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P54734

- PKNA_NOSS1

UniProt

P54734 - PKNA_NOSS1

Protein

Serine/threonine-protein kinase PknA

Gene

pknA

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Probably required for both normal cellular growth and differentiation. Inactivation of pknA leads to colonies that appear light green and rough in the absence of combined nitrogen.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei40 – 401ATPPROSITE-ProRule annotation
    Active sitei139 – 1391Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 239ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 319.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PknA (EC:2.7.11.1)
    Gene namesi
    Name:pknA
    Ordered Locus Names:alr4366
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 564564Serine/threonine-protein kinase PknAPRO_0000171181Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi103690.alr4366.

    Structurei

    3D structure databases

    ProteinModelPortaliP54734.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 271263Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000035389.
    KOiK08884.
    OMAiAYHPRER.
    OrthoDBiEOG6RC3K8.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54734-1 [UniParc]FASTAAdd to Basket

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    MEQLLDNRYR VIKTLGSGGF GETFLAEDSQ MPSNRRCVVK QLRPIHNNPQ    50
    IYQLVQERFQ REAAILEDLG SYSGQIPTLY AYFQSNTQFY VVQEWVEGDT 100
    LTAKLKQQGV LSESAVRDIL INLLPVLEYV HSKRIIHRDI KPDNIILRHR 150
    DGKPVLIDFG AVRESMGTVI NSQGNPTSSI VIGTPGYMPS EQAAGRPVYS 200
    SDLYSLGLTA IYLLTGKQPQ ELETEPHSGE IIWHRYALNI SPTLAAVIDR 250
    AIAYHPRERF TTAREMLEAL QLGVVSYPPT VPYQQPQSSP TVPYQQPPVV 300
    TTPPFATQTN TVAVSPGTAP TPQPINHNNS NKGILMGSLI AGGLIGASVV 350
    IGFALTRPNQ PVTQTTSLPS ETTISNNDTP TVEPSPTDTP ETPISQTVTQ 400
    DPTPQASVRF PINSRPFTTP IDSKPRNTTE PTTSVPQPTT PSEPQITTPV 450
    EATDRPSPEQ AVQNYYETIN QGEYSTAWNL LASSFQNNRK LHPRGYDSYL 500
    DWWGGQVENV DVEQVSLLKA NADTATVNAR LRYFMKSGRQ SSSSVRFSLV 550
    WDADNNRWVV SGAR 564
    Length:564
    Mass (Da):62,385
    Last modified:January 23, 2002 - v2
    Checksum:iAD0485E7AC69E785
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti265 – 2651E → Q in AAB41116. (PubMed:7505448)Curated
    Sequence conflicti522 – 5221A → R in AAB41116. (PubMed:7505448)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00484 Genomic DNA. Translation: AAB41116.1.
    BA000019 Genomic DNA. Translation: BAB76065.1.
    PIRiAF2351.
    RefSeqiNP_488406.1. NC_003272.1.
    WP_010998503.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB76065; BAB76065; BAB76065.
    GeneIDi1107967.
    KEGGiana:alr4366.
    PATRICi22779306. VBINosSp37423_5100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00484 Genomic DNA. Translation: AAB41116.1 .
    BA000019 Genomic DNA. Translation: BAB76065.1 .
    PIRi AF2351.
    RefSeqi NP_488406.1. NC_003272.1.
    WP_010998503.1. NC_003272.1.

    3D structure databases

    ProteinModelPortali P54734.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.alr4366.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB76065 ; BAB76065 ; BAB76065 .
    GeneIDi 1107967.
    KEGGi ana:alr4366.
    PATRICi 22779306. VBINosSp37423_5100.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000035389.
    KOi K08884.
    OMAi AYHPRER.
    OrthoDBi EOG6RC3K8.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 319.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A gene encoding a protein related to eukaryotic protein kinases from the filamentous heterocystous cyanobacterium Anabaena PCC 7120."
      Zhang C.C.
      Proc. Natl. Acad. Sci. U.S.A. 90:11840-11844(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576.

    Entry informationi

    Entry nameiPKNA_NOSS1
    AccessioniPrimary (citable) accession number: P54734
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3