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Protein

Transitional endoplasmic reticulum ATPase homolog 1

Gene

cdc-48.1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it regulates expression of ER stress response genes.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei354 – 3541ATPBy similarity
Binding sitei390 – 3901ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi253 – 2597ATPBy similarity

GO - Molecular functioni

  • ATPase activity Source: WormBase
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • embryo development ending in birth or egg hatching Source: WormBase
  • ER-associated misfolded protein catabolic process Source: WormBase
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-110320. Translesion Synthesis by POLH.
R-CEL-5358346. Hedgehog ligand biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Transitional endoplasmic reticulum ATPase homolog 1
Alternative name(s):
Cell division cycle-related protein 48.1
p97/CDC48 homolog 1
Gene namesi
ORF Names:C06A1.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC06A1.1; CE02114; WBGene00007352; cdc-48.1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • nucleoplasm Source: WormBase
  • nucleus Source: WormBase
  • perinuclear region of cytoplasm Source: WormBase
  • VCP-NPL4-UFD1 AAA ATPase complex Source: WormBase
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Insensitive to tunicamycin, an inducer of ER stress.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 809809Transitional endoplasmic reticulum ATPase homolog 1PRO_0000084577Add
BLAST

Proteomic databases

EPDiP54811.
PaxDbiP54811.
PRIDEiP54811.

Expressioni

Gene expression databases

BgeeiWBGene00007352.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
cdc-48.2P548126EBI-320245,EBI-320265
ubxn-1Q9TXH93EBI-320245,EBI-320236

Protein-protein interaction databases

BioGridi39940. 14 interactions.
DIPiDIP-26650N.
IntActiP54811. 8 interactions.
MINTiMINT-1061999.
STRINGi6239.C06A1.1.2.

Structurei

3D structure databases

ProteinModelPortaliP54811.
SMRiP54811. Positions 23-774.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. CDC48 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00810000125456.
HOGENOMiHOG000223224.
InParanoidiP54811.
KOiK13525.
OMAiNVIIMAA.
OrthoDBiEOG091G024K.
PhylomeDBiP54811.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsiTIGR01243. CDC48. 1 hit.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVPTHQSE KEKKNDELST AILKDKVKPN RLIVDQSEQD DNSVIAVSQA
60 70 80 90 100
KMDELGLFRG DAVILKGKKR KESVAIIVSD ESCPNEKVRM NRVVRNNLRI
110 120 130 140 150
RLGDVVSITP APNLSYGTRI HVLPIDDTIE GLTGNLFDVF LKPYFLEAYR
160 170 180 190 200
PLHKGDIFTV QAAMRTVEFK VVETEPAPAC IVSPDTMIHY EGDPIKREEE
210 220 230 240 250
EESMNDIGYD DLGGVRKQLA QIKEMVELPL RHPQLFKAIG IKPPRGILLF
260 270 280 290 300
GPPGTGKTLI ARAVANETGS FFFLINGPEV MSKMSGESES NLRKAFEECE
310 320 330 340 350
KNQPAILFID EIDAIAPKRE KTNGEVERRI VSQLLTLMDG VKGRSNLVVI
360 370 380 390 400
AATNRPNSID GALRRFGRFD REIDIGIPDA VGRLEILRIH TKNMKLADDV
410 420 430 440 450
DLEQIANECH GFVGADLASL CSEAALQQIR EKMELIDLED DQIDAEVLNS
460 470 480 490 500
LAVTMENFRF AQGKSSPSAL REAVVETPNT TWSDIGGLQN VKRELQELVQ
510 520 530 540 550
YPVEHPEKYL KFGMQPSRGV LFYGPPGCGK TLLAKAIANE CQANFISIKG
560 570 580 590 600
PELLTMWFGE SEANVRDVFD KARAAAPCVL FFDELDSIAK ARGGGAGGDG
610 620 630 640 650
GGASDRVINQ VLTEMDGMNA KKNVFIIGAT NRPDIIDPAV LRPGRLDQLI
660 670 680 690 700
YIPLPDEASR HQILKASLRK TPLSKDLDLT FLAKNTVGFS GADLTEICQR
710 720 730 740 750
ACKLAIRESI EKEIRIEKER QDRQARGEEL MEDDAVDPVP EITRAHFEEA
760 770 780 790 800
MKFARRSVTD NDIRKYEMFA QTLQQSRGFG NNFKFPGEQR GSDAPSAPVP

AQDDDDLYN
Length:809
Mass (Da):89,785
Last modified:October 1, 1996 - v1
Checksum:iECF02EF8B939A777
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49886 Genomic DNA. Translation: CAA90050.1.
PIRiT18970.
RefSeqiNP_496273.1. NM_063872.4.
UniGeneiCel.17764.

Genome annotation databases

EnsemblMetazoaiC06A1.1; C06A1.1; WBGene00007352.
GeneIDi174624.
KEGGicel:CELE_C06A1.1.
UCSCiC06A1.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49886 Genomic DNA. Translation: CAA90050.1.
PIRiT18970.
RefSeqiNP_496273.1. NM_063872.4.
UniGeneiCel.17764.

3D structure databases

ProteinModelPortaliP54811.
SMRiP54811. Positions 23-774.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39940. 14 interactions.
DIPiDIP-26650N.
IntActiP54811. 8 interactions.
MINTiMINT-1061999.
STRINGi6239.C06A1.1.2.

Proteomic databases

EPDiP54811.
PaxDbiP54811.
PRIDEiP54811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC06A1.1; C06A1.1; WBGene00007352.
GeneIDi174624.
KEGGicel:CELE_C06A1.1.
UCSCiC06A1.1.1. c. elegans.

Organism-specific databases

CTDi174624.
WormBaseiC06A1.1; CE02114; WBGene00007352; cdc-48.1.

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00810000125456.
HOGENOMiHOG000223224.
InParanoidiP54811.
KOiK13525.
OMAiNVIIMAA.
OrthoDBiEOG091G024K.
PhylomeDBiP54811.

Enzyme and pathway databases

ReactomeiR-CEL-110320. Translesion Synthesis by POLH.
R-CEL-5358346. Hedgehog ligand biogenesis.

Miscellaneous databases

PROiP54811.

Gene expression databases

BgeeiWBGene00007352.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsiTIGR01243. CDC48. 1 hit.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTERA1_CAEEL
AccessioniPrimary (citable) accession number: P54811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.