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P54739 (PKAA_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase PkaA

EC=2.7.11.1
Gene names
Name:pkaA
Ordered Locus Names:SCO2974
ORF Names:SCE50.02c
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Post-translational modification

Autophosphorylated mainly at Thr and slightly at Ser.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 543543Serine/threonine-protein kinase PkaA
PRO_0000171232

Regions

Domain8 – 276269Protein kinase
Nucleotide binding14 – 229ATP By similarity
Compositional bias301 – 481181Gln/Pro-rich

Sites

Active site1421Proton acceptor By similarity
Binding site481ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P54739 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 0E1965520FA0C200

FASTA54358,182
        10         20         30         40         50         60 
MRPVGSKYLL EEPLGRGATG TVWRARQRET AGAEAAVAGQ PGETVAIKVL KEELASDADI 

        70         80         90        100        110        120 
VMRFLRERSV LLRLTHPNIV RVRDLVVEGE LLALVMDLID GPDLHRYLRE NGPLTPVAAA 

       130        140        150        160        170        180 
LLTAQIADAL AASHADGVVH RDLKPANVLL KQTGGEMHPM LTDFGIARLA DSPGLTRTHE 

       190        200        210        220        230        240 
FVGTPAYVAP ESAEGRPQTS AVDVYGAGIL LYELVTGRPP FGGGSALEVL HQHLSAEPRR 

       250        260        270        280        290        300 
PSTVPDPLWT VIERCLRKNP DDRPSAENLA RGLRVVAEGI GVHANSAQIG AAENVGALLA 

       310        320        330        340        350        360 
PDPAPAQVPG APDAAYDPNG ATSVLPHTSG PAGAADPTAV LPSTGAPDPT AVMPPVPPGQ 

       370        380        390        400        410        420 
PGAPGQGGPE DPHPWQNQLR AARDRNEQTQ VQYLDPNQDP LRRRPQRQVS RPPQQPRQAP 

       430        440        450        460        470        480 
QGPPPQQPGY GYPQQQQPQR YATPQPQQPQ RYAPPPAPEP QQPRREPRPP RQRSANPMRI 

       490        500        510        520        530        540 
PGLGCLKGCL VTVVVLFVAG WLVWELSPLQ EWIGTGKGYW DQLTDWFTTV TDWIGDLGGS 


GGG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D86821 Genomic DNA. Translation: BAA13168.1.
AL939114 Genomic DNA. Translation: CAB87324.1.
PIRJC4070.
RefSeqNP_627197.1. NC_003888.3.

3D structure databases

ProteinModelPortalP54739.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO2974.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB87324; CAB87324; CAB87324.
GeneID1098407.
KEGGsco:SCO2974.
PATRIC23735674. VBIStrCoe124346_3032.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000115552.
KOK08884.
OMAARDRNEQ.
OrthoDBEOG6B35XT.
PhylomeDBP54739.
ProtClustDBCLSK381571.

Enzyme and pathway databases

BRENDA2.7.11.1. 5998.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePKAA_STRCO
AccessionPrimary (citable) accession number: P54739
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families