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Reviewed, UniProtKB/Swiss-Prot P54759 (EPHA7_RAT)

Last modified February 9, 2010. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ephrin type-A receptor 7
    EC=2.7.10.1
Alternative name(s):
    EPH homology kinase 3
      Short name=EHK-3
Gene names
Name: Epha7
Synonyms: Ehk-3, Ehk3
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length998 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Interacts with PRKCABP and GRIP1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Restricted to the nervous system.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

Contains 2 fibronectin type-III domains.

Contains 1 protein kinase domain.

Contains 1 SAM (sterile alpha motif) domain.

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P54759-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: More widely expressed in the embryo.
Isoform Short (identifier: P54759-2)

The sequence of this isoform differs from the canonical sequence as follows:
     600-610: FKFPGTKTYID → SLVTNEHLSVL
Note: Lacks the kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 998974Ephrin type-A receptor 7
PRO_0000016820

Regions

Topological domain25 – 556532Extracellular Potential
Transmembrane557 – 57721 Potential
Topological domain578 – 998421Cytoplasmic Potential
Domain331 – 433103Fibronectin type-III 1
Domain443 – 53593Fibronectin type-III 2
Domain633 – 894262Protein kinase
Domain923 – 98765SAM
Nucleotide binding639 – 6479ATP By similarity
Motif996 – 9983PDZ-binding Potential
Compositional bias192 – 328137Cys-rich

Sites

Active site7581Proton acceptor By similarity
Binding site6651ATP By similarity

Amino acid modifications

Modified residue6081Phosphotyrosine; by autocatalysis Potential
Modified residue6141Phosphotyrosine; by autocatalysis Potential
Modified residue7911Phosphotyrosine; by autocatalysis Potential
Modified residue9401Phosphotyrosine; by autocatalysis Potential
Glycosylation3431N-linked (GlcNAc...) Potential
Glycosylation4101N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence600 – 61011FKFPGTKTYID → SLVTNEHLSVL in isoform Short.
VSP_003012

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Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: A7A82A698924876C

FASTA998111,953
        10         20         30         40         50         60 
MVVQTRYPSW IILCYIWLLG FAHTGEAQAA KEVLLLDSKA QQTELEWISS PPSGWEEISG 

        70         80         90        100        110        120 
LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV ELKFTLRDCN SLPGVLGTCK 

       130        140        150        160        170        180 
ETFNLYYYET DYDTGRNIRE NLYVKIDTIA ADESFTQGDL GERKMKLNTE VREIGPLSKK 

       190        200        210        220        230        240 
GFYLAFQDVG ACIALVSVKV YYKKCWSIIE NLAVFPDTVT GSEFSSLVEV RGTCVSSAEE 

       250        260        270        280        290        300 
EAENSPRMHC SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RRFYKSSSQD LQCSRCPTHS 

       310        320        330        340        350        360 
FSDREGSSRC ECEDGYYRAP SDPPYVACTR PPSAPQNLIF NINQTTVSLE WSPPADNGGR 

       370        380        390        400        410        420 
NDVTYRILCK RCSWEQGECV PCGSNIGYMP QQTGLEDNYV TVMDLLAHAN YTFEVEAVNG 

       430        440        450        460        470        480 
VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM KERVLQRSVE LSWQEPEHPN GVITEYEIKY 

       490        500        510        520        530        540 
YEKDQRERTY STLKTKSTSA SINNLKPGTV YVFQIRAFTA AGYGNYSPRL DVATLEEASG 

       550        560        570        580        590        600 
KMFEATAVSS EQNPVIIIAV VAVAGTIILV FMVFGFIIGR RHCGYSKADQ EGDEELYFHF 

       610        620        630        640        650        660 
KFPGTKTYID PETYEDPNRA VHQFAKELDA SCIKIERVIG AGEFGEVCSG RLKLPGKRDV 

       670        680        690        700        710        720 
AVAIKTLKVG YTEKQRRDFL CEASIMGQFD HPNVVHLEGV VTRGKPVMIV IEFMENGALD 

       730        740        750        760        770        780 
AFLRKHDGQF TVIQLVGMLR GIAAGMRYLA DMGYVHRDLA ARNILVNSNL VCKVSDFGLS 

       790        800        810        820        830        840 
RVIEDDPEAV YTTTGGKIPV RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM 

       850        860        870        880        890        900 
SNQDVIKAIE EGYRLPAPMD CPAGLHQLML DCWQKERAER PKFEQIVGIL DKMIRNPSSL 

       910        920        930        940        950        960 
KTPLGTCSRP ISPLLDQSTP DFTAFCSVGE WLQAIKMERY KDNFTAAGYN SLESVARMTI 

       970        980        990 
DDVMSLGITL VGHQKKIMSS IQTMRAQMLH LHGTGIQV

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Isoform Short.

Checksum: B87536EA0D7CB919
Show »

FASTA998111,848

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References

[1]"Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family."
Valenzuela D.M., Rojas E., Griffiths J.A., Compton D.L., Gisser M., Ip N.Y., Goldfarb M., Yancopoulos G.D.
Oncogene 10:1573-1580(1995) [PubMed: 7731712] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U21954 mRNA. Translation: AAA86830.1.
U21955 mRNA. Translation: AAA86831.1.
IPIIPI00188223.
IPI00231026.
RefSeqNP_599158.1.
UniGeneRn.10181

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP54759. 3 interactions.
STRINGP54759.

PTM databases

PhosphoSiteP54759.

Genome annotation databases

EnsemblENSRNOT00000009899; ENSRNOP00000009899; ENSRNOG00000007030; Rattus norvegicus. [Genome view]
GeneID171287.
KEGGrno:171287.
UCSCNM_134331. rat.

Organism-specific databases

CTD171287.
RGD70957. Epha7.

Phylogenomic databases

eggNOGmaNOG08784.
HOVERGENP54759.
InParanoidP54759.
OMAAGYQQKG.
PhylomeDBP54759.

Enzyme and pathway databases

BRENDA2.7.10.1. 248.

Gene expression databases

ArrayExpressP54759.
GenevestigatorP54759.
GermOnlineENSRNOG00000007030. Rattus norvegicus.

Family and domain databases

InterProIPR001090. Ephrin_rcpt_lig-bd.
IPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR003962. FnIII_subd.
IPR008979. Galactose-bd-like.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR010993. SAM_homology.
IPR013761. SAM_type.
IPR021129. SAM_type1.
IPR020635. Tyr_Pkinase_cat_dom.
IPR020685. Tyr_prot_kinase.
IPR008266. Tyr_prot_kinase_AS.
IPR016257. Tyr_prot_kinase_ephrin_rcpt.
IPR001426. Tyr_prot_kinase_rcpt_V_CS.
[Graphical view]
Gene3DG3DSA:2.60.40.30. FN_III-like. 2 hits.
G3DSA:1.10.150.50. SAM_type. 1 hit.
PANTHERPTHR23256. Tyr_prot_kinase. 1 hit.
PfamPF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSPR00014. FNTYPEIII.
SMARTSM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS01186. EGF_2. 1 hit. Uncertain.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio622031.

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Entry information

Entry nameEPHA7_RAT
AccessionPrimary (citable) accession number: P54759
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 9, 2010
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents