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P54768

- TYDC1_PAPSO

UniProt

P54768 - TYDC1_PAPSO

Protein

Tyrosine/DOPA decarboxylase 1

Gene

TYDC1

Organism
Papaver somniferum (Opium poppy)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Marginally higher substrate specificity for L-DOPA over L-tyrosine.

    Catalytic activityi

    L-tyrosine = tyramine + CO2.
    L-dopa = dopamine + CO2.
    5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2.

    Cofactori

    Pyridoxal phosphate.

    GO - Molecular functioni

    1. aromatic-L-amino-acid decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro
    3. tyrosine decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BRENDAi4.1.1.25. 4515.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine/DOPA decarboxylase 1
    Including the following 2 domains:
    DOPA decarboxylase (EC:4.1.1.28)
    Short name:
    DDC
    Tyrosine decarboxylase (EC:4.1.1.25)
    Gene namesi
    Name:TYDC1
    OrganismiPapaver somniferum (Opium poppy)
    Taxonomic identifieri3469 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsRanunculalesPapaveraceaePapaveroideaePapaver

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518Tyrosine/DOPA decarboxylase 1PRO_0000146999Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei321 – 3211N6-(pyridoxal phosphate)lysineBy similarity

    Expressioni

    Tissue specificityi

    Predominantly expressed in the roots.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP54768.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.Curated

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010977. Aromatic_deC.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    PRINTSiPR00800. YHDCRBOXLASE.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54768-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLPANNFE SMSLCSQNPL DPDEFRRQGH MIIDFLADYY KNVEKYPVRT    50
    QVDPGYLKKR LPESAPYNPE SIETILEDVT NDIIPGLTHW QSPNYFAYFP 100
    SSGSIAGFLG EMLSTGFNVV GFNWMSSPAA TELESIVMNW LGQMLTLPKS 150
    FLFSSDGSSG GGGVLQGTTC EAILCTLTAA RDKMLNKIGR ENINKLVVYA 200
    SDQTLSALQK AAQIAGINPK NFLAIATSKA TNFGLSPNSL QSTILADIES 250
    GLVPLFLCAT VGTTSSTAVD PIGPLCAVAK LHGIWVHIDA AYAGSACICP 300
    EFRHFIDGVE DADSFSLNAH KWFFTTLDCC CLWVKDSDSL VKALSTSPEY 350
    LKNKATDSKQ VIDYKDWQIA LSRRFRSMKL WLVLRSYGIA NLRTFLRSHV 400
    KMAKHFQGLI GMDNRFEIVV PRTFAMVCFR LKPAAIFRKK IVEDDHIEAQ 450
    TNEVNAKLLE SVNASGKIYM THAVVGGVYM IRFAVGATLT EERHVTGAWK 500
    VVQEHTDAIL GALGEDVC 518
    Length:518
    Mass (Da):57,020
    Last modified:October 1, 1996 - v1
    Checksum:iE63A53B45ECF2702
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U08597 Genomic DNA. Translation: AAA62346.1.
    PIRiA55066.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U08597 Genomic DNA. Translation: AAA62346.1 .
    PIRi A55066.

    3D structure databases

    ProteinModelPortali P54768.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 4.1.1.25. 4515.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010977. Aromatic_deC.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    PRINTSi PR00800. YHDCRBOXLASE.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential and tissue-specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy."
      Facchini P.J., de Luca V.
      J. Biol. Chem. 269:26684-26690(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Marianne.

    Entry informationi

    Entry nameiTYDC1_PAPSO
    AccessioniPrimary (citable) accession number: P54768
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3