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Protein

Arylsulfatase F

Gene

ARSF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Enzyme regulationi

Not inhibited by DHEAS or warfarin.

pH dependencei

Optimum pH is 8.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38CalciumBy similarity1
Metal bindingi39CalciumBy similarity1
Active sitei78NucleophileBy similarity1
Metal bindingi78Calcium; via 3-oxoalanineBy similarity1
Binding sitei137SubstrateBy similarity1
Active sitei139By similarity1
Binding sitei293SubstrateBy similarity1
Metal bindingi345CalciumBy similarity1
Metal bindingi346CalciumBy similarity1
Binding sitei370SubstrateBy similarity1

GO - Molecular functioni

  • arylsulfatase activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases

Names & Taxonomyi

Protein namesi
Recommended name:
Arylsulfatase F (EC:3.1.6.-)
Short name:
ASF
Gene namesi
Name:ARSF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000062096.14
HGNCiHGNC:721 ARSF
MIMi300003 gene
neXtProtiNX_P54793

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi416
OpenTargetsiENSG00000062096
PharmGKBiPA25012

Polymorphism and mutation databases

BioMutaiARSF
DMDMi259016386

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003342723 – 590Arylsulfatase FAdd BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei783-oxoalanine (Cys)By similarity1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP54793
PeptideAtlasiP54793
PRIDEiP54793

PTM databases

iPTMnetiP54793
PhosphoSitePlusiP54793

Expressioni

Gene expression databases

BgeeiENSG00000062096
CleanExiHS_ARSF
GenevisibleiP54793 HS

Organism-specific databases

HPAiHPA000549

Interactioni

Protein-protein interaction databases

BioGridi1069092 interactors.
IntActiP54793 1 interactor.
STRINGi9606.ENSP00000352319

Structurei

3D structure databases

ProteinModelPortaliP54793
SMRiP54793
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3867 Eukaryota
COG3119 LUCA
GeneTreeiENSGT00760000119062
HOGENOMiHOG000135352
HOVERGENiHBG004283
InParanoidiP54793
KOiK12374
OMAiTEQPMKA
OrthoDBiEOG091G07AL
PhylomeDBiP54793
TreeFamiTF314186

Family and domain databases

Gene3Di3.40.720.103 hits
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR024607 Sulfatase_CS
IPR000917 Sulfatase_N
PfamiView protein in Pfam
PF00884 Sulfatase, 1 hit
SUPFAMiSSF53649 SSF53649, 1 hit
PROSITEiView protein in PROSITE
PS00523 SULFATASE_1, 1 hit
PS00149 SULFATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPRRPLVFM SLVCALLNTC QAHRVHDDKP NIVLIMVDDL GIGDLGCYGN
60 70 80 90 100
DTMRTPHIDR LAREGVRLTQ HISAASLCSP SRSAFLTGRY PIRSGMVSSG
110 120 130 140 150
NRRVIQNLAV PAGLPLNETT LAALLKKQGY STGLIGKWHQ GLNCDSRSDQ
160 170 180 190 200
CHHPYNYGFD YYYGMPFTLV DSCWPDPSRN TELAFESQLW LCVQLVAIAI
210 220 230 240 250
LTLTFGKLSG WVSVPWLLIF SMILFIFLLG YAWFSSHTSP LYWDCLLMRG
260 270 280 290 300
HEITEQPMKA ERAGSIMVKE AISFLERHSK ETFLLFFSFL HVHTPLPTTD
310 320 330 340 350
DFTGTSKHGL YGDNVEEMDS MVGKILDAID DFGLRNNTLV YFTSDHGGHL
360 370 380 390 400
EARRGHAQLG GWNGIYKGGK GMGGWEGGIR VPGIVRWPGK VPAGRLIKEP
410 420 430 440 450
TSLMDILPTV ASVSGGSLPQ DRVIDGRDLM PLLQGNVRHS EHEFLFHYCG
460 470 480 490 500
SYLHAVRWIP KDDSGSVWKA HYVTPVFQPP ASGGCYVTSL CRCFGEQVTY
510 520 530 540 550
HNPPLLFDLS RDPSESTPLT PATEPLHDFV IKKVANALKE HQETIVPVTY
560 570 580 590
QLSELNQGRT WLKPCCGVFP FCLCDKEEEV SQPRGPNEKR
Length:590
Mass (Da):65,940
Last modified:September 22, 2009 - v4
Checksum:iEA9B7289040AE79A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20 – 29CQAHRVHDDK → WPGHTGCMTTR in CAA66462 (PubMed:9192838).Curated10

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058846527H → Y2 PublicationsCorresponds to variant dbSNP:rs1052638Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97868 mRNA Translation: CAA66462.1
AC112653 Genomic DNA No translation available.
BC022389 mRNA Translation: AAH22389.1
CCDSiCCDS14123.1
PIRiA56217
RefSeqiNP_001188467.1, NM_001201538.1
NP_001188468.1, NM_001201539.1
NP_004033.2, NM_004042.4
UniGeneiHs.101674

Genome annotation databases

EnsembliENST00000359361; ENSP00000352319; ENSG00000062096
ENST00000381127; ENSP00000370519; ENSG00000062096
GeneIDi416
KEGGihsa:416
UCSCiuc004cre.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiARSF_HUMAN
AccessioniPrimary (citable) accession number: P54793
Secondary accession number(s): Q8TCC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 22, 2009
Last modified: February 28, 2018
This is version 144 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome