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P54731 (FAF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FAS-associated factor 1
Gene names
Name:Faf1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length649 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potentiates but cannot initiate FAS-induced apoptosis.

Subunit structure

Interacts with NLRP12 DAPIN/PYRIN domain via its UBA domain By similarity. Specifically interacts with the cytoplasmic domain of FAS.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 1 UBA domain.

Contains 1 UBX domain.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentNucleus
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

cell death

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasmic sequestering of NF-kappaB

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Inferred from direct assay Ref.1. Source: MGI

positive regulation of protein complex assembly

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of cell adhesion

Inferred from mutant phenotype PubMed 11731229. Source: MGI

regulation of protein catabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentCdc48p-Npl4p-Ufd1p AAA ATPase complex

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 11731229. Source: MGI

cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

nuclear envelope

Inferred from direct assay PubMed 11731229. Source: MGI

nucleus

Inferred from sequence or structural similarity. Source: UniProtKB

perinuclear region of cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionheat shock protein binding

Inferred from sequence or structural similarity. Source: UniProtKB

protein binding

Inferred from physical interaction Ref.1. Source: MGI

protein domain specific binding

Inferred from physical interaction Ref.1. Source: MGI

protein kinase binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 649649FAS-associated factor 1
PRO_0000211039

Regions

Domain1 – 5757UBA
Domain568 – 64578UBX

Amino acid modifications

Modified residue3191Phosphoserine By similarity

Experimental info

Sequence conflict7 – 82RE → LP in AAA92091. Ref.1
Sequence conflict3451G → S in AAA92091. Ref.1
Sequence conflict3521F → Y in AAA92091. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P54731 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 0DA48081312EFE8D

FASTA64973,863
        10         20         30         40         50         60 
MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG ILQSDFGGET 

        70         80         90        100        110        120 
MPGPTFDPAS HPAPASTPSS SAFRPVMPSR QIVERQPRML DFRVEYRDRN VDVVLEDSCT 

       130        140        150        160        170        180 
VGEIKQILEN ELQIPVPKML LKGWKTGDVE DSTVLKSLHL PKNNSLYVLT PDLPPPSSSS 

       190        200        210        220        230        240 
HAGALQESLN QNFMLIITHR EVQREYNLNF SGSSTVQEVK RNVYDLTSIP VRHQLWEGWP 

       250        260        270        280        290        300 
ASATDDSMCL AESGLSYPCH RLTVGRRTSP VQTREQSEEQ STDVHMVSDS DGDDFEDASE 

       310        320        330        340        350        360 
FGVDDGEVFG MASSTLRKSP MMPENAENEG DALLQFTAEF SSRYGDCHPV FFIGSLEAAF 

       370        380        390        400        410        420 
QEAFYVKARD RKLLAIYLHH DESVLTNVFC SQMLCAESIV SYLSQNFITW AWDLTKDTNR 

       430        440        450        460        470        480 
ARFLTMCNRH FGSVIAQTIR TQKTDQFPLF LIIMGKRSSN EVLNVIQGNT TVDELMMRLM 

       490        500        510        520        530        540 
AAMEIFSAQQ QEDIKDEDER EARENVKREQ DEAYRLSLEA DRAKREAHER EMAEQFRLEQ 

       550        560        570        580        590        600 
IRKEQEEERE AIRLSLEQAL PPEPKEENAE PVSKLRIRTP SGEFLERRFL ASNKLQIVFD 

       610        620        630        640 
FVASKGFPWD EFKLLSTFPR RDVTQLDPNK SLLEVNLFPQ ETLFLQAKE 

« Hide

References

« Hide 'large scale' references
[1]"A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis."
Chu K., Niu X., Williams L.T.
Proc. Natl. Acad. Sci. U.S.A. 92:11894-11898(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U39643 mRNA. Translation: AAA92091.1.
AL627188, AL627392 Genomic DNA. Translation: CAM13709.1.
AL627392, AL627188 Genomic DNA. Translation: CAM16845.1.
CH466527 Genomic DNA. Translation: EDL30696.1.
BC065098 mRNA. Translation: AAH65098.1.
CCDSCCDS18468.1.
RefSeqNP_032009.2. NM_007983.2.
UniGeneMm.318259.

3D structure databases

ProteinModelPortalP54731.
SMRP54731. Positions 5-44, 98-190, 324-494, 568-649.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199588. 3 interactions.
IntActP54731. 1 interaction.
MINTMINT-1513304.
STRING10090.ENSMUSP00000099785.

PTM databases

PhosphoSiteP54731.

Proteomic databases

MaxQBP54731.
PaxDbP54731.
PRIDEP54731.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102724; ENSMUSP00000099785; ENSMUSG00000010517.
GeneID14084.
KEGGmmu:14084.
UCSCuc008uct.1. mouse.

Organism-specific databases

CTD11124.
MGIMGI:109419. Faf1.

Phylogenomic databases

eggNOGNOG288188.
GeneTreeENSGT00530000063422.
HOGENOMHOG000043073.
HOVERGENHBG002876.
InParanoidQ6P1F8.
OMAWEGWPAS.
OrthoDBEOG72NRPV.
TreeFamTF314172.

Gene expression databases

BgeeP54731.
CleanExMM_FAF1.
GenevestigatorP54731.

Family and domain databases

InterProIPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamPF00789. UBX. 1 hit.
[Graphical view]
SMARTSM00594. UAS. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 3 hits.
PROSITEPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAF1. mouse.
NextBio285104.
PROP54731.
SOURCESearch...

Entry information

Entry nameFAF1_MOUSE
AccessionPrimary (citable) accession number: P54731
Secondary accession number(s): Q6P1F8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot