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Protein

Serine/threonine-protein kinase PkaA

Gene

pkaA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48ATPPROSITE-ProRule annotation1
Active sitei142Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 5998

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PkaA (EC:2.7.11.1)
Gene namesi
Name:pkaA
Ordered Locus Names:SCO2974
ORF Names:SCE50.02c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001712321 – 543Serine/threonine-protein kinase PkaAAdd BLAST543

Post-translational modificationi

Autophosphorylated mainly at Thr and slightly at Ser.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP54739

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO2974

Structurei

3D structure databases

ProteinModelPortaliP54739
SMRiP54739
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 276Protein kinasePROSITE-ProRule annotationAdd BLAST269

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi301 – 481Gln/Pro-richAdd BLAST181

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108UGD Bacteria
COG0515 LUCA
HOGENOMiHOG000115552
InParanoidiP54739
KOiK08884
OMAiMHPMLTD
OrthoDBiPOG091H0264
PhylomeDBiP54739

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P54739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPVGSKYLL EEPLGRGATG TVWRARQRET AGAEAAVAGQ PGETVAIKVL
60 70 80 90 100
KEELASDADI VMRFLRERSV LLRLTHPNIV RVRDLVVEGE LLALVMDLID
110 120 130 140 150
GPDLHRYLRE NGPLTPVAAA LLTAQIADAL AASHADGVVH RDLKPANVLL
160 170 180 190 200
KQTGGEMHPM LTDFGIARLA DSPGLTRTHE FVGTPAYVAP ESAEGRPQTS
210 220 230 240 250
AVDVYGAGIL LYELVTGRPP FGGGSALEVL HQHLSAEPRR PSTVPDPLWT
260 270 280 290 300
VIERCLRKNP DDRPSAENLA RGLRVVAEGI GVHANSAQIG AAENVGALLA
310 320 330 340 350
PDPAPAQVPG APDAAYDPNG ATSVLPHTSG PAGAADPTAV LPSTGAPDPT
360 370 380 390 400
AVMPPVPPGQ PGAPGQGGPE DPHPWQNQLR AARDRNEQTQ VQYLDPNQDP
410 420 430 440 450
LRRRPQRQVS RPPQQPRQAP QGPPPQQPGY GYPQQQQPQR YATPQPQQPQ
460 470 480 490 500
RYAPPPAPEP QQPRREPRPP RQRSANPMRI PGLGCLKGCL VTVVVLFVAG
510 520 530 540
WLVWELSPLQ EWIGTGKGYW DQLTDWFTTV TDWIGDLGGS GGG
Length:543
Mass (Da):58,182
Last modified:October 1, 1996 - v1
Checksum:i0E1965520FA0C200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86821 Genomic DNA Translation: BAA13168.1
AL939114 Genomic DNA Translation: CAB87324.1
PIRiJC4070
RefSeqiNP_627197.1, NC_003888.3
WP_003975838.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB87324; CAB87324; CAB87324
GeneIDi1098407
KEGGisco:SCO2974
PATRICifig|100226.15.peg.3032

Similar proteinsi

Entry informationi

Entry nameiPKAA_STRCO
AccessioniPrimary (citable) accession number: P54739
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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