Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine/DOPA decarboxylase 5

Gene

TYDC5

Organism
Papaver somniferum (Opium poppy)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in providing precursors for alkaloid synthesis in the roots and germinating seedlings.

Catalytic activityi

L-tyrosine = tyramine + CO2.
L-dopa = dopamine + CO2.
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine/DOPA decarboxylase 5
Including the following 2 domains:
DOPA decarboxylase (EC:4.1.1.28)
Short name:
DDC
Tyrosine decarboxylase (EC:4.1.1.25)
Gene namesi
Name:TYDC5
OrganismiPapaver somniferum (Opium poppy)
Taxonomic identifieri3469 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsRanunculalesPapaveraceaePapaveroideaePapaver

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001470021 – 523Tyrosine/DOPA decarboxylase 5Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei321N6-(pyridoxal phosphate)lysineBy similarity1

Expressioni

Tissue specificityi

Roots.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP54771.
SMRiP54771.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiView protein in InterPro
IPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
IPR021115. Pyridoxal-P_BS.
PfamiView protein in Pfam
PF00282. Pyridoxal_deC. 1 hit.
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiView protein in PROSITE
PS00392. DDC_GAD_HDC_YDC. 1 hit.

Sequencei

Sequence statusi: Complete.

P54771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLPTDNLE SMSICSQNPL DPDEFRRQGH MIIDFLADYY KNVKVSSRSQ
60 70 80 90 100
ANPGSQQTLP ETAPNHSESI ETILQDVQND IIPGITHWQS PNYFAYFPSS
110 120 130 140 150
GSVAGFLGEM LSSGFNVVGF NWMSSPAATE LESIVMNWLG QMLNLPKSFL
160 170 180 190 200
FSSDDNAGSS GGGVLQGTTC EAILCTLTAS RDKMLNKIGR ENINKLVVYA
210 220 230 240 250
SDQTHCALQK AAQIAGINPK NFRAIATSKA TDFGLSPQAL LSTILADIES
260 270 280 290 300
GLVPLFLCAT VGTTSSTAVD PIGPLCEVAK QFGIWVHVDA AYAGSACICP
310 320 330 340 350
EFRHFIDGVE EADSFSLNAH KWFFTTLDCC CLWVKDSNAL VKALSTSPEY
360 370 380 390 400
LKNKATDSKQ VIDYKDWQIA LSRRFRSMKL WLVLRSYGVA NLRSFLRSHV
410 420 430 440 450
KMAKHFDGLI AMDKRFEIVV PNTFAMVCFR LKPAAIFNGK LGENGVDYNC
460 470 480 490 500
IEEKTNEINS KLLESVNASG SIYMTHAVVG GVYMIRFAVG ATLTEERHVS
510 520
MAWKVIQEHT DAILGTVDDS VVA
Length:523
Mass (Da):57,304
Last modified:October 1, 1996 - v1
Checksum:i81BA6764AC1EE8DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16804 Genomic DNA. Translation: AAA97535.1.
PIRiT09615.

Similar proteinsi

Entry informationi

Entry nameiTYDC5_PAPSO
AccessioniPrimary (citable) accession number: P54771
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 12, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families