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P54768

- TYDC1_PAPSO

UniProt

P54768 - TYDC1_PAPSO

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Protein

Tyrosine/DOPA decarboxylase 1

Gene

TYDC1

Organism
Papaver somniferum (Opium poppy)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Marginally higher substrate specificity for L-DOPA over L-tyrosine.

Catalytic activityi

L-tyrosine = tyramine + CO2.
L-dopa = dopamine + CO2.
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactori

GO - Molecular functioni

  1. aromatic-L-amino-acid decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
  3. tyrosine decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.25. 4515.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine/DOPA decarboxylase 1
Including the following 2 domains:
DOPA decarboxylase (EC:4.1.1.28)
Short name:
DDC
Tyrosine decarboxylase (EC:4.1.1.25)
Gene namesi
Name:TYDC1
OrganismiPapaver somniferum (Opium poppy)
Taxonomic identifieri3469 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsRanunculalesPapaveraceaePapaveroideaePapaver

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Tyrosine/DOPA decarboxylase 1PRO_0000146999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei321 – 3211N6-(pyridoxal phosphate)lysineBy similarity

Expressioni

Tissue specificityi

Predominantly expressed in the roots.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP54768.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54768-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSLPANNFE SMSLCSQNPL DPDEFRRQGH MIIDFLADYY KNVEKYPVRT
60 70 80 90 100
QVDPGYLKKR LPESAPYNPE SIETILEDVT NDIIPGLTHW QSPNYFAYFP
110 120 130 140 150
SSGSIAGFLG EMLSTGFNVV GFNWMSSPAA TELESIVMNW LGQMLTLPKS
160 170 180 190 200
FLFSSDGSSG GGGVLQGTTC EAILCTLTAA RDKMLNKIGR ENINKLVVYA
210 220 230 240 250
SDQTLSALQK AAQIAGINPK NFLAIATSKA TNFGLSPNSL QSTILADIES
260 270 280 290 300
GLVPLFLCAT VGTTSSTAVD PIGPLCAVAK LHGIWVHIDA AYAGSACICP
310 320 330 340 350
EFRHFIDGVE DADSFSLNAH KWFFTTLDCC CLWVKDSDSL VKALSTSPEY
360 370 380 390 400
LKNKATDSKQ VIDYKDWQIA LSRRFRSMKL WLVLRSYGIA NLRTFLRSHV
410 420 430 440 450
KMAKHFQGLI GMDNRFEIVV PRTFAMVCFR LKPAAIFRKK IVEDDHIEAQ
460 470 480 490 500
TNEVNAKLLE SVNASGKIYM THAVVGGVYM IRFAVGATLT EERHVTGAWK
510
VVQEHTDAIL GALGEDVC
Length:518
Mass (Da):57,020
Last modified:October 1, 1996 - v1
Checksum:iE63A53B45ECF2702
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08597 Genomic DNA. Translation: AAA62346.1.
PIRiA55066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08597 Genomic DNA. Translation: AAA62346.1 .
PIRi A55066.

3D structure databases

ProteinModelPortali P54768.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 4.1.1.25. 4515.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
PRINTSi PR00800. YHDCRBOXLASE.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Differential and tissue-specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy."
    Facchini P.J., de Luca V.
    J. Biol. Chem. 269:26684-26690(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Marianne.

Entry informationi

Entry nameiTYDC1_PAPSO
AccessioniPrimary (citable) accession number: P54768
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3