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Protein

Tyrosine/DOPA decarboxylase 2

Gene

TYDC2

Organism
Papaver somniferum (Opium poppy)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Marginally higher substrate specificity for L-DOPA over L-tyrosine.

Catalytic activityi

L-tyrosine = tyramine + CO2.
L-dopa = dopamine + CO2.
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine/DOPA decarboxylase 2
Including the following 2 domains:
DOPA decarboxylase (EC:4.1.1.28)
Short name:
DDC
Tyrosine decarboxylase (EC:4.1.1.25)
Gene namesi
Name:TYDC2
OrganismiPapaver somniferum (Opium poppy)
Taxonomic identifieri3469 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsRanunculalesPapaveraceaePapaveroideaePapaver

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001470001 – 531Tyrosine/DOPA decarboxylase 2Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319N6-(pyridoxal phosphate)lysineBy similarity1

Expressioni

Tissue specificityi

Predominantly expressed in the roots and stems, while a lower level expression is seen in the sepals and carpels of fully expanded flowers.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP54769.
SMRiP54769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiView protein in InterPro
IPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
IPR021115. Pyridoxal-P_BS.
PfamiView protein in Pfam
PF00282. Pyridoxal_deC. 1 hit.
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 2 hits.
PROSITEiView protein in PROSITE
PS00392. DDC_GAD_HDC_YDC. 1 hit.

Sequencei

Sequence statusi: Complete.

P54769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLNTEDVL ENSSAFGVTN PLDPEEFRRQ GHMIIDFLAD YYRDVEKYPV
60 70 80 90 100
RSQVEPGYLR KRLPETAPYN PESIETILQD VTTEIIPGLT HWQSPNYYAY
110 120 130 140 150
FPSSGSVAGF LGEMLSTGFN VVGFNWMSSP AATELESVVM DWFGKMLNLP
160 170 180 190 200
ESFLFSGSGG GVLQGTSCEA ILCTLTAARD RKLNKIGREH IGRLVVYGSD
210 220 230 240 250
QTHCALQKAA QVAGINPKNF RAIKTFKENS FGLSAATLRE VILEDIEAGL
260 270 280 290 300
IPLFVCPTVG TTSSTAVDPI SPICEVAKEY EMWVHVDAAY AGSACICPEF
310 320 330 340 350
RHFIDGVEEA DSFSLNAHKW FFTTLDCCCL WVKDPSALVK ALSTNPEYLR
360 370 380 390 400
NKATESRQVV DYKDWQIALS RRFRSLKLWM VLRSYGVTNL RNFLRSHVKM
410 420 430 440 450
AKTFEGLICM DGRFEITVPR TFAMVCFRLL PPKTIKVYDN GVHQNGNGVV
460 470 480 490 500
PLRDENENLV LANKLNQVYL ETVNATGSVY MTHAVVGGVY MIRFAVGSTL
510 520 530
TEERHVIYAW KILQEHADLI LGKFSEADFS S
Length:531
Mass (Da):59,362
Last modified:October 1, 1996 - v1
Checksum:iDCE9DB9264250581
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08598 mRNA. Translation: AAA62347.1.
PIRiB55066.

Similar proteinsi

Entry informationi

Entry nameiTYDC2_PAPSO
AccessioniPrimary (citable) accession number: P54769
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 12, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families