P54750 (PDE1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Short name=Cam-PDE 1A
EC=3.1.4.17

Alternative name(s):
61 kDa Cam-PDE
hCam-1

Gene names

Name:

PDE1A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	535 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
Catalytic activity	Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.
Cofactor	Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.
Enzyme regulation	Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.
Subunit structure	Homodimer By similarity.
Tissue specificity	Several tissues, including brain, kidney, testes and heart.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	Calmodulin-binding Metal-binding cAMP cGMP
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of phospholipase C activity Traceable author statement. Source: Reactome blood coagulation Traceable author statement. Source: Reactome epidermal growth factor receptor signaling pathway Traceable author statement. Source: Reactome fibroblast growth factor receptor signaling pathway Traceable author statement. Source: Reactome nerve growth factor receptor signaling pathway Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity Traceable author statement Ref.1. Source: ProtInc metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P54750-1)

Also known as: PDE1A3; PDE1A6;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P54750-2)

Also known as: PDE1A4; PDE1A5;

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGI → MDDHVTIRKKHLQRPIFR

Isoform 3 (identifier: P54750-3)

Also known as: PDE1A10;

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MGSSATEIEE...LEAVYIDETR → MGKKINKLFC...IRKKVKNHIE

Isoform 4 (identifier: P54750-4)

Also known as: PDE1A5;

The sequence of this isoform differs from the canonical sequence as follows:
     522-535: EARTSSQKCEFIHQ → GESDLHKNSEDLVNAEEKHDETHS

Isoform 5 (identifier: P54750-5)

Also known as: PDE1A9;

The sequence of this isoform differs from the canonical sequence as follows:
     522-535: EARTSSQKCEFIHQ → GSVVYEALLPSLSVFTSPLRVWITSSRFLLL

Isoform 6 (identifier: P54750-6)

Also known as: PDE1A1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGI → MDDHVTIRKKHLQRPIFR
     522-535: EARTSSQKCEFIHQ → GESDLHKNSEDLVNAEEKHDETHS

Isoform 7 (identifier: P54750-7)

Also known as: PDE1A8;

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGI → MDDHVTIRKKHLQRPIFR
     522-535: EARTSSQKCEFIHQ → GSVVYEALLPSLSVFTSPLRVWITSSRFLLL

Isoform 8 (identifier: P54750-8)

Also known as: PDE1A11;

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MGSSATEIEE...LEAVYIDETR → MGKKINKLFC...IRKKVKNHIE
     522-535: EARTSSQKCEFIHQ → GESDLHKNSEDLVNAEEKHDETHS

Isoform 9 (identifier: P54750-9)

Also known as: PDE1A12;

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MGSSATEIEE...LEAVYIDETR → MGKKINKLFC...IRKKVKNHIE
     522-535: EARTSSQKCEFIHQ → GSVVYEALLPSLSVFTSPLRVWITSSRFLLL

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed By similarity

Chain

2 – 535

534

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

PRO_0000198785

Regions

Region

24 – 44

21

Calmodulin-binding By similarity

Region

193 – 515

323

Catalytic By similarity

Sites

Active site

219

1

Proton donor By similarity

Metal binding

223

1

Divalent metal cation 1 By similarity

Metal binding

259

1

Divalent metal cation 1 By similarity

Metal binding

260

1

Divalent metal cation 1 By similarity

Metal binding

260

1

Divalent metal cation 2 By similarity

Metal binding

366

1

Divalent metal cation 1 By similarity

Natural variations

Alternative sequence

1 – 72

72

MGSSA…IDETR → MGKKINKLFCFNFLVQCFRG KSKPSKCQIRKKVKNHIE in isoform 3, isoform 8 and isoform 9.

VSP_004548

Alternative sequence

1 – 34

34

MGSSA…RLKGI → MDDHVTIRKKHLQRPIFR in isoform 2, isoform 6 and isoform 7.

VSP_004547

Alternative sequence

522 – 535

14

EARTS…EFIHQ → GESDLHKNSEDLVNAEEKHD ETHS in isoform 4, isoform 6 and isoform 8.

