P54748 (PDE4A_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
EC=3.1.4.17

Alternative name(s):
DPDE2

Gene names

Name:

Pde4a

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	844 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes By similarity.
Catalytic activity	Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.
Cofactor	Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.
Enzyme regulation	Inhibited by rolipram.
Pathway	Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Subunit structure	Interacts with LYN and ARRB2 By similarity.
Subcellular location	Cytoplasm › perinuclear region By similarity.
Tissue specificity	Isoform 2 is testis specific.
Post-translational modification	Proteolytically cleaved by caspase-3 By similarity. Phosphorylation by MAPKAPK2 its activation through PKA phosphorylation.
Sequence similarities	Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Ligand	Metal-binding cAMP
Molecular function	Hydrolase
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cAMP catabolic process Inferred from direct assay PubMed 21724846. Source: UniProtKB response to drug Inferred from expression pattern PubMed 16190900. Source: RGD signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from direct assay PubMed 15242814. Source: RGD perinuclear region of cytoplasm Inferred from direct assay PubMed 15242814. Source: RGD
Molecular_function	3',5'-cyclic-AMP phosphodiesterase activity Inferred from direct assay PubMed 15242814. Source: RGD metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P54748-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P54748-2)

Also known as: PDE4A8;

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: MEPPAAPSER...TGTGGGSSRR → MPSRKRLTLPRIFIVRKNGNS

Isoform 3 (identifier: P54748-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     235-256: WCLEQLETMQTYRSVSEMASHK → MPLVDFFCETCSKPWLVGWWDQ

Isoform 4 (identifier: P54748-4)

Also known as: Medium;

The sequence of this isoform differs from the canonical sequence as follows:
     1-259: Missing.

Isoform 5 (identifier: P54748-5)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     1-318: Missing.
     354-386: Missing.

Isoform 6 (identifier: P54748-6)

Also known as: PDE4A10;

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: MEPPAAPSER...TGTGGGSSRR → ALPLGPESLTHFSFSEEDTLRHPPGRCVS

Note: Incomplete sequence.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 844

844

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

PRO_0000198808

Regions

Nucleotide binding

419 – 423

5

cAMP By similarity

Region

317 – 710

394

Catalytic By similarity

Sites

Active site

419

1

Proton donor By similarity

Metal binding

423

1

Divalent metal cation 1 By similarity

Metal binding

459

1

Divalent metal cation 1 By similarity

Metal binding

460

1

Divalent metal cation 1 By similarity

Metal binding

460

1

Divalent metal cation 2 By similarity

Metal binding

577

1

Divalent metal cation 1 By similarity

Binding site

460

1

cAMP By similarity

Binding site

577

1

cAMP By similarity

Binding site

628

1

cAMP By similarity

Site

69 – 70

2

Cleavage; by caspase-3 By similarity

Site

580

1

Binds AMP, but not cAMP By similarity

Amino acid modifications

Modified residue

147

1

Phosphoserine; by MAPKAPK2 Ref.6

Modified residue

160

1

Phosphoserine By similarity

Cross-link

344

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity

Natural variations

Alternative sequence

1 – 318

318

Missing in isoform 5.

VSP_004569

Alternative sequence

1 – 259

259

Missing in isoform 4.

VSP_004568

Alternative sequence

1 – 234

234

Missing in isoform 3.

VSP_004566

Alternative sequence

1 – 102

102

MEPPA…GSSRR → MPSRKRLTLPRIFIVRKNGN S in isoform 2.

VSP_004565

Alternative sequence

1 – 102

102

MEPPA…GSSRR → ALPLGPESLTHFSFSEEDTL RHPPGRCVS in isoform 6.

VSP_038187

Alternative sequence

235 – 256

22

WCLEQ…MASHK → MPLVDFFCETCSKPWLVGWW DQ in isoform 3.

VSP_004567

Alternative sequence

354 – 386

33

Missing in isoform 5.

VSP_004570

Experimental info

Mutagenesis

147

1

S → A: Abolishes phosphorylation by MAPKAPK2. Ref.6

Mutagenesis

161

1

S → A: Does not affect phosphorylation by MAPKAPK2. Ref.6

Sequence conflict

130

1

A → R in AAF14352. Ref.5

Sequence conflict

465 – 466

2

GV → AL in AAA41848. Ref.4

Sequence conflict

465 – 466

2

GV → AL in AAA41823. Ref.4

Sequence conflict

603 – 604

2

GD → AH in AAA41848. Ref.4

Sequence conflict

603 – 604

2

GD → AH in AAA41823. Ref.4

Sequence conflict

833

1

A → T in AAC37699. Ref.1

Sequence conflict

833

1

A → T in AAA41101. Ref.1

Sequence conflict

833

1

A → T in AAA41102. Ref.1

Sequence conflict

833

1

A → T in AAF14352. Ref.5

Secondary structure

1

.

.

.

844

Helix Strand Turn

Details...

Helix

781 – 787

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 1A5F5101E4DBF1B6	FASTA	844	93,439
	10 20 30 40 50 60 MEPPAAPSER SLSLSLPGPR EGQATLKPPP QHLWRQPRTP IRIQQRGYPD SAERSETERS 70 80 90 100 110 120 PHRPIERADA VDTGDRPGLR TTRMSWPSSF HGTGTGGGSS RRLEAENGPT PSPGRSPLDS 130 140 150 160 170 180 QASPGLVLHA GATTSQRRES FLYRSDSDYD MSPKAVSRSS SVASEAHAED LIVTPFAQVL 190 200 210 220 230 240 ASLRSVRSNF SLLTNVPIPS NKRSPLGGPP SVCKATLSEE TCQQLARETL EELDWCLEQL 250 260 270 280 290 300 ETMQTYRSVS EMASHKFKRM LNRELTHLSE MSRSGNQVSE YISNTFLDKQ NEVEIPSPTP 310 320 330 340 350 360 RQRAFQQPPP SVLRQSQPMS QITGLKKLVH TGSLNTNVPR FGVKTDQEDL LAQELENLSK 370 380 390 400 410 420 WGLNIFCVSE YAGGRSLSCI MYTIFQERDL LKKFHIPVDT MMMYMLTLED HYHADVAYHN 430 440 450 460 470 480 SLHAADVLQS THVLLATPAL DAVFTDLEIL AALFAAAIHD VDHPGVSNQF LINTNSELAL 490 500 510 520 530 540 MYNDESVLEN HHLAVGFKLL QEENCDIFQN LSKRQRQSLR KMVIDMVLAT DMSKHMTLLA 550 560 570 580 590 600 DLKTMVETKK VTSSGVLLLD NYSDRIQVLR NMVHCADLSN PTKPLELYRQ WTDRIMAEFF 610 620 630 640 650 660 QQGDRERERG MEISPMCDKH TASVEKSQVG FIDYIVHPLW ETWADLVHPD AQDILDTLED 670 680 690 700 710 720 NRDWYHSAIR QSPSPPLEEE PGGLGHPSLP DKFQFELTLE EEEEEDSLEV PGLPTTEETF 730 740 750 760 770 780 LAAEDARAQA VDWSKVKGPS TTVVEVAERL KQETASAYGA PQESMEAVGC SFSPGTPILP 790 800 810 820 830 840 DVRTLSSSEE APGLLGLPST AAEVEAPRDH LAATRACSAC SGTSGDNSAI ISAPGRWGSG GDPA
	Isoform 2 (PDE4A8) [UniParc]. Checksum: 9E1E33481260566A	FASTA	763	84,647
	10 20 30 40 50 60 MPSRKRLTLP RIFIVRKNGN SLEAENGPTP SPGRSPLDSQ ASPGLVLHAG ATTSQRRESF 70 80 90 100 110 120 LYRSDSDYDM SPKAVSRSSS VASEAHAEDL IVTPFAQVLA SLRSVRSNFS LLTNVPIPSN 130 140 150 160 170 180 KRSPLGGPPS VCKATLSEET CQQLARETLE ELDWCLEQLE TMQTYRSVSE MASHKFKRML 190 200 210 220 230 240 NRELTHLSEM SRSGNQVSEY ISNTFLDKQN EVEIPSPTPR QRAFQQPPPS VLRQSQPMSQ 250 260 270 280 290 300 ITGLKKLVHT GSLNTNVPRF GVKTDQEDLL AQELENLSKW GLNIFCVSEY AGGRSLSCIM 310 320 330 340 350 360 YTIFQERDLL KKFHIPVDTM MMYMLTLEDH YHADVAYHNS LHAADVLQST HVLLATPALD 370 380 390 400 410 420 AVFTDLEILA ALFAAAIHDV DHPGVSNQFL INTNSELALM YNDESVLENH HLAVGFKLLQ 430 440 450 460 470 480 EENCDIFQNL SKRQRQSLRK MVIDMVLATD MSKHMTLLAD LKTMVETKKV TSSGVLLLDN 490 500 510 520 530 540 YSDRIQVLRN MVHCADLSNP TKPLELYRQW TDRIMAEFFQ QGDRERERGM EISPMCDKHT 550 560 570 580 590 600 ASVEKSQVGF IDYIVHPLWE TWADLVHPDA QDILDTLEDN RDWYHSAIRQ SPSPPLEEEP 610 620 630 640 650 660 GGLGHPSLPD KFQFELTLEE EEEEDSLEVP GLPTTEETFL AAEDARAQAV DWSKVKGPST 670 680 690 700 710 720 TVVEVAERLK QETASAYGAP QESMEAVGCS FSPGTPILPD VRTLSSSEEA PGLLGLPSTA 730 740 750 760 AEVEAPRDHL AATRACSACS GTSGDNSAII SAPGRWGSGG DPA
	Isoform 3 [UniParc]. Checksum: FE439ACE95E1D1AC	FASTA	610	68,161
	10 20 30 40 50 60 MPLVDFFCET CSKPWLVGWW DQFKRMLNRE LTHLSEMSRS GNQVSEYISN TFLDKQNEVE 70 80 90 100 110 120 IPSPTPRQRA FQQPPPSVLR QSQPMSQITG LKKLVHTGSL NTNVPRFGVK TDQEDLLAQE 130 140 150 160 170 180 LENLSKWGLN IFCVSEYAGG RSLSCIMYTI FQERDLLKKF HIPVDTMMMY MLTLEDHYHA 190 200 210 220 230 240 DVAYHNSLHA ADVLQSTHVL LATPALDAVF TDLEILAALF AAAIHDVDHP GVSNQFLINT 250 260 270 280 290 300 NSELALMYND ESVLENHHLA VGFKLLQEEN CDIFQNLSKR QRQSLRKMVI DMVLATDMSK 310 320 330 340 350 360 HMTLLADLKT MVETKKVTSS GVLLLDNYSD RIQVLRNMVH CADLSNPTKP LELYRQWTDR 370 380 390 400 410 420 IMAEFFQQGD RERERGMEIS PMCDKHTASV EKSQVGFIDY IVHPLWETWA DLVHPDAQDI 430 440 450 460 470 480 LDTLEDNRDW YHSAIRQSPS PPLEEEPGGL GHPSLPDKFQ FELTLEEEEE EDSLEVPGLP 490 500 510 520 530 540 TTEETFLAAE DARAQAVDWS KVKGPSTTVV EVAERLKQET ASAYGAPQES MEAVGCSFSP 550 560 570 580 590 600 GTPILPDVRT LSSSEEAPGL LGLPSTAAEV EAPRDHLAAT RACSACSGTS GDNSAIISAP 610 GRWGSGGDPA
	Isoform 4 (Medium) [UniParc]. Checksum: 3A188A286A28E174	FASTA	585	65,059
	10 20 30 40 50 60 MLNRELTHLS EMSRSGNQVS EYISNTFLDK QNEVEIPSPT PRQRAFQQPP PSVLRQSQPM 70 80 90 100 110 120 SQITGLKKLV HTGSLNTNVP RFGVKTDQED LLAQELENLS KWGLNIFCVS EYAGGRSLSC 130 140 150 160 170 180 IMYTIFQERD LLKKFHIPVD TMMMYMLTLE DHYHADVAYH NSLHAADVLQ STHVLLATPA 190 200 210 220 230 240 LDAVFTDLEI LAALFAAAIH DVDHPGVSNQ FLINTNSELA LMYNDESVLE NHHLAVGFKL 250 260 270 280 290 300 LQEENCDIFQ NLSKRQRQSL RKMVIDMVLA TDMSKHMTLL ADLKTMVETK KVTSSGVLLL 310 320 330 340 350 360 DNYSDRIQVL RNMVHCADLS NPTKPLELYR QWTDRIMAEF FQQGDRERER GMEISPMCDK 370 380 390 400 410 420 HTASVEKSQV GFIDYIVHPL WETWADLVHP DAQDILDTLE DNRDWYHSAI RQSPSPPLEE 430 440 450 460 470 480 EPGGLGHPSL PDKFQFELTL EEEEEEDSLE VPGLPTTEET FLAAEDARAQ AVDWSKVKGP 490 500 510 520 530 540 STTVVEVAER LKQETASAYG APQESMEAVG CSFSPGTPIL PDVRTLSSSE EAPGLLGLPS 550 560 570 580 TAAEVEAPRD HLAATRACSA CSGTSGDNSA IISAPGRWGS GGDPA
	Isoform 5 (Short) [UniParc]. Checksum: 53735B34F1122F97	FASTA	493	54,526
	10 20 30 40 50 60 MSQITGLKKL VHTGSLNTNV PRFGVKTDQE DLLAQERDLL KKFHIPVDTM MMYMLTLEDH 70 80 90 100 110 120 YHADVAYHNS LHAADVLQST HVLLATPALD AVFTDLEILA ALFAAAIHDV DHPGVSNQFL 130 140 150 160 170 180 INTNSELALM YNDESVLENH HLAVGFKLLQ EENCDIFQNL SKRQRQSLRK MVIDMVLATD 190 200 210 220 230 240 MSKHMTLLAD LKTMVETKKV TSSGVLLLDN YSDRIQVLRN MVHCADLSNP TKPLELYRQW 250 260 270 280 290 300 TDRIMAEFFQ QGDRERERGM EISPMCDKHT ASVEKSQVGF IDYIVHPLWE TWADLVHPDA 310 320 330 340 350 360 QDILDTLEDN RDWYHSAIRQ SPSPPLEEEP GGLGHPSLPD KFQFELTLEE EEEEDSLEVP 370 380 390 400 410 420 GLPTTEETFL AAEDARAQAV DWSKVKGPST TVVEVAERLK QETASAYGAP QESMEAVGCS 430 440 450 460 470 480 FSPGTPILPD VRTLSSSEEA PGLLGLPSTA AEVEAPRDHL AATRACSACS GTSGDNSAII 490 SAPGRWGSGG DPA
	Isoform 6 (PDE4A10) [UniParc]. Checksum: C1DB345199B5D59C	FASTA	771	85,344
	10 20 30 40 50 60 ALPLGPESLT HFSFSEEDTL RHPPGRCVSL EAENGPTPSP GRSPLDSQAS PGLVLHAGAT 70 80 90 100 110 120 TSQRRESFLY RSDSDYDMSP KAVSRSSSVA SEAHAEDLIV TPFAQVLASL RSVRSNFSLL 130 140 150 160 170 180 TNVPIPSNKR SPLGGPPSVC KATLSEETCQ QLARETLEEL DWCLEQLETM QTYRSVSEMA 190 200 210 220 230 240 SHKFKRMLNR ELTHLSEMSR SGNQVSEYIS NTFLDKQNEV EIPSPTPRQR AFQQPPPSVL 250 260 270 280 290 300 RQSQPMSQIT GLKKLVHTGS LNTNVPRFGV KTDQEDLLAQ ELENLSKWGL NIFCVSEYAG 310 320 330 340 350 360 GRSLSCIMYT IFQERDLLKK FHIPVDTMMM YMLTLEDHYH ADVAYHNSLH AADVLQSTHV 370 380 390 400 410 420 LLATPALDAV FTDLEILAAL FAAAIHDVDH PGVSNQFLIN TNSELALMYN DESVLENHHL 430 440 450 460 470 480 AVGFKLLQEE NCDIFQNLSK RQRQSLRKMV IDMVLATDMS KHMTLLADLK TMVETKKVTS 490 500 510 520 530 540 SGVLLLDNYS DRIQVLRNMV HCADLSNPTK PLELYRQWTD RIMAEFFQQG DRERERGMEI 550 560 570 580 590 600 SPMCDKHTAS VEKSQVGFID YIVHPLWETW ADLVHPDAQD ILDTLEDNRD WYHSAIRQSP 610 620 630 640 650 660 SPPLEEEPGG LGHPSLPDKF QFELTLEEEE EEDSLEVPGL PTTEETFLAA EDARAQAVDW 670 680 690 700 710 720 SKVKGPSTTV VEVAERLKQE TASAYGAPQE SMEAVGCSFS PGTPILPDVR TLSSSEEAPG 730 740 750 760 770 LLGLPSTAAE VEAPRDHLAA TRACSACSGT SGDNSAIISA PGRWGSGGDP A

References

[1]	"Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene." Davis R.L., Takayasu H., Eberwine M., Myres J. Proc. Natl. Acad. Sci. U.S.A. 86:3604-3608(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4 AND 5).
[2]	"Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases." Bolger G.B., Rodgers L., Riggs M. Gene 149:237-244(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5). Tissue: Brain.
[3]	"Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8." Bolger G.B., McPhee I., Houslay M.D. J. Biol. Chem. 271:1065-1071(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Strain: Sprague-Dawley. Tissue: Testis.
[4]	"Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes." Swinnen J.V., Joseph D.R., Conti M. Proc. Natl. Acad. Sci. U.S.A. 86:5325-5329(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 319-677 (ISOFORMS 3/4). Tissue: Testis.
[5]	"Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10." Rena G., Begg F., Ross A., MacKenzie C., McPhee I., Campbell L., Huston E., Sullivan M., Houslay M.D. Mol. Pharmacol. 59:996-1011(2001) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
[6]	"Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation." MacKenzie K.F., Wallace D.A., Hill E.V., Anthony D.F., Henderson D.J., Houslay D.M., Arthur J.S., Baillie G.S., Houslay M.D. Biochem. J. 435:755-769(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-147, MUTAGENESIS OF SER-147 AND SER-161.
[7]	"Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs." Smith K.J., Scotland G., Beattie J., Trayer I.P., Houslay M.D. J. Biol. Chem. 271:16703-16711(1996) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 1-26 OF ISOFORM 3.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L27057 mRNA. Translation: AAC27098.1.
L36467 mRNA. Translation: AAB00357.1.
L27062 mRNA. Translation: AAA56859.1.
M25348 mRNA. Translation: AAA41848.1.
M28411 mRNA. Translation: AAA41823.1.
M26715 mRNA. Translation: AAC37699.1.
M26716 mRNA. Translation: AAA41101.1.
M26717 mRNA. Translation: AAA41102.1.
AF110461 mRNA. Translation: AAF14352.2.

IPI

IPI00188196.
IPI00230851.
IPI00230852.
IPI00230854.
IPI00324065.
IPI00782258.

PIR

I53865.
I67946.

RefSeq

NP_037233.3. NM_013101.3.

UniGene

Rn.91357.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1LOI	NMR	-	A	-	[»]

ProteinModelPortal

P54748.

SMR

P54748. Positions 337-698.

ModBase

Search...

PTM databases

PhosphoSite

P54748.

Proteomic databases

PaxDb

P54748.

PRIDE

P54748.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

25638.

KEGG

rno:25638.

UCSC

RGD:3279. rat.

Organism-specific databases

CTD

5141.

RGD

3279. Pde4a.

Phylogenomic databases

eggNOG

NOG122287.

HOGENOM

HOG000236297.

HOVERGEN

HBG108239.

InParanoid

P54748.

KO

K01120.

OrthoDB

EOG402WRM.

Enzyme and pathway databases

UniPathway

UPA00762; UER00747.

Gene expression databases

ArrayExpress

P54748.

Genevestigator

P54748.

GermOnline

ENSRNOG00000020828. Rattus norvegicus.

Family and domain databases

Gene3D

1.10.1300.10. 1 hit.

InterPro

IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]

Pfam

PF00233. PDEase_I. 1 hit.
[Graphical view]

PRINTS

PR00387. PDIESTERASE1.

SMART

SM00471. HDc. 1 hit.
[Graphical view]

PROSITE

PS00126. PDEASE_I. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P54748.

ChEMBL

CHEMBL4964.

EvolutionaryTrace

P54748.

NextBio

607467.

PMAP-CutDB

P54748.

Entry information

Entry name

PDE4A_RAT

Accession

Primary (citable) accession number: P54748
Secondary accession number(s): P14645, Q9EQR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program