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P54734

- PKNA_NOSS1

UniProt

P54734 - PKNA_NOSS1

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Protein

Serine/threonine-protein kinase PknA

Gene

pknA

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Probably required for both normal cellular growth and differentiation. Inactivation of pknA leads to colonies that appear light green and rough in the absence of combined nitrogen.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401ATPPROSITE-ProRule annotation
Active sitei139 – 1391Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 319.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PknA (EC:2.7.11.1)
Gene namesi
Name:pknA
Ordered Locus Names:alr4366
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Serine/threonine-protein kinase PknAPRO_0000171181Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.alr4366.

Structurei

3D structure databases

ProteinModelPortaliP54734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 271263Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000035389.
KOiK08884.
OMAiAYHPRER.
OrthoDBiEOG6RC3K8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54734-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQLLDNRYR VIKTLGSGGF GETFLAEDSQ MPSNRRCVVK QLRPIHNNPQ
60 70 80 90 100
IYQLVQERFQ REAAILEDLG SYSGQIPTLY AYFQSNTQFY VVQEWVEGDT
110 120 130 140 150
LTAKLKQQGV LSESAVRDIL INLLPVLEYV HSKRIIHRDI KPDNIILRHR
160 170 180 190 200
DGKPVLIDFG AVRESMGTVI NSQGNPTSSI VIGTPGYMPS EQAAGRPVYS
210 220 230 240 250
SDLYSLGLTA IYLLTGKQPQ ELETEPHSGE IIWHRYALNI SPTLAAVIDR
260 270 280 290 300
AIAYHPRERF TTAREMLEAL QLGVVSYPPT VPYQQPQSSP TVPYQQPPVV
310 320 330 340 350
TTPPFATQTN TVAVSPGTAP TPQPINHNNS NKGILMGSLI AGGLIGASVV
360 370 380 390 400
IGFALTRPNQ PVTQTTSLPS ETTISNNDTP TVEPSPTDTP ETPISQTVTQ
410 420 430 440 450
DPTPQASVRF PINSRPFTTP IDSKPRNTTE PTTSVPQPTT PSEPQITTPV
460 470 480 490 500
EATDRPSPEQ AVQNYYETIN QGEYSTAWNL LASSFQNNRK LHPRGYDSYL
510 520 530 540 550
DWWGGQVENV DVEQVSLLKA NADTATVNAR LRYFMKSGRQ SSSSVRFSLV
560
WDADNNRWVV SGAR
Length:564
Mass (Da):62,385
Last modified:January 23, 2002 - v2
Checksum:iAD0485E7AC69E785
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti265 – 2651E → Q in AAB41116. (PubMed:7505448)Curated
Sequence conflicti522 – 5221A → R in AAB41116. (PubMed:7505448)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00484 Genomic DNA. Translation: AAB41116.1.
BA000019 Genomic DNA. Translation: BAB76065.1.
PIRiAF2351.
RefSeqiNP_488406.1. NC_003272.1.
WP_010998503.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB76065; BAB76065; BAB76065.
GeneIDi1107967.
KEGGiana:alr4366.
PATRICi22779306. VBINosSp37423_5100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00484 Genomic DNA. Translation: AAB41116.1 .
BA000019 Genomic DNA. Translation: BAB76065.1 .
PIRi AF2351.
RefSeqi NP_488406.1. NC_003272.1.
WP_010998503.1. NC_003272.1.

3D structure databases

ProteinModelPortali P54734.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.alr4366.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB76065 ; BAB76065 ; BAB76065 .
GeneIDi 1107967.
KEGGi ana:alr4366.
PATRICi 22779306. VBINosSp37423_5100.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000035389.
KOi K08884.
OMAi AYHPRER.
OrthoDBi EOG6RC3K8.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 319.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A gene encoding a protein related to eukaryotic protein kinases from the filamentous heterocystous cyanobacterium Anabaena PCC 7120."
    Zhang C.C.
    Proc. Natl. Acad. Sci. U.S.A. 90:11840-11844(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiPKNA_NOSS1
AccessioniPrimary (citable) accession number: P54734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2002
Last modified: October 1, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3