VSP_004549

Alternative sequence

522 – 535

14

EARTS…EFIHQ → GSVVYEALLPSLSVFTSPLR VWITSSRFLLL in isoform 5, isoform 7 and isoform 9.

VSP_004550

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

535

Helix Strand Turn

Details...

Turn

154 – 157

4

Helix

163 – 169

7

Helix

174 – 185

12

Helix

188 – 191

4

Helix

196 – 208

13

Turn

212 – 214

3

Beta strand

216 – 219

4

Helix

220 – 233

14

Helix

237 – 239

3

Turn

240 – 242

3

Helix

245 – 257

13

Turn

258 – 261

4

Helix

267 – 272

6

Helix

276 – 280

5

Turn

281 – 283

3

Helix

286 – 297

12

Helix

298 – 300

3

Turn

306 – 309

4

Helix

312 – 327

16

Helix

331 – 333

3

Helix

334 – 346

13

Helix

354 – 365

12

Helix

368 – 370

3

Helix

373 – 396

24

Turn

407 – 409

3

Helix

412 – 422

11

Helix

424 – 430

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PDE1A3) (PDE1A6) [UniParc]. Last modified January 23, 2007. Version 2. Checksum: B1878145160BB3D7	FASTA	535	61,252
	10 20 30 40 50 60 MGSSATEIEE LENTTFKYLT GEQTEKMWQR LKGILRCLVK QLERGDVNVV DLKKNIEYAA 70 80 90 100 110 120 SVLEAVYIDE TRRLLDTEDE LSDIQTDSVP SEVRDWLAST FTRKMGMTKK KPEEKPKFRS 130 140 150 160 170 180 IVHAVQAGIF VERMYRKTYH MVGLAYPAAV IVTLKDVDKW SFDVFALNEA SGEHSLKFMI 190 200 210 220 230 240 YELFTRYDLI NRFKIPVSCL ITFAEALEVG YSKYKNPYHN LIHAADVTQT VHYIMLHTGI 250 260 270 280 290 300 MHWLTELEIL AMVFAAAIHD YEHTGTTNNF HIQTRSDVAI LYNDRSVLEN HHVSAAYRLM 310 320 330 340 350 360 QEEEMNILIN LSKDDWRDLR NLVIEMVLST DMSGHFQQIK NIRNSLQQPE GIDRAKTMSL 370 380 390 400 410 420 ILHAADISHP AKSWKLHYRW TMALMEEFFL QGDKEAELGL PFSPLCDRKS TMVAQSQIGF 430 440 450 460 470 480 IDFIVEPTFS LLTDSTEKIV IPLIEEASKA ETSSYVASSS TTIVGLHIAD ALRRSNTKGS 490 500 510 520 530 MSDGSYSPDY SLAAVDLKSF KNNLVDIIQQ NKERWKELAA QEARTSSQKC EFIHQ
	Isoform 2 (PDE1A4) (PDE1A5) [UniParc]. Checksum: 51F86B0EF08C01CE	FASTA	519	59,592
	10 20 30 40 50 60 MDDHVTIRKK HLQRPIFRLR CLVKQLERGD VNVVDLKKNI EYAASVLEAV YIDETRRLLD 70 80 90 100 110 120 TEDELSDIQT DSVPSEVRDW LASTFTRKMG MTKKKPEEKP KFRSIVHAVQ AGIFVERMYR 130 140 150 160 170 180 KTYHMVGLAY PAAVIVTLKD VDKWSFDVFA LNEASGEHSL KFMIYELFTR YDLINRFKIP 190 200 210 220 230 240 VSCLITFAEA LEVGYSKYKN PYHNLIHAAD VTQTVHYIML HTGIMHWLTE LEILAMVFAA 250 260 270 280 290 300 AIHDYEHTGT TNNFHIQTRS DVAILYNDRS VLENHHVSAA YRLMQEEEMN ILINLSKDDW 310 320 330 340 350 360 RDLRNLVIEM VLSTDMSGHF QQIKNIRNSL QQPEGIDRAK TMSLILHAAD ISHPAKSWKL 370 380 390 400 410 420 HYRWTMALME EFFLQGDKEA ELGLPFSPLC DRKSTMVAQS QIGFIDFIVE PTFSLLTDST 430 440 450 460 470 480 EKIVIPLIEE ASKAETSSYV ASSSTTIVGL HIADALRRSN TKGSMSDGSY SPDYSLAAVD 490 500 510 LKSFKNNLVD IIQQNKERWK ELAAQEARTS SQKCEFIHQ
