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P54770 (TYDC3_PAPSO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine/DOPA decarboxylase 3

Including the following 2 domains:

  1. DOPA decarboxylase
    Short name=DDC
    EC=4.1.1.28
  2. Tyrosine decarboxylase
    EC=4.1.1.25
Gene names
Name:TYDC3
OrganismPapaver somniferum (Opium poppy)
Taxonomic identifier3469 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsRanunculalesPapaveraceaePapaveroideaePapaver

Protein attributes

Sequence length533 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Marginally higher substrate specificity for L-DOPA over L-tyrosine.

Catalytic activity

L-tyrosine = tyramine + CO2.

L-dopa = dopamine + CO2.

5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactor

Pyridoxal phosphate.

Subunit structure

Homodimer By similarity.

Tissue specificity

Roots. Ref.1

Developmental stage

Seedlings and mature plants. Ref.1

Induction

By fungal elicitor. Ref.1

Sequence similarities

Belongs to the group II decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 533533Tyrosine/DOPA decarboxylase 3
PRO_0000147001

Amino acid modifications

Modified residue3191N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P54770 [UniParc].

Last modified August 13, 2002. Version 2.
Checksum: EAC9C271D77CDC22

FASTA53359,520
        10         20         30         40         50         60 
MGSLNTEDVL EHSSAFGATN PLDPEEFRRQ GHMIIDFLAD YYRDVEKYPV RSQVEPGYLR 

        70         80         90        100        110        120 
KRLPETAPYN PESIETILQD VTSEIIPGLT HWQSPNYYAY FPSSGSVAGF LGEMLSTGFN 

       130        140        150        160        170        180 
VVGFNWMSSP AATELEGIVM DWFGKMLNLP KSYLFSGTGG GVLQGTTCEA ILCTLTAARD 

       190        200        210        220        230        240 
RKLNKIGREH IGRLVVYGSD QTHCALQKAA QIAGINPKNF RAVKTFKANS FGLAASTLRE 

       250        260        270        280        290        300 
VILEDIEAGL IPLFVCPTVG TTSSTAVDPI GPICEVAKEY EMWVHIDAAY AGSACICPEF 

       310        320        330        340        350        360 
RHFIDGVEEA DSFSLNAHKW FFTTLDCCCL WVKDPSSLVK ALSTNPEYLR NKATESRQVV 

       370        380        390        400        410        420 
DYKDWQIALI RRFRSMKLWM VLRSYGVTNL RNFLRSHVRM AKTFEGLVGA DRRFEITVPR 

       430        440        450        460        470        480 
TFAMVCFRLL PPTTVKVCGE NGVHQNGNGV IAVLRNENEE LVLANKLNQV YLRQVKATGS 

       490        500        510        520        530 
VYMTHAVVGG VYMIRFAVGS TLTEERHVIH AWEVLQEHAD LILSKFDEAN FSS 

« Hide

References

[1]"Expression patterns conferred by tyrosine/dihydroxyphenylalanine decarboxylase promoters from opium poppy are conserved in transgenic tobacco."
Facchini P.J., Penzes-Yost C., Samanani N., Kowalchuk B.
Plant Physiol. 118:69-81(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
Strain: cv. Marianne.
Tissue: Leaf.
[2]"Differential and tissue-specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy."
Facchini P.J., de Luca V.
J. Biol. Chem. 269:26684-26690(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 175-533.
Strain: cv. Marianne.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF025431 Genomic DNA. Translation: AAC61840.1.
U08599 mRNA. Translation: AAA62348.1.
PIRC55066.
T07970.

3D structure databases

ProteinModelPortalP54770.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSPR00800. YHDCRBOXLASE.
SUPFAMSSF53383. SSF53383. 2 hits.
PROSITEPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYDC3_PAPSO
AccessionPrimary (citable) accession number: P54770
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 13, 2002
Last modified: April 16, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families