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Protein

Ephrin type-A receptor 6

Gene

Epha6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei662ATPPROSITE-ProRule annotation1
Active sitei797Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi636 – 644ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ephrin type-A receptor 6 (EC:2.7.10.1)
Alternative name(s):
EPH homology kinase 2
Short name:
EHK-2
Gene namesi
Name:Epha6
Synonyms:Ehk-2, Ehk2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1304614. Epha6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 549ExtracellularSequence analysisAdd BLAST527
Transmembranei550 – 570HelicalSequence analysisAdd BLAST21
Topological domaini571 – 1035CytoplasmicSequence analysisAdd BLAST465

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001681723 – 1035Ephrin type-A receptor 6Add BLAST1013

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi342N-linked (GlcNAc...)Sequence analysis1
Glycosylationi396N-linked (GlcNAc...)Sequence analysis1
Glycosylationi409N-linked (GlcNAc...)Sequence analysis1
Modified residuei605Phosphotyrosine; by autocatalysisSequence analysis1
Modified residuei611Phosphotyrosine; by autocatalysisSequence analysis1
Modified residuei830Phosphotyrosine; by autocatalysisSequence analysis1
Modified residuei977Phosphotyrosine; by autocatalysisSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP54758.

PTM databases

iPTMnetiP54758.
PhosphoSitePlusiP54758.

Expressioni

Tissue specificityi

Brain.

Interactioni

Subunit structurei

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP54758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 211Eph LBDPROSITE-ProRule annotationAdd BLAST179
Domaini330 – 440Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST111
Domaini441 – 536Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini630 – 943Protein kinasePROSITE-ProRule annotationAdd BLAST314
Domaini960 – 1024SAMPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1033 – 1035PDZ-bindingSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi193 – 327Cys-richAdd BLAST135

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
Contains 1 Eph LBD (Eph ligand-binding) domain.PROSITE-ProRule annotation
Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiP54758.
PhylomeDBiP54758.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 2 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P54758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGCEVREFL LQFGFFLPLL TAWTGDCSHV SNQVVLLDTS TVMGELGWKT
60 70 80 90 100
YPLNGWDAIT EMDEHNRPIH TYQVCNVMEP NQNNWLRTNW ISRDAAQKIY
110 120 130 140 150
VEMKFTLRDC NSIPWVLGTC KETFTLYYIE SDESHGTKFK PSQYIKIDTI
160 170 180 190 200
AADESFTQMD LGDRILKLNT EVREVGPIER KGFYLAFQDI GACIALVSVR
210 220 230 240 250
VFYKKCPFTV RNLAMFPDTI PRVDSSSLVE VRGSCVKSSE ERDTPKLYCG
260 270 280 290 300
ADGDWLVPLG RCICTTGYEE IEGSCHACRP GFYKAFAGNT KCSKCPPHSS
310 320 330 340 350
TFVEATSVCH CEKGYFRAEK DPPSMACTRP PSAPRNVAFN INETALILEW
360 370 380 390 400
SPPSDTGGRK DLTYSVICKK CGVDASQCED CGAGLRFIPR PTGLINNSVV
410 420 430 440 450
VLDFVSHVNY TFEIEAMNGV SELSISPKPF TAITVTTDQD APSLIGMMRK
460 470 480 490 500
DWASQNSLAL SWQAPAFSNG AILDYEIKYY EKEHEQLTYS STRSKAPSVI
510 520 530 540 550
ITGLKPATTY IFHIRVRTAT GYSGYSQKFE FETGDETSDM AAEQGQILVI
560 570 580 590 600
ATAAVGGFTL LVILTLFFLI TGRCQWYIKA KMKSEEKRRT HLQNSHLRFP
610 620 630 640 650
GIKTYIDPDT YEDPSLAVHE FEKEIDPSRI RIERVIGAGE FGEVCSGRLK
660 670 680 690 700
TPGKREIPVA IKTLKGGHMD RQRRDFLREA SIMGQFDHPN IIRLEGVVTK
710 720 730 740 750
RSFPAIGVEA FCPSFLRAGF LNGIQAPHPV TAGGSLPPRI PAGRPVMIVV
760 770 780 790 800
EYMENGSLDS FLRKHDGHFT VIQLVGMLRG IASGMKYLSD MGYVHRDLAA
810 820 830 840 850
RNILVNSNLV CKVSDFGLSR VLEDDPEAAY TTTGGKIPIR WTAPEAIAYR
860 870 880 890 900
KFSSASDVWS YGIVMWEVMS YGERPYWEMS NQDVILSIEE GYRLPAPMGC
910 920 930 940 950
PPSLHQLMLH CWQKERNHRP KFTDIVSFLD KLIRNPSALH TLVEDILVMP
960 970 980 990 1000
ESPGDVPEYP LFVTVGDWLD SIKMGQYKSN FMAAGFTTFD LISRMSIEDI
1010 1020 1030
RRIGVILIGH QRRIVSSIQT LRLHMMHIQE KGFHV
Length:1,035
Mass (Da):116,209
Last modified:May 16, 2006 - v2
Checksum:i5ADEDB20A8B5AD95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03078339 Genomic DNA. No translation available.
AABR03079251 Genomic DNA. No translation available.
AABR03078729 Genomic DNA. No translation available.
AABR03078861 Genomic DNA. No translation available.
AABR03078320 Genomic DNA. No translation available.
AABR03078411 Genomic DNA. No translation available.
AABR03078368 Genomic DNA. No translation available.
AABR03080204 Genomic DNA. No translation available.
AABR03000001 Genomic DNA. No translation available.
PIRiS51605.

Genome annotation databases

UCSCiRGD:1304614. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03078339 Genomic DNA. No translation available.
AABR03079251 Genomic DNA. No translation available.
AABR03078729 Genomic DNA. No translation available.
AABR03078861 Genomic DNA. No translation available.
AABR03078320 Genomic DNA. No translation available.
AABR03078411 Genomic DNA. No translation available.
AABR03078368 Genomic DNA. No translation available.
AABR03080204 Genomic DNA. No translation available.
AABR03000001 Genomic DNA. No translation available.
PIRiS51605.

3D structure databases

ProteinModelPortaliP54758.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP54758.
PhosphoSitePlusiP54758.

Proteomic databases

PRIDEiP54758.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1304614. rat.

Organism-specific databases

RGDi1304614. Epha6.

Phylogenomic databases

HOGENOMiHOG000233856.
HOVERGENiHBG062180.
InParanoidiP54758.
PhylomeDBiP54758.

Miscellaneous databases

PROiP54758.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di1.10.150.50. 1 hit.
2.60.120.260. 1 hit.
2.60.40.10. 2 hits.
InterProiIPR027936. Eph_TM.
IPR001090. Ephrin_rcpt_lig-bd_dom.
IPR003961. FN3_dom.
IPR008979. Galactose-bd-like.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016257. Tyr_kinase_ephrin_rcpt.
IPR001426. Tyr_kinase_rcpt_V_CS.
[Graphical view]
PfamiPF14575. EphA2_TM. 1 hit.
PF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 2 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00615. EPH_lbd. 1 hit.
SM01411. Ephrin_rec_like. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF49265. SSF49265. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS01186. EGF_2. 1 hit.
PS51550. EPH_LBD. 1 hit.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEPHA6_RAT
AccessioniPrimary (citable) accession number: P54758
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 16, 2006
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.