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Protein

Protein ZDS2

Gene

ZDS2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a negative regulator of polarized growth via an alternative mechanism to ZDS1. In heat-stressed cells appears to play a role in localizing BCY1 to the cytoplasm. Seems to interact with, and down-regulate, CDC42. Also acts as a suppressor of PKC1. May act as an integration point for distinct signaling pathways helping to maintain a balance among these different pathways.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell aging Source: SGD
  • chromatin silencing at rDNA Source: SGD
  • establishment of cell polarity Source: SGD
  • positive regulation of G2/M transition of mitotic cell cycle Source: SGD
  • regulation of protein localization Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32692-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ZDS2
Gene namesi
Name:ZDS2
Synonyms:MCS1
Ordered Locus Names:YML109W
ORF Names:YM8339.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML109W.
SGDiS000004577. ZDS2.

Subcellular locationi

GO - Cellular componenti

  • cell septum Source: GO_Central
  • cellular bud neck Source: SGD
  • cellular bud tip Source: SGD
  • cytoplasm Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 942942Protein ZDS2PRO_0000066570Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP54786.

PTM databases

iPTMnetiP54786.

Interactioni

Subunit structurei

Interacts with SKG6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-29637,EBI-29637
BOI1P380413EBI-29637,EBI-3719
CDC55Q003629EBI-29637,EBI-1942
SLA1P327903EBI-29637,EBI-17313

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi35095. 76 interactions.
DIPiDIP-1517N.
IntActiP54786. 56 interactions.
MINTiMINT-411150.

Structurei

3D structure databases

ProteinModelPortaliP54786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To yeast ZDS1/NRC1/CES1.Curated

Phylogenomic databases

GeneTreeiENSGT00530000067622.
HOGENOMiHOG000144432.
InParanoidiP54786.
OMAiFMYSYLN.
OrthoDBiEOG092C3MX2.

