P54769 (TYDC2_PAPSO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine/DOPA decarboxylase 2

Including the following 2 domains:

1. DOPA decarboxylase
   Short name=DDC
   EC=4.1.1.28
2. Tyrosine decarboxylase
   EC=4.1.1.25

Gene names

Name:

TYDC2

Organism

Papaver somniferum (Opium poppy)

Taxonomic identifier

3469 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › stem eudicotyledons › Ranunculales › Papaveraceae › Papaver

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Marginally higher substrate specificity for L-DOPA over L-tyrosine.
Catalytic activity	L-tyrosine = tyramine + CO2. L-dopa = dopamine + CO2. 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.
Cofactor	Pyridoxal phosphate.
Subunit structure	Homodimer By similarity.
Tissue specificity	Predominantly expressed in the roots and stems, while a lower level expression is seen in the sepals and carpels of fully expanded flowers.
Sequence similarities	Belongs to the group II decarboxylase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological_process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	aromatic-L-amino-acid decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro tyrosine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 531	531	Tyrosine/DOPA decarboxylase 2		PRO_0000147000
Amino acid modifications
	Modified residue	319	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P54769 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: DCE9DB9264250581	FASTA	531	59,362
	10 20 30 40 50 60 MGSLNTEDVL ENSSAFGVTN PLDPEEFRRQ GHMIIDFLAD YYRDVEKYPV RSQVEPGYLR 70 80 90 100 110 120 KRLPETAPYN PESIETILQD VTTEIIPGLT HWQSPNYYAY FPSSGSVAGF LGEMLSTGFN 130 140 150 160 170 180 VVGFNWMSSP AATELESVVM DWFGKMLNLP ESFLFSGSGG GVLQGTSCEA ILCTLTAARD 190 200 210 220 230 240 RKLNKIGREH IGRLVVYGSD QTHCALQKAA QVAGINPKNF RAIKTFKENS FGLSAATLRE 250 260 270 280 290 300 VILEDIEAGL IPLFVCPTVG TTSSTAVDPI SPICEVAKEY EMWVHVDAAY AGSACICPEF 310 320 330 340 350 360 RHFIDGVEEA DSFSLNAHKW FFTTLDCCCL WVKDPSALVK ALSTNPEYLR NKATESRQVV 370 380 390 400 410 420 DYKDWQIALS RRFRSLKLWM VLRSYGVTNL RNFLRSHVKM AKTFEGLICM DGRFEITVPR 430 440 450 460 470 480 TFAMVCFRLL PPKTIKVYDN GVHQNGNGVV PLRDENENLV LANKLNQVYL ETVNATGSVY 490 500 510 520 530 MTHAVVGGVY MIRFAVGSTL TEERHVIYAW KILQEHADLI LGKFSEADFS S

References

[1]	"Differential and tissue-specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy." Facchini P.J., de Luca V. J. Biol. Chem. 269:26684-26690(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Marianne.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U08598 mRNA. Translation: AAA62347.1.
PIR	B55066.
3D structure databases
ProteinModelPortal	P54769.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR010977. Aromatic_deC. IPR002129. PyrdxlP-dep_de-COase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. IPR021115. Pyridoxal-P_BS. [Graphical view]
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
PRINTS	PR00800. YHDCRBOXLASE.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00392. DDC_GAD_HDC_YDC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYDC2_PAPSO

Accession

Primary (citable) accession number: P54769

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program