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Protein

Growth arrest-specific protein 1

Gene

GAS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.1 Publication

GO - Biological processi

  • cell cycle arrest Source: UniProtKB-KW
  • cell fate commitment Source: UniProtKB
  • cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
  • developmental growth Source: UniProtKB
  • negative regulation of mitotic cell cycle Source: UniProtKB
  • negative regulation of protein processing Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • regulation of ER to Golgi vesicle-mediated transport Source: UniProtKB
  • regulation of smoothened signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Enzyme and pathway databases

ReactomeiREACT_268573. Ligand-receptor interactions.
SignaLinkiP54826.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 1
Short name:
GAS-1
Gene namesi
Name:GAS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:4165. GAS1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA28578.

Polymorphism and mutation databases

BioMutaiGAS1.
DMDMi218512049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3939Sequence AnalysisAdd
BLAST
Chaini40 – 318279Growth arrest-specific protein 1PRO_0000021318Add
BLAST
Propeptidei319 – 34527Removed in mature formSequence AnalysisPRO_0000021319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Lipidationi318 – 3181GPI-anchor amidated serineSequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP54826.
PaxDbiP54826.
PRIDEiP54826.

PTM databases

PhosphoSiteiP54826.

Expressioni

Gene expression databases

BgeeiP54826.
CleanExiHS_GAS1.
GenevisibleiP54826. HS.

Organism-specific databases

HPAiCAB024164.
HPA036085.

Interactioni

Protein-protein interaction databases

BioGridi108889. 2 interactions.
STRINGi9606.ENSP00000298743.

Structurei

3D structure databases

ProteinModelPortaliP54826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi87 – 915Poly-Ala
Compositional biasi285 – 2884Poly-Asp
Compositional biasi319 – 3224Poly-Gly
Compositional biasi337 – 3415Poly-Leu

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG85081.
GeneTreeiENSGT00390000001195.
HOGENOMiHOG000233688.
HOVERGENiHBG005804.
InParanoidiP54826.
KOiK06232.
OMAiCWQALLQ.
OrthoDBiEOG7CNZGJ.
PhylomeDBiP54826.
TreeFamiTF329660.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
[Graphical view]
PfamiPF02351. GDNF. 2 hits.
[Graphical view]
SMARTiSM00907. GDNF. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAALLGGGG EARGGTVPGA WLCLMALLQL LGSAPRGSGL AHGRRLICWQ
60 70 80 90 100
ALLQCQGEPE CSYAYNQYAE ACAPVLAQHG GGDAPGAAAA AFPASAASFS
110 120 130 140 150
SRWRCPSHCI SALIQLNHTR RGPALEDCDC AQDENCKSTK RAIEPCLPRT
160 170 180 190 200
SGGGAGGPGA GGVMGCTEAR RRCDRDSRCN LALSRYLTYC GKVFNGLRCT
210 220 230 240 250
DECRTVIEDM LAMPKAALLN DCVCDGLERP ICESVKENMA RLCFGAELGN
260 270 280 290 300
GPGSSGSDGG LDDYYDEDYD DEQRTGGAGG EQPLDDDDGV PHPPRPGSGA
310 320 330 340
AASGGRGDLP YGPGRRSSGG GGRLAPRGAW TPLASILLLL LGPLF
Length:345
Mass (Da):35,693
Last modified:December 16, 2008 - v2
Checksum:i31A0CBEEC3632F82
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161A → V in AAA72368 (PubMed:8127893).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13698 mRNA. Translation: AAA72368.1.
AL158149 Genomic DNA. Translation: CAH71308.1.
BC074908 mRNA. Translation: AAH74908.1.
BC074809 mRNA. Translation: AAH74809.1.
BC132682 mRNA. Translation: AAI32683.1.
BC136586 mRNA. Translation: AAI36587.1.
CCDSiCCDS6674.1.
PIRiA53138.
RefSeqiNP_002039.2. NM_002048.2.
UniGeneiHs.65029.

Genome annotation databases

EnsembliENST00000298743; ENSP00000298743; ENSG00000180447.
GeneIDi2619.
KEGGihsa:2619.
UCSCiuc004aox.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13698 mRNA. Translation: AAA72368.1.
AL158149 Genomic DNA. Translation: CAH71308.1.
BC074908 mRNA. Translation: AAH74908.1.
BC074809 mRNA. Translation: AAH74809.1.
BC132682 mRNA. Translation: AAI32683.1.
BC136586 mRNA. Translation: AAI36587.1.
CCDSiCCDS6674.1.
PIRiA53138.
RefSeqiNP_002039.2. NM_002048.2.
UniGeneiHs.65029.

3D structure databases

ProteinModelPortaliP54826.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108889. 2 interactions.
STRINGi9606.ENSP00000298743.

PTM databases

PhosphoSiteiP54826.

Polymorphism and mutation databases

BioMutaiGAS1.
DMDMi218512049.

Proteomic databases

MaxQBiP54826.
PaxDbiP54826.
PRIDEiP54826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298743; ENSP00000298743; ENSG00000180447.
GeneIDi2619.
KEGGihsa:2619.
UCSCiuc004aox.4. human.

Organism-specific databases

CTDi2619.
GeneCardsiGC09M089559.
H-InvDBHIX0034867.
HGNCiHGNC:4165. GAS1.
HPAiCAB024164.
HPA036085.
MIMi139185. gene.
neXtProtiNX_P54826.
Orphaneti93925. Alobar holoprosencephaly.
93924. Lobar holoprosencephaly.
280200. Microform holoprosencephaly.
93926. Midline interhemispheric variant of holoprosencephaly.
220386. Semilobar holoprosencephaly.
280195. Septopreoptic holoprosencephaly.
PharmGKBiPA28578.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG85081.
GeneTreeiENSGT00390000001195.
HOGENOMiHOG000233688.
HOVERGENiHBG005804.
InParanoidiP54826.
KOiK06232.
OMAiCWQALLQ.
OrthoDBiEOG7CNZGJ.
PhylomeDBiP54826.
TreeFamiTF329660.

Enzyme and pathway databases

ReactomeiREACT_268573. Ligand-receptor interactions.
SignaLinkiP54826.

Miscellaneous databases

GeneWikiiGAS1.
GenomeRNAii2619.
NextBioi10313.
PROiP54826.
SOURCEiSearch...

Gene expression databases

BgeeiP54826.
CleanExiHS_GAS1.
GenevisibleiP54826. HS.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
[Graphical view]
PfamiPF02351. GDNF. 2 hits.
[Graphical view]
SMARTiSM00907. GDNF. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene."
    del Sal G., Collavin L., Ruaro M.E., Edomi P., Saccone S., Valle G.D., Schneider C.
    Proc. Natl. Acad. Sci. U.S.A. 91:1848-1852(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Liver.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiGAS1_HUMAN
AccessioniPrimary (citable) accession number: P54826
Secondary accession number(s): B9EGM4, Q6B086
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 16, 2008
Last modified: July 22, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.