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P54743

- PKNA_MYCLE

UniProt

P54743 - PKNA_MYCLE

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Protein

Serine/threonine-protein kinase PknA

Gene

pknA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATPPROSITE-ProRule annotation
Active sitei141 – 1411Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknA (EC:2.7.11.1)
Gene namesi
Name:pknA
Ordered Locus Names:ML0017
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0017.

Subcellular locationi

Cell membrane By similarity; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 341341CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Topological domaini363 – 43775ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Serine/threonine-protein kinase PknAPRO_0000171204Add
BLAST

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0017.

Structurei

3D structure databases

ProteinModelPortaliP54743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 272260Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000037187.
KOiK08884.
OMAiRPFEGDN.
OrthoDBiEOG6B35XT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54743-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPRIGVMLS GRYRLHRLIA TGGMGQVWEA VDSRLGRRVA VKVLKGEFSS
60 70 80 90 100
DPEFIERFRA EARTTAMLNH PGIASVHDYG ESHMDGEGRT AYLVMELVNG
110 120 130 140 150
EPLNSVLKRT GRLSLRHALD MLEQTGRALQ IAHAAGLVHR DVKPGNILIT
160 170 180 190 200
PTGQVKITDF GIAKAVDAAP VTQTGMVMGT AQYIAPEQAL GHDATPASDV
210 220 230 240 250
YSLGVIGYEV VSGKRPFTGD GALTVAMKHI KEPPPPLPAD LPPNVRELIE
260 270 280 290 300
ITLVKNPGMR YPSGGLFAEA VAAVRAGHRP PRPNQTPSSG RASPTTIPSS
310 320 330 340 350
TQARAAVACG TKTPAPRRSR PSTSGNRPPP ARNTFSSGQR ALLWAAGMLG
360 370 380 390 400
ALAIIIAVLI VINSYAGNEQ HQPPTPTVTD TGTPPATKTL SGFPAAYCEY
410 420 430
RVNWTNHKEI SNSGLPKQAA RAQLAGATDI SPVAGQT
Length:437
Mass (Da):46,312
Last modified:April 27, 2001 - v3
Checksum:iF08F07240C7C29D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti281 – 35575PRPNQ…ALAII → RGPTKHHLPAGPLQRPSRQA HRPEQLLLAAPRLRHLADPD RQQAEIARRRRETRSRLDNA RCSGPPGCSERWRSS in CAA94719. (PubMed:8969512)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70722 Genomic DNA. Translation: CAA94719.1.
AL583917 Genomic DNA. Translation: CAC29525.1.
PIRiA86911.
T10010.
RefSeqiNP_301143.1. NC_002677.1.
WP_010907468.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29525; CAC29525; CAC29525.
GeneIDi908171.
KEGGimle:ML0017.
PATRICi18050126. VBIMycLep78757_0021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70722 Genomic DNA. Translation: CAA94719.1 .
AL583917 Genomic DNA. Translation: CAC29525.1 .
PIRi A86911.
T10010.
RefSeqi NP_301143.1. NC_002677.1.
WP_010907468.1. NC_002677.1.

3D structure databases

ProteinModelPortali P54743.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0017.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29525 ; CAC29525 ; CAC29525 .
GeneIDi 908171.
KEGGi mle:ML0017.
PATRICi 18050126. VBIMycLep78757_0021.

Organism-specific databases

Lepromai ML0017.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000037187.
KOi K08884.
OMAi RPFEGDN.
OrthoDBi EOG6B35XT.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene arrangement and organization in an approximately 76 kb fragment encompassing the oriC region of the chromosome of Mycobacterium leprae."
    Fsihi H., de Rossi E., Salazar L., Cantoni R., Labo M., Riccardi G., Takiff H.E., Eiglmeier K., Bergh S., Cole S.T.
    Microbiology 142:3147-3161(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiPKNA_MYCLE
AccessioniPrimary (citable) accession number: P54743
Secondary accession number(s): Q50184
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 27, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3