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Protein

Origin recognition complex subunit 3

Gene

ORC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.1 Publication

GO - Molecular functioni

  • chromatin binding Source: SGD
  • DNA replication origin binding Source: SGD

GO - Biological processi

  • chromatin silencing at silent mating-type cassette Source: SGD
  • DNA replication initiation Source: SGD
  • pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: SGD

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

BioCyciYEAST:G3O-32109-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 3
Alternative name(s):
Origin recognition complex 62 kDa subunit
Gene namesi
Name:ORC3
Synonyms:OAF1, OIF1
Ordered Locus Names:YLL004W
ORF Names:L1365
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL004W
SGDiS000003927 ORC3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001270862 – 616Origin recognition complex subunit 3Add BLAST615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP54790
PaxDbiP54790
PRIDEiP54790

PTM databases

iPTMnetiP54790

Interactioni

Subunit structurei

Component of the origin recognition complex (ORC) composed of at least ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. Interacts with ORC6.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31247, 242 interactors
DIPiDIP-2286N
IntActiP54790, 23 interactors
MINTiP54790
STRINGi4932.YLL004W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UDBelectron microscopy3.90C1-616[»]
5V8Felectron microscopy3.90C1-616[»]
ProteinModelPortaliP54790
SMRiP54790
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC3 family.Curated

Phylogenomic databases

HOGENOMiHOG000001104
InParanoidiP54790
KOiK02605
OMAiRENPING
OrthoDBiEOG092C239F

Family and domain databases

InterProiView protein in InterPro
IPR020795 ORC3
PANTHERiPTHR12748 PTHR12748, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLNQSKKM NVSEFADAQR SHYTVYPSLP QSNKNDKHIP FVKLLSGKES
60 70 80 90 100
EVNVEKRWEL YHQLHSHFHD QVDHIIDNIE ADLKAEISDL LYSETTQKRR
110 120 130 140 150
CFNTIFLLGS DSTTKIELKD ESSRYNVLIE LTPKESPNVR MMLRRSMYKL
160 170 180 190 200
YSAADAEEHP TIKYEDINDE DGDFTEQNND VSYDLSLVEN FKRLFGKDLA
210 220 230 240 250
MVFNFKDVDS INFNTLDNFI ILLKSAFKYD HVKISLIFNI NTNLSNIEKN
260 270 280 290 300
LRQSTIRLLK RNYHKLDVSS NKGFKYGNQI FQSFLDTVDG KLNLSDRFVE
310 320 330 340 350
FILSKMANNT NHNLQLLTKM LDYSLMSYFF QNAFSVFIDP VNVDFLNDDY
360 370 380 390 400
LKILSRCPTF MFFVEGLIKQ HAPADEILSL LTNKNRGLEE FFVEFLVREN
410 420 430 440 450
PINGHAKFVA RFLEEELNIT NFNLIELYHN LLIGKLDSYL DRWSACKEYK
460 470 480 490 500
DRLHFEPIDT IFQELFTLDN RSGLLTQSIF PSYKSNIEDN LLSWEQVLPS
510 520 530 540 550
LDKENYDTLS GDLDKIMAPV LGQLFKLYRE ANMTINIYDF YIAFRETLPK
560 570 580 590 600
EEILNFIRKD PSNTKLLELA ETPDAFDKVA LILFMQAIFA FENMGLIKFQ
610
STKSYDLVEK CVWRGI
Length:616
Mass (Da):72,077
Last modified:October 1, 1996 - v1
Checksum:i3FAAEE3F645D3F9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34861 Genomic DNA Translation: AAB38249.1
U48888 Genomic DNA Translation: AAC49270.1
X91488 Genomic DNA Translation: CAA62765.1
Z73109 Genomic DNA Translation: CAA97447.1
BK006945 Genomic DNA Translation: DAA09315.1
PIRiS64746
RefSeqiNP_013097.1, NM_001181824.1

Genome annotation databases

EnsemblFungiiYLL004W; YLL004W; YLL004W
GeneIDi850656
KEGGisce:YLL004W

Similar proteinsi

Entry informationi

Entry nameiORC3_YEAST
AccessioniPrimary (citable) accession number: P54790
Secondary accession number(s): D6VXZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health