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P54739

- PKAA_STRCO

UniProt

P54739 - PKAA_STRCO

Protein

Serine/threonine-protein kinase PkaA

Gene

pkaA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei48 – 481ATPPROSITE-ProRule annotation
    Active sitei142 – 1421Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 229ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 5998.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PkaA (EC:2.7.11.1)
    Gene namesi
    Name:pkaA
    Ordered Locus Names:SCO2974
    ORF Names:SCE50.02c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 543543Serine/threonine-protein kinase PkaAPRO_0000171232Add
    BLAST

    Post-translational modificationi

    Autophosphorylated mainly at Thr and slightly at Ser.

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO2974.

    Structurei

    3D structure databases

    ProteinModelPortaliP54739.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 276269Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi301 – 481181Gln/Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000115552.
    KOiK08884.
    OMAiMHPMLTD.
    OrthoDBiEOG6B35XT.
    PhylomeDBiP54739.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54739-1 [UniParc]FASTAAdd to Basket

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    MRPVGSKYLL EEPLGRGATG TVWRARQRET AGAEAAVAGQ PGETVAIKVL    50
    KEELASDADI VMRFLRERSV LLRLTHPNIV RVRDLVVEGE LLALVMDLID 100
    GPDLHRYLRE NGPLTPVAAA LLTAQIADAL AASHADGVVH RDLKPANVLL 150
    KQTGGEMHPM LTDFGIARLA DSPGLTRTHE FVGTPAYVAP ESAEGRPQTS 200
    AVDVYGAGIL LYELVTGRPP FGGGSALEVL HQHLSAEPRR PSTVPDPLWT 250
    VIERCLRKNP DDRPSAENLA RGLRVVAEGI GVHANSAQIG AAENVGALLA 300
    PDPAPAQVPG APDAAYDPNG ATSVLPHTSG PAGAADPTAV LPSTGAPDPT 350
    AVMPPVPPGQ PGAPGQGGPE DPHPWQNQLR AARDRNEQTQ VQYLDPNQDP 400
    LRRRPQRQVS RPPQQPRQAP QGPPPQQPGY GYPQQQQPQR YATPQPQQPQ 450
    RYAPPPAPEP QQPRREPRPP RQRSANPMRI PGLGCLKGCL VTVVVLFVAG 500
    WLVWELSPLQ EWIGTGKGYW DQLTDWFTTV TDWIGDLGGS GGG 543
    Length:543
    Mass (Da):58,182
    Last modified:October 1, 1996 - v1
    Checksum:i0E1965520FA0C200
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86821 Genomic DNA. Translation: BAA13168.1.
    AL939114 Genomic DNA. Translation: CAB87324.1.
    PIRiJC4070.
    RefSeqiNP_627197.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB87324; CAB87324; CAB87324.
    GeneIDi1098407.
    KEGGisco:SCO2974.
    PATRICi23735674. VBIStrCoe124346_3032.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86821 Genomic DNA. Translation: BAA13168.1 .
    AL939114 Genomic DNA. Translation: CAB87324.1 .
    PIRi JC4070.
    RefSeqi NP_627197.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali P54739.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO2974.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB87324 ; CAB87324 ; CAB87324 .
    GeneIDi 1098407.
    KEGGi sco:SCO2974.
    PATRICi 23735674. VBIStrCoe124346_3032.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000115552.
    KOi K08884.
    OMAi MHPMLTD.
    OrthoDBi EOG6B35XT.
    PhylomeDBi P54739.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 5998.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and expression of serine/threonine kinase-encoding genes from Streptomyces coelicolor A3(2)."
      Urabe H., Ogawara H.
      Gene 153:99-104(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: A3(2) / NRRL B-16638.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiPKAA_STRCO
    AccessioniPrimary (citable) accession number: P54739
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3