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P54756

- EPHA5_HUMAN

UniProt

P54756 - EPHA5_HUMAN

Protein

Ephrin type-A receptor 5

Gene

EPHA5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 155 (01 Oct 2014)
      Sequence version 3 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei707 – 7071ATPPROSITE-ProRule annotation
    Active sitei800 – 8001Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi681 – 6899ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ephrin receptor activity Source: UniProtKB
    3. GPI-linked ephrin receptor activity Source: UniProtKB
    4. transmembrane-ephrin receptor activity Source: UniProtKB

    GO - Biological processi

    1. axon guidance Source: UniProtKB
    2. cAMP-mediated signaling Source: UniProtKB
    3. ephrin receptor signaling pathway Source: UniProtKB
    4. hippocampus development Source: UniProtKB
    5. negative regulation of synapse assembly Source: Ensembl
    6. neuron development Source: UniProtKB
    7. positive regulation of CREB transcription factor activity Source: UniProtKB
    8. regulation of actin cytoskeleton organization Source: UniProtKB
    9. regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
    10. regulation of Rac GTPase activity Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Neurogenesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 2681.
    SignaLinkiP54756.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ephrin type-A receptor 5 (EC:2.7.10.1)
    Alternative name(s):
    Brain-specific kinase
    EPH homology kinase 1
    Short name:
    EHK-1
    EPH-like kinase 7
    Short name:
    EK7
    Short name:
    hEK7
    Gene namesi
    Name:EPHA5
    Synonyms:BSK, EHK1, HEK7, TYRO4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:3389. EPHA5.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell projectionaxon By similarity. Cell projectiondendrite 2 Publications

    GO - Cellular componenti

    1. axon Source: UniProtKB-SubCell
    2. dendrite Source: UniProtKB
    3. external side of plasma membrane Source: UniProtKB
    4. integral component of plasma membrane Source: InterPro
    5. neuronal cell body Source: UniProtKB
    6. perinuclear region of cytoplasm Source: UniProtKB
    7. plasma membrane Source: UniProtKB
    8. rough endoplasmic reticulum Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27821.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 10371013Ephrin type-A receptor 5PRO_0000016812Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi369 – 3691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis
    Modified residuei650 – 6501Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei656 – 6561Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei833 – 8331Phosphotyrosine; by autocatalysisSequence Analysis
    Modified residuei982 – 9821Phosphotyrosine; by autocatalysisBy similarity

    Post-translational modificationi

    Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion By similarity.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP54756.
    PaxDbiP54756.
    PRIDEiP54756.

    PTM databases

    PhosphoSiteiP54756.

    Expressioni

    Tissue specificityi

    Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.2 Publications

    Gene expression databases

    ArrayExpressiP54756.
    BgeeiP54756.
    CleanExiHS_EPHA5.
    GenevestigatoriP54756.

    Interactioni

    Subunit structurei

    Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses By similarity.By similarity

    Protein-protein interaction databases

    BioGridi108358. 3 interactions.
    IntActiP54756. 1 interaction.
    MINTiMINT-4722838.
    STRINGi9606.ENSP00000273854.

    Structurei

    Secondary structure

    1
    1037
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi61 – 655
    Turni66 – 683
    Beta strandi76 – 8914
    Beta strandi95 – 1017
    Beta strandi105 – 1073
    Beta strandi111 – 1144
    Beta strandi126 – 13510
    Helixi137 – 1393
    Beta strandi148 – 15710
    Helixi166 – 1683
    Beta strandi172 – 1787
    Beta strandi188 – 1925
    Beta strandi196 – 2027
    Beta strandi207 – 21913
    Beta strandi221 – 23010
    Helixi663 – 6653
    Helixi672 – 6743
    Beta strandi675 – 6839
    Beta strandi685 – 69410
    Beta strandi702 – 7087
    Helixi715 – 72814
    Beta strandi739 – 7435
    Beta strandi745 – 7484
    Beta strandi750 – 7545
    Helixi761 – 7666
    Turni767 – 7704
    Helixi774 – 79320
    Helixi803 – 8053
    Beta strandi806 – 8083
    Beta strandi814 – 8163
    Helixi842 – 8443
    Helixi847 – 8526
    Helixi857 – 87317
    Turni878 – 8814
    Helixi884 – 89310
    Helixi905 – 91410
    Helixi919 – 9213
    Helixi925 – 93612

