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P54770

- TYDC3_PAPSO

UniProt

P54770 - TYDC3_PAPSO

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Protein

Tyrosine/DOPA decarboxylase 3

Gene

TYDC3

Organism
Papaver somniferum (Opium poppy)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Marginally higher substrate specificity for L-DOPA over L-tyrosine.

Catalytic activityi

L-tyrosine = tyramine + CO2.
L-dopa = dopamine + CO2.
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactori

Pyridoxal phosphate.

GO - Molecular functioni

  1. aromatic-L-amino-acid decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
  3. tyrosine decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine/DOPA decarboxylase 3
Including the following 2 domains:
DOPA decarboxylase (EC:4.1.1.28)
Short name:
DDC
Tyrosine decarboxylase (EC:4.1.1.25)
Gene namesi
Name:TYDC3
OrganismiPapaver somniferum (Opium poppy)
Taxonomic identifieri3469 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsRanunculalesPapaveraceaePapaveroideaePapaver

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Tyrosine/DOPA decarboxylase 3PRO_0000147001Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei319 – 3191N6-(pyridoxal phosphate)lysineBy similarity

Expressioni

Tissue specificityi

Roots.1 Publication

Developmental stagei

Seedlings and mature plants.1 Publication

Inductioni

By fungal elicitor.1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP54770.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 2 hits.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54770-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSLNTEDVL EHSSAFGATN PLDPEEFRRQ GHMIIDFLAD YYRDVEKYPV
60 70 80 90 100
RSQVEPGYLR KRLPETAPYN PESIETILQD VTSEIIPGLT HWQSPNYYAY
110 120 130 140 150
FPSSGSVAGF LGEMLSTGFN VVGFNWMSSP AATELEGIVM DWFGKMLNLP
160 170 180 190 200
KSYLFSGTGG GVLQGTTCEA ILCTLTAARD RKLNKIGREH IGRLVVYGSD
210 220 230 240 250
QTHCALQKAA QIAGINPKNF RAVKTFKANS FGLAASTLRE VILEDIEAGL
260 270 280 290 300
IPLFVCPTVG TTSSTAVDPI GPICEVAKEY EMWVHIDAAY AGSACICPEF
310 320 330 340 350
RHFIDGVEEA DSFSLNAHKW FFTTLDCCCL WVKDPSSLVK ALSTNPEYLR
360 370 380 390 400
NKATESRQVV DYKDWQIALI RRFRSMKLWM VLRSYGVTNL RNFLRSHVRM
410 420 430 440 450
AKTFEGLVGA DRRFEITVPR TFAMVCFRLL PPTTVKVCGE NGVHQNGNGV
460 470 480 490 500
IAVLRNENEE LVLANKLNQV YLRQVKATGS VYMTHAVVGG VYMIRFAVGS
510 520 530
TLTEERHVIH AWEVLQEHAD LILSKFDEAN FSS
Length:533
Mass (Da):59,520
Last modified:August 13, 2002 - v2
Checksum:iEAC9C271D77CDC22
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF025431 Genomic DNA. Translation: AAC61840.1.
U08599 mRNA. Translation: AAA62348.1.
PIRiC55066.
T07970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF025431 Genomic DNA. Translation: AAC61840.1 .
U08599 mRNA. Translation: AAA62348.1 .
PIRi C55066.
T07970.

3D structure databases

ProteinModelPortali P54770.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
InterProi IPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
PRINTSi PR00800. YHDCRBOXLASE.
SUPFAMi SSF53383. SSF53383. 2 hits.
PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Expression patterns conferred by tyrosine/dihydroxyphenylalanine decarboxylase promoters from opium poppy are conserved in transgenic tobacco."
    Facchini P.J., Penzes-Yost C., Samanani N., Kowalchuk B.
    Plant Physiol. 118:69-81(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    Strain: cv. Marianne.
    Tissue: Leaf.
  2. "Differential and tissue-specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy."
    Facchini P.J., de Luca V.
    J. Biol. Chem. 269:26684-26690(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 175-533.
    Strain: cv. Marianne.

Entry informationi

Entry nameiTYDC3_PAPSO
AccessioniPrimary (citable) accession number: P54770
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 13, 2002
Last modified: October 1, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3