FAS-associated factor 1 - Mus musculus (Mouse)

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P54731 (FAF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 90. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
FAS-associated factor 1

Gene names

Name:

Faf1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	649 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potentiates but cannot initiate FAS-induced apoptosis.
Subunit structure	Interacts with NLRP12 DAPIN/PYRIN domain via its UBA domain By similarity. Specifically interacts with the cytoplasmic domain of FAS.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 UBA domain. Contains 1 UBX domain.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cell death Inferred from sequence or structural similarity. Source: UniProtKB cytoplasmic sequestering of NF-kappaB Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of apoptotic process Inferred from direct assay Ref.1. Source: MGI positive regulation of protein complex assembly Inferred from sequence or structural similarity. Source: UniProtKB regulation of cell adhesion Inferred from mutant phenotype PubMed 11731229. Source: MGI regulation of protein catabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	Cdc48p-Npl4p-Ufd1p AAA ATPase complex Inferred from electronic annotation. Source: Compara cytosol Inferred from sequence or structural similarity. Source: UniProtKB nuclear envelope Inferred from direct assay PubMed 11731229. Source: MGI perinuclear region of cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	heat shock protein binding Inferred from sequence or structural similarity. Source: UniProtKB protein kinase binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 649

649

FAS-associated factor 1

PRO_0000211039

Regions

Domain

1 – 57

UBA

Domain

568 – 645

UBX

Amino acid modifications

Modified residue

269

Phosphoserine Ref.6

Modified residue

319

Phosphoserine By similarity

Modified residue

579

Phosphothreonine Ref.5

Experimental info

Sequence conflict

7 – 8

RE → LP in AAA92091. Ref.1

Sequence conflict

345

G → S in AAA92091. Ref.1

Sequence conflict

352

F → Y in AAA92091. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P54731 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 0DA48081312EFE8D
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FASTA

649

73,863

        10         20         30         40         50         60 
MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG ILQSDFGGET 

        70         80         90        100        110        120 
MPGPTFDPAS HPAPASTPSS SAFRPVMPSR QIVERQPRML DFRVEYRDRN VDVVLEDSCT 

       130        140        150        160        170        180 
VGEIKQILEN ELQIPVPKML LKGWKTGDVE DSTVLKSLHL PKNNSLYVLT PDLPPPSSSS 

       190        200        210        220        230        240 
HAGALQESLN QNFMLIITHR EVQREYNLNF SGSSTVQEVK RNVYDLTSIP VRHQLWEGWP 

       250        260        270        280        290        300 
ASATDDSMCL AESGLSYPCH RLTVGRRTSP VQTREQSEEQ STDVHMVSDS DGDDFEDASE 

       310        320        330        340        350        360 
FGVDDGEVFG MASSTLRKSP MMPENAENEG DALLQFTAEF SSRYGDCHPV FFIGSLEAAF 

       370        380        390        400        410        420 
QEAFYVKARD RKLLAIYLHH DESVLTNVFC SQMLCAESIV SYLSQNFITW AWDLTKDTNR 

       430        440        450        460        470        480 
ARFLTMCNRH FGSVIAQTIR TQKTDQFPLF LIIMGKRSSN EVLNVIQGNT TVDELMMRLM 

       490        500        510        520        530        540 
AAMEIFSAQQ QEDIKDEDER EARENVKREQ DEAYRLSLEA DRAKREAHER EMAEQFRLEQ 

       550        560        570        580        590        600 
IRKEQEEERE AIRLSLEQAL PPEPKEENAE PVSKLRIRTP SGEFLERRFL ASNKLQIVFD 

       610        620        630        640 
FVASKGFPWD EFKLLSTFPR RDVTQLDPNK SLLEVNLFPQ ETLFLQAKE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis." Chu K., Niu X., Williams L.T. Proc. Natl. Acad. Sci. U.S.A. 92:11894-11898(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[5]	"A differential phosphoproteomic analysis of retinoic acid-treated P19 cells." Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D. J. Proteome Res. 6:3174-3186(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-579, MASS SPECTROMETRY. Tissue: Teratocarcinoma.
[6]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U39643 mRNA. Translation: AAA92091.1. AL627188, AL627392 Genomic DNA. Translation: CAM13709.1. AL627392, AL627188 Genomic DNA. Translation: CAM16845.1. CH466527 Genomic DNA. Translation: EDL30696.1. BC065098 mRNA. Translation: AAH65098.1.
IPI	IPI00108791.
RefSeq	NP_032009.2. NM_007983.2.
UniGene	Mm.318259.
3D structure databases
ProteinModelPortal	P54731.
SMR	P54731. Positions 5-44, 98-190, 324-494, 568-649.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1513304.
STRING	10090.ENSMUSP00000099785.
PTM databases
PhosphoSite	P54731.
Proteomic databases
PaxDb	P54731.
PRIDE	P54731.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000102724; ENSMUSP00000099785; ENSMUSG00000010517.
GeneID	14084.
KEGG	mmu:14084.
UCSC	uc008uct.1. mouse.
Organism-specific databases
CTD	11124.
MGI	MGI:109419. Faf1.
Phylogenomic databases
eggNOG	NOG288188.
GeneTree	ENSGT00530000063422.
HOGENOM	HOG000043073.
HOVERGEN	HBG002876.
InParanoid	Q6P1F8.
OMA	RLLTMCT.
OrthoDB	EOG4229JC.
Gene expression databases
Bgee	P54731.
CleanEx	MM_FAF1.
Genevestigator	P54731.
GermOnline	ENSMUSG00000010517. Mus musculus.
Family and domain databases
InterPro	IPR006577. UAS. IPR001012. UBX. [Graphical view]
Pfam	PF00789. UBX. 1 hit. [Graphical view]
SMART	SM00594. UAS. 1 hit. SM00166. UBX. 1 hit. [Graphical view]
PROSITE	PS50030. UBA. False negative. PS50033. UBX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FAF1. mouse.
NextBio	285104.
SOURCE	Search...

Entry information

Entry name

FAF1_MOUSE

Accession

Primary (citable) accession number: P54731
Secondary accession number(s): Q6P1F8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents