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P54767

- DCE_SOLLC

UniProt

P54767 - DCE_SOLLC

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Protein

Glutamate decarboxylase

Gene
N/A
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis (By similarity).By similarity

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

Pyridoxal phosphate.

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: EnsemblPlants/Gramene

GO - Biological processi

  1. glutamate metabolic process Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Calmodulin-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15560.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase (EC:4.1.1.15)
Short name:
GAD
Alternative name(s):
ERT D1
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. plasmodesma Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Glutamate decarboxylasePRO_0000146975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

ProMEXiP54767.

Structurei

3D structure databases

ProteinModelPortaliP54767.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni471 – 50232Calmodulin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

KOiK01580.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

P54767-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLTTTSIRD SEESLHCTFA SRYVQEPLPK FKMPKKSMPK EAAYQIVNDE
60 70 80 90 100
LMLDGNPRLN LASFVSTWME PECDKLIMSS INKNYVDMDE YPVTTELQNR
110 120 130 140 150
CVNMLAHLFH APVGDDETAV GVGTVGSSEA IMLAGLAFKR KWQSKRKAEG
160 170 180 190 200
KPFDKPNIVT GANVQVCWEK FARYFEVELK EVKLKEGYYV MDPAKAVEIV
210 220 230 240 250
DENTICVAAI LGSTLTGEFE DVKLLNELLT KKNKETGWET PIHVDAASGG
260 270 280 290 300
FIAPFLWPDL EWDFRLPLVK SINVSGHKYG LVYAGVGWVI WRSKEDLPDE
310 320 330 340 350
LVFHINYLGS DQPTFTLNFS KGSYQIIAQY YQLIRLGFEG YKNVMKNCLS
360 370 380 390 400
NAKVLTEGIT KMGRFDIVSK DVGVPVVAFS LRDSSKYTVF EVSEHLRRFG
410 420 430 440 450
WIVPAYTMPP DAEHIAVLRV VIREDFSHSL AERLVSDIEK ILSELDTQPP
460 470 480 490 500
RLPTKAVRVT AEEVRDDKGD GLHHFHMDTV ETQKDIIKHW RKIAGKKTSG

VC
Length:502
Mass (Da):56,785
Last modified:October 1, 1996 - v1
Checksum:i1C5F9BD0084272A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80840 mRNA. Translation: CAA56812.1.
PIRiS56177.
RefSeqiNP_001234041.1. NM_001247112.1.
UniGeneiLes.21402.
Les.249.

Genome annotation databases

GeneIDi544313.
KEGGisly:544313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80840 mRNA. Translation: CAA56812.1 .
PIRi S56177.
RefSeqi NP_001234041.1. NM_001247112.1.
UniGenei Les.21402.
Les.249.

3D structure databases

ProteinModelPortali P54767.
ModBasei Search...
MobiDBi Search...

Proteomic databases

ProMEXi P54767.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 544313.
KEGGi sly:544313.

Phylogenomic databases

KOi K01580.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-15560.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "A role for glutamate decarboxylase during tomato ripening: the characterisation of a cDNA encoding a putative glutamate decarboxylase with a calmodulin-binding site."
    Gallego P.P., Whotton L., Picton S., Grierson D., Gray J.E.
    Plant Mol. Biol. 27:1143-1151(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Ailsa Craig.
    Tissue: Pericarp.

Entry informationi

Entry nameiDCE_SOLLC
AccessioniPrimary (citable) accession number: P54767
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3