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P54731

- FAF1_MOUSE

UniProt

P54731 - FAF1_MOUSE

Protein

FAS-associated factor 1

Gene

Faf1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Potentiates but cannot initiate FAS-induced apoptosis.

    GO - Molecular functioni

    1. heat shock protein binding Source: UniProtKB
    2. protein binding Source: MGI
    3. protein domain specific binding Source: MGI
    4. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cell death Source: UniProtKB
    3. cytoplasmic sequestering of NF-kappaB Source: UniProtKB
    4. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
    5. positive regulation of protein complex assembly Source: UniProtKB
    6. regulation of cell adhesion Source: MGI
    7. regulation of protein catabolic process Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FAS-associated factor 1
    Gene namesi
    Name:Faf1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:109419. Faf1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. Cdc48p-Npl4p-Ufd1p AAA ATPase complex Source: Ensembl
    2. cytoplasm Source: MGI
    3. cytosol Source: UniProtKB
    4. nuclear envelope Source: MGI
    5. nucleus Source: UniProtKB
    6. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 649649FAS-associated factor 1PRO_0000211039Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei319 – 3191PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP54731.
    PaxDbiP54731.
    PRIDEiP54731.

    PTM databases

    PhosphoSiteiP54731.

    Expressioni

    Gene expression databases

    BgeeiP54731.
    CleanExiMM_FAF1.
    GenevestigatoriP54731.

    Interactioni

    Subunit structurei

    Interacts with NLRP12 DAPIN/PYRIN domain via its UBA domain By similarity. Specifically interacts with the cytoplasmic domain of FAS.By similarity

    Protein-protein interaction databases

    BioGridi199588. 3 interactions.
    IntActiP54731. 1 interaction.
    MINTiMINT-1513304.
    STRINGi10090.ENSMUSP00000099785.

    Structurei

    3D structure databases

    ProteinModelPortaliP54731.
    SMRiP54731. Positions 5-44, 98-190, 324-494, 568-649.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 5757UBAAdd
    BLAST
    Domaini568 – 64578UBXPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 UBA domain.Curated
    Contains 1 UBX domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG288188.
    GeneTreeiENSGT00530000063422.
    HOGENOMiHOG000043073.
    HOVERGENiHBG002876.
    InParanoidiQ6P1F8.
    OMAiWEGWPAS.
    OrthoDBiEOG72NRPV.
    TreeFamiTF314172.

    Family and domain databases

    InterProiIPR012336. Thioredoxin-like_fold.
    IPR006577. UAS.
    IPR029071. Ubiquitin-rel_dom.
    IPR001012. UBX_dom.
    [Graphical view]
    PfamiPF00789. UBX. 1 hit.
    [Graphical view]
    SMARTiSM00594. UAS. 1 hit.
    SM00166. UBX. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    SSF54236. SSF54236. 3 hits.
    PROSITEiPS50033. UBX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P54731-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG    50
    ILQSDFGGET MPGPTFDPAS HPAPASTPSS SAFRPVMPSR QIVERQPRML 100
    DFRVEYRDRN VDVVLEDSCT VGEIKQILEN ELQIPVPKML LKGWKTGDVE 150
    DSTVLKSLHL PKNNSLYVLT PDLPPPSSSS HAGALQESLN QNFMLIITHR 200
    EVQREYNLNF SGSSTVQEVK RNVYDLTSIP VRHQLWEGWP ASATDDSMCL 250
    AESGLSYPCH RLTVGRRTSP VQTREQSEEQ STDVHMVSDS DGDDFEDASE 300
    FGVDDGEVFG MASSTLRKSP MMPENAENEG DALLQFTAEF SSRYGDCHPV 350
    FFIGSLEAAF QEAFYVKARD RKLLAIYLHH DESVLTNVFC SQMLCAESIV 400
    SYLSQNFITW AWDLTKDTNR ARFLTMCNRH FGSVIAQTIR TQKTDQFPLF 450
    LIIMGKRSSN EVLNVIQGNT TVDELMMRLM AAMEIFSAQQ QEDIKDEDER 500
    EARENVKREQ DEAYRLSLEA DRAKREAHER EMAEQFRLEQ IRKEQEEERE 550
    AIRLSLEQAL PPEPKEENAE PVSKLRIRTP SGEFLERRFL ASNKLQIVFD 600
    FVASKGFPWD EFKLLSTFPR RDVTQLDPNK SLLEVNLFPQ ETLFLQAKE 649
    Length:649
    Mass (Da):73,863
    Last modified:July 27, 2011 - v2
    Checksum:i0DA48081312EFE8D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 82RE → LP in AAA92091. (PubMed:8524870)Curated
    Sequence conflicti345 – 3451G → S in AAA92091. (PubMed:8524870)Curated
    Sequence conflicti352 – 3521F → Y in AAA92091. (PubMed:8524870)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39643 mRNA. Translation: AAA92091.1.
    AL627188, AL627392 Genomic DNA. Translation: CAM13709.1.
    AL627392, AL627188 Genomic DNA. Translation: CAM16845.1.
    CH466527 Genomic DNA. Translation: EDL30696.1.
    BC065098 mRNA. Translation: AAH65098.1.
    CCDSiCCDS18468.1.
    RefSeqiNP_032009.2. NM_007983.2.
    UniGeneiMm.318259.