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2R2PX-ray2.40A653-939[»]
    4ET7X-ray2.60A59-235[»]
    ProteinModelPortaliP54756.
    SMRiP54756. Positions 57-562, 662-940, 966-1026.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP54756.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 573549ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini595 – 1037443CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei574 – 59421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 238179Eph LBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini357 – 467111Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini468 – 56295Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini675 – 936262Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini965 – 102965SAMPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1035 – 10373PDZ-bindingSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi220 – 354135Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation
    Contains 1 Eph LBD (Eph ligand-binding) domain.PROSITE-ProRule annotation
    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG062180.
    InParanoidiP54756.
    KOiK05106.
    OMAiPSLIWRC.
    OrthoDBiEOG7VTDM6.
    PhylomeDBiP54756.
    TreeFamiTF315608.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    InterProiIPR027936. Eph_TM.
    IPR001090. Ephrin_rcpt_lig-bd_dom.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016257. Tyr_kinase_ephrin_rcpt.
    IPR001426. Tyr_kinase_rcpt_V_CS.
    [Graphical view]
    PfamiPF14575. EphA2_TM. 1 hit.
    PF01404. Ephrin_lbd. 1 hit.
    PF00041. fn3. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00615. EPH_lbd. 1 hit.
    SM00060. FN3. 2 hits.
    SM00454. SAM. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    SSF49265. SSF49265. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS01186. EGF_2. 1 hit.
    PS51550. EPH_LBD. 1 hit.
    PS50853. FN3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
    PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: P54756-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRGSGPRGAG RRRPPSGGGD TPITPASLAG CYSAPRRAPL WTCLLLCAAL     50
    RTLLASPSNE VNLLDSRTVM GDLGWIAFPK NGWEEIGEVD ENYAPIHTYQ 100
    VCKVMEQNQN NWLLTSWISN EGASRIFIEL KFTLRDCNSL PGGLGTCKET 150
    FNMYYFESDD QNGRNIKENQ YIKIDTIAAD ESFTELDLGD RVMKLNTEVR 200
    DVGPLSKKGF YLAFQDVGAC IALVSVRVYY KKCPSVVRHL AVFPDTITGA 250
    DSSQLLEVSG SCVNHSVTDE PPKMHCSAEG EWLVPIGKCM CKAGYEEKNG 300
    TCQVCRPGFF KASPHIQSCG KCPPHSYTHE EASTSCVCEK DYFRRESDPP 350
    TMACTRPPSA PRNAISNVNE TSVFLEWIPP ADTGGRKDVS YYIACKKCNS 400
    HAGVCEECGG HVRYLPRQSG LKNTSVMMVD LLAHTNYTFE IEAVNGVSDL 450
    SPGARQYVSV NVTTNQAAPS PVTNVKKGKI AKNSISLSWQ EPDRPNGIIL 500
    EYEIKYFEKD QETSYTIIKS KETTITAEGL KPASVYVFQI RARTAAGYGV 550
    FSRRFEFETT PVFAASSDQS QIPVIAVSVT VGVILLAVVI GVLLSGSCCE 600
    CGCGRASSLC AVAHPSLIWR CGYSKAKQDP EEEKMHFHNG HIKLPGVRTY 650
    IDPHTYEDPN QAVHEFAKEI EASCITIERV IGAGEFGEVC SGRLKLPGKR 700
    ELPVAIKTLK VGYTEKQRRD FLGEASIMGQ FDHPNIIHLE GVVTKSKPVM 750
    IVTEYMENGS LDTFLKKNDG QFTVIQLVGM LRGISAGMKY LSDMGYVHRD 800
    LAARNILINS NLVCKVSDFG LSRVLEDDPE AAYTTRGGKI PIRWTAPEAI 850
    AFRKFTSASD VWSYGIVMWE VVSYGERPYW EMTNQDVIKA VEEGYRLPSP 900
    MDCPAALYQL MLDCWQKERN SRPKFDEIVN MLDKLIRNPS SLKTLVNASC 950
    RVSNLLAEHS PLGSGAYRSV GEWLEAIKMG RYTEIFMENG YSSMDAVAQV 1000
    TLEDLRRLGV TLVGHQKKIM NSLQEMKVQL VNGMVPL 1037
    Length:1,037
    Mass (Da):114,803
    Last modified:September 22, 2009 - v3
    Checksum:i578C2F4D950DE419
    GO
    Isoform 2 (identifier: P54756-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         597-619: SCCECGCGRASSLCAVAHPSLIW → R

