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P54740

- PKAB_STRCO

UniProt

P54740 - PKAB_STRCO

Protein

Serine/threonine-protein kinase PkaB

Gene

pkaB

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361ATPPROSITE-ProRule annotation
    Active sitei130 – 1301Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 239ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 5998.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PkaB (EC:2.7.11.1)
    Gene namesi
    Name:pkaB
    Ordered Locus Names:SCO2973
    ORF Names:SCE50.01, SCE59.32c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Serine/threonine-protein kinase PkaBPRO_0000171233Add
    BLAST

    Post-translational modificationi

    Autophosphorylated mainly at Thr.

    Keywords - PTMi

    Phosphoprotein

    PTM databases

    PhosSiteiP0502123.

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO2973.

    Structurei

    3D structure databases

    ProteinModelPortaliP54740.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 270262Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000053674.
    KOiK08884.
    OMAiRRHVTET.
    OrthoDBiEOG6B35XT.
    PhylomeDBiP54740.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54740-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARKIGSRYT AHQILGRGSA GTVWLGEGPD GPVAIKLLRE DLASDQELVS    50
    RFVQERTALL GLDHPHVVSV RDLVVDGNDL ALVMDLVRGT DLRTRLDRER 100
    RLAPEAAVAV VADVADGLAA AHAAGVVHRD VKPENVLLDM QGPLGPGGSH 150
    PALLTDFGVA KLIDTPRRTR ATKIIGTPDY LAPEIVEGLP PRAAVDIYAL 200
    ATVLYELLAG FTPFGGGHPG AVLRRHVTET VVPLPGIPDE LWQLLVQCLA 250
    KAPASRLRAS ELSARLRELL PMLAGMAPLD VDEPDAEQPE DAPDASAASP 300
    AAPVSTAEPV RRRGAVPLVP GAKPADSNRD THTSMRVPAP DELAGGARGT 350
    ARAPRASGAP RPGSARNRAA TRRRRIAVGA GAVALVAAIG VGTWLATGGD 400
    EDGGGPQDTR NSAPAAP 417
    Length:417
    Mass (Da):43,417
    Last modified:October 1, 1996 - v1
    Checksum:i3D66720FF17D3DE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86821 Genomic DNA. Translation: BAA13169.1.
    AL939114 Genomic DNA. Translation: CAD55460.1.
    PIRiJC4071.
    RefSeqiNP_733588.1. NC_003888.3.
    WP_011028691.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAD55460; CAD55460; CAD55460.
    GeneIDi1098406.
    KEGGisco:SCO2973.
    PATRICi23735672. VBIStrCoe124346_3031.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86821 Genomic DNA. Translation: BAA13169.1 .
    AL939114 Genomic DNA. Translation: CAD55460.1 .
    PIRi JC4071.
    RefSeqi NP_733588.1. NC_003888.3.
    WP_011028691.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali P54740.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO2973.

    PTM databases

    PhosSitei P0502123.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD55460 ; CAD55460 ; CAD55460 .
    GeneIDi 1098406.
    KEGGi sco:SCO2973.
    PATRICi 23735672. VBIStrCoe124346_3031.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000053674.
    KOi K08884.
    OMAi RRHVTET.
    OrthoDBi EOG6B35XT.
    PhylomeDBi P54740.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 5998.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and expression of serine/threonine kinase-encoding genes from Streptomyces coelicolor A3(2)."
      Urabe H., Ogawara H.
      Gene 153:99-104(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: A3(2) / NRRL B-16638.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiPKAB_STRCO
    AccessioniPrimary (citable) accession number: P54740
    Secondary accession number(s): Q9L061, Q9L1S2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3