    Genome annotation databases

    EnsembliENSMUST00000102724; ENSMUSP00000099785; ENSMUSG00000010517.
    GeneIDi14084.
    KEGGimmu:14084.
    UCSCiuc008uct.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39643 mRNA. Translation: AAA92091.1 .
    AL627188 , AL627392 Genomic DNA. Translation: CAM13709.1 .
    AL627392 , AL627188 Genomic DNA. Translation: CAM16845.1 .
    CH466527 Genomic DNA. Translation: EDL30696.1 .
    BC065098 mRNA. Translation: AAH65098.1 .
    CCDSi CCDS18468.1.
    RefSeqi NP_032009.2. NM_007983.2.
    UniGenei Mm.318259.

    3D structure databases

    ProteinModelPortali P54731.
    SMRi P54731. Positions 5-44, 98-190, 324-494, 568-649.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199588. 3 interactions.
    IntActi P54731. 1 interaction.
    MINTi MINT-1513304.
    STRINGi 10090.ENSMUSP00000099785.

    PTM databases

    PhosphoSitei P54731.

    Proteomic databases

    MaxQBi P54731.
    PaxDbi P54731.
    PRIDEi P54731.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102724 ; ENSMUSP00000099785 ; ENSMUSG00000010517 .
    GeneIDi 14084.
    KEGGi mmu:14084.
    UCSCi uc008uct.1. mouse.

    Organism-specific databases

    CTDi 11124.
    MGIi MGI:109419. Faf1.

    Phylogenomic databases

    eggNOGi NOG288188.
    GeneTreei ENSGT00530000063422.
    HOGENOMi HOG000043073.
    HOVERGENi HBG002876.
    InParanoidi Q6P1F8.
    OMAi WEGWPAS.
    OrthoDBi EOG72NRPV.
    TreeFami TF314172.

    Miscellaneous databases

    ChiTaRSi FAF1. mouse.
    NextBioi 285104.
    PROi P54731.
    SOURCEi Search...

    Gene expression databases

    Bgeei P54731.
    CleanExi MM_FAF1.
    Genevestigatori P54731.

    Family and domain databases

    InterProi IPR012336. Thioredoxin-like_fold.
    IPR006577. UAS.
    IPR029071. Ubiquitin-rel_dom.
    IPR001012. UBX_dom.
    [Graphical view ]
    Pfami PF00789. UBX. 1 hit.
    [Graphical view ]
    SMARTi SM00594. UAS. 1 hit.
    SM00166. UBX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    SSF54236. SSF54236. 3 hits.
    PROSITEi PS50033. UBX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis."
      Chu K., Niu X., Williams L.T.
      Proc. Natl. Acad. Sci. U.S.A. 92:11894-11898(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiFAF1_MOUSE
    AccessioniPrimary (citable) accession number: P54731
    Secondary accession number(s): Q6P1F8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3