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Protein

Peroxisome assembly factor 2

Gene

Pex6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Probably required for protein import into peroxisomes. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi470 – 477ATPSequence analysis8
Nucleotide bindingi742 – 749ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • peroxisome organization Source: RGD
  • protein import into peroxisome matrix, translocation Source: Ensembl
  • protein stabilization Source: Ensembl

Keywordsi

Biological processPeroxisome biogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome assembly factor 2
Short name:
PAF-2
Alternative name(s):
Peroxin-6
Peroxisomal biogenesis factor 6
Peroxisomal-type ATPase 1
Gene namesi
Name:Pex6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi621637 Pex6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane, Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi476K → A: No loss of function. 1 Publication1
Mutagenesisi748K → A: Loss of function. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846091 – 978Peroxisome assembly factor 2Add BLAST978

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei119Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP54777
PRIDEiP54777

Expressioni

Gene expression databases

BgeeiENSRNOG00000016655
GenevisibleiP54777 RN

Interactioni

Subunit structurei

Interacts directly with PEX26 and PEX1. Mediates the indirect interaction between PEX1 and PEX26. Interacts with ZFAND6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250712, 2 interactors
STRINGi10116.ENSRNOP00000022582

Structurei

3D structure databases

ProteinModelPortaliP54777
SMRiP54777
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0736 Eukaryota
ENOG410XNT9 LUCA
GeneTreeiENSGT00550000074953
HOGENOMiHOG000241031
HOVERGENiHBG002311
InParanoidiP54777
KOiK13339
OMAiPSVSWHD
OrthoDBiEOG091G048C
PhylomeDBiP54777

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

P54777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAVLHVLE PFPTETPPLA VLLPPGGPWP VTGVGLVLAL RPASESPAGP
60 70 80 90 100
ALLVAAVEGS GAQCEQRGPG PPPLLVSRTL LRVLALSPGA RVRARPVRRP
110 120 130 140 150
PALGWALLGT SPGPGLGPRV GPLLVRRGET LPVPGSRVLE TRPALQGLLG
160 170 180 190 200
PGTRLAVTEL QGRTKLDPES RDHNHPPPPP VVSSFAVSHS IRQLRGVLGG
210 220 230 240 250
TGDALGVSRS CLRSLGLFQG EWVWVARVGE LPNTSQPHLA QVQVLEPRWD
260 270 280 290 300
LSARLGPNSG QPGEPLADGL VFVPATLAFN LGCDPLEVGE LRIQRYLEDS
310 320 330 340 350
TAAEDKGSCS LLPGPPFARE LHIEVLPSPH CGVNGKYDHV LYQHFHTPRV
360 370 380 390 400
VQEGDVLCVS TAGQVEILEG SLERLPRWRE VFFKVKKTVG EAPDGPASAF
410 420 430 440 450
LADTTHTSLY LAGTTLSRVP PLPSGRSPPW DSLSPPGLEA LVNELCAVLK
460 470 480 490 500
PHLQPGGTLL TGTSCVLLQG PPGSGKTTAV TAACSRLGLH LLKVPCSSLC
510 520 530 540 550
ADSSRTVETK LQTTFSRARR CRPVVLLLTA LDLLGRDRDG LGEDARVVAT
560 570 580 590 600
LRHLLLDEDP LSRCPPLMVV ATTSRVQDLP TDVRTAFPHE LEVPVLSESQ
610 620 630 640 650
RLSVLQALTA HLPLGQEVNL SQLARRCAGF VVGDLYALLT HASRAACTRI
660 670 680 690 700
KAAGLAMSEE DEGELCAAGF PLLAEDFGQA LDQLQTAHSQ AVGAPKIPSV
710 720 730 740 750
SWHDVGGLQD VKKEILETIQ LPLEHPELLS LGLRRSGLLL HGPPGTGKTL
760 770 780 790 800
LAKAVATECS LTFLSVKGPE LINMYVGQSE ENVREVFARA RAAAPCIIFF
810 820 830 840 850
DELDSLAPSR GRSGDSGGVM DRVVSQLLAE LDGLHSTQDV FVIGATNRPD
860 870 880 890 900
LLDPALLRPG RFDKLVFVGA SEDRASQLRV LSAITRKFKL EASVSLMNVL
910 920 930 940 950
DCCPPQLTGA DLYSLCSDAM MTALKRRVRD LEEGLEPRSS ALLLTMEDLL
960 970
QAAARLQPSV SEQELLRYKR IQRKFAAC
Length:978
Mass (Da):104,426
Last modified:October 1, 1996 - v1
Checksum:iF723193B7E95EA97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299D → G in BAA24931 (Ref. 2) Curated1
Sequence conflicti333V → A in BAA24931 (Ref. 2) Curated1
Sequence conflicti343Q → R in BAA24931 (Ref. 2) Curated1
Sequence conflicti546R → C in BAA24931 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63673 mRNA Translation: BAA09824.1
D89660 Genomic DNA Translation: BAA24931.1
RefSeqiNP_476466.1, NM_057125.1
UniGeneiRn.10675

Genome annotation databases

EnsembliENSRNOT00000022582; ENSRNOP00000022582; ENSRNOG00000016655
GeneIDi117265
KEGGirno:117265
UCSCiRGD:621637 rat

Similar proteinsi

Entry informationi

Entry nameiPEX6_RAT
AccessioniPrimary (citable) accession number: P54777
Secondary accession number(s): O55097
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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