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P54767

- DCE_SOLLC

UniProt

P54767 - DCE_SOLLC

Protein

Glutamate decarboxylase

Gene
N/A
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the production of GABA. The calmodulin-binding is calcium-dependent and it is proposed that this may, directly or indirectly, form a calcium regulated control of GABA biosynthesis By similarity.By similarity

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.

    Cofactori

    Pyridoxal phosphate.

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Ligandi

    Calmodulin-binding, Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-15560.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylase (EC:4.1.1.15)
    Short name:
    GAD
    Alternative name(s):
    ERT D1
    OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
    Taxonomic identifieri4081 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
    ProteomesiUP000004994: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. plasmodesma Source: EnsemblPlants/Gramene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Glutamate decarboxylasePRO_0000146975Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei278 – 2781N6-(pyridoxal phosphate)lysineBy similarity

    Proteomic databases

    ProMEXiP54767.

    Structurei

    3D structure databases

    ProteinModelPortaliP54767.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni471 – 50232Calmodulin-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.Curated

    Phylogenomic databases

    KOiK01580.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P54767-1 [UniParc]FASTAAdd to Basket

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    MVLTTTSIRD SEESLHCTFA SRYVQEPLPK FKMPKKSMPK EAAYQIVNDE    50
    LMLDGNPRLN LASFVSTWME PECDKLIMSS INKNYVDMDE YPVTTELQNR 100
    CVNMLAHLFH APVGDDETAV GVGTVGSSEA IMLAGLAFKR KWQSKRKAEG 150
    KPFDKPNIVT GANVQVCWEK FARYFEVELK EVKLKEGYYV MDPAKAVEIV 200
    DENTICVAAI LGSTLTGEFE DVKLLNELLT KKNKETGWET PIHVDAASGG 250
    FIAPFLWPDL EWDFRLPLVK SINVSGHKYG LVYAGVGWVI WRSKEDLPDE 300
    LVFHINYLGS DQPTFTLNFS KGSYQIIAQY YQLIRLGFEG YKNVMKNCLS 350
    NAKVLTEGIT KMGRFDIVSK DVGVPVVAFS LRDSSKYTVF EVSEHLRRFG 400
    WIVPAYTMPP DAEHIAVLRV VIREDFSHSL AERLVSDIEK ILSELDTQPP 450
    RLPTKAVRVT AEEVRDDKGD GLHHFHMDTV ETQKDIIKHW RKIAGKKTSG 500
    VC 502
    Length:502
    Mass (Da):56,785
    Last modified:October 1, 1996 - v1
    Checksum:i1C5F9BD0084272A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80840 mRNA. Translation: CAA56812.1.
    PIRiS56177.
    RefSeqiNP_001234041.1. NM_001247112.1.
    UniGeneiLes.21402.
    Les.249.

    Genome annotation databases

    GeneIDi544313.
    KEGGisly:544313.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80840 mRNA. Translation: CAA56812.1 .
    PIRi S56177.
    RefSeqi NP_001234041.1. NM_001247112.1.
    UniGenei Les.21402.
    Les.249.

    3D structure databases

    ProteinModelPortali P54767.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    ProMEXi P54767.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 544313.
    KEGGi sly:544313.

    Phylogenomic databases

    KOi K01580.

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-15560.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A role for glutamate decarboxylase during tomato ripening: the characterisation of a cDNA encoding a putative glutamate decarboxylase with a calmodulin-binding site."
      Gallego P.P., Whotton L., Picton S., Grierson D., Gray J.E.
      Plant Mol. Biol. 27:1143-1151(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Ailsa Craig.
      Tissue: Pericarp.

    Entry informationi

    Entry nameiDCE_SOLLC
    AccessioniPrimary (citable) accession number: P54767
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3