	Isoform 3 (PDE1A10) [UniParc]. Checksum: 74C082300051D62C	FASTA	501	57,483
	10 20 30 40 50 60 MGKKINKLFC FNFLVQCFRG KSKPSKCQIR KKVKNHIERL LDTEDELSDI QTDSVPSEVR 70 80 90 100 110 120 DWLASTFTRK MGMTKKKPEE KPKFRSIVHA VQAGIFVERM YRKTYHMVGL AYPAAVIVTL 130 140 150 160 170 180 KDVDKWSFDV FALNEASGEH SLKFMIYELF TRYDLINRFK IPVSCLITFA EALEVGYSKY 190 200 210 220 230 240 KNPYHNLIHA ADVTQTVHYI MLHTGIMHWL TELEILAMVF AAAIHDYEHT GTTNNFHIQT 250 260 270 280 290 300 RSDVAILYND RSVLENHHVS AAYRLMQEEE MNILINLSKD DWRDLRNLVI EMVLSTDMSG 310 320 330 340 350 360 HFQQIKNIRN SLQQPEGIDR AKTMSLILHA ADISHPAKSW KLHYRWTMAL MEEFFLQGDK 370 380 390 400 410 420 EAELGLPFSP LCDRKSTMVA QSQIGFIDFI VEPTFSLLTD STEKIVIPLI EEASKAETSS 430 440 450 460 470 480 YVASSSTTIV GLHIADALRR SNTKGSMSDG SYSPDYSLAA VDLKSFKNNL VDIIQQNKER 490 500 WKELAAQEAR TSSQKCEFIH Q
	Isoform 4 (PDE1A5) [UniParc]. Checksum: BE2A280A504FDB9E	FASTA	545	62,309
	10 20 30 40 50 60 MGSSATEIEE LENTTFKYLT GEQTEKMWQR LKGILRCLVK QLERGDVNVV DLKKNIEYAA 70 80 90 100 110 120 SVLEAVYIDE TRRLLDTEDE LSDIQTDSVP SEVRDWLAST FTRKMGMTKK KPEEKPKFRS 130 140 150 160 170 180 IVHAVQAGIF VERMYRKTYH MVGLAYPAAV IVTLKDVDKW SFDVFALNEA SGEHSLKFMI 190 200 210 220 230 240 YELFTRYDLI NRFKIPVSCL ITFAEALEVG YSKYKNPYHN LIHAADVTQT VHYIMLHTGI 250 260 270 280 290 300 MHWLTELEIL AMVFAAAIHD YEHTGTTNNF HIQTRSDVAI LYNDRSVLEN HHVSAAYRLM 310 320 330 340 350 360 QEEEMNILIN LSKDDWRDLR NLVIEMVLST DMSGHFQQIK NIRNSLQQPE GIDRAKTMSL 370 380 390 400 410 420 ILHAADISHP AKSWKLHYRW TMALMEEFFL QGDKEAELGL PFSPLCDRKS TMVAQSQIGF 430 440 450 460 470 480 IDFIVEPTFS LLTDSTEKIV IPLIEEASKA ETSSYVASSS TTIVGLHIAD ALRRSNTKGS 490 500 510 520 530 540 MSDGSYSPDY SLAAVDLKSF KNNLVDIIQQ NKERWKELAA QGESDLHKNS EDLVNAEEKH DETHS
	Isoform 5 (PDE1A9) [UniParc]. Checksum: 0956259BB3F5E938	FASTA	552	63,040
	10 20 30 40 50 60 MGSSATEIEE LENTTFKYLT GEQTEKMWQR LKGILRCLVK QLERGDVNVV DLKKNIEYAA 70 80 90 100 110 120 SVLEAVYIDE TRRLLDTEDE LSDIQTDSVP SEVRDWLAST FTRKMGMTKK KPEEKPKFRS 130 140 150 160 170 180 IVHAVQAGIF VERMYRKTYH MVGLAYPAAV IVTLKDVDKW SFDVFALNEA SGEHSLKFMI 190 200 210 220 230 240 YELFTRYDLI NRFKIPVSCL ITFAEALEVG YSKYKNPYHN LIHAADVTQT VHYIMLHTGI 250 260 270 280 290 300 MHWLTELEIL AMVFAAAIHD YEHTGTTNNF HIQTRSDVAI LYNDRSVLEN HHVSAAYRLM 310 320 330 340 350 360 QEEEMNILIN LSKDDWRDLR NLVIEMVLST DMSGHFQQIK NIRNSLQQPE GIDRAKTMSL 370 380 390 400 410 420 ILHAADISHP AKSWKLHYRW TMALMEEFFL QGDKEAELGL PFSPLCDRKS TMVAQSQIGF 430 440 450 460 470 480 IDFIVEPTFS LLTDSTEKIV IPLIEEASKA ETSSYVASSS TTIVGLHIAD ALRRSNTKGS 490 500 510 520 530 540 MSDGSYSPDY SLAAVDLKSF KNNLVDIIQQ NKERWKELAA QGSVVYEALL PSLSVFTSPL 550 RVWITSSRFL LL
	Isoform 6 (PDE1A1) [UniParc]. Checksum: 39CF97424CCC0CE2	FASTA	529	60,649
	10 20 30 40 50 60 MDDHVTIRKK HLQRPIFRLR CLVKQLERGD VNVVDLKKNI EYAASVLEAV YIDETRRLLD 70 80 90 100 110 120 TEDELSDIQT DSVPSEVRDW LASTFTRKMG MTKKKPEEKP KFRSIVHAVQ AGIFVERMYR 130 140 150 160 170 180 KTYHMVGLAY PAAVIVTLKD VDKWSFDVFA LNEASGEHSL KFMIYELFTR YDLINRFKIP 190 200 210 220 230 240 VSCLITFAEA LEVGYSKYKN PYHNLIHAAD VTQTVHYIML HTGIMHWLTE LEILAMVFAA 250 260 270 280 290 300 AIHDYEHTGT TNNFHIQTRS DVAILYNDRS VLENHHVSAA YRLMQEEEMN ILINLSKDDW 310 320 330 340 350 360 RDLRNLVIEM VLSTDMSGHF QQIKNIRNSL QQPEGIDRAK TMSLILHAAD ISHPAKSWKL 370 380 390 400 410 420 HYRWTMALME EFFLQGDKEA ELGLPFSPLC DRKSTMVAQS QIGFIDFIVE PTFSLLTDST 430 440 450 460 470 480 EKIVIPLIEE ASKAETSSYV ASSSTTIVGL HIADALRRSN TKGSMSDGSY SPDYSLAAVD 490 500 510 520 LKSFKNNLVD IIQQNKERWK ELAAQGESDL HKNSEDLVNA EEKHDETHS
	Isoform 7 (PDE1A8) [UniParc]. Checksum: 8CDAD40B298EB3FF	FASTA	536	61,380
	10 20 30 40 50 60 MDDHVTIRKK HLQRPIFRLR CLVKQLERGD VNVVDLKKNI EYAASVLEAV YIDETRRLLD 70 80 90 100 110 120 TEDELSDIQT DSVPSEVRDW LASTFTRKMG MTKKKPEEKP KFRSIVHAVQ AGIFVERMYR 130 140 150 160 170 180 KTYHMVGLAY PAAVIVTLKD VDKWSFDVFA LNEASGEHSL KFMIYELFTR YDLINRFKIP 190 200 210 220 230 240 VSCLITFAEA LEVGYSKYKN PYHNLIHAAD VTQTVHYIML HTGIMHWLTE LEILAMVFAA 250 260 270 280 290 300 AIHDYEHTGT TNNFHIQTRS DVAILYNDRS VLENHHVSAA YRLMQEEEMN ILINLSKDDW 310 320 330 340 350 360 RDLRNLVIEM VLSTDMSGHF QQIKNIRNSL QQPEGIDRAK TMSLILHAAD ISHPAKSWKL 370 380 390 400 410 420 HYRWTMALME EFFLQGDKEA ELGLPFSPLC DRKSTMVAQS QIGFIDFIVE PTFSLLTDST 430 440 450 460 470 480 EKIVIPLIEE ASKAETSSYV ASSSTTIVGL HIADALRRSN TKGSMSDGSY SPDYSLAAVD 490 500 510 520 530 LKSFKNNLVD IIQQNKERWK ELAAQGSVVY EALLPSLSVF TSPLRVWITS SRFLLL
	Isoform 8 (PDE1A11) [UniParc]. Checksum: 415D4C1242D9B547	FASTA	511	58,540
	10 20 30 40 50 60 MGKKINKLFC FNFLVQCFRG KSKPSKCQIR KKVKNHIERL LDTEDELSDI QTDSVPSEVR 70 80 90 100 110 120 DWLASTFTRK MGMTKKKPEE KPKFRSIVHA VQAGIFVERM YRKTYHMVGL AYPAAVIVTL 130 140 150 160 170 180 KDVDKWSFDV FALNEASGEH SLKFMIYELF TRYDLINRFK IPVSCLITFA EALEVGYSKY 190 200 210 220 230 240 KNPYHNLIHA ADVTQTVHYI MLHTGIMHWL TELEILAMVF AAAIHDYEHT GTTNNFHIQT 250 260 270 280 290 300 RSDVAILYND RSVLENHHVS AAYRLMQEEE MNILINLSKD DWRDLRNLVI EMVLSTDMSG 310 320 330 340 350 360 HFQQIKNIRN SLQQPEGIDR AKTMSLILHA ADISHPAKSW KLHYRWTMAL MEEFFLQGDK 370 380 390 400 410 420 EAELGLPFSP LCDRKSTMVA QSQIGFIDFI VEPTFSLLTD STEKIVIPLI EEASKAETSS 430 440 450 460 470 480 YVASSSTTIV GLHIADALRR SNTKGSMSDG SYSPDYSLAA VDLKSFKNNL VDIIQQNKER 490 500 510 WKELAAQGES DLHKNSEDLV NAEEKHDETH S
