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P54791 (ORC4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Origin recognition complex subunit 4
Alternative name(s):
Origin recognition complex 56 kDa subunit
Gene names
Name:ORC4
Ordered Locus Names:YPR162C
ORF Names:P9325.5
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.

Subunit structure

Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6.

Subcellular location

Nucleus.

Miscellaneous

Present with 2170 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the ORC4 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ORC1P547844EBI-12580,EBI-12568
ORC5P508745EBI-12580,EBI-12584

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Origin recognition complex subunit 4
PRO_0000127091

Amino acid modifications

Modified residue91Phosphoserine Ref.6

Sequences

Sequence LengthMass (Da)Tools
P54791 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: ACF064F2C633F13F

FASTA52960,705
        10         20         30         40         50         60 
MTISEARLSP QVNLLPIKRH SNEEVEETAA ILKKRTIDNE KCKDSDPGFG SLQRRLLQQL 

        70         80         90        100        110        120 
YGTLPTDEKI IFTYLQDCQQ EIDRIIKQSI IQKESHSVIL VGPRQSYKTY LLDYELSLLQ 

       130        140        150        160        170        180 
QSYKEQFITI RLNGFIHSEQ TAINGIATQL EQQLQKIHGS EEKIDDTSLE TISSGSLTEV 

       190        200        210        220        230        240 
FEKILLLLDS TTKTRNEDSG EVDRESITKI TVVFIFDEID TFAGPVRQTL LYNLFDMVEH 

       250        260        270        280        290        300 
SRVPVCIFGC TTKLNILEYL EKRVKSRFSQ RVIYMPQIQN LDDMVDAVRN LLTVRSEISP 

       310        320        330        340        350        360 
WVSQWNETLE KELSDPRSNL NRHIRMNFET FRSLPTLKNS IIPLVATSKN FGSLCTAIKS 

       370        380        390        400        410        420 
CSFLDIYNKN QLSNNLTGRL QSLSDLELAI LISAARVALR AKDGSFNFNL AYAEYEKMIK 

       430        440        450        460        470        480 
AINSRIPTVA PTTNVGTGQS TFSIDNTIKL WLKKDVKNVW ENLVQLDFFT EKSAVGLRDN 

       490        500        510        520 
ATAAFYASNY QFQGTMIPFD LRSYQMQIIL QELRRIIPKS NMYYSWTQL 

« Hide

References

« Hide 'large scale' references
[1]"The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing."
Bell S.P., Mitchell J., Leber J., Kobayashi R., Stillman B.
Cell 83:563-568(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U34862 Genomic DNA. Translation: AAB38250.1.
U25840 Genomic DNA. Translation: AAB68149.1.
AY723871 Genomic DNA. Translation: AAU09788.1.
BK006949 Genomic DNA. Translation: DAA11579.1.
PIRS59821.
RefSeqNP_015488.1. NM_001184259.1.

3D structure databases

ProteinModelPortalP54791.
SMRP54791. Positions 95-120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36335. 21 interactions.
DIPDIP-2287N.
IntActP54791. 15 interactions.
MINTMINT-669611.
STRING4932.YPR162C.

Proteomic databases

PaxDbP54791.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPR162C; YPR162C; YPR162C.
GeneID856291.
KEGGsce:YPR162C.

Organism-specific databases

CYGDYPR162c.
SGDS000006366. ORC4.

Phylogenomic databases

eggNOGNOG289784.
GeneTreeENSGT00390000016542.
HOGENOMHOG000001008.
KOK02606.
OMACTTKLNI.
OrthoDBEOG70610P.

Enzyme and pathway databases

BioCycYEAST:G3O-34291-MONOMER.

Gene expression databases

GenevestigatorP54791.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR016527. ORC4.
IPR027417. P-loop_NTPase.
[Graphical view]
PIRSFPIRSF007858. ORC4. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

NextBio981632.
PROP54791.

Entry information

Entry nameORC4_YEAST
AccessionPrimary (citable) accession number: P54791
Secondary accession number(s): D6W4G3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families