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P54826 (GAS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Growth arrest-specific protein 1

Short name=GAS-1
Gene names
Name:GAS1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. Ref.1

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity.

Ontologies

Keywords
   Biological processCell cycle
Growth arrest
   Cellular componentCell membrane
Membrane
   DomainSignal
   PTMGlycoprotein
GPI-anchor
Lipoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Inferred from electronic annotation. Source: Ensembl

camera-type eye development

Inferred from electronic annotation. Source: Ensembl

cell cycle arrest

Inferred from electronic annotation. Source: UniProtKB-KW

cell fate commitment

Inferred from sequence or structural similarity. Source: UniProtKB

cellular response to vascular endothelial growth factor stimulus

Inferred from expression pattern PubMed 15070677. Source: UniProtKB

cerebellum morphogenesis

Inferred from electronic annotation. Source: Ensembl

developmental growth

Inferred from sequence or structural similarity. Source: UniProtKB

dorsal/ventral neural tube patterning

Inferred from electronic annotation. Source: Ensembl

embryonic cranial skeleton morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic digit morphogenesis

Inferred from electronic annotation. Source: Ensembl

eye morphogenesis

Inferred from electronic annotation. Source: Ensembl

middle ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

negative regulation of mitotic cell cycle

Inferred from direct assay Ref.1. Source: UniProtKB

negative regulation of protein processing

Inferred from mutant phenotype PubMed 21357679. Source: UniProtKB

negative regulation of smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

odontogenesis

Inferred from electronic annotation. Source: Ensembl

outer ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

palate development

Inferred from electronic annotation. Source: Ensembl

positive regulation of epithelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of mesenchymal cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of smoothened signaling pathway

Inferred from electronic annotation. Source: Ensembl

programmed cell death

Inferred from electronic annotation. Source: Ensembl

regulation of ER to Golgi vesicle-mediated transport

Inferred from mutant phenotype PubMed 21357679. Source: UniProtKB

regulation of apoptotic process

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of smoothened signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentanchored component of plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of membrane

Non-traceable author statement Ref.1. Source: UniProtKB

plasma membrane

Inferred from direct assay Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3939 Potential
Chain40 – 318279Growth arrest-specific protein 1
PRO_0000021318
Propeptide319 – 34527Removed in mature form Potential
PRO_0000021319

Regions

Compositional bias87 – 915Poly-Ala
Compositional bias285 – 2884Poly-Asp
Compositional bias319 – 3224Poly-Gly
Compositional bias337 – 3415Poly-Leu

Amino acid modifications

Lipidation3181GPI-anchor amidated serine Potential
Glycosylation1171N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2161A → V in AAA72368. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P54826 [UniParc].

Last modified December 16, 2008. Version 2.
Checksum: 31A0CBEEC3632F82

FASTA34535,693
        10         20         30         40         50         60 
MVAALLGGGG EARGGTVPGA WLCLMALLQL LGSAPRGSGL AHGRRLICWQ ALLQCQGEPE 

        70         80         90        100        110        120 
CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS SRWRCPSHCI SALIQLNHTR 

       130        140        150        160        170        180 
RGPALEDCDC AQDENCKSTK RAIEPCLPRT SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN 

       190        200        210        220        230        240 
LALSRYLTYC GKVFNGLRCT DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA 

       250        260        270        280        290        300 
RLCFGAELGN GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA 

       310        320        330        340 
AASGGRGDLP YGPGRRSSGG GGRLAPRGAW TPLASILLLL LGPLF 

« Hide

References

« Hide 'large scale' references
[1]"Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene."
del Sal G., Collavin L., Ruaro M.E., Edomi P., Saccone S., Valle G.D., Schneider C.
Proc. Natl. Acad. Sci. U.S.A. 91:1848-1852(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Tissue: Liver.
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13698 mRNA. Translation: AAA72368.1.
AL158149 Genomic DNA. Translation: CAH71308.1.
BC074908 mRNA. Translation: AAH74908.1.
BC074809 mRNA. Translation: AAH74809.1.
BC132682 mRNA. Translation: AAI32683.1.
BC136586 mRNA. Translation: AAI36587.1.
PIRA53138.
RefSeqNP_002039.2. NM_002048.2.
UniGeneHs.65029.

3D structure databases

ProteinModelPortalP54826.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108889. 3 interactions.
STRING9606.ENSP00000298743.

PTM databases

PhosphoSiteP54826.

Polymorphism databases

DMDM218512049.

Proteomic databases

PaxDbP54826.
PRIDEP54826.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298743; ENSP00000298743; ENSG00000180447.
GeneID2619.
KEGGhsa:2619.
UCSCuc004aox.4. human.

Organism-specific databases

CTD2619.
GeneCardsGC09M089559.
H-InvDBHIX0034867.
HGNCHGNC:4165. GAS1.
HPACAB024164.
HPA036085.
MIM139185. gene.
neXtProtNX_P54826.
Orphanet93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBPA28578.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85081.
HOGENOMHOG000233688.
HOVERGENHBG005804.
InParanoidP54826.
KOK06232.
OMACWQALLQ.
OrthoDBEOG7CNZGJ.
PhylomeDBP54826.
TreeFamTF329660.

Enzyme and pathway databases

SignaLinkP54826.

Gene expression databases

BgeeP54826.
CleanExHS_GAS1.
GenevestigatorP54826.

Family and domain databases

InterProIPR016017. GDNF/GAS1.
[Graphical view]
PfamPF02351. GDNF. 2 hits.
[Graphical view]
SMARTSM00907. GDNF. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGAS1.
GenomeRNAi2619.
NextBio10313.
PROP54826.
SOURCESearch...

Entry information

Entry nameGAS1_HUMAN
AccessionPrimary (citable) accession number: P54826
Secondary accession number(s): B9EGM4, Q6B086
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 16, 2008
Last modified: April 16, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM