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Protein

FAS-associated factor 1

Gene

Faf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Potentiates but cannot initiate FAS-induced apoptosis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated factor 1
Gene namesi
Name:Faf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:109419. Faf1.

Subcellular locationi

GO - Cellular componenti

  • Cdc48p-Npl4p-Ufd1p AAA ATPase complex Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: UniProtKB
  • nuclear envelope Source: MGI
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 649649FAS-associated factor 1PRO_0000211039Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei319 – 3191PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP54731.
PaxDbiP54731.
PRIDEiP54731.

PTM databases

PhosphoSiteiP54731.

Expressioni

Gene expression databases

BgeeiP54731.
CleanExiMM_FAF1.
GenevestigatoriP54731.

Interactioni

Subunit structurei

Interacts with NLRP12 DAPIN/PYRIN domain via its UBA domain (By similarity). Specifically interacts with the cytoplasmic domain of FAS.By similarity

Protein-protein interaction databases

BioGridi199588. 4 interactions.
IntActiP54731. 1 interaction.
MINTiMINT-1513304.
STRINGi10090.ENSMUSP00000099785.

Structurei

3D structure databases

ProteinModelPortaliP54731.
SMRiP54731. Positions 5-44, 98-190, 324-494, 568-649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5757UBAAdd
BLAST
Domaini568 – 64578UBXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 UBA domain.Curated
Contains 1 UBX domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG288188.
GeneTreeiENSGT00530000063422.
HOGENOMiHOG000043073.
HOVERGENiHBG002876.
InParanoidiP54731.
OMAiVLSNVFC.
OrthoDBiEOG72NRPV.
TreeFamiTF314172.

Family and domain databases

InterProiIPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00594. UAS. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 3 hits.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P54731-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNMDREMI LADFQACTGI ENIDEAITLL EQNNWDLVAA INGVIPQENG
60 70 80 90 100
ILQSDFGGET MPGPTFDPAS HPAPASTPSS SAFRPVMPSR QIVERQPRML
110 120 130 140 150
DFRVEYRDRN VDVVLEDSCT VGEIKQILEN ELQIPVPKML LKGWKTGDVE
160 170 180 190 200
DSTVLKSLHL PKNNSLYVLT PDLPPPSSSS HAGALQESLN QNFMLIITHR
210 220 230 240 250
EVQREYNLNF SGSSTVQEVK RNVYDLTSIP VRHQLWEGWP ASATDDSMCL
260 270 280 290 300
AESGLSYPCH RLTVGRRTSP VQTREQSEEQ STDVHMVSDS DGDDFEDASE
310 320 330 340 350
FGVDDGEVFG MASSTLRKSP MMPENAENEG DALLQFTAEF SSRYGDCHPV
360 370 380 390 400
FFIGSLEAAF QEAFYVKARD RKLLAIYLHH DESVLTNVFC SQMLCAESIV
410 420 430 440 450
SYLSQNFITW AWDLTKDTNR ARFLTMCNRH FGSVIAQTIR TQKTDQFPLF
460 470 480 490 500
LIIMGKRSSN EVLNVIQGNT TVDELMMRLM AAMEIFSAQQ QEDIKDEDER
510 520 530 540 550
EARENVKREQ DEAYRLSLEA DRAKREAHER EMAEQFRLEQ IRKEQEEERE
560 570 580 590 600
AIRLSLEQAL PPEPKEENAE PVSKLRIRTP SGEFLERRFL ASNKLQIVFD
610 620 630 640
FVASKGFPWD EFKLLSTFPR RDVTQLDPNK SLLEVNLFPQ ETLFLQAKE
Length:649
Mass (Da):73,863
Last modified:July 27, 2011 - v2
Checksum:i0DA48081312EFE8D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 82RE → LP in AAA92091 (PubMed:8524870).Curated
Sequence conflicti345 – 3451G → S in AAA92091 (PubMed:8524870).Curated
Sequence conflicti352 – 3521F → Y in AAA92091 (PubMed:8524870).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39643 mRNA. Translation: AAA92091.1.
AL627188, AL627392 Genomic DNA. Translation: CAM13709.1.
AL627392, AL627188 Genomic DNA. Translation: CAM16845.1.
CH466527 Genomic DNA. Translation: EDL30696.1.
BC065098 mRNA. Translation: AAH65098.1.
CCDSiCCDS18468.1.
RefSeqiNP_032009.2. NM_007983.2.
UniGeneiMm.318259.

Genome annotation databases

EnsembliENSMUST00000102724; ENSMUSP00000099785; ENSMUSG00000010517.
GeneIDi14084.
KEGGimmu:14084.
UCSCiuc008uct.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39643 mRNA. Translation: AAA92091.1.
AL627188, AL627392 Genomic DNA. Translation: CAM13709.1.
AL627392, AL627188 Genomic DNA. Translation: CAM16845.1.
CH466527 Genomic DNA. Translation: EDL30696.1.
BC065098 mRNA. Translation: AAH65098.1.
CCDSiCCDS18468.1.
RefSeqiNP_032009.2. NM_007983.2.
UniGeneiMm.318259.

3D structure databases

ProteinModelPortaliP54731.
SMRiP54731. Positions 5-44, 98-190, 324-494, 568-649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199588. 4 interactions.
IntActiP54731. 1 interaction.
MINTiMINT-1513304.
STRINGi10090.ENSMUSP00000099785.

PTM databases

PhosphoSiteiP54731.

Proteomic databases

MaxQBiP54731.
PaxDbiP54731.
PRIDEiP54731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102724; ENSMUSP00000099785; ENSMUSG00000010517.
GeneIDi14084.
KEGGimmu:14084.
UCSCiuc008uct.1. mouse.

Organism-specific databases

CTDi11124.
MGIiMGI:109419. Faf1.

Phylogenomic databases

eggNOGiNOG288188.
GeneTreeiENSGT00530000063422.
HOGENOMiHOG000043073.
HOVERGENiHBG002876.
InParanoidiP54731.
OMAiVLSNVFC.
OrthoDBiEOG72NRPV.
TreeFamiTF314172.

Miscellaneous databases

ChiTaRSiFaf1. mouse.
NextBioi285104.
PROiP54731.
SOURCEiSearch...

Gene expression databases

BgeeiP54731.
CleanExiMM_FAF1.
GenevestigatoriP54731.

Family and domain databases

InterProiIPR012336. Thioredoxin-like_fold.
IPR006577. UAS.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF00789. UBX. 1 hit.
[Graphical view]
SMARTiSM00594. UAS. 1 hit.
SM00166. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF54236. SSF54236. 3 hits.
PROSITEiPS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis."
    Chu K., Niu X., Williams L.T.
    Proc. Natl. Acad. Sci. U.S.A. 92:11894-11898(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiFAF1_MOUSE
AccessioniPrimary (citable) accession number: P54731
Secondary accession number(s): Q6P1F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: May 27, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.