Reviewed,
UniProtKB/Swiss-Prot P54754 (EPHB3_MOUSE)
Last modified
February 9, 2010.
Version 103.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ephrin type-B receptor 3 EC=2.7.10.1 Alternative name(s): Developmental kinase 5 Short name=mDK-5 Tyrosine-protein kinase receptor SEK-4 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 993 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Receptor for members of the ephrin-B family. |
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Subcellular location | |
| Tissue specificity | Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk. Ref.3 |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 29 | 29 | Potential | ||||||
| Chain | 30 – 993 | 964 | Ephrin type-B receptor 3 | PRO_0000016832 | |||||
Regions | |||||||||
| Topological domain | 30 – 554 | 525 | Extracellular Potential | ||||||
| Transmembrane | 555 – 575 | 21 | Potential | ||||||
| Topological domain | 576 – 993 | 418 | Cytoplasmic Potential | ||||||
| Domain | 332 – 438 | 107 | Fibronectin type-III 1 | ||||||
| Domain | 448 – 539 | 92 | Fibronectin type-III 2 | ||||||
| Domain | 628 – 891 | 264 | Protein kinase | ||||||
| Domain | 920 – 984 | 65 | SAM | ||||||
| Nucleotide binding | 634 – 642 | 9 | ATP By similarity | ||||||
| Motif | 991 – 993 | 3 | PDZ-binding Potential | ||||||
| Compositional bias | 191 – 328 | 138 | Cys-rich | ||||||
Sites | |||||||||
| Active site | 753 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 660 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 595 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 603 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 609 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 787 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 966 | 1 | Phosphothreonine By similarity | ||||||
| Glycosylation | 343 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 440 | 1 | N-linked (GlcNAc...) Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 719 | 1 | R → Q in CAA53599. Ref.2 | ||||||
Sequences
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References
| [1] | "Cloning, characterization, and differential expression of MDK2 and MDK5, two novel receptor tyrosine kinases of the eck/eph family." Ciossek T., Lerch M.M., Ullrich A. Oncogene 11:2085-2095(1995) [PubMed: 7478528] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Embryo. |
| [2] | "Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain." Becker N., Seitanidou T., Murphy P., Mattei M.-G., Topilko P., Nieto A., Wilkinson D.G., Charnay P., Gilardi P. Mech. Dev. 47:3-17(1994) [PubMed: 7947319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 719-993. Strain: BALB/c. Tissue: Brain. |
| [3] | "Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons." Imondi R., Wideman C., Kaprielian Z. Development 127:1397-1410(2000) [PubMed: 10704386] [Abstract] Cited for: TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z49086 mRNA. Translation: CAA88910.1. X76012 mRNA. Translation: CAA53599.1. |
| IPI | IPI00130442. |
| PIR | I48653. I48761. |
| UniGene | Mm.6972 |
3D structure databases | |
| SMR | P54754. Positions 30-204, 445-542, 601-898, 909-988. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P54754. |
PTM databases | |
| PhosphoSite | P54754. |
Proteomic databases | |
| PRIDE | P54754. |
Genome annotation databases | |
| Ensembl | ENSMUST00000006112; ENSMUSP00000006112; ENSMUSG00000005958; Mus musculus. [Genome view] |
Organism-specific databases | |
| MGI | MGI:104770. Ephb3. |
Phylogenomic databases | |
| eggNOG | roNOG12692. |
| HOGENOM | HBG755340. |
| HOVERGEN | P54754. |
| InParanoid | P54754. |
Enzyme and pathway databases | |
| BRENDA | 2.7.10.1. 244. |
Gene expression databases | |
| ArrayExpress | P54754. |
| Bgee | P54754. |
| CleanEx | MM_EPHB3. |
| Genevestigator | P54754. |
| GermOnline | ENSMUSG00000005958. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001090. Ephrin_rcpt_lig-bd. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003962. FnIII_subd. IPR008979. Galactose-bd-like. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001660. SAM. IPR010993. SAM_homology. IPR013761. SAM_type. IPR021129. SAM_type1. IPR020635. Tyr_Pkinase_cat_dom. IPR020685. Tyr_prot_kinase. IPR008266. Tyr_prot_kinase_AS. IPR016257. Tyr_prot_kinase_ephrin_rcpt. IPR001426. Tyr_prot_kinase_rcpt_V_CS. [Graphical view] |
| Gene3D | G3DSA:2.60.40.30. FN_III-like. 2 hits. G3DSA:1.10.150.50. SAM_type. 1 hit. |
| PANTHER | PTHR23256. Tyr_prot_kinase. 1 hit. |
| Pfam | PF01404. Ephrin_lbd. 1 hit. PF00041. fn3. 2 hits. PF00536. SAM_1. 1 hit. [Graphical view] |
| PIRSF | PIRSF000666. TyrPK_ephrin_receptor. 1 hit. |
| PRINTS | PR00014. FNTYPEIII. |
| SMART | SM00615. EPH_lbd. 1 hit. SM00060. FN3. 2 hits. SM00454. SAM. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view] |
| PROSITE | PS50853. FN3. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit. PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit. PS50105. SAM_DOMAIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | EPHB3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P54754 Secondary accession number(s): Q62214 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

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