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Protein

Transitional endoplasmic reticulum ATPase homolog 2

Gene

cdc-48.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it regulates expression of ER stress response genes.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei353 – 3531ATPBy similarity
Binding sitei389 – 3891ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi252 – 2587ATPBy similarity

GO - Molecular functioni

  • ATPase activity Source: WormBase
  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: WormBase
  • ER-associated misfolded protein catabolic process Source: WormBase
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-110320. Translesion Synthesis by POLH.
R-CEL-5358346. Hedgehog ligand biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Transitional endoplasmic reticulum ATPase homolog 2
Alternative name(s):
Cell division cycle-related protein 48.2
p97/CDC48 homolog 2
Gene namesi
ORF Names:C41C4.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC41C4.8; CE05402; WBGene00008053; cdc-48.2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: WormBase
  • VCP-NPL4-UFD1 AAA ATPase complex Source: WormBase
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Insensitive to tunicamycin, an inducer of ER stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 810810Transitional endoplasmic reticulum ATPase homolog 2PRO_0000084578Add
BLAST

Proteomic databases

EPDiP54812.
PaxDbiP54812.
PRIDEiP54812.

PTM databases

iPTMnetiP54812.

Expressioni

Gene expression databases

BgeeiWBGene00008053.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-320265,EBI-320265
atx-3O178503EBI-320265,EBI-320650
cdc-48.1P548116EBI-320265,EBI-320245

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi39638. 11 interactions.
DIPiDIP-26566N.
IntActiP54812. 6 interactions.
MINTiMINT-1090535.
STRINGi6239.C41C4.8.3.

Structurei

3D structure databases

ProteinModelPortaliP54812.
SMRiP54812. Positions 23-772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. CDC48 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00810000125456.
HOGENOMiHOG000223224.
InParanoidiP54812.
KOiK13525.
OMAiASETVIH.
OrthoDBiEOG091G024K.
PhylomeDBiP54812.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsiTIGR01243. CDC48. 1 hit.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVPTQRDE KEKKNDELAT AILKDKKRPN RLIIDQSDND DNSMVMLSQA
60 70 80 90 100
KMDELGLFRG DSVILKGKKR RETVSIVLNA DNCPNDKIKM NKVVRNNLRS
110 120 130 140 150
RLGDVVSISS AQLEYGKRVH VLPIDDTIEG LTGNLFDVFL RPYFTDAYRP
160 170 180 190 200
VHKGDIFTVQ AAMRTVEFKV VETDPAPACI VAPDTVIHYE GDPIKREEEE
210 220 230 240 250
EALNEVGYDD LGGVRKQLAQ IKEMVELPLR HPQLFKAIGV KPPRGILLFG
260 270 280 290 300
PPGTGKTLIA RAVANETGAF FFLINGPEIM SKMSGESESN LRKAFAECEK
310 320 330 340 350
NSPAILFIDE IDAIAPKREK AHGEVEKRIV SQLLTLMDGL KTRAHVVVIA
360 370 380 390 400
ATNRPNSIDG ALRRFGRFDR EIDIGIPDAV GRLEILRIHT KNMKLGEDVD
410 420 430 440 450
LEQVANECHG FVGADLASLC SEAAIQQIRE KMELIDLEDD TIDAEVLNSL
460 470 480 490 500
AVTMENFRFA MGKSSPSALR EAVVETPNTT WSDIGGLQNV KRELQELVQY
510 520 530 540 550
PVEHPEKYLK FGMQPSRGVL FYGPPGCGKT LLAKAIANEC QANFISIKGP
560 570 580 590 600
ELLTMWFGES EANVRDVFDK ARAAAPCVLF FDELDSIAKA RGGSVGDAGG
610 620 630 640 650
AADRVINQVL TEMDGMNAKK NVFIIGATNR PDIIDPAVLR PGRLDQLIYI
660 670 680 690 700
PLPDEASRLQ IFKASLRKTP LSADLDLNFL AKNTVGFSGA DLTEICQRAC
710 720 730 740 750
KLAIRESIER EIRQEKERQD RSARGEELME DELADPVPEI TRAHFEEAMK
760 770 780 790 800
FARRSVTDND IRKYEMFAQT LQQSRGFGNN FKFPGEAPSA GQPVGGNGGS
810
GGNDDDDLYN
Length:810
Mass (Da):89,640
Last modified:May 30, 2000 - v2
Checksum:i904DA78FA1B007AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48045, Z48334 Genomic DNA. Translation: CAA88105.1.
PIRiT19879.
RefSeqiNP_495705.1. NM_063304.5.
UniGeneiCel.7497.

Genome annotation databases

EnsemblMetazoaiC41C4.8.1; C41C4.8.1; WBGene00008053.
C41C4.8.2; C41C4.8.2; WBGene00008053.
GeneIDi174309.
KEGGicel:CELE_C41C4.8.
UCSCiC41C4.8.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48045, Z48334 Genomic DNA. Translation: CAA88105.1.
PIRiT19879.
RefSeqiNP_495705.1. NM_063304.5.
UniGeneiCel.7497.

3D structure databases

ProteinModelPortaliP54812.
SMRiP54812. Positions 23-772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39638. 11 interactions.
DIPiDIP-26566N.
IntActiP54812. 6 interactions.
MINTiMINT-1090535.
STRINGi6239.C41C4.8.3.

PTM databases

iPTMnetiP54812.

Proteomic databases

EPDiP54812.
PaxDbiP54812.
PRIDEiP54812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC41C4.8.1; C41C4.8.1; WBGene00008053.
C41C4.8.2; C41C4.8.2; WBGene00008053.
GeneIDi174309.
KEGGicel:CELE_C41C4.8.
UCSCiC41C4.8.1. c. elegans.

Organism-specific databases

CTDi174309.
WormBaseiC41C4.8; CE05402; WBGene00008053; cdc-48.2.

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00810000125456.
HOGENOMiHOG000223224.
InParanoidiP54812.
KOiK13525.
OMAiASETVIH.
OrthoDBiEOG091G024K.
PhylomeDBiP54812.

Enzyme and pathway databases

ReactomeiR-CEL-110320. Translesion Synthesis by POLH.
R-CEL-5358346. Hedgehog ligand biogenesis.

Miscellaneous databases

PROiP54812.

Gene expression databases

BgeeiWBGene00008053.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsiTIGR01243. CDC48. 1 hit.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTERA2_CAEEL
AccessioniPrimary (citable) accession number: P54812
Secondary accession number(s): Q18560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: September 7, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.