Family and domain databases

InterProiIPR013941. ZDS1_C.
[Graphical view]
PfamiPF08632. Zds_C. 1 hit.
[Graphical view]
SMARTiSM01327. Zds_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLMEDMQNK DGHNTVENSS GGTDSNNNIQ MRRMRKTQLS KKELFEKRKS
60 70 80 90 100
DVLIAAKSLD TEIQNVKNLK RLSIGSMDLV IDPELEFKVN SRNSYSSDSS
110 120 130 140 150
KESLQESLHE ENIIRSEQKE EQGSEDNDAY EEGDATNVDD SIDITQTEYL
160 170 180 190 200
HDEETLEKEK IIRNASSSTS SSARVTSRNR RLSGVKTLAH DVVLDVENDH
210 220 230 240 250
DSKMVDLTQN LLWVPADQHP NVKPENYLEL IQDTLQNIQI STNQDIDENK
260 270 280 290 300
LELGNNHVIS NRKRTGSVVR RPSRLKTSYT KFDDEPPLAD KPQEGEIQVD
310 320 330 340 350
KRISSSDIKT IRSVSLKEIT EELTKISNNA GLTDSDAVTL ARSLSMSGSF
360 370 380 390 400
TNESLHLNGN HTENDNEFAS NMFNETGLTI PERSSLRRSK FNTYKIRLEG
410 420 430 440 450
SSLPQAVKLN SLMNIQTNDN RRSASSPASY TQVPQEQASL NDFHEIFDHY
460 470 480 490 500
RRTSTDWSTE NEKYVDSTNY YSDEEDLTHA SISQESSLLS TDSSNNSVLI
510 520 530 540 550
KPHNTGSMIS EKLDQHVSSS EKSNTNNSEA NHGWSWLNSS NGSLNANEQT
560 570 580 590 600
YQQLTDDEDD EECVDNEKAD FVNLSVSRRA KSTKRASERI NHSKNRHSPI
610 620 630 640 650
FQIHSEEAKS VVITPSVVSS SESQPSKPTA PAVVEKKVEL PTDTQASTHK
660 670 680 690 700
KNSLEKRLAK LFKRKQHNGT CKSDVKVIKK SVKKELKKKA SHSSLSKFRK
710 720 730 740 750
SPKKKPQEAE VERPSSPTKT ITTEDIDTAS VIEPEVRSSN ASTLLPDSHT
760 770 780 790 800
SHSSEFVVET ISELDGDDSF DISGGDVNYD VEVHSSISRD TTAGLEEDIG
810 820 830 840 850
AEREDNTSPT APQISTLPPR KLTFEDVVKP DYSNAPIKFT DSAFGFPLPM
860 870 880 890 900
ITNSTVIMFD HRLGINVERA IYRLSHLKLS DPGRELRQQV LLSNFMYSYL
910 920 930 940
NLVNHTLYME QVGTGDIAFN GDSALGMMDK NDSDGTILIP DI
Length:942
Mass (Da):105,496
Last modified:October 1, 1996 - v1
Checksum:iA1C9DD9A539E4291
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71M → V in AAB37541 (PubMed:8816438).Curated
Sequence conflicti23 – 231T → S in AAB37541 (PubMed:8816438).Curated
Sequence conflicti530 – 5301A → P in AAB37541 (PubMed:8816438).Curated
Sequence conflicti546 – 5461A → G in AAB37541 (PubMed:8816438).Curated
Sequence conflicti633 – 6331V → A in AAB37541 (PubMed:8816438).Curated
Sequence conflicti668 – 6681N → S in AAB37541 (PubMed:8816438).Curated
Sequence conflicti711 – 7111V → VNC in AAB37541 (PubMed:8816438).Curated
Sequence conflicti723 – 7231Missing in AAB37541 (PubMed:8816438).Curated
Sequence conflicti729 – 7291A → E in AAB37541 (PubMed:8816438).Curated
Sequence conflicti833 – 8331S → P in AAB37541 (PubMed:8816438).Curated
Sequence conflicti914 – 94229TGDIA…LIPDI → HWRYSLQW in AAB37541 (PubMed:8816438).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32938 Genomic DNA. Translation: AAB37541.1.
Z49210 Genomic DNA. Translation: CAA89109.1.
BK006946 Genomic DNA. Translation: DAA09789.1.
PIRiS53963.
RefSeqiNP_013598.1. NM_001182471.1.

Genome annotation databases

EnsemblFungiiYML109W; YML109W; YML109W.
GeneIDi854931.
KEGGisce:YML109W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32938 Genomic DNA. Translation: AAB37541.1.
Z49210 Genomic DNA. Translation: CAA89109.1.
BK006946 Genomic DNA. Translation: DAA09789.1.
PIRiS53963.
RefSeqiNP_013598.1. NM_001182471.1.

3D structure databases

ProteinModelPortaliP54786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35095. 76 interactions.
DIPiDIP-1517N.
IntActiP54786. 56 interactions.
MINTiMINT-411150.

PTM databases

iPTMnetiP54786.

Proteomic databases

MaxQBiP54786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML109W; YML109W; YML109W.
GeneIDi854931.
KEGGisce:YML109W.

Organism-specific databases

EuPathDBiFungiDB:YML109W.
SGDiS000004577. ZDS2.

Phylogenomic databases

GeneTreeiENSGT00530000067622.
HOGENOMiHOG000144432.
InParanoidiP54786.
OMAiFMYSYLN.
OrthoDBiEOG092C3MX2.

Enzyme and pathway databases

BioCyciYEAST:G3O-32692-MONOMER.

Miscellaneous databases

PROiP54786.

Family and domain databases

InterProiIPR013941. ZDS1_C.
[Graphical view]
PfamiPF08632. Zds_C. 1 hit.
[Graphical view]
SMARTiSM01327. Zds_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZDS2_YEAST
AccessioniPrimary (citable) accession number: P54786
Secondary accession number(s): D6W0H5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

'ZDS' means 'zillion different screens' as both ZDS1 and ZDS2 have been found by a wide variety of genetic screens.
Present with 105 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.