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Protein

Transitional endoplasmic reticulum ATPase homolog 2

Gene

cdc-48.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it regulates expression of ER stress response genes.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei353ATPBy similarity1
Binding sitei389ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi252 – 258ATPBy similarity7

GO - Molecular functioni

  • ATPase activity Source: WormBase
  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: WormBase
  • ER-associated misfolded protein catabolic process Source: WormBase
  • negative regulation of protein localization to centrosome Source: UniProtKB
  • protein localization to nucleus Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-110320 Translesion Synthesis by POLH
R-CEL-382556 ABC-family proteins mediated transport
R-CEL-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-CEL-5358346 Hedgehog ligand biogenesis
R-CEL-5689877 Josephin domain DUBs
R-CEL-6798695 Neutrophil degranulation
R-CEL-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Transitional endoplasmic reticulum ATPase homolog 2
Alternative name(s):
Cell division cycle-related protein 48.2
p97/CDC48 homolog 2
Gene namesi
ORF Names:C41C4.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC41C4.8 ; CE05402 ; WBGene00008053 ; cdc-48.2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

Insensitive to tunicamycin, an inducer of ER stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845781 – 810Transitional endoplasmic reticulum ATPase homolog 2Add BLAST810

Proteomic databases

EPDiP54812
PaxDbiP54812
PeptideAtlasiP54812
PRIDEiP54812

PTM databases

iPTMnetiP54812

Expressioni

Gene expression databases

BgeeiWBGene00008053

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi39638, 11 interactors
DIPiDIP-26566N
IntActiP54812, 6 interactors
STRINGi6239.C41C4.8.3

Structurei

3D structure databases

ProteinModelPortaliP54812
SMRiP54812
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. CDC48 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0730 Eukaryota
COG0464 LUCA
GeneTreeiENSGT00900000141071
HOGENOMiHOG000223224
InParanoidiP54812
KOiK13525
OMAiPIDDTTE
OrthoDBiEOG091G024K
PhylomeDBiP54812

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR005938 AAA_ATPase_CDC48
IPR009010 Asp_de-COase-like_dom_sf
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR004201 Cdc48_dom2
IPR029067 CDC48_domain_2-like_sf
IPR003338 CDC4_N-term_subdom
IPR027417 P-loop_NTPase
IPR015415 Vps4_C
PfamiView protein in Pfam
PF00004 AAA, 2 hits
PF02933 CDC48_2, 1 hit
PF02359 CDC48_N, 1 hit
PF09336 Vps4_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SM01072 CDC48_2, 1 hit
SM01073 CDC48_N, 1 hit
SUPFAMiSSF50692 SSF50692, 1 hit
SSF52540 SSF52540, 2 hits
SSF54585 SSF54585, 1 hit
TIGRFAMsiTIGR01243 CDC48, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 2 hits

Sequencei

Sequence statusi: Complete.

P54812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVPTQRDE KEKKNDELAT AILKDKKRPN RLIIDQSDND DNSMVMLSQA
60 70 80 90 100
KMDELGLFRG DSVILKGKKR RETVSIVLNA DNCPNDKIKM NKVVRNNLRS
110 120 130 140 150
RLGDVVSISS AQLEYGKRVH VLPIDDTIEG LTGNLFDVFL RPYFTDAYRP
160 170 180 190 200
VHKGDIFTVQ AAMRTVEFKV VETDPAPACI VAPDTVIHYE GDPIKREEEE
210 220 230 240 250
EALNEVGYDD LGGVRKQLAQ IKEMVELPLR HPQLFKAIGV KPPRGILLFG
260 270 280 290 300
PPGTGKTLIA RAVANETGAF FFLINGPEIM SKMSGESESN LRKAFAECEK
310 320 330 340 350
NSPAILFIDE IDAIAPKREK AHGEVEKRIV SQLLTLMDGL KTRAHVVVIA
360 370 380 390 400
ATNRPNSIDG ALRRFGRFDR EIDIGIPDAV GRLEILRIHT KNMKLGEDVD
410 420 430 440 450
LEQVANECHG FVGADLASLC SEAAIQQIRE KMELIDLEDD TIDAEVLNSL
460 470 480 490 500
AVTMENFRFA MGKSSPSALR EAVVETPNTT WSDIGGLQNV KRELQELVQY
510 520 530 540 550
PVEHPEKYLK FGMQPSRGVL FYGPPGCGKT LLAKAIANEC QANFISIKGP
560 570 580 590 600
ELLTMWFGES EANVRDVFDK ARAAAPCVLF FDELDSIAKA RGGSVGDAGG
610 620 630 640 650
AADRVINQVL TEMDGMNAKK NVFIIGATNR PDIIDPAVLR PGRLDQLIYI
660 670 680 690 700
PLPDEASRLQ IFKASLRKTP LSADLDLNFL AKNTVGFSGA DLTEICQRAC
710 720 730 740 750
KLAIRESIER EIRQEKERQD RSARGEELME DELADPVPEI TRAHFEEAMK
760 770 780 790 800
FARRSVTDND IRKYEMFAQT LQQSRGFGNN FKFPGEAPSA GQPVGGNGGS
810
GGNDDDDLYN
Length:810
Mass (Da):89,640
Last modified:May 30, 2000 - v2
Checksum:i904DA78FA1B007AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48045, Z48334 Genomic DNA Translation: CAA88105.1
PIRiT19879
RefSeqiNP_495705.1, NM_063304.5
UniGeneiCel.7497

Genome annotation databases

EnsemblMetazoaiC41C4.8.1; C41C4.8.1; WBGene00008053
C41C4.8.2; C41C4.8.2; WBGene00008053
GeneIDi174309
KEGGicel:CELE_C41C4.8
UCSCiC41C4.8.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTERA2_CAEEL
AccessioniPrimary (citable) accession number: P54812
Secondary accession number(s): Q18560
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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