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P54740

- PKAB_STRCO

UniProt

P54740 - PKAB_STRCO

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Protein

Serine/threonine-protein kinase PkaB

Gene

pkaB

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361ATPPROSITE-ProRule annotation
Active sitei130 – 1301Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5998.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PkaB (EC:2.7.11.1)
Gene namesi
Name:pkaB
Ordered Locus Names:SCO2973
ORF Names:SCE50.01, SCE59.32c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Serine/threonine-protein kinase PkaBPRO_0000171233Add
BLAST

Post-translational modificationi

Autophosphorylated mainly at Thr.

Keywords - PTMi

Phosphoprotein

PTM databases

PhosSiteiP0502123.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO2973.

Structurei

3D structure databases

ProteinModelPortaliP54740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 270262Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000053674.
InParanoidiP54740.
KOiK08884.
OMAiRRHVTET.
OrthoDBiEOG6B35XT.
PhylomeDBiP54740.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54740-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARKIGSRYT AHQILGRGSA GTVWLGEGPD GPVAIKLLRE DLASDQELVS
60 70 80 90 100
RFVQERTALL GLDHPHVVSV RDLVVDGNDL ALVMDLVRGT DLRTRLDRER
110 120 130 140 150
RLAPEAAVAV VADVADGLAA AHAAGVVHRD VKPENVLLDM QGPLGPGGSH
160 170 180 190 200
PALLTDFGVA KLIDTPRRTR ATKIIGTPDY LAPEIVEGLP PRAAVDIYAL
210 220 230 240 250
ATVLYELLAG FTPFGGGHPG AVLRRHVTET VVPLPGIPDE LWQLLVQCLA
260 270 280 290 300
KAPASRLRAS ELSARLRELL PMLAGMAPLD VDEPDAEQPE DAPDASAASP
310 320 330 340 350
AAPVSTAEPV RRRGAVPLVP GAKPADSNRD THTSMRVPAP DELAGGARGT
360 370 380 390 400
ARAPRASGAP RPGSARNRAA TRRRRIAVGA GAVALVAAIG VGTWLATGGD
410
EDGGGPQDTR NSAPAAP
Length:417
Mass (Da):43,417
Last modified:October 1, 1996 - v1
Checksum:i3D66720FF17D3DE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86821 Genomic DNA. Translation: BAA13169.1.
AL939114 Genomic DNA. Translation: CAD55460.1.
PIRiJC4071.
RefSeqiNP_733588.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAD55460; CAD55460; CAD55460.
GeneIDi1098406.
KEGGisco:SCO2973.
PATRICi23735672. VBIStrCoe124346_3031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86821 Genomic DNA. Translation: BAA13169.1 .
AL939114 Genomic DNA. Translation: CAD55460.1 .
PIRi JC4071.
RefSeqi NP_733588.1. NC_003888.3.

3D structure databases

ProteinModelPortali P54740.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO2973.

PTM databases

PhosSitei P0502123.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD55460 ; CAD55460 ; CAD55460 .
GeneIDi 1098406.
KEGGi sco:SCO2973.
PATRICi 23735672. VBIStrCoe124346_3031.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000053674.
InParanoidi P54740.
KOi K08884.
OMAi RRHVTET.
OrthoDBi EOG6B35XT.
PhylomeDBi P54740.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 5998.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing and expression of serine/threonine kinase-encoding genes from Streptomyces coelicolor A3(2)."
    Urabe H., Ogawara H.
    Gene 153:99-104(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / NRRL B-16638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiPKAB_STRCO
AccessioniPrimary (citable) accession number: P54740
Secondary accession number(s): Q9L061, Q9L1S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3