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P54768 (TYDC1_PAPSO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine/DOPA decarboxylase 1

Including the following 2 domains:

  1. DOPA decarboxylase
    Short name=DDC
    EC=4.1.1.28
  2. Tyrosine decarboxylase
    EC=4.1.1.25
Gene names
Name:TYDC1
OrganismPapaver somniferum (Opium poppy)
Taxonomic identifier3469 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsRanunculalesPapaveraceaePapaveroideaePapaver

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Marginally higher substrate specificity for L-DOPA over L-tyrosine.

Catalytic activity

L-tyrosine = tyramine + CO2.

L-dopa = dopamine + CO2.

5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

Cofactor

Pyridoxal phosphate.

Subunit structure

Homodimer By similarity.

Tissue specificity

Predominantly expressed in the roots.

Sequence similarities

Belongs to the group II decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Tyrosine/DOPA decarboxylase 1
PRO_0000146999

Amino acid modifications

Modified residue3211N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P54768 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E63A53B45ECF2702

FASTA51857,020
        10         20         30         40         50         60 
MGSLPANNFE SMSLCSQNPL DPDEFRRQGH MIIDFLADYY KNVEKYPVRT QVDPGYLKKR 

        70         80         90        100        110        120 
LPESAPYNPE SIETILEDVT NDIIPGLTHW QSPNYFAYFP SSGSIAGFLG EMLSTGFNVV 

       130        140        150        160        170        180 
GFNWMSSPAA TELESIVMNW LGQMLTLPKS FLFSSDGSSG GGGVLQGTTC EAILCTLTAA 

       190        200        210        220        230        240 
RDKMLNKIGR ENINKLVVYA SDQTLSALQK AAQIAGINPK NFLAIATSKA TNFGLSPNSL 

       250        260        270        280        290        300 
QSTILADIES GLVPLFLCAT VGTTSSTAVD PIGPLCAVAK LHGIWVHIDA AYAGSACICP 

       310        320        330        340        350        360 
EFRHFIDGVE DADSFSLNAH KWFFTTLDCC CLWVKDSDSL VKALSTSPEY LKNKATDSKQ 

       370        380        390        400        410        420 
VIDYKDWQIA LSRRFRSMKL WLVLRSYGIA NLRTFLRSHV KMAKHFQGLI GMDNRFEIVV 

       430        440        450        460        470        480 
PRTFAMVCFR LKPAAIFRKK IVEDDHIEAQ TNEVNAKLLE SVNASGKIYM THAVVGGVYM 

       490        500        510 
IRFAVGATLT EERHVTGAWK VVQEHTDAIL GALGEDVC 

« Hide

References

[1]"Differential and tissue-specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy."
Facchini P.J., de Luca V.
J. Biol. Chem. 269:26684-26690(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Marianne.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U08597 Genomic DNA. Translation: AAA62346.1.
PIRA55066.

3D structure databases

ProteinModelPortalP54768.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA4.1.1.25. 4515.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
PRINTSPR00800. YHDCRBOXLASE.
SUPFAMSSF53383. SSF53383. 1 hit.
PROSITEPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYDC1_PAPSO
AccessionPrimary (citable) accession number: P54768
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families