SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P54739

- PKAA_STRCO

UniProt

P54739 - PKAA_STRCO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Serine/threonine-protein kinase PkaA
Gene
pkaA, SCO2974, SCE50.02c
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481ATP By similarity
Active sitei142 – 1421Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 5998.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PkaA (EC:2.7.11.1)
Gene namesi
Name:pkaA
Ordered Locus Names:SCO2974
ORF Names:SCE50.02c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Serine/threonine-protein kinase PkaA
PRO_0000171232Add
BLAST

Post-translational modificationi

Autophosphorylated mainly at Thr and slightly at Ser.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO2974.

Structurei

3D structure databases

ProteinModelPortaliP54739.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 276269Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi301 – 481181Gln/Pro-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000115552.
KOiK08884.
OMAiMHPMLTD.
OrthoDBiEOG6B35XT.
PhylomeDBiP54739.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54739-1 [UniParc]FASTAAdd to Basket

« Hide

MRPVGSKYLL EEPLGRGATG TVWRARQRET AGAEAAVAGQ PGETVAIKVL    50
KEELASDADI VMRFLRERSV LLRLTHPNIV RVRDLVVEGE LLALVMDLID 100
GPDLHRYLRE NGPLTPVAAA LLTAQIADAL AASHADGVVH RDLKPANVLL 150
KQTGGEMHPM LTDFGIARLA DSPGLTRTHE FVGTPAYVAP ESAEGRPQTS 200
AVDVYGAGIL LYELVTGRPP FGGGSALEVL HQHLSAEPRR PSTVPDPLWT 250
VIERCLRKNP DDRPSAENLA RGLRVVAEGI GVHANSAQIG AAENVGALLA 300
PDPAPAQVPG APDAAYDPNG ATSVLPHTSG PAGAADPTAV LPSTGAPDPT 350
AVMPPVPPGQ PGAPGQGGPE DPHPWQNQLR AARDRNEQTQ VQYLDPNQDP 400
LRRRPQRQVS RPPQQPRQAP QGPPPQQPGY GYPQQQQPQR YATPQPQQPQ 450
RYAPPPAPEP QQPRREPRPP RQRSANPMRI PGLGCLKGCL VTVVVLFVAG 500
WLVWELSPLQ EWIGTGKGYW DQLTDWFTTV TDWIGDLGGS GGG 543
Length:543
Mass (Da):58,182
Last modified:October 1, 1996 - v1
Checksum:i0E1965520FA0C200
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86821 Genomic DNA. Translation: BAA13168.1.
AL939114 Genomic DNA. Translation: CAB87324.1.
PIRiJC4070.
RefSeqiNP_627197.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB87324; CAB87324; CAB87324.
GeneIDi1098407.
KEGGisco:SCO2974.
PATRICi23735674. VBIStrCoe124346_3032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86821 Genomic DNA. Translation: BAA13168.1 .
AL939114 Genomic DNA. Translation: CAB87324.1 .
PIRi JC4070.
RefSeqi NP_627197.1. NC_003888.3.

3D structure databases

ProteinModelPortali P54739.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO2974.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB87324 ; CAB87324 ; CAB87324 .
GeneIDi 1098407.
KEGGi sco:SCO2974.
PATRICi 23735674. VBIStrCoe124346_3032.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000115552.
KOi K08884.
OMAi MHPMLTD.
OrthoDBi EOG6B35XT.
PhylomeDBi P54739.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 5998.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing and expression of serine/threonine kinase-encoding genes from Streptomyces coelicolor A3(2)."
    Urabe H., Ogawara H.
    Gene 153:99-104(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / NRRL B-16638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiPKAA_STRCO
AccessioniPrimary (citable) accession number: P54739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi