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P54743 (PKNA_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase PknA

EC=2.7.11.1
Gene names
Name:pknA
Ordered Locus Names:ML0017
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Cell membrane; Single-pass membrane protein By similarity.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437Serine/threonine-protein kinase PknA
PRO_0000171204

Regions

Topological domain1 – 341341Cytoplasmic Potential
Transmembrane342 – 36221Helical; Potential
Topological domain363 – 43775Extracellular Potential
Domain13 – 272260Protein kinase
Nucleotide binding19 – 279ATP By similarity

Sites

Active site1411Proton acceptor By similarity
Binding site421ATP By similarity

Experimental info

Sequence conflict281 – 35575PRPNQ…ALAII → RGPTKHHLPAGPLQRPSRQA HRPEQLLLAAPRLRHLADPD RQQAEIARRRRETRSRLDNA RCSGPPGCSERWRSS in CAA94719. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P54743 [UniParc].

Last modified April 27, 2001. Version 3.
Checksum: F08F07240C7C29D0

FASTA43746,312
        10         20         30         40         50         60 
MSPRIGVMLS GRYRLHRLIA TGGMGQVWEA VDSRLGRRVA VKVLKGEFSS DPEFIERFRA 

        70         80         90        100        110        120 
EARTTAMLNH PGIASVHDYG ESHMDGEGRT AYLVMELVNG EPLNSVLKRT GRLSLRHALD 

       130        140        150        160        170        180 
MLEQTGRALQ IAHAAGLVHR DVKPGNILIT PTGQVKITDF GIAKAVDAAP VTQTGMVMGT 

       190        200        210        220        230        240 
AQYIAPEQAL GHDATPASDV YSLGVIGYEV VSGKRPFTGD GALTVAMKHI KEPPPPLPAD 

       250        260        270        280        290        300 
LPPNVRELIE ITLVKNPGMR YPSGGLFAEA VAAVRAGHRP PRPNQTPSSG RASPTTIPSS 

       310        320        330        340        350        360 
TQARAAVACG TKTPAPRRSR PSTSGNRPPP ARNTFSSGQR ALLWAAGMLG ALAIIIAVLI 

       370        380        390        400        410        420 
VINSYAGNEQ HQPPTPTVTD TGTPPATKTL SGFPAAYCEY RVNWTNHKEI SNSGLPKQAA 

       430 
RAQLAGATDI SPVAGQT 

« Hide

References

« Hide 'large scale' references
[1]"Gene arrangement and organization in an approximately 76 kb fragment encompassing the oriC region of the chromosome of Mycobacterium leprae."
Fsihi H., de Rossi E., Salazar L., Cantoni R., Labo M., Riccardi G., Takiff H.E., Eiglmeier K., Bergh S., Cole S.T.
Microbiology 142:3147-3161(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Massive gene decay in the leprosy bacillus."
Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. expand/collapse author list , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G.
Nature 409:1007-1011(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TN.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z70722 Genomic DNA. Translation: CAA94719.1.
AL583917 Genomic DNA. Translation: CAC29525.1.
PIRA86911.
T10010.
RefSeqNP_301143.1. NC_002677.1.

3D structure databases

ProteinModelPortalP54743.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML0017.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC29525; CAC29525; CAC29525.
GeneID908171.
KEGGmle:ML0017.
PATRIC18050126. VBIMycLep78757_0021.

Organism-specific databases

LepromaML0017.
CMRSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000037187.
KOK08884.
OMARPFEGDN.
OrthoDBEOG6B35XT.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePKNA_MYCLE
AccessionPrimary (citable) accession number: P54743
Secondary accession number(s): Q50184
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 27, 2001
Last modified: May 14, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families