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P54743

- PKNA_MYCLE

UniProt

P54743 - PKNA_MYCLE

Protein

Serine/threonine-protein kinase PknA

Gene

pknA

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421ATPPROSITE-ProRule annotation
    Active sitei141 – 1411Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PknA (EC:2.7.11.1)
    Gene namesi
    Name:pknA
    Ordered Locus Names:ML0017
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0017.

    Subcellular locationi

    Cell membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Serine/threonine-protein kinase PknAPRO_0000171204Add
    BLAST

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML0017.

    Structurei

    3D structure databases

    ProteinModelPortaliP54743.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 341341CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini363 – 43775ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 272260Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000037187.
    KOiK08884.
    OMAiRPFEGDN.
    OrthoDBiEOG6B35XT.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54743-1 [UniParc]FASTAAdd to Basket

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    MSPRIGVMLS GRYRLHRLIA TGGMGQVWEA VDSRLGRRVA VKVLKGEFSS    50
    DPEFIERFRA EARTTAMLNH PGIASVHDYG ESHMDGEGRT AYLVMELVNG 100
    EPLNSVLKRT GRLSLRHALD MLEQTGRALQ IAHAAGLVHR DVKPGNILIT 150
    PTGQVKITDF GIAKAVDAAP VTQTGMVMGT AQYIAPEQAL GHDATPASDV 200
    YSLGVIGYEV VSGKRPFTGD GALTVAMKHI KEPPPPLPAD LPPNVRELIE 250
    ITLVKNPGMR YPSGGLFAEA VAAVRAGHRP PRPNQTPSSG RASPTTIPSS 300
    TQARAAVACG TKTPAPRRSR PSTSGNRPPP ARNTFSSGQR ALLWAAGMLG 350
    ALAIIIAVLI VINSYAGNEQ HQPPTPTVTD TGTPPATKTL SGFPAAYCEY 400
    RVNWTNHKEI SNSGLPKQAA RAQLAGATDI SPVAGQT 437
    Length:437
    Mass (Da):46,312
    Last modified:April 27, 2001 - v3
    Checksum:iF08F07240C7C29D0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti281 – 35575PRPNQ…ALAII → RGPTKHHLPAGPLQRPSRQA HRPEQLLLAAPRLRHLADPD RQQAEIARRRRETRSRLDNA RCSGPPGCSERWRSS in CAA94719. (PubMed:8969512)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70722 Genomic DNA. Translation: CAA94719.1.
    AL583917 Genomic DNA. Translation: CAC29525.1.
    PIRiA86911.
    T10010.
    RefSeqiNP_301143.1. NC_002677.1.
    WP_010907468.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC29525; CAC29525; CAC29525.
    GeneIDi908171.
    KEGGimle:ML0017.
    PATRICi18050126. VBIMycLep78757_0021.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70722 Genomic DNA. Translation: CAA94719.1 .
    AL583917 Genomic DNA. Translation: CAC29525.1 .
    PIRi A86911.
    T10010.
    RefSeqi NP_301143.1. NC_002677.1.
    WP_010907468.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali P54743.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0017.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC29525 ; CAC29525 ; CAC29525 .
    GeneIDi 908171.
    KEGGi mle:ML0017.
    PATRICi 18050126. VBIMycLep78757_0021.

    Organism-specific databases

    Lepromai ML0017.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000037187.
    KOi K08884.
    OMAi RPFEGDN.
    OrthoDBi EOG6B35XT.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene arrangement and organization in an approximately 76 kb fragment encompassing the oriC region of the chromosome of Mycobacterium leprae."
      Fsihi H., de Rossi E., Salazar L., Cantoni R., Labo M., Riccardi G., Takiff H.E., Eiglmeier K., Bergh S., Cole S.T.
      Microbiology 142:3147-3161(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiPKNA_MYCLE
    AccessioniPrimary (citable) accession number: P54743
    Secondary accession number(s): Q50184
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3