	Isoform 9 (PDE1A12) [UniParc]. Checksum: 4C1AF30315076AF7	FASTA	518	59,271
	10 20 30 40 50 60 MGKKINKLFC FNFLVQCFRG KSKPSKCQIR KKVKNHIERL LDTEDELSDI QTDSVPSEVR 70 80 90 100 110 120 DWLASTFTRK MGMTKKKPEE KPKFRSIVHA VQAGIFVERM YRKTYHMVGL AYPAAVIVTL 130 140 150 160 170 180 KDVDKWSFDV FALNEASGEH SLKFMIYELF TRYDLINRFK IPVSCLITFA EALEVGYSKY 190 200 210 220 230 240 KNPYHNLIHA ADVTQTVHYI MLHTGIMHWL TELEILAMVF AAAIHDYEHT GTTNNFHIQT 250 260 270 280 290 300 RSDVAILYND RSVLENHHVS AAYRLMQEEE MNILINLSKD DWRDLRNLVI EMVLSTDMSG 310 320 330 340 350 360 HFQQIKNIRN SLQQPEGIDR AKTMSLILHA ADISHPAKSW KLHYRWTMAL MEEFFLQGDK 370 380 390 400 410 420 EAELGLPFSP LCDRKSTMVA QSQIGFIDFI VEPTFSLLTD STEKIVIPLI EEASKAETSS 430 440 450 460 470 480 YVASSSTTIV GLHIADALRR SNTKGSMSDG SYSPDYSLAA VDLKSFKNNL VDIIQQNKER 490 500 510 WKELAAQGSV VYEALLPSLS VFTSPLRVWI TSSRFLLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases." Loughney K., Martins T.J., Harris E.A.S., Sadhu K., Hicks J.B., Sonnenburg W.K., Beavo J.A., Ferguson K. J. Biol. Chem. 271:796-806(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization." Michibata H., Yanaka N., Kanoh Y., Okumura K., Omori K. Biochim. Biophys. Acta 1517:278-287(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8 AND 9). Tissue: Heart.
[3]	"Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants." Fidock M.D., Miller M., Lanfear J. Cell. Signal. 14:53-60(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Uterus.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U40370 mRNA. Translation: AAC50436.1.
AB038224 Genomic DNA. Translation: BAB20049.1.
AB038224 Genomic DNA. Translation: BAB20050.1.
AB038224 Genomic DNA. Translation: BAB20051.1.
AB038224 Genomic DNA. Translation: BAB20052.1.
AB038224 Genomic DNA. Translation: BAB20053.1.
AB038224 Genomic DNA. Translation: BAB20054.1.
AB038224 Genomic DNA. Translation: BAB20055.1.
AB038224 Genomic DNA. Translation: BAB20056.1.
AB038224 Genomic DNA. Translation: BAB20057.1.
AJ401610 mRNA. Translation: CAC82208.1.
AL110263 mRNA. Translation: CAB53703.1.
CH471058 Genomic DNA. Translation: EAX10966.1.
CH471058 Genomic DNA. Translation: EAX10974.1.
BC022480 mRNA. Translation: AAH22480.1.