    Show »
    Length:1,015
    Mass (Da):112,624
    Checksum:i0C0121184BCE631E
    GO
    Isoform 3 (identifier: P54756-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-69: Missing.
         563-563: F → SV

    Show »
    Length:969
    Mass (Da):107,699
    Checksum:i3038A240682F6E84
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111R → H in CAA64700. (PubMed:9191074)Curated
    Sequence conflicti87 – 871G → D in CAD97914. (PubMed:17974005)Curated
    Sequence conflicti506 – 5061Y → H in CAA64700. (PubMed:9191074)Curated
    Sequence conflicti611 – 6111A → V in CAD97914. (PubMed:17974005)Curated
    Sequence conflicti616 – 6161S → I in CAA64700. (PubMed:9191074)Curated
    Sequence conflicti820 – 8201G → E in CAD97914. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti81 – 811N → T.1 Publication
    Corresponds to variant rs33932471 [ dbSNP | Ensembl ].
    VAR_042138
    Natural varianti235 – 2351S → A.1 Publication
    Corresponds to variant rs55710198 [ dbSNP | Ensembl ].
    VAR_042139
    Natural varianti330 – 3301E → Q.1 Publication
    Corresponds to variant rs56205382 [ dbSNP | Ensembl ].
    VAR_042140
    Natural varianti417 – 4171R → Q in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_042141
    Natural varianti503 – 5031E → K in a lung large cell carcinoma sample; somatic mutation. 1 Publication
    VAR_042142
    Natural varianti506 – 5061Y → C.1 Publication
    Corresponds to variant rs56074660 [ dbSNP | Ensembl ].
    VAR_045912
    Natural varianti582 – 5821G → E in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_042143
    Natural varianti672 – 6721A → T.1 Publication
    Corresponds to variant rs36050417 [ dbSNP | Ensembl ].
    VAR_042144
    Natural varianti673 – 6731S → T.1 Publication
    Corresponds to variant rs56359290 [ dbSNP | Ensembl ].
    VAR_042145
    Natural varianti856 – 8561T → I in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication
    VAR_042146
    Natural varianti959 – 9591H → R.1 Publication
    Corresponds to variant rs56312931 [ dbSNP | Ensembl ].
    VAR_042147
    Natural varianti1032 – 10321N → S in a lung large cell carcinoma sample; somatic mutation. 1 Publication
    VAR_042148

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6969Missing in isoform 3. 1 PublicationVSP_039118Add
    BLAST
    Alternative sequencei563 – 5631F → SV in isoform 3. 1 PublicationVSP_039119
    Alternative sequencei597 – 61923SCCEC…PSLIW → R in isoform 2. CuratedVSP_002999Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95425 mRNA. Translation: CAA64700.1.
    AC018683 Genomic DNA. No translation available.
    AC104137 Genomic DNA. No translation available.
    AC105923 Genomic DNA. No translation available.
    AC115223 Genomic DNA. No translation available.
    BX537946 mRNA. Translation: CAD97914.1.
    L36644 mRNA. Translation: AAA74245.1.
    CCDSiCCDS3513.1. [P54756-1]
    CCDS3514.1. [P54756-2]
    RefSeqiNP_004430.4. NM_004439.6. [P54756-1]
    NP_872272.2. NM_182472.3. [P54756-2]
    UniGeneiHs.654492.

    Genome annotation databases

    EnsembliENST00000273854; ENSP00000273854; ENSG00000145242. [P54756-1]
    ENST00000354839; ENSP00000346899; ENSG00000145242. [P54756-2]
    GeneIDi2044.
    KEGGihsa:2044.
    UCSCiuc003hcx.3. human. [P54756-3]
    uc003hcy.3. human. [P54756-1]
    uc003hcz.3. human. [P54756-2]

    Polymorphism databases

    DMDMi259016353.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95425 mRNA. Translation: CAA64700.1 .
    AC018683 Genomic DNA. No translation available.
    AC104137 Genomic DNA. No translation available.
    AC105923 Genomic DNA. No translation available.
    AC115223 Genomic DNA. No translation available.
    BX537946 mRNA. Translation: CAD97914.1 .
    L36644 mRNA. Translation: AAA74245.1 .
    CCDSi CCDS3513.1. [P54756-1 ]
    CCDS3514.1. [P54756-2 ]
    RefSeqi NP_004430.4. NM_004439.6. [P54756-1 ]
    NP_872272.2. NM_182472.3. [P54756-2 ]
    UniGenei Hs.654492.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2R2P X-ray 2.40 A 653-939 [» ]
    4ET7 X-ray 2.60 A 59-235 [» ]
    ProteinModelPortali P54756.
    SMRi P54756. Positions 57-562, 662-940, 966-1026.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108358. 3 interactions.
    IntActi P54756. 1 interaction.
    MINTi MINT-4722838.
    STRINGi 9606.ENSP00000273854.

