Source: Ensembl
  15. negative regulation of epithelial cell proliferation Source: Ensembl
  16. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  17. negative regulation of mitotic cell cycle Source: UniProtKB
  18. negative regulation of protein processing Source: UniProtKB
  19. negative regulation of smoothened signaling pathway Source: Ensembl
  20. odontogenesis Source: Ensembl
  21. outer ear morphogenesis Source: Ensembl
  22. palate development Source: Ensembl
  23. positive regulation of epithelial cell proliferation Source: Ensembl
  24. positive regulation of mesenchymal cell proliferation Source: Ensembl
  25. positive regulation of smoothened signaling pathway Source: Ensembl
  26. programmed cell death Source: Ensembl
  27. regulation of apoptotic process Source: UniProtKB
  28. regulation of ER to Golgi vesicle-mediated transport Source: UniProtKB
  29. regulation of smoothened signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Enzyme and pathway databases

SignaLinkiP54826.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 1
Short name:
GAS-1
Gene namesi
Name:GAS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:4165. GAS1.

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of plasma membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA28578.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 318279Growth arrest-specific protein 1PRO_0000021318Add
BLAST
Propeptidei319 – 34527Removed in mature formSequence AnalysisPRO_0000021319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Lipidationi318 – 3181GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP54826.
PaxDbiP54826.
PRIDEiP54826.

PTM databases

PhosphoSiteiP54826.

Expressioni

Gene expression databases

BgeeiP54826.
CleanExiHS_GAS1.
GenevestigatoriP54826.

Organism-specific databases

HPAiCAB024164.
HPA036085.

Interactioni

Protein-protein interaction databases

BioGridi108889. 3 interactions.
STRINGi9606.ENSP00000298743.

Structurei

3D structure databases

ProteinModelPortaliP54826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi87 – 915Poly-Ala
Compositional biasi285 – 2884Poly-Asp
Compositional biasi319 – 3224Poly-Gly
Compositional biasi337 – 3415Poly-Leu

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG85081.
GeneTreeiENSGT00390000001195.
HOGENOMiHOG000233688.
HOVERGENiHBG005804.
InParanoidiP54826.
KOiK06232.
OMAiCWQALLQ.
OrthoDBiEOG7CNZGJ.
PhylomeDBiP54826.
TreeFamiTF329660.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
[Graphical view]
PfamiPF02351. GDNF. 2 hits.
[Graphical view]
SMARTiSM00907. GDNF. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54826-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAALLGGGG EARGGTVPGA WLCLMALLQL LGSAPRGSGL AHGRRLICWQ
60 70 80 90 100
ALLQCQGEPE CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS
110 120 130 140 150
SRWRCPSHCI SALIQLNHTR RGPALEDCDC AQDENCKSTK RAIEPCLPRT
160 170 180 190 200
SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN LALSRYLTYC GKVFNGLRCT
210 220 230 240 250
DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA RLCFGAELGN
260 270 280 290 300
GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA
310 320 330 340
AASGGRGDLP YGPGRRSSGG GGRLAPRGAW TPLASILLLL LGPLF
Length:345
Mass (Da):35,693
Last modified:December 16, 2008 - v2
Checksum:i31A0CBEEC3632F82
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161A → V in AAA72368. (PubMed:8127893)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13698 mRNA. Translation: AAA72368.1.
AL158149 Genomic DNA. Translation: CAH71308.1.
BC074908 mRNA. Translation: AAH74908.1.
BC074809 mRNA. Translation: AAH74809.1.
BC132682 mRNA. Translation: AAI32683.1.
BC136586 mRNA. Translation: AAI36587.1.
CCDSiCCDS6674.1.
PIRiA53138.
RefSeqiNP_002039.2. NM_002048.2.
UniGeneiHs.65029.

Genome annotation databases

EnsembliENST00000298743; ENSP00000298743; ENSG00000180447.
GeneIDi2619.
KEGGihsa:2619.
UCSCiuc004aox.4. human.

Polymorphism databases

DMDMi218512049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13698 mRNA. Translation: AAA72368.1 .
AL158149 Genomic DNA. Translation: CAH71308.1 .
BC074908 mRNA. Translation: AAH74908.1 .
BC074809 mRNA. Translation: AAH74809.1 .
BC132682 mRNA. Translation: AAI32683.1 .
BC136586 mRNA. Translation: AAI36587.1 .
CCDSi CCDS6674.1.
PIRi A53138.
RefSeqi NP_002039.2. NM_002048.2.
UniGenei Hs.65029.

3D structure databases

ProteinModelPortali P54826.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108889. 3 interactions.
STRINGi 9606.ENSP00000298743.

PTM databases

PhosphoSitei P54826.

Polymorphism databases

DMDMi 218512049.

Proteomic databases

MaxQBi P54826.
PaxDbi P54826.
PRIDEi P54826.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298743 ; ENSP00000298743 ; ENSG00000180447 .
GeneIDi 2619.
KEGGi hsa:2619.
UCSCi uc004aox.4. human.

Organism-specific databases

CTDi 2619.
GeneCardsi GC09M089559.
H-InvDB HIX0034867.
HGNCi HGNC:4165. GAS1.
HPAi CAB024164.
HPA036085.
MIMi 139185. gene.
neXtProti NX_P54826.
Orphaneti 93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBi PA28578.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85081.
GeneTreei ENSGT00390000001195.
HOGENOMi HOG000233688.
HOVERGENi HBG005804.
InParanoidi P54826.
KOi K06232.
OMAi CWQALLQ.
OrthoDBi EOG7CNZGJ.
PhylomeDBi P54826.
TreeFami TF329660.

Enzyme and pathway databases

SignaLinki P54826.

Miscellaneous databases

GeneWikii GAS1.
GenomeRNAii 2619.
NextBioi 10313.
PROi P54826.
SOURCEi Search...

Gene expression databases

Bgeei P54826.
CleanExi HS_GAS1.
Genevestigatori P54826.

Family and domain databases

InterProi IPR016017. GDNF/GAS1.
[Graphical view ]
Pfami PF02351. GDNF. 2 hits.
[Graphical view ]
SMARTi SM00907. GDNF. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene."
    del Sal G., Collavin L., Ruaro M.E., Edomi P., Saccone S., Valle G.D., Schneider C.
    Proc. Natl. Acad. Sci. U.S.A. 91:1848-1852(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Liver.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiGAS1_HUMAN
AccessioniPrimary (citable) accession number: P54826
Secondary accession number(s): B9EGM4, Q6B086
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 16, 2008
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3