IPI

IPI00008282.
IPI00171816.
IPI00221139.
IPI00221140.
IPI00335536.
IPI00377231.
IPI00395021.
IPI00395024.
IPI00399272.

PIR

T14783.

RefSeq

NP_001003683.1. NM_001003683.2.
NP_001245242.1. NM_001258313.1.
NP_001245243.1. NM_001258314.1.
NP_005010.2. NM_005019.4.

UniGene

Hs.191046.
Hs.742174.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1LXQ	model	-	A	154-432	[»]

ProteinModelPortal

P54750.

ModBase

Search...

Protein-protein interaction databases

IntAct

P54750. 1 interaction.

PTM databases

PhosphoSite

P54750.

Polymorphism databases

DMDM

1705942.

Proteomic databases

PaxDb

P54750.

PRIDE

P54750.

Protocols and materials databases

DNASU

5136.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000331935; ENSP00000331574; ENSG00000115252.
ENST00000346717; ENSP00000329112; ENSG00000115252.
ENST00000351439; ENSP00000309269; ENSG00000115252.
ENST00000358139; ENSP00000350858; ENSG00000115252.
ENST00000409365; ENSP00000386767; ENSG00000115252.
ENST00000410103; ENSP00000387037; ENSG00000115252.
ENST00000435564; ENSP00000410309; ENSG00000115252.
ENST00000456212; ENSP00000408874; ENSG00000115252.

GeneID

5136.

KEGG

hsa:5136.

UCSC

uc002uoq.1. human.
uc002uor.3. human.
uc002uos.3. human.
uc002uou.3. human.

Organism-specific databases

CTD

5136.

GeneCards

GC02M182971.

HGNC

HGNC:8774. PDE1A.

HPA

HPA022151.

MIM

171890. gene.

neXtProt

NX_P54750.

PharmGKB

PA33122.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG139098.

HOVERGEN

HBG056120.

KO

K13755.

OMA

RKSYHMV.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_604. Hemostasis.
REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P54750.

Bgee

P54750.

Genevestigator

P54750.

GermOnline

ENSG00000115252. Homo sapiens.

Family and domain databases

Gene3D

1.10.1300.10. 2 hits.

InterPro

IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]

Pfam

PF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]

PRINTS

PR00387. PDIESTERASE1.

SMART

SM00471. HDc. 1 hit.
[Graphical view]

PROSITE

PS00126. PDEASE_I. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P54750.

ChEMBL

CHEMBL3421.

ChiTaRS

PDE1A. human.

GenomeRNAi

5136.

NextBio

19802.

SOURCE

Search...

Entry information

Entry name

PDE1A_HUMAN

Accession

Primary (citable) accession number: P54750
Secondary accession number(s): D3DPG5 , Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 135 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.