    Chemistry

    BindingDBi P54756.
    ChEMBLi CHEMBL2363043.
    GuidetoPHARMACOLOGYi 1825.

    PTM databases

    PhosphoSitei P54756.

    Polymorphism databases

    DMDMi 259016353.

    Proteomic databases

    MaxQBi P54756.
    PaxDbi P54756.
    PRIDEi P54756.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273854 ; ENSP00000273854 ; ENSG00000145242 . [P54756-1 ]
    ENST00000354839 ; ENSP00000346899 ; ENSG00000145242 . [P54756-2 ]
    GeneIDi 2044.
    KEGGi hsa:2044.
    UCSCi uc003hcx.3. human. [P54756-3 ]
    uc003hcy.3. human. [P54756-1 ]
    uc003hcz.3. human. [P54756-2 ]

    Organism-specific databases

    CTDi 2044.
    GeneCardsi GC04M066193.
    HGNCi HGNC:3389. EPHA5.
    MIMi 600004. gene.
    neXtProti NX_P54756.
    PharmGKBi PA27821.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG062180.
    InParanoidi P54756.
    KOi K05106.
    OMAi PSLIWRC.
    OrthoDBi EOG7VTDM6.
    PhylomeDBi P54756.
    TreeFami TF315608.

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 2681.
    SignaLinki P54756.

    Miscellaneous databases

    ChiTaRSi EPHA5. human.
    EvolutionaryTracei P54756.
    GeneWikii EPH_receptor_A5.
    GenomeRNAii 2044.
    NextBioi 8305.
    PROi P54756.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P54756.
    Bgeei P54756.
    CleanExi HS_EPHA5.
    Genevestigatori P54756.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.60.120.260. 1 hit.
    2.60.40.10. 2 hits.
    InterProi IPR027936. Eph_TM.
    IPR001090. Ephrin_rcpt_lig-bd_dom.
    IPR003961. Fibronectin_type3.
    IPR008979. Galactose-bd-like.
    IPR013783. Ig-like_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016257. Tyr_kinase_ephrin_rcpt.
    IPR001426. Tyr_kinase_rcpt_V_CS.
    [Graphical view ]
    Pfami PF14575. EphA2_TM. 1 hit.
    PF01404. Ephrin_lbd. 1 hit.
    PF00041. fn3. 2 hits.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00615. EPH_lbd. 1 hit.
    SM00060. FN3. 2 hits.
    SM00454. SAM. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    SSF49265. SSF49265. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS01186. EGF_2. 1 hit.
    PS51550. EPH_LBD. 1 hit.
    PS50853. FN3. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
    PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult human brain and glial tumors."
      Miescher G.C., Taylor V., Olivieri G., Mindermann T., Shrock E., Steck A.J.
      Brain Res. Mol. Brain Res. 46:17-24(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Retina.
    4. "cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases."
      Fox G.M., Holst P.L., Chute H.T., Lindberg R.A., Janssen A.M., Basu R., Welcher A.A.
      Oncogene 10:897-905(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-1037.
      Tissue: Brain.
    5. "Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation."
      Winslow J.W., Moran P., Valverde J., Shih A., Yuan J.Q., Wong S.C., Tsai S.P., Goddard A., Henzel W.J., Hefti F., Beck K.D., Caras I.W.
      Neuron 14:973-981(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF EFNA5 AS LIGAND, PHOSPHORYLATION.
    6. "Unified nomenclature for Eph family receptors and their ligands, the ephrins."
      Eph nomenclature committee
      Cell 90:403-404(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.
    7. "Immunohistochemical localization of EphA5 in the adult human central nervous system."
      Olivieri G., Miescher G.C.
      J. Histochem. Cytochem. 47:855-861(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    8. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-81; ALA-235; GLN-330; GLN-417; LYS-503; CYS-506; GLU-582; THR-672; THR-673; ILE-856; ARG-959 AND SER-1032.

    Entry informationi

    Entry nameiEPHA5_HUMAN
    AccessioniPrimary (citable) accession number: P54756
    Secondary accession number(s): Q7Z3F2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 155 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3