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Protein

Origin recognition complex subunit 4

Gene

ORC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.

Miscellaneous

Present with 2170 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • DNA replication origin binding Source: SGD

GO - Biological processi

  • chromatin silencing at silent mating-type cassette Source: SGD
  • DNA replication initiation Source: SGD
  • pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

BioCyciYEAST:G3O-34291-MONOMER
ReactomeiR-SCE-68616 Assembly of the ORC complex at the origin of replication
R-SCE-68949 Orc1 removal from chromatin
R-SCE-68962 Activation of the pre-replicative complex

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 4
Alternative name(s):
Origin recognition complex 56 kDa subunit
Gene namesi
Name:ORC4
Ordered Locus Names:YPR162C
ORF Names:P9325.5
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR162C
SGDiS000006366 ORC4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001270911 – 529Origin recognition complex subunit 4Add BLAST529

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP54791
PaxDbiP54791
PRIDEiP54791

PTM databases

iPTMnetiP54791

Interactioni

Subunit structurei

Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi36335, 308 interactors
DIPiDIP-2287N
IntActiP54791, 17 interactors
MINTiP54791
STRINGi4932.YPR162C

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UDBelectron microscopy3.90D1-529[»]
5V8Felectron microscopy3.90D1-529[»]
ProteinModelPortaliP54791
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC4 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000016542
HOGENOMiHOG000001008
InParanoidiP54791
KOiK02606
OMAiCTTKLNI
OrthoDBiEOG092C1ZIR

Family and domain databases

InterProiView protein in InterPro
IPR016527 ORC4
IPR032705 ORC4_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF14629 ORC4_C, 1 hit
PIRSFiPIRSF007858 ORC4, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P54791-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTISEARLSP QVNLLPIKRH SNEEVEETAA ILKKRTIDNE KCKDSDPGFG
60 70 80 90 100
SLQRRLLQQL YGTLPTDEKI IFTYLQDCQQ EIDRIIKQSI IQKESHSVIL
110 120 130 140 150
VGPRQSYKTY LLDYELSLLQ QSYKEQFITI RLNGFIHSEQ TAINGIATQL
160 170 180 190 200
EQQLQKIHGS EEKIDDTSLE TISSGSLTEV FEKILLLLDS TTKTRNEDSG
210 220 230 240 250
EVDRESITKI TVVFIFDEID TFAGPVRQTL LYNLFDMVEH SRVPVCIFGC
260 270 280 290 300
TTKLNILEYL EKRVKSRFSQ RVIYMPQIQN LDDMVDAVRN LLTVRSEISP
310 320 330 340 350
WVSQWNETLE KELSDPRSNL NRHIRMNFET FRSLPTLKNS IIPLVATSKN
360 370 380 390 400
FGSLCTAIKS CSFLDIYNKN QLSNNLTGRL QSLSDLELAI LISAARVALR
410 420 430 440 450
AKDGSFNFNL AYAEYEKMIK AINSRIPTVA PTTNVGTGQS TFSIDNTIKL
460 470 480 490 500
WLKKDVKNVW ENLVQLDFFT EKSAVGLRDN ATAAFYASNY QFQGTMIPFD
510 520
LRSYQMQIIL QELRRIIPKS NMYYSWTQL
Length:529
Mass (Da):60,705
Last modified:October 1, 1996 - v1
Checksum:iACF064F2C633F13F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34862 Genomic DNA Translation: AAB38250.1
U25840 Genomic DNA Translation: AAB68149.1
AY723871 Genomic DNA Translation: AAU09788.1
BK006949 Genomic DNA Translation: DAA11579.1
PIRiS59821
RefSeqiNP_015488.1, NM_001184259.1

Genome annotation databases

EnsemblFungiiYPR162C; YPR162C; YPR162C
GeneIDi856291
KEGGisce:YPR162C

Similar proteinsi

Entry informationi

Entry nameiORC4_YEAST
AccessioniPrimary (citable) accession number: P54791
Secondary accession number(s): D6W4G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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