P54826 (GAS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Growth arrest-specific protein 1
Short name=GAS-1

Gene names

Name:

GAS1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. Ref.1
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity.

Ontologies

Keywords
Biological process	Cell cycle Growth arrest
Cellular component	Cell membrane Membrane
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Inferred from electronic annotation. Source: Compara camera-type eye development Inferred from electronic annotation. Source: Compara cell cycle arrest Inferred from electronic annotation. Source: UniProtKB-KW cell fate commitment Inferred from sequence or structural similarity. Source: UniProtKB cellular response to vascular endothelial growth factor stimulus Inferred from expression pattern PubMed 15070677. Source: UniProtKB cerebellum morphogenesis Inferred from electronic annotation. Source: Compara developmental growth Inferred from sequence or structural similarity. Source: UniProtKB dorsal/ventral neural tube patterning Inferred from electronic annotation. Source: Compara embryonic cranial skeleton morphogenesis Inferred from electronic annotation. Source: Compara embryonic digit morphogenesis Inferred from electronic annotation. Source: Compara eye morphogenesis Inferred from electronic annotation. Source: Compara middle ear morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of mitotic cell cycle Inferred from direct assay Ref.1. Source: UniProtKB negative regulation of protein processing Inferred from mutant phenotype PubMed 21357679. Source: UniProtKB negative regulation of smoothened signaling pathway Inferred from electronic annotation. Source: Compara odontogenesis Inferred from electronic annotation. Source: Compara outer ear morphogenesis Inferred from electronic annotation. Source: Compara palate development Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of mesenchymal cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of smoothened signaling pathway Inferred from electronic annotation. Source: Compara programmed cell death Inferred from electronic annotation. Source: Compara regulation of ER to Golgi vesicle-mediated transport Inferred from mutant phenotype PubMed 21357679. Source: UniProtKB regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB regulation of smoothened signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	anchored to plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 39	39	Potential
	Chain	40 – 318	279	Growth arrest-specific protein 1		PRO_0000021318
	Propeptide	319 – 345	27	Removed in mature form Potential		PRO_0000021319
Regions
	Compositional bias	87 – 91	5	Poly-Ala
	Compositional bias	285 – 288	4	Poly-Asp
	Compositional bias	319 – 322	4	Poly-Gly
	Compositional bias	337 – 341	5	Poly-Leu
Amino acid modifications
	Lipidation	318	1	GPI-anchor amidated serine Potential
	Glycosylation	117	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	216	1	A → V in AAA72368. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P54826 [UniParc]. Last modified December 16, 2008. Version 2. Checksum: 31A0CBEEC3632F82	FASTA	345	35,693
	10 20 30 40 50 60 MVAALLGGGG EARGGTVPGA WLCLMALLQL LGSAPRGSGL AHGRRLICWQ ALLQCQGEPE 70 80 90 100 110 120 CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS SRWRCPSHCI SALIQLNHTR 130 140 150 160 170 180 RGPALEDCDC AQDENCKSTK RAIEPCLPRT SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN 190 200 210 220 230 240 LALSRYLTYC GKVFNGLRCT DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA 250 260 270 280 290 300 RLCFGAELGN GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA 310 320 330 340 AASGGRGDLP YGPGRRSSGG GGRLAPRGAW TPLASILLLL LGPLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene." del Sal G., Collavin L., Ruaro M.E., Edomi P., Saccone S., Valle G.D., Schneider C. Proc. Natl. Acad. Sci. U.S.A. 91:1848-1852(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Tissue: Liver.
[2]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L13698 mRNA. Translation: AAA72368.1. AL158149 Genomic DNA. Translation: CAH71308.1. BC074908 mRNA. Translation: AAH74908.1. BC074809 mRNA. Translation: AAH74809.1. BC132682 mRNA. Translation: AAI32683.1. BC136586 mRNA. Translation: AAI36587.1.
IPI	IPI00008832.
PIR	A53138.
RefSeq	NP_002039.2. NM_002048.2.
UniGene	Hs.65029.
3D structure databases
ProteinModelPortal	P54826.
SMR	P54826. Positions 165-243.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000298743.
PTM databases
PhosphoSite	P54826.
Polymorphism databases
DMDM	218512049.
Proteomic databases
PaxDb	P54826.
PRIDE	P54826.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298743; ENSP00000298743; ENSG00000180447.
GeneID	2619.
KEGG	hsa:2619.
UCSC	uc004aox.4. human.
Organism-specific databases
CTD	2619.
GeneCards	GC09M089559.
H-InvDB	HIX0034867.
HGNC	HGNC:4165. GAS1.
HPA	CAB024164.
MIM	139185. gene.
neXtProt	NX_P54826.
Orphanet	93925. Alobar holoprosencephaly. 93924. Lobar holoprosencephaly. 280200. Microform holoprosencephaly. 93926. Midline interhemispheric variant of holoprosencephaly. 220386. Semilobar holoprosencephaly. 280195. Septopreoptic holoprosencephaly.
PharmGKB	PA28578.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85081.
HOGENOM	HOG000233688.
HOVERGEN	HBG005804.
InParanoid	P54826.
KO	K06232.
OMA	PECSYAY.
OrthoDB	EOG4NCMDN.
PhylomeDB	P54826.
Enzyme and pathway databases
Pathway_Interaction_DB	foxm1pathway. FOXM1 transcription factor network. hedgehog_2pathway. Signaling events mediated by the Hedgehog family.
Gene expression databases
Bgee	P54826.
CleanEx	HS_GAS1.
Genevestigator	P54826.
GermOnline	ENSG00000180447. Homo sapiens.
Family and domain databases
InterPro	IPR016017. GDNF/GAS1. [Graphical view]
Pfam	PF02351. GDNF. 2 hits. [Graphical view]
SMART	SM00907. GDNF. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2619.
NextBio	10313.
SOURCE	Search...

Entry information

Entry name

GAS1_HUMAN

Accession

Primary (citable) accession number: P54826
Secondary accession number(s): B9EGM4, Q6B086

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	December 16, 2008
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.