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Protein

Serine/threonine-protein kinase pkn2

Gene

pkn2

Organism
Myxococcus xanthus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regulates the activity of endogenous beta-lactamase or related enzymes, by blocking their secretion by phosphorylation, in response to an external signal yet to be identified.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATPPROSITE-ProRule annotation1
Active sitei135Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 27ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 3551

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase pkn2 (EC:2.7.11.1)
Gene namesi
Name:pkn2
OrganismiMyxococcus xanthus
Taxonomic identifieri34 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 605CytoplasmicSequence analysisAdd BLAST605
Transmembranei606 – 623HelicalSequence analysisAdd BLAST18
Topological domaini624 – 830PeriplasmicSequence analysisAdd BLAST207

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001712281 – 830Serine/threonine-protein kinase pkn2Add BLAST830

Proteomic databases

PRIDEiP54736

Structurei

3D structure databases

ProteinModelPortaliP54736
SMRiP54736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 283Protein kinasePROSITE-ProRule annotationAdd BLAST271
Domaini396 – 511Guanylate cyclasePROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108V5V Bacteria
COG0515 LUCA

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR011009 Kinase-like_dom_sf
IPR029787 Nucleotide_cyclase
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF55073 SSF55073, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P54736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAPDSLVLD GRFRVLRPLG SGGMGEVYLG EQVSLGRKVA IKVLHHDLHA
60 70 80 90 100
QAGMAERFKR EARLLSAVEH PAVVRIVDFG ESGDHACLVM EFVEGESLYD
110 120 130 140 150
VLTPGPMPPG RALPLLQQLA EGLAAIHDKG IIHRDLKPEN VFISKSARGE
160 170 180 190 200
QARLLDFGIA RLVEPDAASS VSQIGVVLGT PEYLSPEQAV GAKVDTRSDL
210 220 230 240 250
YSFGVLTYRV LSGRLPFDGP LPRNFLSQHA SAAPLPLDRA APTLSRYVGL
260 270 280 290 300
LSLVMRLLEK DASKRPQSAH ELADALAAAH SALSAFTPGL GTPAYVPQPG
310 320 330 340 350
SGATPSSGTS VFGTGSASGS SSGPTGTAAF AGVAPAPQAS SGTAAFGVAS
360 370 380 390 400
SSGSASGALP AASPHTGTAS FGLKSSGGVA AVTGGNASVV KPQNLTVMLT
410 420 430 440 450
DIQGFTERTS RQTHEENARM LETHDKLLMP LVKEHDGRLV QKRGDALLVV
460 470 480 490 500
FRSPTAGVLC GMAMQDRLWR HNQTVPEVDR LNVRVCLHAG EVLATPDSVL
510 520 530 540 550
GEPMEVIEAV EHVASAGEVT FTEAVNLARN RAEATAEPCG AITLPGRNEQ
560 570 580 590 600
LQLYRCQRAA EGPPFGDRFA SQGSRGNALA PLLAKLQAVK LPTGLGELLR
610 620 630 640 650
QRRREAALVA GAVVLLGAGA AWLSQRNDAG TRAFALLEDG KLNEALALMD
660 670 680 690 700
AATDEEKELP SLRRARVAAN HAKGHHISER TALSHLKEEE LEDVEPLILD
710 720 730 740 750
GLAEDYGKEP LTVLGNALAR FPKDRLRAHY EDLAEEAYSL RQWGALRYLE
760 770 780 790 800
FVKAADGVNL VRAYSEALNS PDCDIRTQAA NRLAGLGDAD AIPAMERVTS
810 820 830
LPKAKGLLGS KDCGHEAAAT AIKSLKQKSD
Length:830
Mass (Da):87,680
Last modified:October 1, 1996 - v1
Checksum:iBD53F33CE057FA1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94857 Genomic DNA Translation: AAA98813.1
PIRiA57060
RefSeqiWP_011556352.1, NZ_FNOH01000001.1

Similar proteinsi

Entry informationi

Entry nameiPKN2_MYXXA
AccessioniPrimary (citable) accession number: P54736
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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