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P54740

- PKAB_STRCO

UniProt

P54740 - PKAB_STRCO

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Protein
Serine/threonine-protein kinase PkaB
Gene
pkaB, SCO2973, SCE50.01, SCE59.32c
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361ATP By similarity
Active sitei130 – 1301Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5998.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PkaB (EC:2.7.11.1)
Gene namesi
Name:pkaB
Ordered Locus Names:SCO2973
ORF Names:SCE50.01, SCE59.32c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Serine/threonine-protein kinase PkaB
PRO_0000171233Add
BLAST

Post-translational modificationi

Autophosphorylated mainly at Thr.

Keywords - PTMi

Phosphoprotein

PTM databases

PhosSiteiP0502123.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO2973.

Structurei

3D structure databases

ProteinModelPortaliP54740.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 270262Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000053674.
KOiK08884.
OMAiRRHVTET.
OrthoDBiEOG6B35XT.
PhylomeDBiP54740.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54740-1 [UniParc]FASTAAdd to Basket

« Hide

MARKIGSRYT AHQILGRGSA GTVWLGEGPD GPVAIKLLRE DLASDQELVS    50
RFVQERTALL GLDHPHVVSV RDLVVDGNDL ALVMDLVRGT DLRTRLDRER 100
RLAPEAAVAV VADVADGLAA AHAAGVVHRD VKPENVLLDM QGPLGPGGSH 150
PALLTDFGVA KLIDTPRRTR ATKIIGTPDY LAPEIVEGLP PRAAVDIYAL 200
ATVLYELLAG FTPFGGGHPG AVLRRHVTET VVPLPGIPDE LWQLLVQCLA 250
KAPASRLRAS ELSARLRELL PMLAGMAPLD VDEPDAEQPE DAPDASAASP 300
AAPVSTAEPV RRRGAVPLVP GAKPADSNRD THTSMRVPAP DELAGGARGT 350
ARAPRASGAP RPGSARNRAA TRRRRIAVGA GAVALVAAIG VGTWLATGGD 400
EDGGGPQDTR NSAPAAP 417
Length:417
Mass (Da):43,417
Last modified:October 1, 1996 - v1
Checksum:i3D66720FF17D3DE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86821 Genomic DNA. Translation: BAA13169.1.
AL939114 Genomic DNA. Translation: CAD55460.1.
PIRiJC4071.
RefSeqiNP_733588.1. NC_003888.3.
WP_011028691.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAD55460; CAD55460; CAD55460.
GeneIDi1098406.
KEGGisco:SCO2973.
PATRICi23735672. VBIStrCoe124346_3031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86821 Genomic DNA. Translation: BAA13169.1 .
AL939114 Genomic DNA. Translation: CAD55460.1 .
PIRi JC4071.
RefSeqi NP_733588.1. NC_003888.3.
WP_011028691.1. NC_003888.3.

3D structure databases

ProteinModelPortali P54740.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO2973.

PTM databases

PhosSitei P0502123.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD55460 ; CAD55460 ; CAD55460 .
GeneIDi 1098406.
KEGGi sco:SCO2973.
PATRICi 23735672. VBIStrCoe124346_3031.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000053674.
KOi K08884.
OMAi RRHVTET.
OrthoDBi EOG6B35XT.
PhylomeDBi P54740.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 5998.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing and expression of serine/threonine kinase-encoding genes from Streptomyces coelicolor A3(2)."
    Urabe H., Ogawara H.
    Gene 153:99-104(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / NRRL B-16638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiPKAB_STRCO
AccessioniPrimary (citable) accession number: P54740
Secondary accession number(s): Q9L061, Q9L1S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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