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P54770

- TYDC3_PAPSO

UniProt

P54770 - TYDC3_PAPSO

Protein

Tyrosine/DOPA decarboxylase 3

Gene

TYDC3

Organism
Papaver somniferum (Opium poppy)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (13 Aug 2002)
      Previous versions | rss
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    Functioni

    Marginally higher substrate specificity for L-DOPA over L-tyrosine.

    Catalytic activityi

    L-tyrosine = tyramine + CO2.
    L-dopa = dopamine + CO2.
    5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

    Cofactori

    Pyridoxal phosphate.

    GO - Molecular functioni

    1. aromatic-L-amino-acid decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro
    3. tyrosine decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine/DOPA decarboxylase 3
    Including the following 2 domains:
    DOPA decarboxylase (EC:4.1.1.28)
    Short name:
    DDC
    Tyrosine decarboxylase (EC:4.1.1.25)
    Gene namesi
    Name:TYDC3
    OrganismiPapaver somniferum (Opium poppy)
    Taxonomic identifieri3469 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsRanunculalesPapaveraceaePapaveroideaePapaver

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 533533Tyrosine/DOPA decarboxylase 3PRO_0000147001Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei319 – 3191N6-(pyridoxal phosphate)lysineBy similarity

    Expressioni

    Tissue specificityi

    Roots.1 Publication

    Developmental stagei

    Seedlings and mature plants.1 Publication

    Inductioni

    By fungal elicitor.1 Publication

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP54770.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.Curated

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProiIPR010977. Aromatic_deC.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    PRINTSiPR00800. YHDCRBOXLASE.
    SUPFAMiSSF53383. SSF53383. 2 hits.
    PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54770-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLNTEDVL EHSSAFGATN PLDPEEFRRQ GHMIIDFLAD YYRDVEKYPV    50
    RSQVEPGYLR KRLPETAPYN PESIETILQD VTSEIIPGLT HWQSPNYYAY 100
    FPSSGSVAGF LGEMLSTGFN VVGFNWMSSP AATELEGIVM DWFGKMLNLP 150
    KSYLFSGTGG GVLQGTTCEA ILCTLTAARD RKLNKIGREH IGRLVVYGSD 200
    QTHCALQKAA QIAGINPKNF RAVKTFKANS FGLAASTLRE VILEDIEAGL 250
    IPLFVCPTVG TTSSTAVDPI GPICEVAKEY EMWVHIDAAY AGSACICPEF 300
    RHFIDGVEEA DSFSLNAHKW FFTTLDCCCL WVKDPSSLVK ALSTNPEYLR 350
    NKATESRQVV DYKDWQIALI RRFRSMKLWM VLRSYGVTNL RNFLRSHVRM 400
    AKTFEGLVGA DRRFEITVPR TFAMVCFRLL PPTTVKVCGE NGVHQNGNGV 450
    IAVLRNENEE LVLANKLNQV YLRQVKATGS VYMTHAVVGG VYMIRFAVGS 500
    TLTEERHVIH AWEVLQEHAD LILSKFDEAN FSS 533
    Length:533
    Mass (Da):59,520
    Last modified:August 13, 2002 - v2
    Checksum:iEAC9C271D77CDC22
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025431 Genomic DNA. Translation: AAC61840.1.
    U08599 mRNA. Translation: AAA62348.1.
    PIRiC55066.
    T07970.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025431 Genomic DNA. Translation: AAC61840.1 .
    U08599 mRNA. Translation: AAA62348.1 .
    PIRi C55066.
    T07970.

    3D structure databases

    ProteinModelPortali P54770.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    InterProi IPR010977. Aromatic_deC.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    PRINTSi PR00800. YHDCRBOXLASE.
    SUPFAMi SSF53383. SSF53383. 2 hits.
    PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression patterns conferred by tyrosine/dihydroxyphenylalanine decarboxylase promoters from opium poppy are conserved in transgenic tobacco."
      Facchini P.J., Penzes-Yost C., Samanani N., Kowalchuk B.
      Plant Physiol. 118:69-81(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
      Strain: cv. Marianne.
      Tissue: Leaf.
    2. "Differential and tissue-specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy."
      Facchini P.J., de Luca V.
      J. Biol. Chem. 269:26684-26690(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 175-533.
      Strain: cv. Marianne.

    Entry informationi

    Entry nameiTYDC3_PAPSO
    AccessioniPrimary (citable) accession number: P54770
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: August 13, 2002
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3